Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration
出版年份 2018 全文链接
标题
Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration
作者
关键词
-
出版物
Frontiers in Neuroscience
Volume 12, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2018-07-10
DOI
10.3389/fnins.2018.00466
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis
- (2018) Michael M. Gaschler et al. ACS Chemical Biology
- NEET Proteins: A New Link Between Iron Metabolism, Reactive Oxygen Species, and Cancer
- (2018) Ron Mittler et al. ANTIOXIDANTS & REDOX SIGNALING
- GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues
- (2018) Matilde Maiorino et al. ANTIOXIDANTS & REDOX SIGNALING
- Why should neuroscientists worry about iron? The emerging role of ferroptosis in the pathophysiology of neuroprogressive diseases
- (2018) Gerwyn Morris et al. BEHAVIOURAL BRAIN RESEARCH
- Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
- (2018) Irina Ingold et al. CELL
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- (2018) Lorenzo Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis
- (2018) Anja Jelinek et al. FREE RADICAL BIOLOGY AND MEDICINE
- Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease
- (2018) Russell H. Swerdlow JOURNAL OF ALZHEIMERS DISEASE
- Nexus between mitochondrial function, iron, copper and glutathione in Parkinson's disease
- (2018) Jeffrey R. Liddell et al. NEUROCHEMISTRY INTERNATIONAL
- The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
- (2018) Masayuki Yamamoto et al. PHYSIOLOGICAL REVIEWS
- Neuronal Cell Death
- (2018) Michael Fricker et al. PHYSIOLOGICAL REVIEWS
- Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair
- (2018) Wei Cai et al. PROGRESS IN NEUROBIOLOGY
- The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway
- (2018) Qiongyuan Hu et al. Cell Death & Disease
- Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review
- (2018) Sahar Sheykhansari et al. Cell Death & Disease
- Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System
- (2018) Jan Lewerenz et al. Frontiers in Neuroscience
- Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis
- (2018) Ron Shah et al. ACS Central Science
- Effect of delayed-release dimethyl fumarate on no evidence of disease activity in relapsing-remitting multiple sclerosis: integrated analysis of the phase III DEFINE and CONFIRM studies
- (2017) E. Havrdova et al. EUROPEAN JOURNAL OF NEUROLOGY
- TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway
- (2017) Diane Moujalled et al. HUMAN MOLECULAR GENETICS
- NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression
- (2017) Delin Chen et al. MOLECULAR CELL
- Tau-mediated iron export prevents ferroptotic damage after ischemic stroke
- (2017) Q-z Tuo et al. MOLECULAR PSYCHIATRY
- Ferroptosis and cell death mechanisms in Parkinson's disease
- (2017) Stephanie J. Guiney et al. NEUROCHEMISTRY INTERNATIONAL
- Collaborative Power of Nrf2 and PPARγ Activators against Metabolic and Drug-Induced Oxidative Injury
- (2017) Choongho Lee Oxidative Medicine and Cellular Longevity
- Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis
- (2017) Marietta Zille et al. STROKE
- Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells
- (2017) Farhan Basit et al. Cell Death & Disease
- The oxido-metabolic driver ATF4 enhances temozolamide chemo-resistance in human gliomas
- (2017) Daishi Chen et al. Oncotarget
- Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
- (2017) Z Fan et al. Oncogenesis
- BID links ferroptosis to mitochondrial cell death pathways
- (2017) Sandra Neitemeier et al. Redox Biology
- Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis
- (2017) Jong-Lyel Roh et al. Redox Biology
- Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration
- (2017) William Sealy Hambright et al. Redox Biology
- The KEAP1–NRF2 System in Cancer
- (2017) Keiko Taguchi et al. Frontiers in Oncology
- Oxidative Stress Induced by Lipid Peroxidation Is Related with Inflammation of Demyelination and Neurodegeneration in Multiple Sclerosis
- (2017) Pin Wang et al. EUROPEAN NEUROLOGY
- Increased Iron and Free Radical Generation in Preclinical Alzheimer Disease and Mild Cognitive Impairment
- (2017) Mark A. Smith et al. JOURNAL OF ALZHEIMERS DISEASE
- The Roles of NRF2 in Modulating Cellular Iron Homeostasis
- (2017) Michael John Kerins et al. ANTIOXIDANTS & REDOX SIGNALING
- CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation
- (2016) Hua Yuan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Identification of ACSL4 as a biomarker and contributor of ferroptosis
- (2016) Hua Yuan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis
- (2016) Xiaofang Sun et al. HEPATOLOGY
- Role of iron in neurodegenerative diseases
- (2016) Kai Li et al. JOURNAL OF NEURAL TRANSMISSION
- Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics
- (2016) Abdel A. Belaidi et al. JOURNAL OF NEUROCHEMISTRY
- Nuclear factor erythroid-derived 2-like 2 (NFE2L2, Nrf2) mediates exercise-induced mitochondrial biogenesis and the anti-oxidant response in mice
- (2016) Troy L. Merry et al. JOURNAL OF PHYSIOLOGY-LONDON
- Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib
- (2016) Aline Houessinon et al. Molecular Cancer
- Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
- (2016) Valerian E Kagan et al. Nature Chemical Biology
- ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
- (2016) Sebastian Doll et al. Nature Chemical Biology
- Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC
- (2016) Bruce Do Van et al. NEUROBIOLOGY OF DISEASE
- Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
- (2016) Wan Seok Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis
- (2016) Yue-Qi Wang et al. Frontiers in Aging Neuroscience
- A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis
- (2016) Tanja Krainz et al. ACS Central Science
- Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death
- (2015) Scott J. Dixon et al. ACS Chemical Biology
- Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update
- (2015) Melissa A. Bradley-Whitman et al. ARCHIVES OF TOXICOLOGY
- The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis
- (2015) Yang Liu et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- The emerging role of Nrf2 in mitochondrial function
- (2015) Albena T. Dinkova-Kostova et al. FREE RADICAL BIOLOGY AND MEDICINE
- Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
- (2015) Xiaofang Sun et al. HEPATOLOGY
- Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis
- (2015) Liuji Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of Ferroptotic Cancer Cell Death by GPX4
- (2014) Wan Seok Yang et al. CELL
- PMI: A ΔΨm Independent Pharmacological Regulator of Mitophagy
- (2014) Daniel A. East et al. CHEMISTRY & BIOLOGY
- The role of lipid peroxidation in neurological disorders
- (2014) Mototada Shichiri JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
- Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models
- (2014) Rachid Skouta et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
- (2014) Jose Pedro Friedmann Angeli et al. NATURE CELL BIOLOGY
- Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration
- (2014) Scott Ayton et al. Biomed Research International
- Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease
- (2013) David Devos et al. ANTIOXIDANTS & REDOX SIGNALING
- Novel Hematopoietic Target Genes in the NRF2-Mediated Transcriptional Pathway
- (2013) Michelle R. Campbell et al. Oxidative Medicine and Cellular Longevity
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain
- (2012) Si-Eun Yoo et al. FREE RADICAL BIOLOGY AND MEDICINE
- Iron Accumulation in Deep Cortical Layers Accounts for MRI Signal Abnormalities in ALS: Correlating 7 Tesla MRI and Pathology
- (2012) Justin Y. Kwan et al. PLoS One
- Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles
- (2011) Abena S. Agyeman et al. BREAST CANCER RESEARCH AND TREATMENT
- Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis
- (2011) Arie Neymotin et al. FREE RADICAL BIOLOGY AND MEDICINE
- Glutathione Peroxidase 4 Is Required for Maturation of Photoreceptor Cells
- (2011) Takashi Ueta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Decreased glutathione accelerates neurological deficit and mitochondrial pathology in familial ALS-linked hSOD1G93A mice model
- (2011) Marcelo R. Vargas et al. NEUROBIOLOGY OF DISEASE
- Mitochondrial dysfunction in ALS
- (2011) Mauro Cozzolino et al. PROGRESS IN NEUROBIOLOGY
- Beneficial Role of Nrf2 in Regulating NADPH Generation and Consumption
- (2011) Kai Connie Wu et al. TOXICOLOGICAL SCIENCES
- Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington’s disease mice
- (2010) Junghee Lee et al. ACTA NEUROPATHOLOGICA
- Nrf2-regulated PPARγ Expression Is Critical to Protection against Acute Lung Injury in Mice
- (2010) Hye-Youn Cho et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- The role of PARP activation in glutamate-induced necroptosis in HT-22 cells
- (2010) Xingshun Xu et al. BRAIN RESEARCH
- Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter
- (2010) S. Marro et al. HAEMATOLOGICA
- Brain mitochondria from rats treated with sulforaphane are resistant to redox-regulated permeability transition
- (2010) Tiffany Greco et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Lipid Oxidation and Peroxidation in CNS Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities
- (2009) Rao Muralikrishna Adibhatla et al. ANTIOXIDANTS & REDOX SIGNALING
- Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death
- (2008) Alexander Seiler et al. Cell Metabolism
- Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1
- (2008) Claude A. Piantadosi et al. CIRCULATION RESEARCH
- PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria
- (2008) Shih-Ching Lo et al. EXPERIMENTAL CELL RESEARCH
- Structural basis for the activation of PPARγ by oxidized fatty acids
- (2008) Toshimasa Itoh et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started