Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role

A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression

(2017) Simon Grelet et al.   NATURE CELL BIOLOGY

PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion

(2016) Nils Halberg et al.   CANCER CELL

Retromer Sets a Trap for Endosomal Cargo Sorting

(2016) Ludger Johannes et al.   CELL

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

(2016) Xinping Yang et al.   CELL

RNA splicing, cell signaling, and response to therapies

(2016) Cherine Abou Faycal et al.   CURRENT OPINION IN ONCOLOGY

Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis

(2016) Hao Gu et al.   JOURNAL OF CLINICAL INVESTIGATION

A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation

(2016) Xinjian Li et al.   NATURE CELL BIOLOGY

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition

(2015) Eunhee Kim et al.   CANCER CELL

Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo

(2015) Cara Lunn Shirai et al.   CANCER CELL

GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules

(2015) Jen-Hsuan Wei et al.   CELL

AIF inhibits tumor metastasis by protecting PTEN from oxidation

(2015) S.-M. Shen et al.   EMBO REPORTS

The core spliceosome as target and effector of non-canonical ATM signalling

(2015) Maria Tresini et al.   NATURE

The spliceosome is a therapeutic vulnerability in MYC-driven cancer

(2015) Tiffany Y.-T. Hsu et al.   NATURE

MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

(2015) Cheryl M. Koh et al.   NATURE

Intron retention is a widespread mechanism of tumor-suppressor inactivation

(2015) Hyunchul Jung et al.   NATURE GENETICS

2016 update of the PRIDE database and its related tools

(2015) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Genomic functions of U2AF in constitutive and regulated splicing

(2015) Tongbin Wu et al.   RNA Biology

Widespread intron retention diversifies most cancer transcriptomes

(2015) Heidi Dvinge et al.   Genome Medicine

Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function

(2014) Antonella Papa et al.   CELL

Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers

(2014) Fran Supek et al.   CELL

Therapeutic Targeting of Cancers with Loss of PTEN Function

(2014) Lloye Dillon et al.   CURRENT DRUG TARGETS

Mechanisms for U2AF to define 3′ splice sites and regulate alternative splicing in the human genome

(2014) Changwei Shao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Splicing factor SRSF6 promotes hyperplasia of sensitized skin

(2014) Mads A Jensen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of genetic variants associated with alternative splicing using sQTLseekeR

(2014) Jean Monlong et al.   Nature Communications

Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas

(2013) Sebastian Bender et al.   CANCER CELL

Direct Competition between hnRNP C and U2AF65 Protects the Transcriptome from the Exonization of Alu Elements

(2013) Kathi Zarnack et al.   CELL

Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

(2012) Marcin Imielinski et al.   CELL

Lactate Dehydrogenase B Is Critical for Hyperactive mTOR-Mediated Tumorigenesis

(2011) X. Zha et al.   CANCER RESEARCH

Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner

(2011) Min Sup Song et al.   CELL

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

WWP2 is an E3 ubiquitin ligase for PTEN

(2011) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

(2011) Timothy A Graubert et al.   NATURE GENETICS

SomaticSF3B1Mutation in Myelodysplasia with Ring Sideroblasts

(2011) E. Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

SF3B1and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

(2011) Lili Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

PTEN Loss Compromises Homologous Recombination Repair in Astrocytes: Implications for Glioblastoma Therapy with Temozolomide or Poly(ADP-Ribose) Polymerase Inhibitors

(2010) B. McEllin et al.   CANCER RESEARCH

An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis

(2010) Michael J. Moore et al.   CELL

Phosphorylation mechanism and structure of serine-arginine protein kinases

(2010) Gourisankar Ghosh et al.   FEBS Journal

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

(2010) C. J. David et al.   GENES & DEVELOPMENT

Emerging New Roles of GM130, a cis-Golgi Matrix Protein, in Higher Order Cell Functions

(2010) Nobuhiro Nakamura   JOURNAL OF PHARMACOLOGICAL SCIENCES

PTEN Deficiency in Endometrioid Endometrial Adenocarcinomas Predicts Sensitivity to PARP Inhibitors

(2010) K. J. Dedes et al.   Science Translational Medicine

Downregulation of ANP32B, a novel substrate of caspase-3, enhances caspase-3 activation and apoptosis induction in myeloid leukemic cells

(2009) S.-M. Shen et al.   CARCINOGENESIS

GOLPH3 Bridges Phosphatidylinositol-4- Phosphate and Actomyosin to Stretch and Shape the Golgi to Promote Budding

(2009) Holly C. Dippold et al.   CELL

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Synthetic lethal targeting ofPTENmutant cells with PARP inhibitors

(2009) Ana M. Mendes-Pereira et al.   EMBO Molecular Medicine

Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping

(2009) Yuanchao Xue et al.   MOLECULAR CELL

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing

(2009) Celia J. Webby et al.   SCIENCE

The nuclear affairs of PTEN

(2008) S. M. Planchon et al.   JOURNAL OF CELL SCIENCE

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network

(2008) Min Sup Song et al.   NATURE

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS

PTEN: a new guardian of the genome

(2008) Y Yin et al.   ONCOGENE