Cardiovascular disease: The rise of the genetic risk score

Informed Consent

(2017) Christine Grady et al.   NEW ENGLAND JOURNAL OF MEDICINE

First things first: risk model performance metrics should reflect the clinical application

(2017) Kathleen F. Kerr et al.   STATISTICS IN MEDICINE

Feasibility of Obtaining Measures of Lifestyle From a Smartphone App

(2017) Michael V. McConnell et al.   JAMA Cardiology

Genetic Predisposition to High Blood Pressure and Lifestyle Factors

(2017) Raha Pazoki et al.   CIRCULATION

Recent Update to the US Cholesterol Treatment Guidelines

(2016) Matthew Nayor et al.   CIRCULATION

A randomized study of multimedia informational aids for research on medical practices: Implications for informed consent

(2016) Stephanie A Kraft et al.   Clinical Trials

The ASCVD Risk Estimator App

(2016) Ty J. Gluckman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetics: Implications for Prevention and Management of Coronary Artery Disease

(2016) Themistocles L. Assimes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

(2016) Chunyu Liu et al.   NATURE GENETICS

Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease

(2016) Amit V. Khera et al.   NEW ENGLAND JOURNAL OF MEDICINE

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Clinical Interpretation and Implications of Whole-Genome Sequencing

(2014) Frederick E. Dewey et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example

(2014) Benjamin A. Goldstein et al.   Frontiers in Genetics

Multilocus Genetic Risk Scores for Coronary Heart Disease Prediction

(2013) Andrea Ganna et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults

(2013) Neil J. Stone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A note on the evaluation of novel biomarkers: do not rely on integrated discrimination improvement and net reclassification index

(2013) Jørgen Hilden et al.   STATISTICS IN MEDICINE

Genetics and Cardiovascular Disease

(2012) Euan A. Ashley et al.   CIRCULATION

Randomized Trial of Personal Genomics for Preventive Cardiology

(2012) Joshua W. Knowles et al.   Circulation-Cardiovascular Genetics

What makes UK Biobank special?

(2012) Rory Collins   LANCET

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

Impact of Coronary Computed Tomographic Angiography Results on Patient and Physician Behavior in a Low-Risk Population

(2011) John W. McEvoy   ARCHIVES OF INTERNAL MEDICINE

Long-term Effects of Carotid Screening on Patient Outcomes and Behaviors

(2011) Heather M. Johnson   ARCHIVES OF INTERNAL MEDICINE

Effect of Direct-to-Consumer Genomewide Profiling to Assess Disease Risk

(2011) Cinnamon S. Bloss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence

(2011) Frederick E. Dewey et al.   PLoS Genetics

Genetic Risk Reclassification for Type 2 Diabetes by Age Below or Above 50 Years Using 40 Type 2 Diabetes Risk Single Nucleotide Polymorphisms

(2010) J. M. de Miguel-Yanes et al.   DIABETES CARE

Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population

(2010) B. Fontaine-Bisson et al.   DIABETOLOGIA

A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses

(2010) Samuli Ripatti et al.   LANCET

Clinical assessment incorporating a personal genome

(2010) Euan A Ashley et al.   LANCET

Rare Variants Create Synthetic Genome-Wide Associations

(2010) Samuel P. Dickson et al.   PLOS BIOLOGY

An agenda for personalized medicine

(2009) Pauline C. Ng et al.   NATURE

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Keeping Pace with the Times — The Genetic Information Nondiscrimination Act of 2008

(2008) Kathy L. Hudson et al.   NEW ENGLAND JOURNAL OF MEDICINE