期刊
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
卷 90, 期 4, 页码 583-589出版社
WILEY
DOI: 10.1002/jctb.4591
关键词
PAT; monitoring; system analysis; control; bioprocesses; process development
This paper provides a perspective on the increasingly critical role that systems analysis and process control play in bioprocess development today. This is of particular importance to the manufacturers of biotech therapeutics since the product quality is critical and depends on the process and its control. Because a large number of process variables and raw materials can influence the overall outcome of a bioprocess, the correct determination of the process trajectory is often an intensive exercise. A follow-up involving design of a suitable process control strategy for implementation of process conditions would be logical. However, such an exercise can no longer consider each unit operation one at a time but rather requires holistic inclusion of all upstream and downstream unit operations for successfully meeting the global standards laid down by various regulatory agencies by exploring the potential of process analytical technology (PAT) to achieve bigger objectives. In this perspective, the focus is on the core issues associated with process integration and how these may influence future process development. (c) 2014 Society of Chemical Industry
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据