Treating cachexia using soluble ACVR2B improves survival, alters mTOR localization, and attenuates liver and spleen responses

Circulating monocyte chemoattractant protein-1 (MCP-1) is associated with cachexia in treatment-naïve pancreatic cancer patients

(2018) Erin E. Talbert et al.   Journal of Cachexia Sarcopenia and Muscle

Perioperative cytokine levels portend early death after pancreatectomy for ductal adenocarcinoma

(2017) Heather L. Lewis et al.   JOURNAL OF SURGICAL ONCOLOGY

Treatment of Sarcopenia with Bimagrumab: Results from a Phase II, Randomized, Controlled, Proof-of-Concept Study

(2017) Daniel Rooks et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy

(2017) Frederic Morvan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating Activin A predicts survival in cancer patients

(2017) Audrey Loumaye et al.   Journal of Cachexia Sarcopenia and Muscle

Ethical guidelines for publishing in the journal of cachexia, sarcopenia and muscle: update 2017

(2017) Stephan von Haehling et al.   Journal of Cachexia Sarcopenia and Muscle

The pathogenesis and treatment of cardiac atrophy in cancer cachexia

(2016) Kate T. Murphy   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia

(2016) Justin L. Chen et al.   CANCER RESEARCH

Physical Activity and Cancer Outcomes: A Precision Medicine Approach

(2016) C. M. Friedenreich et al.   CLINICAL CANCER RESEARCH

Impaired regeneration: A role for the muscle microenvironment in cancer cachexia

(2016) Erin E. Talbert et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Computed tomography-defined muscle and fat wasting are associated with cancer clinical outcomes

(2016) Seyyed Mohammad Reza Kazemi-Bajestani et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

High circulating activin A level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma

(2016) Mir Alireza Hoda et al.   Oncotarget

Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults

(2016) Steven C. Moore et al.   JAMA Internal Medicine

ActRII blockade protects mice from cancer cachexia and prolongs survival in the presence of anti-cancer treatments

(2016) Shinji Hatakeyama et al.   Skeletal Muscle

Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes

(2016) T. A. Nissinen et al.   Scientific Reports

Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival

(2015) Amelia J. Johnston et al.   CELL

Complete reversal of muscle wasting in experimental cancer cachexia: Additive effects of activin type II receptor inhibition and β-2 agonist

(2015) Míriam Toledo et al.   INTERNATIONAL JOURNAL OF CANCER

Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia

(2015) Yu-Chou Tseng et al.   JNCI-Journal of the National Cancer Institute

Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice

(2015) Heikki Kainulainen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Combination of exercise training and erythropoietin prevents cancer-induced muscle alterations

(2015) Fabrizio Pin et al.   Oncotarget

MAP3K11/GDF15 axis is a critical driver of cancer cachexia

(2015) Lorena Lerner et al.   Journal of Cachexia Sarcopenia and Muscle

Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia

(2015) Yu-Chou Tseng et al.   JNCI-Journal of the National Cancer Institute

Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine  -thalassemia

(2014) R. N. V. S. Suragani et al.   BLOOD

Novel Role for Tumor-Induced Expansion of Myeloid-Derived Cells in Cancer Cachexia

(2014) A. G. Cuenca et al.   JOURNAL OF IMMUNOLOGY

Validation of a method to measure total spontaneous physical activity of sedentary and voluntary running mice

(2014) M. Silvennoinen et al.   JOURNAL OF NEUROSCIENCE METHODS

Distinct Behaviour of Sorafenib in Experimental Cachexia-Inducing Tumours: The Role of STAT3

(2014) Míriam Toledo et al.   PLoS One

Exercise restores decreased physical activity levels and increases markers of autophagy and oxidative capacity in myostatin/activin-blocked mdx mice

(2013) Juha J. Hulmi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Diaphragm and ventilatory dysfunction during cancer cachexia

(2013) Brandon M. Roberts et al.   FASEB JOURNAL

Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis

(2013) Jeremy D. Waight et al.   JOURNAL OF CLINICAL INVESTIGATION

Erythropoietin administration partially prevents adipose tissue loss in experimental cancer cachexia models

(2013) Fabio Penna et al.   JOURNAL OF LIPID RESEARCH

The mechanical activation of mTOR signaling: an emerging role for late endosome/lysosomal targeting

(2013) Brittany L. Jacobs et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

BMP signaling controls muscle mass

(2013) Roberta Sartori et al.   NATURE GENETICS

Why cachexia kills: examining the causality of poor outcomes in wasting conditions

(2013) Kamyar Kalantar-Zadeh et al.   Journal of Cachexia Sarcopenia and Muscle

Muscle protein synthesis, mTORC1/MAPK/Hippo signaling, and capillary density are altered by blocking of myostatin and activins

(2012) Juha J. Hulmi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Importance of functional and metabolic impairments in the characterization of the C-26 murine model of cancer cachexia

(2012) K. T. Murphy et al.   Disease Models & Mechanisms

A single ascending-dose study of muscle regulator ace-031 in healthy volunteers

(2012) Kenneth M. Attie et al.   MUSCLE & NERVE

Understanding the mechanisms and treatment options in cancer cachexia

(2012) Kenneth Fearon et al.   Nature Reviews Clinical Oncology

Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice

(2011) B. L. Mundy-Bosse et al.   CANCER RESEARCH

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia

(2011) Andrea Bonetto et al.   PLoS One

Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response

(2011) Maria Antsiferova et al.   Nature Communications

Treating cancer cachexia to treat cancer

(2011) Se-Jin Lee et al.   Skeletal Muscle

Molecular, cellular and physiological characterization of the cancer cachexia-inducing C26 colon carcinoma in mouse

(2010) Paola Aulino et al.   BMC CANCER

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

(2010) Xiaolan Zhou et al.   CELL

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique

(2010) Craig A. Goodman et al.   FASEB JOURNAL

Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia

(2009) Margaret E. Benny Klimek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dietary supplementation with a specific combination of high protein, leucine and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

(2009) K van Norren et al.   BRITISH JOURNAL OF CANCER

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

Mechanisms of Cancer Cachexia

(2009) Michael J. Tisdale   PHYSIOLOGICAL REVIEWS

The role of cytokines in cancer cachexia

(2009) Josep M Argilés et al.   Current Opinion in Supportive and Palliative Care

Muscle myostatin signalling is enhanced in experimental cancer cachexia

(2008) P. Costelli et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Cachexia, survival and the acute phase response

(2008) Nathan A Stephens et al.   Current Opinion in Supportive and Palliative Care