Sequential Multivariate Cell Culture Modeling at Multiple Scales Supports Systematic Shaping of a Monoclonal Antibody Toward a Quality Target

Monitoring Quality of Biotherapeutic Products Using Multivariate Data Analysis

(2016) Anurag S. Rathore et al.   AAPS Journal

Hybrid modeling as a QbD/PAT tool in process development: an industrial E. coli case study

(2016) Moritz von Stosch et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production

(2016) Thomas E. Matthews et al.   BIOTECHNOLOGY AND BIOENGINEERING

Process performance and product quality in an integrated continuous antibody production process

(2016) Daniel J. Karst et al.   BIOTECHNOLOGY AND BIOENGINEERING

Robust factor selection in early cell culture process development for the production of a biosimilar monoclonal antibody

(2016) Michael Sokolov et al.   BIOTECHNOLOGY PROGRESS

Controlling the time evolution of mAb N-linked glycosylation, Part I: Microbioreactor experiments

(2016) Thomas K. Villiger et al.   BIOTECHNOLOGY PROGRESS

High-throughput profiling of nucleotides and nucleotide sugars to evaluate their impact on antibody N-glycosylation

(2016) Thomas K. Villiger et al.   JOURNAL OF BIOTECHNOLOGY

Harnessing QbD, Programming Languages, and Automation for Reproducible Biology

(2016) Michael I. Sadowski et al.   TRENDS IN BIOTECHNOLOGY

Advanced process monitoring and feedback control to enhance cell culture process production and robustness

(2015) An Zhang et al.   BIOTECHNOLOGY AND BIOENGINEERING

A framework for real-time glycosylation monitoring (RT-GM) in mammalian cell culture

(2015) Tharmala Tharmalingam et al.   BIOTECHNOLOGY AND BIOENGINEERING

Fingerprint detection and process prediction by multivariate analysis of fed-batch monoclonal antibody cell culture data

(2015) Michael Sokolov et al.   BIOTECHNOLOGY PROGRESS

Screening and assessment of performance and molecule quality attributes of industrial cell lines across different fed-batch systems

(2015) Yolande Rouiller et al.   BIOTECHNOLOGY PROGRESS

Generic Raman-based calibration models enabling real-time monitoring of cell culture bioreactors

(2015) Hamidreza Mehdizadeh et al.   BIOTECHNOLOGY PROGRESS

Progress toward forecasting product quality and quantity of mammalian cell culture processes by performance-based modeling

(2015) Timo Schmidberger et al.   BIOTECHNOLOGY PROGRESS

Combining mechanistic and data-driven approaches to gain process knowledge on the control of the metabolic shift to lactate uptake in a fed-batch CHO process

(2015) Dénes Zalai et al.   BIOTECHNOLOGY PROGRESS

Tailoring recombinant protein quality by rational media design

(2015) David Brühlmann et al.   BIOTECHNOLOGY PROGRESS

Advanced Development Strategies for Biopharmaceutical Cell Culture Processes

(2015) Denes Zalai et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Sensor systems for bioprocess monitoring

(2015) Philipp Biechele et al.   ENGINEERING IN LIFE SCIENCES

Sequential/parallel production of potential Malaria vaccines – A direct way from single batch to quasi-continuous integrated production

(2015) Reiner Luttmann et al.   JOURNAL OF BIOTECHNOLOGY

End-to-end integrated fully continuous production of recombinant monoclonal antibodies

(2015) Rahul Godawat et al.   JOURNAL OF BIOTECHNOLOGY

White Paper on Continuous Bioprocessing May 20–21 2014 Continuous Manufacturing Symposium

(2015) Konstantin B. Konstantinov et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review

(2015) Levente L. Simon et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Control of galactosylated glycoforms distribution in cell culture system

(2014) Neil A. McCracken et al.   BIOTECHNOLOGY PROGRESS

Cross-scale predictive modeling of CHO cell culture growth and metabolites using Raman spectroscopy and multivariate analysis

(2014) Brandon Berry et al.   BIOTECHNOLOGY PROGRESS

Towards real-time monitoring of therapeutic protein quality in mammalian cell processes

(2014) Daniel A.M. Pais et al.   CURRENT OPINION IN BIOTECHNOLOGY

Evaluating the impact of cell culture process parameters on monoclonal antibody N-glycosylation

(2014) Marija Ivarsson et al.   JOURNAL OF BIOTECHNOLOGY

Mini-review: soft sensors as means for PAT in the manufacture of bio-therapeutics

(2014) Carl-Fredrik Mandenius et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Integrating systems analysis and control for implementing process analytical technology in bioprocess development

(2014) James Gomes et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Glucose concentration control of a fed-batch mammalian cell bioprocess using a nonlinear model predictive controller

(2014) Stephen Craven et al.   JOURNAL OF PROCESS CONTROL

Biopharmaceutical benchmarks 2014

(2014) Gary Walsh   NATURE BIOTECHNOLOGY

Overview of integrated models for bioprocess engineering

(2014) Ajoy Velayudhan   Current Opinion in Chemical Engineering

Application of dielectric spectroscopy for monitoring high cell density in monoclonal antibody producing CHO cell cultivations

(2013) László Párta et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Development of a scale down cell culture model using multivariate analysis as a qualification tool

(2013) Valerie Liu Tsang et al.   BIOTECHNOLOGY PROGRESS

A high-throughput media design approach for high performance mammalian fed-batch cultures

(2013) Yolande Rouiller et al.   mAbs

Towards better understanding of an industrial cell factory: investigating the feasibility of real-time metabolic flux analysis in Pichia pastoris

(2013) Mariana L Fazenda et al.   Microbial Cell Factories

Quality attributes of recombinant therapeutic proteins: An assessment of impact on safety and efficacy as part of a quality by design development approach

(2012) Alex Eon-Duval et al.   BIOTECHNOLOGY PROGRESS

Single-use disposable technologies for biopharmaceutical manufacturing

(2012) Abhinav A. Shukla et al.   TRENDS IN BIOTECHNOLOGY

Chemometrics applications in biotech processes: Assessing process comparability

(2011) Nitish Bhushan et al.   BIOTECHNOLOGY PROGRESS

At-line NIR spectroscopy as effective PAT monitoring technique in Mab cultivations during process development and manufacturing

(2011) Christian Hakemeyer et al.   TALANTA

High-throughput process development for biopharmaceutical drug substances

(2011) Rahul Bhambure et al.   TRENDS IN BIOTECHNOLOGY

Glycan labeling strategies and their use in identification and quantification

(2010) L. R. Ruhaak et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A review of advanced small-scale parallel bioreactor technology for accelerated process development: Current state and future need

(2010) Rachel Bareither et al.   BIOTECHNOLOGY PROGRESS

Cross-validation of component models: A critical look at current methods

(2008) R. Bro et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Application of Multivariate Data Analysis for Identification and Successful Resolution of a Root Cause for a Bioprocessing Application

(2008) A.O. Kirdar et al.   BIOTECHNOLOGY PROGRESS

Identifying Inhibitory Threshold Values of Repressing Metabolites in CHO Cell Culture Using Multivariate Analysis Methods

(2008) Z. Xing et al.   BIOTECHNOLOGY PROGRESS