Article
Physiology
Alba Maestro-Benedicto, Mercedes Rivas-Lasarte, Juan Fernandez-Martinez, Laura Lopez-Lopez, Eduard Sole-Gonzalez, Vicens Brossa, Sonia Mirabet, Eulalia Roig, Juan Cinca, Jesus Alvarez-Garcia, Alessandro Sionis
Summary: Adding lung ultrasound (LUS) evaluation at discharge can improve the predictive value of most contemporary heart failure (HF) risk scores.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Respiratory System
Mohsen Sadatsafavi, Amin Adibi, Milo Puhan, Andrea Gershon, Shawn D. Aaron, Don D. Sin
Summary: Decision curve analysis is a novel method for quantifying the net benefit of a risk prediction model, providing a way to answer the critical question of clinical utility.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Kirsty McDowell, Ross Campbell, Joanne Simpson, Jonathan W. Cunningham, Akshay S. Desai, Pardeep S. Jhund, Martin P. Lefkowitz, Jean L. Rouleau, Karl Swedberg, Michael R. Zile, Scott D. Solomon, Milton Packer, John J. V. McMurray
Summary: This study investigated the improvement in risk prediction of heart failure by adding candidate biomarkers to comprehensive models with routinely collected clinical and laboratory variables. Four biomarkers (hs-TnT, GDF-15, cystatin C, and TIMP-1) were independently associated with all outcomes. However, only hs-TnT remained an independent predictor of the three endpoints when all biomarkers were added simultaneously to the PREDICT-HF model. Individually or in combination, the other biomarkers did not significantly improve discrimination or reclassification of prediction.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Betul Toprak, Stephanie Brandt, Jan Brederecke, Francesco Gianfagna, Julie K. K. Vishram-Nielsen, Francisco M. Ojeda, Simona Costanzo, Christin S. Borschel, Stefan Soderberg, Ioannis Katsoularis, Stephan Camen, Erkki Vartiainen, Maria Benedetta Donati, Jukka Kontto, Martin Bobak, Ellisiv B. Mathiesen, Allan Linneberg, Wolfgang Koenig, Maja-Lisa Lochen, Augusto Di Castelnuovo, Stefan Blankenberg, Giovanni de Gaetano, Kari Kuulasmaa, Veikko Salomaa, Licia Iacoviello, Teemu Niiranen, Tanja Zeller, Renate B. Schnabel
Summary: The study aims to find reliable circulating predictors for incident atrial fibrillation (AF) using classical regressions and machine learning techniques. Fourteen routinely available biomarkers reflecting different pathophysiological pathways were examined in relation to incident AF. NT-proBNP was identified as the strongest blood-based predictor of incident AF.
Article
Biology
Aki Koivu, Mikko Sairanen, Antti Airola, Tapio Pahikkala, Wing-cheong Leung, Tsz-kin Lo, Daljit Singh Sahota
Summary: The article introduces an adaptive risk prediction system (ARPS) that considers changing characteristics and automatically deploys updated risk models. Utilizing 8 years of real-life Down syndrome screening data, the study developed a method for detecting distribution shifts and a probabilistic risk modeling system that adapts to new data.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Review
Clinical Neurology
Andrew J. Vickers, Ford Holland
Summary: Decision curve analysis is a valuable method for evaluating the clinical value of prediction models in orthopedics. By comparing the net benefit and threshold probability of prediction models, their clinical value can be determined. Decision curves help draw conclusions on the clinical value of prediction models.
Article
Public, Environmental & Occupational Health
Zhe Xu, Matthew Arnold, Luanluan Sun, David Stevens, Ryan Chung, Samantha Ip, Jessica Barrett, Stephen Kaptoge, Lisa Pennells, Emanuele Di Angelantonio, Angela M. Wood
Summary: Incorporating variability of risk factors from electronic health records improves cardiovascular disease (CVD) risk discrimination for individuals with type 2 diabetes.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Health Care Sciences & Services
Tommi Tervonen, Thibaud Prawitz, Gin Nie Chua, Johanna Hyacinthe, Cathy Anne Pinto
Summary: This study aimed to assess the impact of patient preferences on the net clinical benefit of antiplatelet therapy for the secondary prevention of cardiovascular complications. The findings suggest that patient preference weighting can have a significant effect on the net clinical benefit and should be considered in personalized benefit-risk assessments.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ruilin Quan, Shian Huang, Lingpin Pang, Jieyan Shen, Weifeng Wu, Fangming Tang, Xiulong Zhu, Weiqing Su, Jingzhi Sun, Zaixin Yu, Lemin Wang, Xianyang Zhu, Changming Xiong, Jianguo He
Summary: This study aimed to explore outcome correlates and evaluate the incremental prognostic value of pulmonary hemodynamics for risk prediction in patients with pulmonary hypertension due to left heart disease (PH-LHD). The results showed that diastolic pressure gradient and mixed venous oxygen saturation were the most strongly associated hemodynamic predictors with mortality, and their inclusion in the risk prediction models improved the predictive ability.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
K. Roseberry, H. Le-Niculescu, D. F. Levey, R. Bhagar, K. Soe, J. Rogers, S. Palkowitz, N. Pina, W. A. Anastasiadis, S. S. Gill, S. M. Kurian, A. Shekhar, A. B. Niculescu
Summary: Anxiety disorders are prevalent and have a negative impact on people's lives. Lack of objective tests results in underdiagnosis and inadequate treatment, leading to adverse events and addictions. In this study, we identified blood biomarkers for anxiety and found potential medications for treatment.
MOLECULAR PSYCHIATRY
(2023)
Article
Sport Sciences
Garrett S. Bullock, Ellen Shanley, Charles A. Thigpen, Nigel K. Arden, Thomas K. Noonan, Michael J. Kissenberth, Douglas J. Wyland, Gary S. Collins
Summary: This study aimed to perform temporal recalibration on a previously developed injury prediction model and assess its performance in professional baseball pitchers. The results showed that the recalibrated model demonstrated the best discrimination and R-square, indicating improved accuracy in predicting arm injuries in professional baseball players.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2023)
Article
Statistics & Probability
Hani Samawi, Ding-Geng Chen, Ferdous Ahmed, Jing Kersey
Summary: This paper introduces innovative post-test diagnostic accuracy measures and a new cut-point selection criterion based on the expected relative net benefit. Our approach does not depend on the disease's prevalence, maximizing net benefit and reducing the clinical consequences of the diagnostic errors.
COMMUNICATIONS IN STATISTICS-THEORY AND METHODS
(2023)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Surgery
Prapaporn Noparatayaporn, Montarat Thavorncharoensap, Usa Chaikledkaew, Bhavani Shankara Bagepally, Ammarin Thakkinstian
Summary: This systematic review analyzed 28 full economic evaluation studies comparing bariatric surgery with usual care, finding that bariatric surgery is cost-effective for a mixed obesity group and those with diabetes in high-income countries.
Article
Computer Science, Information Systems
Uros Radenkovic, Marko Micovic, Zaharije Radivojevic
Summary: This paper evaluates the application of value prediction in instruction execution. Two models are introduced, one focusing on correctly predicted operands and the other allowing imprecisely predicted operands as long as the instruction results remain correct. Simulation experiments show that a model with imprecisely predicted operands, but still correct results, can achieve better execution time than a model with correctly predicted operands.
Article
Genetics & Heredity
J. S. Floyd, C. M. Sitlani, C. L. Avery, R. Noordam, X. Li, A. V. Smith, S. M. Gogarten, J. Li, L. Broer, D. S. Evans, S. Trompet, J. A. Brody, J. D. Stewart, J. D. Eicher, A. A. Seyerle, J. Roach, L. A. Lange, H. J. Lin, J. A. Kors, T. B. Harris, R. Li-Gao, N. Sattar, S. R. Cummings, K. L. Wiggins, M. D. Napier, T. Sturmer, J. C. Bis, K. F. Kerr, A. G. Uitterlinden, K. D. Taylor, D. J. Stott, R. de Mutsert, L. J. Launer, E. L. Busch, R. Mendez-Giraldez, N. Sotoodehnia, E. Z. Soliman, Y. Li, Q. Duan, F. R. Rosendaal, P. E. Slagboom, K. C. Wilhelmsen, A. P. Reiner, Y-Di Chen, S. R. Heckbert, R. C. Kaplan, K. M. Rice, J. W. Jukema, A. D. Johnson, Y. Liu, D. O. Mook-Kanamori, V. Gudnason, J. G. Wilson, J. I. Rotter, C. C. Laurie, B. M. Psaty, E. A. Whitsel, L. A. Cupples, B. H. Stricker
PHARMACOGENOMICS JOURNAL
(2018)
Article
Cardiac & Cardiovascular Systems
Amanda A. Seyerle, Henry J. Lin, Stephanie M. Gogarten, Adrienne Stilp, Raul Mendez Giraldez, Elsayed Soliman, Antoine Baldassari, Mariaelisa Graff, Susan Heckbert, Kathleen F. Kerr, Charles Kooperberg, Carlos Rodriguez, Xiuqing Guo, Jie Yao, Nona Sotoodehnia, Kent D. Taylor, Eric A. Whitsel, Jerome I. Rotter, Cathy C. Laurie, Christy L. Avery
Article
Genetics & Heredity
A. A. Seyerle, C. M. Sitlani, R. Noordam, S. M. Gogarten, J. Li, X. Li, D. S. Evans, F. Sun, M. A. Laaksonen, A. Isaacs, K. Kristiansson, H. M. Highland, J. D. Stewart, T. B. Harris, S. Trompet, J. C. Bis, G. M. Peloso, J. A. Brody, L. Broer, E. L. Busch, Q. Duan, A. M. Stilp, C. J. O'Donnell, P. W. Macfarlane, J. S. Floyd, J. A. Kors, H. J. Lin, R. Li-Gao, T. Sofer, R. Mendez-Giraldez, S. R. Cummings, S. R. Heckbert, A. Hofman, I Ford, Y. Li, L. J. Launer, K. Porthan, C. Newton-Cheh, M. D. Napier, K. F. Kerr, A. P. Reiner, K. M. Rice, J. Roach, B. M. Buckley, E. Z. Soliman, R. de Mutsert, N. Sotoodehnia, A. G. Uitterlinden, K. E. North, C. R. Lee, V Gudnason, T. Sturmer, F. R. Rosendaal, K. D. Taylor, K. L. Wiggins, J. G. Wilson, Y-D Chen, R. C. Kaplan, K. Wilhelmsen, L. A. Cupples, V Salomaa, C. van Duijn, J. W. Jukema, Y. Liu, D. O. Mook-Kanamori, L. A. Lange, R. S. Vasan, A. Smith, B. H. Stricker, C. C. Laurie, J. Rotter, E. A. Whitsel, B. M. Psaty, C. L. Avery
PHARMACOGENOMICS JOURNAL
(2018)
Article
Health Care Sciences & Services
Allison Meisner, Chirag R. Parikh, Kathleen F. Kerr
STATISTICAL METHODS IN MEDICAL RESEARCH
(2019)
Letter
Cardiac & Cardiovascular Systems
Kathleen F. Kerr, Heather R. Thiessen-Philbrook, Chirag R. Parikh
ANNALS OF THORACIC SURGERY
(2018)
Article
Psychiatry
Erin C. Dunn, Tamar Sofer, Min-Jung Wang, Thomas W. Soare, Linda C. Gallo, Stephanie M. Gogarten, Kathleen F. Kerr, Chia-Yen Chen, Murray B. Stein, Robert J. Ursano, Xiuqing Guo, Yucheng Jia, Jie Yao, Jerome Rotter, Maria Argos, Jianwen Cai, Krista Perreira, Sylvia Wassertheil-Smoller, Jordan W. Smoller
JOURNAL OF PSYCHIATRIC RESEARCH
(2018)
Article
Gastroenterology & Hepatology
George N. Ioannou, Pamela K. Green, Lauren A. Beste, Elijah J. Mun, Kathleen F. Kerr, Kristin Berry
JOURNAL OF HEPATOLOGY
(2018)
Article
Health Care Sciences & Services
Kathleen F. Kerr, Marshall D. Brown, Tracey L. Marsh, Holly Janes
MEDICAL DECISION MAKING
(2019)
Article
Anesthesiology
Shad B. Smith, Marc Parisien, Eric Bair, Inna Belfer, Anne-Julie Chabot-Dore, Pavel Gris, Samar Khoury, Shannon Tansley, Yelizaveta Torosyan, Dmitri Zaykin, Olaf Bernhardt, Priscila de Oliveira Serrano, Richard Gracely, Deepti Jain, Marjo-Riitta Jaervelin, Linda Kaste, Kathleen Kerr, Thomas Kocher, Raija Lahdesmaki, Nadia Laniado, Cathy Laurie, Cecelia Laurie, Minna Mannikko, Carolina Meloto, Andrea Nackley, Sarah Nelson, Paula Pesonen, Margarete Ribeiro-Dasilva, Celia Rizzatti-Barbosa, Anne Sanders, Christian Schwahn, Kirsi Sipila, Tamar Sofer, Alexander Teumer, Jeffrey Mogil, Roger Fillingim, Joel Greenspan, Richard Ohrbach, Gary Slade, William Maixner, Luda Diatchenko
Article
Gastroenterology & Hepatology
George N. Ioannou, Pamela Green, Kathleen F. Kerr, Kristin Berry
JOURNAL OF HEPATOLOGY
(2019)
Editorial Material
Health Care Sciences & Services
Kathleen F. Kerr, Tracey L. Marsh, Holly Janes
MEDICAL DECISION MAKING
(2019)
Article
Neurosciences
Tessandra Stewart, Min Shi, Aanchal Mehrotra, Patrick Aro, David Soltys, Kathleen E. Kerr, Cyrus P. Zabetian, Elaine R. Peskind, Peggy Taylor, Leslie M. Shaw, John Q. Trojanowski, Jing Zhang
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Multidisciplinary Sciences
Brenton R. Swenson, Tin Louie, Henry J. Lin, Raul Mendez-Giraldez, Jennifer E. Below, Cathy C. Laurie, Kathleen F. Kerr, Heather Highland, Timothy A. Thornton, Kelli K. Ryckman, Charles Kooperberg, Elsayed Z. Soliman, Amanda A. Seyerle, Xiuqing Guo, Kent D. Taylor, Jie Yao, Susan R. Heckbert, Dawood Darbar, Lauren E. Petty, Barbara McKnight, Susan Cheng, Natalie A. Bello, Eric A. Whitsel, Craig L. Hanis, Mike A. Nalls, Daniel S. Evans, Jerome I. Rotter, Tamar Sofer, Christy L. Avery, Nona Sotoodehnia
Article
Multidisciplinary Sciences
Tamar Sofer, Leslie Emery, Deepti Jain, Alicia M. Ellis, Cathy C. Laurie, Matthew A. Allison, Jiwon Lee, Nuzulul Kurniansyah, Kathleen F. Kerr, Hector M. Gonzalez, Wassim Tarraf, Michael H. Criqui, Leslie A. Lange, Walter R. Palmas, Nora Franceschini, Christina L. Wassel
SCIENTIFIC REPORTS
(2019)
Article
Urology & Nephrology
Kathleen F. Kerr, Eric R. Morenz, Jeremy Roth, Heather Thiessen-Philbrook, Steven G. Coca, Chirag R. Parikh
KIDNEY INTERNATIONAL REPORTS
(2019)