Article
Engineering, Electrical & Electronic
Nurul Izni Rusli, Irene Pia Vincentini, Frederik Ceyssens, Michael Kraft
Summary: This paper presents a feasibility study on integrating multiple biosensors on a single chip, including amperometric, potentiometric, and impedimetric detection techniques, as well as physical sensors. The fabricated sensors showed good performance, such as linear working range and fast response time, indicating a promising step towards realizing a real-time measurement platform for bioprocesses.
IEEE SENSORS JOURNAL
(2021)
Review
Biotechnology & Applied Microbiology
Jonathan C. Moore, Itzel Ramos, Stephen Van Dien
Summary: This article discusses the optimization strategy of separating growth and production in dual-phase fermentation through synthetic biology strategies, and provides practical examples and recommendations for reliable scaling to commercial production.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Philippe Nimmegeers, Dominique Vercammen, Satyajeet Bhonsale, Filip Logist, Jan Van Impe
Summary: Bioprocesses are used to produce high added value products, which are complex and governed by intricate mechanisms. Current bioprocess control solely focuses on material balances, missing opportunities to operate more sustainably with available process knowledge. This article presents a metabolic network-based model predictive control method, utilizing a combined moving horizon-model predictive control strategy to optimize bioprocesses.
APPLIED SCIENCES-BASEL
(2021)
Review
Biochemical Research Methods
Izabella Surowiec, Jochen Scholz
Summary: Biocapacitance measurement, a widely used technique for monitoring bioprocesses involving living cells, has evolved from the food industry to the biopharma industry. With the shift in biopharma towards new therapies like virus-based and cell-based treatments, biocapacitance measurement has also entered this field, presenting new opportunities for process development and control. The authors believe that future advancements and applications of biocapacitance measurement will further enhance the understanding and improve monitoring and control of bioprocesses.
CURRENT OPINION IN BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Fangxu Jia, Chenyu Liu, Xingcheng Zhao, Jiayi Chen, Ziyan Zhang, Hong Yao
Summary: The study evaluates the feasibility of using pH, conductivity, and oxidation reduction potential profiles for monitoring and controlling the anammox process in synthetic wastewater treatment. The results show that these parameter profiles have high accuracy and reproducibility in indicating the endpoint of the anammox reaction. Positive correlations are found between TN removal and Delta pH, Delta Cond, and Delta ORP. The slope of the conductivity curve is significantly linearly correlated with the specific anammox activity, making it a useful immediate feedback signal for inhibiting anammox activity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Automation & Control Systems
Qihang Fang, Gang Xiong, MengChu Zhou, Tariku Sinshaw Tamir, Chao-Bo Yan, Huaiyu Wu, Zhen Shen, Fei-Yue Wang
Summary: Additive manufacturing is a novel and flexible production technology, but open-loop control methods cannot ensure its reliability and repeatability. This paper proposes an AM control framework that addresses the issues of defect detection, fault diagnosis, and closed-loop control, and summarizes the measurement requirements and future challenges.
IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING
(2022)
Article
Mathematics
Marta Benkova, Dagmar Bednarova, Gabriela Bogdanovska, Marcela Pavlickova
Summary: This study aims to assess the possibilities of using different types of control charts depending on the nature of the process and provide a tool to help operators monitor coking time. An autoregressive nature of the variable being monitored was considered and three traditional control charts along with a dynamic EWMA control chart were used. The advantage of the dynamic EWMA control chart is that it works with directly measured coking time data.
Article
Chemistry, Multidisciplinary
Chien-Hua Lin, Ming-Che Lu, Su-Fen Yang, Ming-Yung Lee
Summary: This article discusses the applicability of using a Bayesian method to construct an exponentially weighted moving average control chart for monitoring variance in a service process, showing that the method can quickly detect changes in process variance.
APPLIED SCIENCES-BASEL
(2021)
Article
Automation & Control Systems
Josh A. Taylor, Alain Rapaport, Denis Dochain
Summary: This paper optimizes a general model of bioprocesses and proposes a convex relaxation method to efficiently solve the problem of microbial growth in biochemical reactors. The feasibility and accuracy of the model are verified through numerical experiments.
IEEE TRANSACTIONS ON AUTOMATIC CONTROL
(2022)
Article
Automation & Control Systems
Mohammad Shamsuzzaman, Salah Haridy, Ahmed Maged, Hamdi Bashir, Ahm Shamsuzzoha, Ahad Ali
Summary: One major source of environmental pollution is industrial effluents, especially zinc pollutants in wastewater. Continuous and effective monitoring of zinc in industrial effluents is essential for safeguarding water quality. However, real-life environmental data often do not follow normal distribution, making it challenging to use traditional statistical monitoring techniques. This study proposes an optimal X scheme for monitoring non-normal zinc data in industrial effluents, minimizing costs and ensuring the monitoring scheme's accuracy.
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
(2022)
Review
Biochemical Research Methods
Ines F. Pinto, Saara Mikkonen, Leila Josefsson, Meeri E-L Makinen, Ruben R. G. Soares, Aman Russom, Asa Emmer, Veronique Chotteau
Summary: This review discusses the importance of deep knowledge and control of a larger panel of culture components in mammalian cell cultures for process optimization, control, and robustness. It highlights key advances in microfluidic affinity assays and microchip capillary electrophoresis for the miniaturization and integration of Process Analytical Technology. The article also introduces a comprehensive toolbox of discrete analytical components that can potentially support the translation of mature microfluidic technologies towards novel applications.
CURRENT OPINION IN BIOTECHNOLOGY
(2021)
Article
Mathematics, Applied
Tsen- Kuo, Tung-Lin Chuang
Summary: Process capability index is a useful tool for evaluating process quality and ensuring product quality. This study developed control charts to differentiate between accuracy and precision. The advantage of using these charts is the ability to monitor both process quality and capability.
Article
Engineering, Chemical
Mantas Butkus, Donatas Levisauskas, Vytautas Galvanauskas
Summary: An adaptive control system is proposed for set-point control and disturbance rejection of biotechnological-process parameters. Using a gain scheduling algorithm, PID (PI) controller parameters are adjusted based on input/output signals, showing robust behavior and outperforming conventional controllers in simulation experiments.
Article
Energy & Fuels
Ivo Havlik, Sascha Beutel, Thomas Scheper, Kenneth F. Reardon
Summary: Microalgae are promising sources of fuels and chemicals. Efficient process control for microalgal cultivations requires on-line sensing of process variables. Optical sensors play a central role in monitoring the physical and chemical environment, while on-line sensors for biological variables are still in an earlier developmental stage and rely on indirect measurement and extensive data processing.
Article
Microbiology
Luca Torello Pianale, Peter Rugbjerg, Lisbeth Olsson
Summary: This study developed a versatile and easy-to-use toolbox, which includes fluorescent biosensors that can sense the yeast intracellular environment. These biosensors were evaluated using an advanced micro-cultivation system, and it was found that they did not significantly affect key physiological parameters. The toolbox can be used to explore yeast diversity and physiological responses in natural and complex industrial conditions.
FRONTIERS IN MICROBIOLOGY
(2022)
