Review
Pathology
Sun-Ji Park, Chuang Li, Ying Maggie Chen
Summary: Maintaining Ca2+ homeostasis is crucial for cellular function and survival, with the endoplasmic reticulum acting as the major intracellular Ca2+ store. Dysregulation of ER Ca2+ homeostasis is associated with various diseases, particularly in kidney diseases, highlighting the importance of ER Ca2+ channels, pumps, and binding proteins. Despite advancements in understanding, treatment for ER Ca2+ imbalance in kidney diseases remains elusive.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Biophysics
Victor Nicolai Friedhoff, Benjamin Lindner, Martin Falcke
Summary: This article investigates the randomness and properties of Ca2+ signaling in cells. The researchers found that the generation of Ca2+ spikes follows certain patterns and can be described as a process from one state to another. They proposed a theoretical model to explain the differences in spike behavior between different cell types and stimulating agonists, as well as the variability observed in experiments.
BIOPHYSICAL JOURNAL
(2023)
Article
Cell Biology
Arthur Bassot, Junsheng Chen, Kei Takahashi-Yamashiro, Megan C. Yap, Christine Silvia Gibhardt, Giang N. T. Le, Saaya Hario, Yusuke Nasu, Jack Moore, Tomas Gutierrez, Lucas Mina, Heather Mast, Audric Moses, Rakesh Bhat, Klaus Ballanyi, Helene Lemieux, Roberto Sitia, Ester Zito, Ivan Bogeski, Robert E. Campbell, Thomas Simmen
Summary: Endoplasmic reticulum (ER) homeostasis relies on molecular regulators, such as calnexin and NOX4, to maintain mitochondrial metabolism and ER-mitochondria contacts. During ER stress induction, the PERK-ERO1a complex interacts and promotes oxidation of MERC proteins, controlling mitochondrial dynamics and improving ER-mitochondria Ca2+ flux for bioenergetics maintenance. This complex plays a crucial role in quick metabolic adaptation to ER stress.
Article
Cell Biology
Ana M. Rossi, Andrew M. Riley, Genevieve Dupont, Taufiq Rahman, Barry V. L. Potter, Colin W. Taylor
Summary: Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are intracellular Ca2+ channels linking extracellular stimuli to Ca2+ signals. Research shows that quantal responses to low IP3 concentrations do not require heterogeneous Ca2+ stores, and IP(3)Rs exhibit incremental responses to IP3 stimulation. This suggests that Ca2+ signals evoked by IP3 pulses arise from rapid activation and inactivation of a small fraction of IP(3)Rs.
Article
Multidisciplinary Sciences
Nagendra Babu Thillaiappan, Holly A. Smith, Peace Atakpa-Adaji, Colin W. Taylor
Summary: The study demonstrates that the KRas-induced KRAP protein tethers a subset of IP3 receptors to actin, enabling them to evoke calcium signals. Loss of KRAP results in the disappearance of Ca2+ puffs and a global response to increased cytosolic Ca2+ concentration from more intense stimulation.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Iqbal Dulloo, Peace Atakpa-Adaji, Yi-Chun Yeh, Clemence Levet, Sonia Muliyil, Fangfang Lu, Colin W. Taylor, Matthew Freeman
Summary: This study reveals that iRhom pseudoproteases regulate cell death by modulating the inhibitory interaction between BCL-2 and IP3 receptors. Loss of iRhoms leads to resistance to ER stress-induced apoptosis. This finding extends the potential pathological significance of iRhoms to diseases dependent on protein misfolding and aggregation.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Kyle E. Harvey, Emily K. LaVigne, Mohd Saleem Dar, Amy E. Salyer, Evan P. S. Pratt, Paxton A. Sample, Uma Aryal, Humaira Gowher, Gregory H. Hockerman
Summary: The role of RyR2 in pancreatic beta-cell function involves regulation of IRBIT levels and activity, maintenance of insulin content and secretion, and modulation of the proteome possibly through DNA methylation.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Charlotte Buckley, Xun Zhang, Calum Wilson, John G. McCarron
Summary: The study showed that CBX and 18 beta GA inhibit intercellular communication by blocking IP3-mediated Ca2+ release and depolarising the mitochondrial membrane potential. This effect can be reversed upon drug washout and is not affected by K+-channel blockers.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Dianicha Santana Nunez, Asrar B. Malik, Quinn Lee, Sang Joon Ahn, Arnold Coctecon-Murillo, Dana Lazarko, Irena Levitan, Dolly Mehta, Yulia A. Komarova
Summary: Endothelial cells sense shear stress through Piezo1 and activate ER Ca2+ entry and release via IP3R2. The involvement of sAC and IP3R2 in this process is crucial.
Article
Multidisciplinary Sciences
Kyle E. Harvey, Shiqi Tang, Emily K. LaVigne, Evan P. S. Pratt, Gregory H. Hockerman
Summary: In this study, the researchers found that RyR2 is required for the regulation of insulin content and glucose-stimulated insulin secretion in INS-1 cells, partly through its interaction with IRBIT. The experiments showed that the absence of RyR2 led to a decrease in store-operated Ca2+ entry and PLC activity, as well as an increase in cellular PIP2 levels. Furthermore, RyR2 was found to regulate beta-cell electrical activity by controlling Ca-v current density and SK channel activation.
Article
Physics, Fluids & Plasmas
Irina Bashkirtseva, Lev Ryashko
Summary: The stochastic excitability of spiking oscillatory regimes in calcium kinetics is investigated using the Li-Rinzel conceptual model. The probabilistic mechanisms of noise-induced generation of large-amplitude oscillations in parametric zones are studied numerically and analytically. The phenomenon of coherence resonance is discussed, and a parametric statistical description of interspike intervals is applied. The role of confidence ellipses and separatrices in determining sub- and supercritical regions is demonstrated.
Article
Food Science & Technology
Xueqin Feng, Tiantian Yu, Yumeng Zhang, Lijuan Li, Miaomiao Qu, Jishui Wang, Fangxiang Dong, Lihua Zhang, Fengge Wang, Fanyong Zhang, Xiuwen Zhou, Zhice Xu, Dongmei Man
Summary: The study shows that prenatal high sucrose diet can lead to vascular dysfunction in fetal offspring by enhancing AT1 receptor, LTCC function, and IP3Rs-associated calcium channels.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Robin Irvine
Summary: The text shares some personal memories from a significant adventure I had with Mike.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Review
Neurosciences
Pragnya Chakraborty, Gaiti Hasan
Summary: Key components of endoplasmic reticulum (ER) Ca2+ release and store-operated Ca2+ entry (SOCE) are expressed in all metazoan cells. This review presents evidence on how these two mechanisms impact neuronal physiology and their interaction with ion channels in neurons. The careful regulation of neural SOCE is essential due to the detrimental effects of Ca2+ imbalance on neurons. The study also discusses different mechanisms of SOCE regulation in Drosophila and mammalian neurons, and their significance in human neurodegenerative diseases.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Multidisciplinary Sciences
Na Tang, Wen Tian, Guang-Yuan Ma, Xiong Xiao, Lei Zhou, Ze-Zhi Li, Xiao-Xiao Liu, Chong-Yao Li, Ke-Han Wu, Wenjuan Liu, Xue-Ying Wang, Yuan-Yuan Gao, Xin Yang, Jianzhao Qi, Ding Li, Yang Liu, Wen-Sheng Chen, Jinming Gao, Xiao-Qiang Li, Wei Cao
Summary: Deficiency of TRPC1 and TRPC6 channels ameliorates LPS-induced heart failure, prolongs survival, and suppresses cardiac inflammation and ER Ca2+ release.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Katsuhiro Kawaai, Hideaki Ando, Nobuhiko Satoh, Hideomi Yamada, Naoko Ogawa, Matsumi Hirose, Akihiro Mizutani, Benjamin Bonneau, George Seki, Katsuhiko Mikoshiba
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
Mamoru Sasaki, Shotaro Chubachi, Naofumi Kameyama, Minako Sato, Mizuha Haraguchi, Masaki Miyazaki, Saeko Takahashi, Takayoshi Nakano, Yukiko Kuroda, Tomoko Betsuyaku, Koichi Matsuo
Article
Endocrinology & Metabolism
Koichi Matsuo, Shuting Ji, Ayako Miya, Masaki Yoda, Yuzuru Hamada, Tomoya Tanaka, Ryoko Takao-Kawabata, Katsuhiro Kawaai, Yukiko Kuroda, Shinsuke Shibata
Article
Multidisciplinary Sciences
Mio Edamoto, Yukiko Kuroda, Masaki Yoda, Katsuhiro Kawaai, Koichi Matsuo
SCIENTIFIC REPORTS
(2019)
Article
Neurosciences
Keiko Tominaga-Yoshino, Tomoyoshi Urakubo, Yukiko Ueno, Katsuhiro Kawaai, Shinichi Saito, Tomoko Tashiro, Akihiko Ogura
Article
Endocrinology & Metabolism
Yukiko Kuroda, Katsuhiro Kawaai, Naoya Hatano, Yanlin Wu, Hidekazu Takano, Atsushi Momose, Takuya Ishimoto, Takayoshi Nakano, Paul Roschger, Stephane Blouin, Koichi Matsuo
Summary: The study identified a new subtype of osteoblasts, known as auditory osteoblasts, that produce type II collagen and are responsible for the highly mineralized hearing-related bones. These osteoblasts exhibit differences from conventional osteoblasts and chondrocytes, showing higher bone matrix mineralization and apatite orientation in auditory ossicles and the bony labyrinth.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ryo Itoh, Naoya Hatano, Momoko Murakami, Kosuke Mitsumori, Satoko Kawasaki, Tomoka Wakagi, Yoshino Kanzaki, Hiroyuki Kojima, Katsuhiro Kawaai, Katsuhiko Mikoshiba, Koichi Hamada, Akihiro Mizutani
Summary: The research found that IRBIT and L-IRBIT interact with anion exchanger 2 (AE2), affecting its activity and expression level, and thereby influencing cell volume homeostasis and cell migration.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Kenji Tanaka, Shuma Ohara, Tadaaki Matsuzaka, Aira Matsugaki, Takuya Ishimoto, Ryosuke Ozasa, Yukiko Kuroda, Koichi Matsuo, Takayoshi Nakano
Summary: The auditory brainstem response (ABR) is commonly used to assess auditory function, but determining the ABR threshold has been a challenge. Existing methods lack accuracy, efficiency, and convenience. We proposed an improved algorithm based on mutual covariance to objectively determine the ABR threshold. This method effectively reduced the burden on experimental animals and provided more efficient and accurate results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Yoshikazu Kuboi, Yukiko Kuroda, Masayoshi Ohkuro, Sotaro Motoi, Yoshiya Tomimori, Hisataka Yasuda, Nobuyuki Yasuda, Toshio Imai, Koichi Matsuo
Summary: The chemokine fractalkine (FKN) regulates the survival and differentiation of osteoclast precursor cells (OCPs) through the CX3CR1 receptor. Blocking the FKN-CX3CR1 axis may be a therapeutic option for noninflammatory bone loss diseases.
Meeting Abstract
Endocrinology & Metabolism
Koichi Matsuo, Masaki Yoda, Yukiko Kuroda, Katsuhiro Kawaai, Yanlin Wu, Hidekazu Takano, Atsushi Momose
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Meeting Abstract
Endocrinology & Metabolism
Yukiko Kuroda, Koichi Matsuo
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)