G protein–coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog
出版年份 2018 全文链接
标题
G protein–coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog
作者
关键词
-
出版物
Science Signaling
Volume 11, Issue 516, Pages eaao5749
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2018-02-08
DOI
10.1126/scisignal.aao5749
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- An essential role for Grk2 in Hedgehog signalling downstream of Smoothened
- (2016) Zhonghua Zhao et al. EMBO REPORTS
- Smoothened determines β-arrestin–mediated removal of the G protein–coupled receptor Gpr161 from the primary cilium
- (2016) Kasturi Pal et al. JOURNAL OF CELL BIOLOGY
- Structural basis of Smoothened regulation by its extracellular domains
- (2016) Eamon F. X. Byrne et al. NATURE
- Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics
- (2016) Bryn S. Moore et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
- (2016) Giovanni Luchetti et al. eLife
- Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma
- (2015) Scott X. Atwood et al. CANCER CELL
- Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma
- (2015) Hayley J. Sharpe et al. CANCER CELL
- Ciliary adenylyl cyclases control the Hedgehog pathway
- (2015) L. Vuolo et al. JOURNAL OF CELL SCIENCE
- Inactivation of a Gα s –PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis
- (2015) Ramiro Iglesias-Bartolome et al. NATURE CELL BIOLOGY
- G-protein-coupled receptors and localized signaling in the primary cilium during ventral neural tube patterning
- (2014) Sun-Hee Hwang et al. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
- A Predictive Model of Bifunctional Transcription Factor Signaling during Embryonic Tissue Patterning
- (2014) Jan Philipp Junker et al. DEVELOPMENTAL CELL
- EFCAB7 and IQCE Regulate Hedgehog Signaling by Tethering the EVC-EVC2 Complex to the Base of Primary Cilia
- (2014) Ganesh V. Pusapati et al. DEVELOPMENTAL CELL
- Mapping the Putative G Protein-coupled Receptor (GPCR) Docking Site on GPCR Kinase 2
- (2014) Alexandre Beautrait et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma
- (2014) Xuelian He et al. NATURE MEDICINE
- Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling
- (2014) Pawel Niewiadomski et al. Cell Reports
- In Vitro Generation of Neuromesodermal Progenitors Reveals Distinct Roles for Wnt Signalling in the Specification of Spinal Cord and Paraxial Mesoderm Identity
- (2014) Mina Gouti et al. PLOS BIOLOGY
- Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists
- (2013) James Kim et al. CANCER CELL
- The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling
- (2013) Saikat Mukhopadhyay et al. CELL
- Structural insights into G protein-coupled receptor kinase function
- (2013) Kristoff T Homan et al. CURRENT OPINION IN CELL BIOLOGY
- Morphogen interpretation: the transcriptional logic of neural tube patterning
- (2013) Michael Cohen et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Neuropilin-2 contributes to tumorigenicity in a mouse model of Hedgehog pathway medulloblastoma
- (2013) Melanie G. Hayden Gephart et al. JOURNAL OF NEURO-ONCOLOGY
- Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification
- (2013) Jean B Regard et al. NATURE MEDICINE
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Mechanistic Differences in the Transcriptional Interpretation of Local and Long-Range Shh Morphogen Signaling
- (2012) Tony Oosterveen et al. DEVELOPMENTAL CELL
- GRK2: multiple roles beyond G protein-coupled receptor desensitization
- (2012) Tama Evron et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Gli Proteins in Development and Disease
- (2011) Chi-chung Hui et al. Annual Review of Cell and Developmental Biology
- Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube
- (2011) M. Tuson et al. DEVELOPMENT
- Sonic Hedgehog-induced Proliferation Requires Specific Gα Inhibitory Proteins
- (2011) Mercedes Barzi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors
- (2011) D. M. Thal et al. MOLECULAR PHARMACOLOGY
- G protein-coupled receptor kinases: More than just kinases and not only for GPCRs
- (2011) Eugenia V. Gurevich et al. PHARMACOLOGY & THERAPEUTICS
- Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened
- (2011) Yongbin Chen et al. PLOS BIOLOGY
- Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance
- (2010) Gerrit J. P. Dijkgraaf et al. CANCER RESEARCH
- The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
- (2010) E. W. Humke et al. GENES & DEVELOPMENT
- G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila
- (2010) Y. Chen et al. GENES & DEVELOPMENT
- A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes
- (2010) Hanna Tukachinsky et al. JOURNAL OF CELL BIOLOGY
- Role of the Amino Terminus of G Protein-Coupled Receptor Kinase 2 in Receptor Phosphorylation
- (2009) Christina S. Pao et al. BIOCHEMISTRY
- Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
- (2009) R. L. Yauch et al. SCIENCE
- Establishing and Interpreting Graded Sonic Hedgehog Signaling during Vertebrate Neural Tube Patterning: The Role of Negative Feedback
- (2009) V. Ribes et al. Cold Spring Harbor Perspectives in Biology
- Smoothened Signaling in Vertebrates Is Facilitated by a G Protein-coupled Receptor Kinase
- (2008) Melanie Philipp et al. MOLECULAR BIOLOGY OF THE CELL
- G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling
- (2008) Stacey K. Ogden et al. NATURE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started