Inhibition of Cathepsins B Induces Neuroprotection Against Secondary Degeneration in Ipsilateral Substantia Nigra After Focal Cortical Infarction in Adult Male Rats

Protein kinase A mediates scopolamine-induced mTOR activation and an antidepressant response

(2018) Jianyang Dong et al.   JOURNAL OF AFFECTIVE DISORDERS

Restoring brain function after stroke — bridging the gap between animals and humans

(2017) Nick S. Ward   Nature Reviews Neurology

Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats

(2016) Yang Xu et al.   BRAIN RESEARCH BULLETIN

Inhibition of cathepsin B by caspase-3 inhibitors blocks programmed cell death in Arabidopsis

(2016) Y Ge et al.   CELL DEATH AND DIFFERENTIATION

A Direct Cortico-Nigral Pathway as Revealed by Constrained Spherical Deconvolution Tractography in Humans

(2016) Alberto Cacciola et al.   Frontiers in Human Neuroscience

Inhibition of Cathepsin B Alleviates Secondary Degeneration in Ipsilateral Thalamus After Focal Cerebral Infarction in Adult Rats

(2016) Xialin Zuo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Decoding post-stroke motor function from structural brain imaging

(2016) Jane M. Rondina et al.   NeuroImage-Clinical

Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease

(2015) Ana Serrano-Puebla et al.   Annals of the New York Academy of Sciences

Chronic stress exacerbates neuronal loss associated with secondary neurodegeneration and suppresses microglial-like cells following focal motor cortex ischemia in the mouse

(2015) Kimberley A. Jones et al.   BRAIN BEHAVIOR AND IMMUNITY

Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents

(2015) Jürgen Brojatsch et al.   CELL CYCLE

MRI Susceptibility Changes Suggestive of Iron Deposition in the Thalamus after Ischemic Stroke

(2015) Ellis S. van Etten et al.   CEREBROVASCULAR DISEASES

MRI Heralds Secondary Nigral Lesion after Brain Ischemia in Mice: A Secondary Time Window for Neuroprotection

(2015) Vincent Prinz et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of cathepsin B activity reduces apoptosis by preventing cytochrome c release from mitochondria in porcine parthenotes

(2015) Seon-Hyang KIM et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Beclin-1 Deficiency Alters Autophagosome Formation, Lysosome Biogenesis and Enhances Neuronal Vulnerability of HT22 Hippocampal Cells

(2015) J. Fekadu et al.   MOLECULAR NEUROBIOLOGY

Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate

(2015) Gregory Hook et al.   Frontiers in Neurology

The role of calpains in traumatic brain injury

(2014) Shuang Liu et al.   BRAIN INJURY

Inhibition of cysteine cathepsin B and L activation in astrocytes contributes to neuroprotection against cerebral ischemia via blocking the tBid-mitochondrial apoptotic signaling pathway

(2014) Min Xu et al.   GLIA

Hypoxia-Inducible Factor 1α Mediates Neuroprotection of Hypoxic Postconditioning Against Global Cerebral Ischemia

(2014) Tingna Zhu et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Treatment with CA-074Me, a Cathepsin B inhibitor, reduces lung interstitial inflammation and fibrosis in a rat model of polymyositis

(2014) Li Zhang et al.   LABORATORY INVESTIGATION

Lysosomal membrane permeabilization in cell death: Concepts and challenges

(2014) Urška Repnik et al.   MITOCHONDRION

Remote thalamic microstructural abnormalities related to cognitive function in ischemic stroke patients.

(2014) Marina Fernández-Andújar et al.   NEUROPSYCHOLOGY

Progressive Volume Loss and White Matter Degeneration in Cstb-Deficient Mice: A Diffusion Tensor and Longitudinal Volumetry MRI Study

(2014) Otto Manninen et al.   PLoS One

Tacrine induces apoptosis through lysosome- and mitochondria-dependent pathway in HepG2 cells

(2014) Chunpeng Gao et al.   TOXICOLOGY IN VITRO

Brain-wide map of efferent projections from rat barrel cortex

(2014) Izabela M. Zakiewicz et al.   Frontiers in Neuroinformatics

Lysosomal cell death at a glance

(2013) S. Aits et al.   JOURNAL OF CELL SCIENCE

Selective Neuronal Loss in Ischemic Stroke and Cerebrovascular Disease

(2013) Jean-Claude Baron et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebrolysin reduces amyloid-β deposits, apoptosis and autophagy in the thalamus and improves functional recovery after cortical infarction

(2013) Shihui Xing et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Cysteine Cathepsins in Neurological Disorders

(2013) Anja Pišlar et al.   MOLECULAR NEUROBIOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CA-074Me, a cathepsin B inhibitor, decreases APP accumulation and protects primary rat cortical neurons treated with okadaic acid

(2013) Kwangmin Cho et al.   NEUROSCIENCE LETTERS

At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy

(2013) Han-Ming Shen et al.   TRENDS IN BIOCHEMICAL SCIENCES

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

Lysosomal Membrane Permeabilization as a Key Player in Brain Ischemic Cell Death: a “Lysosomocentric” Hypothesis for Ischemic Brain Damage

(2013) Peter Lipton   Translational Stroke Research

Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction

(2012) Shihui Xing et al.   Autophagy

Loss of substance P and inflammation precede delayed neurodegeneration in the substantia nigra after cerebral ischemia

(2012) Beatriz Rodriguez-Grande et al.   BRAIN BEHAVIOR AND IMMUNITY

Nogo-A is associated with secondary degeneration of substantia nigra in hypertensive rats with focal cortical infarction

(2012) Fang Wang et al.   BRAIN RESEARCH

Secondary Neurodegeneration in Remote Regions After Focal Cerebral Infarction

(2012) Jian Zhang et al.   STROKE

Autophagosomes accumulation is associated with β-amyloid deposits and secondary damage in the thalamus after focal cortical infarction in hypertensive rats

(2011) Jian Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Inflammasome activation and IL-1β/IL-18 processing are influenced by distinct pathways in microglia

(2011) Richa Hanamsagar et al.   JOURNAL OF NEUROCHEMISTRY

Severe Global Cerebral Ischemia-Induced Programmed Necrosis of Hippocampal CA1 Neurons in Rat Is Prevented by 3-Methyladenine: A Widely Used Inhibitor of Autophagy

(2011) Jin-Ye Wang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Magnetic Resonance Imaging Investigation of Secondary Degeneration of the Mesencephalic Substantia Nigra After Cerebral Infarction

(2011) Yasuko Ohe et al.   Journal of Stroke & Cerebrovascular Diseases

Long-term changes in the ipsilateral substantia nigra after transient focal cerebral ischaemia in rats

(2010) Hiroto Uchida et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Reduction of β-Amyloid Deposits by γ-Secretase Inhibitor is Associated with the Attenuation of Secondary Damage in the Ipsilateral Thalamus and Sensory Functional Improvement after Focal Cortical Infarction in Hypertensive Rats

(2010) Yusheng Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Lysosomal rupture, necroapoptotic interactions and potential crosstalk between cysteine proteases in neurons shortly after focal ischemia

(2010) Münire Kilinc et al.   NEUROBIOLOGY OF DISEASE

Acute Corticospinal Tract Wallerian Degeneration Is Associated With Stroke Outcome

(2010) Giselle DeVetten et al.   STROKE

Induction of glioma apoptosis by microglia-secreted molecules: The role of nitric oxide and cathepsin B

(2009) So-Young Hwang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Endostatin expression in neurons during the early stage of cerebral ischemia is associated with neuronal apoptotic cell death in adult hypertensive rat model of stroke

(2009) Qinghua Hou et al.   BRAIN RESEARCH

Involvement of cathepsin B in the processing and secretion of interleukin-1β in chromogranin A-stimulated microglia

(2009) Kayo Terada et al.   GLIA

Corticospinal Tract Pre-Wallerian Degeneration

(2009) Trish Domi et al.   STROKE

Possible involvement of cathepsin B released by microglia in methylmercury-induced cerebellar pathological changes in the adult rat

(2008) Misao Sakamoto et al.   NEUROSCIENCE LETTERS

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE