The mechanical activation of mTOR signaling: an emerging role for late endosome/lysosomal targeting

Direct uptake and degradation of DNA by lysosomes

(2013) Yuuki Fujiwara et al.   Autophagy

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis

(2012) Kai Zhao et al.   JOURNAL OF LIPID RESEARCH

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

(2012) Christian C. Dibble et al.   MOLECULAR CELL

Understanding the mechanisms and treatment options in cancer cachexia

(2012) Kenneth Fearon et al.   Nature Reviews Clinical Oncology

Muscle Fiber Type-Dependent Differences in the Regulation of Protein Synthesis

(2012) Craig A. Goodman et al.   PLoS One

Mechanical Stimulation Induces mTOR Signaling via an ERK-Independent Mechanism: Implications for a Direct Activation of mTOR by Phosphatidic Acid

(2012) Jae Sung You et al.   PLoS One

Rheb1 Is Required for mTORC1 and Myelination in Postnatal Brain Development

(2011) Jia Zou et al.   DEVELOPMENTAL CELL

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle

(2011) Troy A. Hornberger   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect

(2011) Mee-Sup Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway

(2011) Mee-Sup Yoon et al.   JOURNAL OF CELL BIOLOGY

The role of skeletal muscle mTOR in the regulation of mechanical load-induced growth

(2011) Craig A. Goodman et al.   JOURNAL OF PHYSIOLOGY-LONDON

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Strength Training as a Countermeasure to Aging Muscle and Chronic Disease

(2011) Ben F. Hurley et al.   SPORTS MEDICINE

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes

(2010) Mitsunori Miyazaki et al.   FEBS Journal

The Late Endosome is Essential for mTORC1 Signaling

(2010) Rory J. Flinn et al.   MOLECULAR BIOLOGY OF THE CELL

A Phosphatidylinositol 3-Kinase/Protein Kinase B-independent Activation of Mammalian Target of Rapamycin Signaling Is Sufficient to Induce Skeletal Muscle Hypertrophy

(2010) Craig A. Goodman et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

Specific Activation of mTORC1 by Rheb G-proteinin VitroInvolves Enhanced Recruitment of Its Substrate Protein

(2009) Tatsuhiro Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role for LAMP-2 in endosomal cholesterol transport

(2009) Alexander Schneede et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis

(2009) Micah J. Drummond et al.   JOURNAL OF PHYSIOLOGY-LONDON

The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions

(2009) T. K. O’Neil et al.   JOURNAL OF PHYSIOLOGY-LONDON

Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway

(2009) Hui H. Zhang et al.   PLoS One

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Fast/Glycolytic Muscle Fiber Growth Reduces Fat Mass and Improves Metabolic Parameters in Obese Mice

(2008) Yasuhiro Izumiya et al.   Cell Metabolism

mVps34 is activated following high-resistance contractions

(2008) Matthew G. MacKenzie et al.   JOURNAL OF PHYSIOLOGY-LONDON

5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a Phospholipase D Pharmacological Inhibitor That Alters Cell Spreading and Inhibits Chemotaxis

(2008) W. Su et al.   MOLECULAR PHARMACOLOGY

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Phospholipase D1 is an effector of Rheb in the mTOR pathway

(2008) Y. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE