Proteomic Dissection of Nanotopography-Sensitive Mechanotransductive Signaling Hubs that Foster Neuronal Differentiation in PC12 Cells

ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions

(2017) Mark A. Eckert et al.   JOURNAL OF CELL SCIENCE

Calpain-Mediated Proteolysis of Talin and FAK Regulates Adhesion Dynamics Necessary for Axon Guidance

(2017) Patrick C. Kerstein et al.   JOURNAL OF NEUROSCIENCE

Brorin is required for neurogenesis, gliogenesis, and commissural axon guidance in the zebrafish forebrain

(2017) Ayumi Miyake et al.   PLoS One

Stepping into the omics era: Opportunities and challenges for biomaterials science and engineering

(2016) Nathalie Groen et al.   Acta Biomaterialia

Regulation of neurogenesis by calcium signaling

(2016) Anna B. Toth et al.   CELL CALCIUM

Material Cues as Potent Regulators of Epigenetics and Stem Cell Function

(2016) Spencer W. Crowder et al.   Cell Stem Cell

Lamellipodial tension, not integrin/ligand binding, is the crucial factor to realise integrin activation and cell migration

(2016) Carsten Schulte et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Cluster-assembled cubic zirconia films with tunable and stable nanoscale morphology against thermal annealing

(2016) F. Borghi et al.   JOURNAL OF APPLIED PHYSICS

LAR protein tyrosine phosphatase regulates focal adhesions through CDK1

(2016) Adil R. Sarhan et al.   JOURNAL OF CELL SCIENCE

Mouse mesenchymal stem cells inhibit high endothelial cell activation and lymphocyte homing to lymph nodes by releasing TIMP-1

(2016) L Zanotti et al.   LEUKEMIA

Directed migration of cancer cells guided by the graded texture of the underlying matrix

(2016) JinSeok Park et al.   NATURE MATERIALS

ERp57 in neurodegeneration and regeneration

(2016) Claudio Hetz et al.   Neural Regeneration Research

2016 update of the PRIDE database and its related tools

(2016) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

(2016) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Scale Invariant Disordered Nanotopography Promotes Hippocampal Neuron Development and Maturation with Involvement of Mechanotransductive Pathways

(2016) Carsten Schulte et al.   Frontiers in Cellular Neuroscience

Mammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain Function

(2016) Carla Garza-Lombó et al.   Frontiers in Cellular Neuroscience

Conversion of nanoscale topographical information of cluster-assembled zirconia surfaces into mechanotransductive events promotes neuronal differentiation

(2016) Carsten Schulte et al.   JOURNAL OF NANOBIOTECHNOLOGY

Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits

(2016) Valentina Zamboni et al.   Scientific Reports

A guide to mechanobiology: Where biology and physics meet

(2015) Karin A. Jansen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Insights into the regulation of neuronal viability by nucleophosmin/B23

(2015) Jason A Pfister et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Nanomanufacturing of titania interfaces with controlled structural and functional properties by supersonic cluster beam deposition

(2015) Alessandro Podestà et al.   JOURNAL OF APPLIED PHYSICS

Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling To Enhance Neurite Outgrowth in Developing Neurons

(2015) Matthew R. Cohen et al.   MOLECULAR AND CELLULAR BIOLOGY

Full length talin stimulates integrin activation and axon regeneration

(2015) Chin Lik Tan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

YAP is essential for tissue tension to ensure vertebrate 3D body shape

(2015) Sean Porazinski et al.   NATURE

E-cadherin junctions as active mechanical integrators in tissue dynamics

(2015) Thomas Lecuit et al.   NATURE CELL BIOLOGY

Inhibition of Nischarin Expression Promotes Neurite Outgrowth through Regulation of PAK Activity

(2015) Yuemin Ding et al.   PLoS One

RNA ligation in neurons by RtcB inhibits axon regeneration

(2015) Sara Guckian Kosmaczewski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging properties of adhesion complexes: what are they and what do they do?

(2015) Jonathan D. Humphries et al.   TRENDS IN CELL BIOLOGY

Mechanochemical regulation of growth cone motility

(2015) Patrick C. Kerstein et al.   Frontiers in Cellular Neuroscience

The epitranscriptome in modulating spatiotemporal RNA translation in neuronal post-synaptic function

(2015) Shobbir Hussain et al.   Frontiers in Cellular Neuroscience

Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling

(2015) Joseph Robertson et al.   Nature Communications

VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function

(2015) Fu-Lei Tang et al.   Cell Reports

A new look at sodium channel   subunits

(2015) S. Namadurai et al.   Open Biology

Nanotopographical surfaces for stem cell fate control: Engineering mechanobiology from the bottom

(2015) Weiqiang Chen et al.   Nano Today

Inhibitory Mechanism of FAT4 Gene Expression in Response to Actin Dynamics during Src-Induced Carcinogenesis

(2015) Takao Ito et al.   PLoS One

Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration

(2015) Valentina Castillo et al.   PLoS One

p600/UBR4 in the central nervous system

(2014) Kari Parsons et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

AHNAK: The giant jack of all trades

(2014) T.A. Davis et al.   CELLULAR SIGNALLING

Regulation of Neuronal Migration by Dchs1-Fat4 Planar Cell Polarity

(2014) Sana Zakaria et al.   CURRENT BIOLOGY

The GRIP1/14-3-3 Pathway Coordinates Cargo Trafficking and Dendrite Development

(2014) Julia C. Geiger et al.   DEVELOPMENTAL CELL

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

(2014) S. Blanco et al.   EMBO JOURNAL

RNA Protein Granules ModulatetauIsoform Expression and Induce Neuronal Sprouting

(2014) Katharina Moschner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency of GDNF Receptor GFR 1 in Alzheimer's Neurons Results in Neuronal Death

(2014) Y. Konishi et al.   JOURNAL OF NEUROSCIENCE

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

(2014) Matthew J. Paszek et al.   NATURE

Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate

(2014) Matthew J. Dalby et al.   NATURE MATERIALS

Endostatin Is a Trans-Synaptic Signal for Homeostatic Synaptic Plasticity

(2014) Tingting Wang et al.   NEURON

Aberrant Neural Stem Cell Proliferation and Increased Adult Neurogenesis in Mice Lacking Chromatin Protein HMGB2

(2014) Ariel B. Abraham et al.   PLoS One

GRIP1 interlinks N-cadherin and AMPA receptors at vesicles to promote combined cargo transport into dendrites

(2014) Frank F. Heisler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth

(2014) H.-E. Hsia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionarily Dynamic Alternative Splicing of GPR56 Regulates Regional Cerebral Cortical Patterning

(2014) B.-I. Bae et al.   SCIENCE

High Mobility Group Nucleosome-Binding Family Proteins Promote Astrocyte Differentiation of Neural Precursor Cells

(2014) Motoshi Nagao et al.   STEM CELLS

How voltage-gated calcium channels gate forms of homeostatic synaptic plasticity

(2014) C. Andrew Frank   Frontiers in Cellular Neuroscience

Neuronal Signaling through Endocytosis

(2014) K. E. Cosker et al.   Cold Spring Harbor Perspectives in Biology

Nuclear functions of prefoldin

(2014) G. Millan-Zambrano et al.   Open Biology

Materiomics: An -omicsApproach to Biomaterials Research

(2013) Steven W. Cranford et al.   ADVANCED MATERIALS

Biophysical Cues and Cell Behavior: The Big Impact of Little Things

(2013) Joshua Z. Gasiorowski et al.   Annual Review of Biomedical Engineering

Mechanics in Neuronal Development and Repair

(2013) Kristian Franze et al.   Annual Review of Biomedical Engineering

Nuclear Receptor Coactivators: Master Regulators of Human Health and Disease

(2013) Subhamoy Dasgupta et al.   Annual Review of Medicine

The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties

(2013) Sophie Wiszniak et al.   DEVELOPMENTAL BIOLOGY

A Ca2+-dependent Mechanism of Neuronal Survival Mediated by the Microtubule-associated Protein p600

(2013) Camille Belzil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Lipin 1 and Charge on the Phosphatidic Acid Head Group Control Its Phosphatidic Acid Phosphatase Activity and Membrane Association

(2013) James M. Eaton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology

(2013) Venus Thomanetz et al.   JOURNAL OF CELL BIOLOGY

The role of integrin-linked kinase in the molecular architecture of focal adhesions

(2013) N. Elad et al.   JOURNAL OF CELL SCIENCE

Deficiency of G3BP1, the stress granules assembly factor, results in abnormal synaptic plasticity and calcium homeostasis in neurons

(2013) Sophie Martin et al.   JOURNAL OF NEUROCHEMISTRY

Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2

(2013) Emanuela Toffolo et al.   JOURNAL OF NEUROCHEMISTRY

Mechanosensitive TRPC1 Channels Promote Calpain Proteolysis of Talin to Regulate Spinal Axon Outgrowth

(2013) P. C. Kerstein et al.   JOURNAL OF NEUROSCIENCE

HMGN1 Modulates Nucleosome Occupancy and DNase I Hypersensitivity at the CpG Island Promoters of Embryonic Stem Cells

(2013) Tao Deng et al.   MOLECULAR AND CELLULAR BIOLOGY

Crosstalk between mTOR complexes

(2013) Jianling Xie et al.   NATURE CELL BIOLOGY

The microcephaly protein Asp regulates neuroepithelium morphogenesis by controlling the spatial distribution of myosin II

(2013) Maria A. Rujano et al.   NATURE CELL BIOLOGY

Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development

(2013) Silvia Cappello et al.   NATURE GENETICS

Biophysical regulation of epigenetic state and cell reprogramming

(2013) Timothy L. Downing et al.   NATURE MATERIALS

mTORC2 controls actin polymerization required for consolidation of long-term memory

(2013) Wei Huang et al.   NATURE NEUROSCIENCE

GPR56 Functions Together with α3β1 Integrin in Regulating Cerebral Cortical Development

(2013) Sung-Jin Jeong et al.   PLoS One

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

LAR-RPTPs: synaptic adhesion molecules that shape synapse development

(2013) Ji Won Um et al.   TRENDS IN CELL BIOLOGY

Nitric oxide synthase mediates PC12 differentiation induced by the surface topography of nanostructured TiO2

(2013) Margherita Tamplenizza et al.   JOURNAL OF NANOBIOTECHNOLOGY

Nanotopography Influences Adhesion, Spreading, and Self-Renewal of Human Embryonic Stem Cells

(2012) Weiqiang Chen et al.   ACS Nano

Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration

(2012) Yichang Jia et al.   CELL

Inside-out, outside-in, and inside–outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction

(2012) Bo Shen et al.   CURRENT OPINION IN CELL BIOLOGY

Rab14 and Its Exchange Factor FAM116 Link Endocytic Recycling and Adherens Junction Stability in Migrating Cells

(2012) Andrea Linford et al.   DEVELOPMENTAL CELL

Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4

(2012) S. S. Dhar et al.   GENES & DEVELOPMENT

Function and cancer genomics of FAT family genes

(2012) MASARU KATOH   INTERNATIONAL JOURNAL OF ONCOLOGY

Human High Temperature Requirement Serine Protease A1 (HTRA1) Degrades Tau Protein Aggregates

(2012) Annette Tennstaedt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative regulators of integrin activity

(2012) J. Pouwels et al.   JOURNAL OF CELL SCIENCE

Molecular force transduction by ion channels – diversity and unifying principles

(2012) Sergei Sukharev et al.   JOURNAL OF CELL SCIENCE

Cyclic AMP Response Element Modulator-1 (CREM-1) Involves in Neuronal Apoptosis after Traumatic Brain Injury

(2012) Xinmin Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Critical Role of GFR 1 in the Development and Function of the Main Olfactory System

(2012) C. Marks et al.   JOURNAL OF NEUROSCIENCE

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

(2012) Marlen Knobloch et al.   NATURE

ADF/Cofilin-Mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain

(2012) Kevin C. Flynn et al.   NEURON

Mechanical feedback between membrane tension and dynamics

(2012) Nils C. Gauthier et al.   TRENDS IN CELL BIOLOGY

The regulation of integrin function by divalent cations

(2012) Kun Zhang et al.   Cell Adhesion & Migration

VPS35 regulates developing mouse hippocampal neuronal morphogenesis by promoting retrograde trafficking of BACE1

(2012) C.-L. Wang et al.   Biology Open

The calcium: an early signal that initiates the formation of the nervous system during embryogenesis

(2012) Catherine Leclerc et al.   Frontiers in Molecular Neuroscience

CAMTA1, a 1p36 Tumor Suppressor Candidate, Inhibits Growth and Activates Differentiation Programs in Neuroblastoma Cells

(2011) K.-O. Henrich et al.   CANCER RESEARCH

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Role for Dpy-30 in ES Cell-Fate Specification by Regulation of H3K4 Methylation within Bivalent Domains

(2011) Hao Jiang et al.   CELL

Regulation of axonal outgrowth and pathfinding by integrin-ecm interactions

(2011) Jonathan P. Myers et al.   Developmental Neurobiology

ASPM regulates Wnt signaling pathway activity in the developing brain

(2011) J. J. Buchman et al.   GENES & DEVELOPMENT

ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility

(2011) Masao Maeda et al.   MOLECULAR BIOLOGY OF THE CELL

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

(2011) Jean-Cheng Kuo et al.   NATURE CELL BIOLOGY

Bridging membrane and cytoskeleton dynamics in the secretory and endocytic pathways

(2011) Mihaela Anitei et al.   NATURE CELL BIOLOGY

Normalization with genes encoding ribosomal proteins but not GAPDH provides an accurate quantification of gene expressions in neuronal differentiation of PC12 cells

(2010) Lihan Zhou et al.   BMC GENOMICS

Syntaxin-4 Defines a Domain for Activity-Dependent Exocytosis in Dendritic Spines

(2010) Matthew J. Kennedy et al.   CELL

Liprin-α1 affects the distribution of low-affinity β1 integrins and stabilizes their permanence at the cell surface

(2010) Claudia Asperti et al.   EXPERIMENTAL CELL RESEARCH

Regulation of cellular actin architecture by S100A10

(2010) M. Juliane Jung et al.   EXPERIMENTAL CELL RESEARCH

Src-dependent phosphorylation of ROCK participates in regulation of focal adhesion dynamics

(2010) H.-H. Lee et al.   JOURNAL OF CELL SCIENCE

Cell mechanics and the cytoskeleton

(2010) Daniel A. Fletcher et al.   NATURE

E3 Ligase Nedd4 Promotes Axon Branching by Downregulating PTEN

(2010) Jovana Drinjakovic et al.   NEURON

Neurite outgrowth from PC12 cells is enhanced by an inhibitor of mechanical channels

(2010) Philip A. Gottlieb et al.   NEUROSCIENCE LETTERS

G Protein Subunit G 13 Binds to Integrin  IIb 3 and Mediates Integrin "Outside-In" Signaling

(2010) H. Gong et al.   SCIENCE

Role of Syntaxin 4 in Activity-Dependent Exocytosis and Synaptic Plasticity in Hippocampal Neurons

(2010) P. Mohanasundaram et al.   Science Signaling

A New Form of Neurite Outgrowth Sustained by the Exocytosis of Enlargeosomes Expressed under the Control of REST

(2010) Carsten Schulte et al.   TRAFFIC

Basement membrane protein nidogen-1 shapes hippocampal synaptic plasticity and excitability

(2009) Anju Vasudevan et al.   HIPPOCAMPUS

Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells

(2009) Ellen J. Ezratty et al.   JOURNAL OF CELL BIOLOGY

Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum

(2009) B. J. McHugh et al.   JOURNAL OF CELL SCIENCE

Rapid neurite outgrowth in neurosecretory cells and neurons is sustained by the exocytosis of a cytoplasmic organelle, the enlargeosome

(2009) G. Racchetti et al.   JOURNAL OF CELL SCIENCE

Liprin- 1 promotes cell spreading on the extracellular matrix by affecting the distribution of activated integrins

(2009) C. Asperti et al.   JOURNAL OF CELL SCIENCE

Ran on tracks - cytoplasmic roles for a nuclear regulator

(2009) D. Yudin et al.   JOURNAL OF CELL SCIENCE

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1

(2009) Junyu Xu et al.   NATURE NEUROSCIENCE

A Role for SNAP25 in Internalization of Kainate Receptors and Synaptic Plasticity

(2009) Sanja Selak et al.   NEURON

Interplay of Cadherin-Mediated Cell Adhesion and Canonical Wnt Signaling

(2009) J. Heuberger et al.   Cold Spring Harbor Perspectives in Biology

HtrA1-dependent proteolysis of TGF-β controls both neuronal maturation and developmental survival

(2008) S Launay et al.   CELL DEATH AND DIFFERENTIATION

Thrombospondins: from structure to therapeutics

(2008) C. B. Carlson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Orphan G Protein-coupled Receptor GPR56 Regulates Neural Progenitor Cell Migration via a Gα12/13 and Rho Pathway

(2008) Tokuichi Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

80K-H Interacts with Inositol 1,4,5-Trisphosphate (IP3) Receptors and Regulates IP3-induced Calcium Release Activity

(2008) Katsuhiro Kawaai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin β1 is involved in the signaling of glial cell line-derived neurotrophic factor

(2008) Jun-Ping Cao et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Nischarin Inhibits LIM Kinase To Regulate Cofilin Phosphorylation and Cell Invasion

(2008) Y. Ding et al.   MOLECULAR AND CELLULAR BIOLOGY

Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia

(2008) S G Potkin et al.   MOLECULAR PSYCHIATRY

Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors

(2008) Clara L Essmann et al.   NATURE NEUROSCIENCE

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Role of Npm1 in proliferation, apoptosis and differentiation of neural stem cells

(2007) Yang Qing et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES