Review
Neurosciences
Jithin D. Nair, Kevin A. Wilkinson, Jeremy M. Henley, Jack R. Mellor
Summary: This article reviews the roles of kainate receptors in synaptic plasticity, focusing on their impact on postsynaptic signaling and presynaptic auto-receptor functions. It also explores the plasticity of kainate receptors themselves and their contribution to synaptic transmission plasticity.
Review
Neurosciences
Jeremy M. Henley, Jithin D. Nair, Richard Seager, Busra P. Yucel, Gavin Woodhall, Benjamin S. Henley, Karolina Talandyte, Hope I. Needs, Kevin A. Wilkinson
Summary: Epilepsy is caused by abnormal neuronal network activity. The review focuses on the role and regulation of kainate and AMPA receptors in seizure activity, discussing the impact of GluK2 and GluA2 subunits on their respective receptors' properties.
Review
Cell Biology
Huiqin Zhang, Xuefan Jiang, Lina Ma, Wei Wei, Zehui Li, Surui Chang, Jiayu Wen, Jiahui Sun, Hao Li
Summary: Synaptic dysfunction is closely related to Alzheimer's disease (AD), mainly due to the disruption caused by beta-amyloid (Aβ). Aβ disrupts glutamate receptors and mediates synaptic toxicity through multiple mechanisms. Synaptic dysfunction plays a critical role in cognitive impairment of AD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Qiongzhen Huang, Changlin Lian, Yaoyuan Dong, Huijun Zeng, Boyang Liu, Ningbo Xu, Zhenyan He, Hongbo Guo
Summary: SNAP25 is found to have decreased expression in glioma tissues and cell lines, correlating with poor prognosis. Overexpression of SNAP25 inhibits tumor growth by limiting glutamate metabolism, suppressing dendritic formation, and promoting metabolic inhibition of glioma cells. These findings suggest that SNAP25 could be a potential therapeutic target for glioma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Neurosciences
Baris Alten, Qiangjun Zhou, Ok-Ho Shin, Luis Esquivies, Pei-Yi Lin, K. Ian White, Ron Sun, Wendy K. Chung, Lisa M. Monteggia, Axel T. Brunger, Ege T. Kavalali
Summary: Recent studies have shown that mutations in the SNAP25 gene may cause developmental and epileptic encephalopathies, but the specific mechanisms are not yet clear. Research has found that mutations in SNAP25 can lead to related synaptic transmission phenotypes, but specific alterations in spontaneous neurotransmitter release are key factors in disease heterogeneity.
Article
Neurosciences
Kevin M. Manz, Jose C. Zepeda, Zack Zurawski, Heidi E. Hamm, Brad A. Grueter
Summary: The nucleus accumbens (NAc) plays a role in behaviors such as addiction and depression. G(i/o)-coupled G-protein-coupled receptors (GPCRs) at glutamatergic synapses onto medium spiny projection neurons (MSNs) regulate these behaviors. In this study, the authors investigated which G(i/o) systems in the NAc utilize G beta gamma-SNARE signaling to inhibit glutamatergic transmission. They found that SNAP25 contributes significantly to the actions of certain GPCRs in dampening glutamatergic transmission.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Cell Biology
Wenrui Qu, Baoming Yuan, Jun Liu, Qianqian Liu, Xi Zhang, Ranji Cui, Wei Yang, Bingjin Li
Summary: The role of GluA1-mediated synaptic plasticity in the early development of AD is well established, but the complex mechanisms involved are not fully understood. Deficits in synaptic plasticity are a central factor of AD etiology, and understanding the role of GluA1 and its regulatory mechanisms is crucial for developing disease-modifying therapies.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Rajesh Vinnakota, Surbhi Dhingra, Jyoti Kumari, Mohammed Yousuf Ansari, Ekta Shukla, Mayuri Dattatray Nerkar, Janesh Kumar
Summary: This study characterized the biochemical, biophysical, and functional properties of the purified extracellular domain of Neto1, revealing a conformation-dependent interaction with GluK2 receptors. Furthermore, the shape and conformation of Neto1-ECD seem to be altered by calcium ions, indicating a possible role in modulating Neto1 functions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Neurosciences
Huili Li, Junfa Li, Yun Guan, Yun Wang
Summary: Studies suggest that dysregulation of KA receptors may play a role in both peripheral and central sensitization in pain, as well as disrupt the finely-tuned process of glutamic acid transmission.
Article
Neurosciences
Sari E. Lauri, Maria Ryazantseva, Ester Orav, Aino Vesikansa, Tomi Taira
Summary: Kainate receptors play important roles in the developing brain, with altered expression potentially leading to changes in neural network connectivity and excitability, resulting in long-lasting alterations in behaviorally relevant circuits.
Review
Neurosciences
Sergio Valbuena, Juan Lerma
Summary: Synaptic plasticity, characterized as key processes allowing the brain to operate dynamically, involves various modulators including kainate receptors, which play an important role in regulating neurotransmitter release and bidirectionally modulating plasticity.
Article
Multidisciplinary Sciences
Christos Papantoniou, Ulrike Laugks, Julia Betzin, Cristina Capitanio, Jose Javier Ferrero, Jose Sanchez-Prieto, Susanne Schoch, Nils Brose, Wolfgang Baumeister, Benjamin H. H. Cooper, Cordelia Imig, Vladan Lucic
Summary: Synaptic vesicle tethering, priming, and neurotransmitter release require the coordinated action of multiple protein complexes. Using cryo-electron tomography, researchers simultaneously imaged presynaptic protein complexes and lipids in their native composition, conformation, and environment at molecular resolution. The findings suggest that sequential states of synaptic vesicles precede neurotransmitter release, with Munc13-containing bridges localizing vesicles close to the plasma membrane, constituting a primed state. Munc13 activation supports the transition to the primed state through vesicle tethering, while protein kinase C promotes the same transition by reducing vesicle interlinking. This study highlights the cellular function of an extended assembly comprising multiple molecularly diverse complexes.
Review
Biochemistry & Molecular Biology
Christian Bonansco, Waldo Cerpa, Nibaldo C. C. Inestrosa
Summary: Synaptic transmission requires precise regulation, and Wnt signaling has been implicated in various forms of synaptic plasticity. Understanding the functional role of cellular signaling pathways involved in brain development is possible through the analysis of synapses from an electrophysiological perspective. The application of quantal theory can help dissect the function of structural changes associated with the birth and maturation of synapses. This article focuses on the role of the Wnt signaling pathway in regulating glutamatergic synaptic transmission and the conversion of silent synapses into functional synapses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Jeffrey C. Watkins, Richard H. Evans, Alex Bayes, Sam A. Booker, Alasdair Gibb, Angela M. Mabb, Mark Mayer, Jack R. Mellor, Elek Molnar, Li Niu, Arturo Ortega, Yuriy Pankratov, David Ramos-Vicente, Ada Rodriguez-Campuzano, Antonio Rodriguez-Moreno, Lu-Yang Wang, Yu Tian Wang, Lonnie Wollmuth, David J. A. Wyllie, Min Zhuo, Bruno G. Frenguelli
Summary: The excerpt discusses a seminal review written by Jeff Watkins and Dick Evans in 1981 on excitatory amino acids and their receptors, providing compelling evidence for the role of EAAs as neurotransmitters in the nervous system. The research on EAAs has continued to thrive into the 21st Century, with EAAs and their receptors flourishing in various disciplines and clinical conditions.
Article
Biochemistry & Molecular Biology
Katharine E. McCann, Daniel J. Lustberg, Emma K. Shaughnessy, Kelly E. Carstens, Shannon Farris, Georgia M. Alexander, Daniel Radzicki, Meilan Zhao, Serena M. Dudek
Summary: Mineralocorticoid receptors in the brain, specifically in the CA2 region of the hippocampus, play a crucial role in regulating neuronal properties and behaviors associated with CA2. Experiments showed that modulation of MRs affected molecular markers, synaptic inputs, synaptic currents, social behavior, and responses to novelty in CA2.
MOLECULAR PSYCHIATRY
(2021)
Editorial Material
Neurosciences
J. Lerma
Editorial Material
Neurosciences
J. Lerma
Article
Multidisciplinary Sciences
Merce Izquierdo-Serra, Antoni Bautista-Barrufet, Ana Trapero, Aida Garrido-Charles, Ariadna Diaz-Tahoces, Nuria Camarero, Silvia Pittolo, Sergio Valbuena, Ariadna Perez-Jimenez, Marina Gay, Alejandro Garcia-Moll, Carles Rodriguez-Escrich, Juan Lerma, Pedro de la Villa, Eduardo Fernandez, Miquel A. . Pericas, Amadeu Llebaria, Pau Gorostiza
NATURE COMMUNICATIONS
(2016)
Article
Chemistry, Multidisciplinary
Michela Comune, Akhilesh Rai, Kiran K. Chereddy, Sandra Pinto, Sezin Aday, Andre F. Ferreira, Alessandra Zonari, Josephine Blersch, Rodrigo Cunha, Ricardo Rodrigues, Juan Lerma, Pedro N. Simoes, Veronique Preat, Lino Ferreira
JOURNAL OF CONTROLLED RELEASE
(2017)
Editorial Material
Neurosciences
Juan Lerma
Meeting Abstract
Clinical Neurology
V. Arora, M. I. Aller, J. Lerma
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Cell Biology
Ana P. Simoes, Carla G. Silva, Joana M. Marques, Daniela Pochmann, Lisiane O. Porciuncula, Sofia Ferreira, Jean P. Oses, Rui O. Beleza, Joana I. Real, Attila Kofalvi, Ben A. Bahr, Juan Lerma, Rodrigo A. Cunha, Ricardo J. Rodrigues
CELL DEATH & DISEASE
(2018)
Article
Cell Biology
Vineet Arora, Valeria Pecoraro, M. Isabel Aller, Celia Roman, Ana V. Paternain, Juan Lerma
Article
Multidisciplinary Sciences
Sergio Valbuena, Alvaro Garcia, Wilfrid Mazier, Ana Paternain, Juan Lerma
NATURE COMMUNICATIONS
(2019)
Review
Neurosciences
Sergio Valbuena, Juan Lerma
Summary: Synaptic plasticity, characterized as key processes allowing the brain to operate dynamically, involves various modulators including kainate receptors, which play an important role in regulating neurotransmitter release and bidirectionally modulating plasticity.
Review
Biochemical Research Methods
Amr Eed, Antonio Cerdan Cerda, Juan Lerma, Silvia De Santis
JOURNAL OF NEUROSCIENCE METHODS
(2020)
Article
Neurosciences
Sergio Valbuena, Juan Lerma
Summary: The article reviews the impact of changes in synaptic protein expression levels on brain disorders, highlighting the role of gene mutations in psychiatric disorders and Down syndrome. These mutations do not affect the receptors' properties, but instead alter subunit expression levels, leading to abnormal synaptic function and behavioral deficits associated with these disorders.
Meeting Abstract
Pharmacology & Pharmacy
A. Garrido-Charles, M. Izquierdo-Serra, A. Bautista-Barrufet, A. Trapero, A. Diaz-Tahoces, N. Camarero, S. Pittolo, S. Valbuena, A. Perez-Jimenez, M. Gay, A. Garcia-Moll, C. Rodriguez-Escrich, J. Lerma, P. de la Villa, E. Fernandez, M. A. Pericás, A. Llebaria, P. Gorostiza
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2017)