In vivo brain GPCR signaling elucidated by phosphoproteomics

Highly Potent and Selective New Diphenethylamines Interacting with the κ-Opioid Receptor: Synthesis, Pharmacology, and Structure–Activity Relationships

(2017) Filippo Erli et al.   JOURNAL OF MEDICINAL CHEMISTRY

CB1 receptor antagonism prevents long-term hyperexcitability after head injury by regulation of dynorphin-KOR system and mGluR5 in rat hippocampus

(2016) Xiu Wang et al.   BRAIN RESEARCH

The G-protein biased partial κ opioid receptor agonist 6′-GNTI blocks hippocampal paroxysmal discharges without inducing aversion

(2016) Luca Zangrandi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation

(2016) M M Harraz et al.   MOLECULAR PSYCHIATRY

Mass-spectrometric exploration of proteome structure and function

(2016) Ruedi Aebersold et al.   NATURE

Structure-based discovery of opioid analgesics with reduced side effects

(2016) Aashish Manglik et al.   NATURE

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

(2016) Tarsis F. Brust et al.   Science Signaling

Proteomic maps of breast cancer subtypes

(2016) Stefka Tyanova et al.   Nature Communications

Everolimus improves neuropsychiatric symptoms in a patient with tuberous sclerosis carrying a novel TSC2 mutation

(2016) Su-Kyeong Hwang et al.   Molecular Brain

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

(2016) Tarsis F. Brust et al.   Science Signaling

Phosphoproteomics in the Age of Rapid and Deep Proteome Profiling

(2015) Nicholas M. Riley et al.   ANALYTICAL CHEMISTRY

Biased agonism at kappa opioid receptors: Implication in pain and mood disorders

(2015) Shalini Dogra et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GPCR signaling and cardiac function

(2015) Leany A. Capote et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons

(2015) J. M. Ehrich et al.   JOURNAL OF NEUROSCIENCE

High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics

(2015) Sean J Humphrey et al.   NATURE BIOTECHNOLOGY

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus

(2015) Jenny Morgenweck et al.   NEUROPHARMACOLOGY

2016 update of the PRIDE database and its related tools

(2015) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

The Neurology of mTOR

(2014) Jonathan O. Lipton et al.   NEURON

Potential role of G protein-coupled receptor (GPCR) heterodimerization in neuropsychiatric disorders: A focus on depression

(2014) Kinga Szafran et al.   Pharmacological Reports

Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling

(2014) Kirti Sharma et al.   Cell Reports

Functional Selectivity of 6′-Guanidinonaltrindole (6′-GNTI) at κ-Opioid Receptors in Striatal Neurons

(2013) Cullen L. Schmid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SynaptomeDB: an ontology-based knowledgebase for synaptic genes

(2012) Mehdi Pirooznia et al.   BIOINFORMATICS

6′-Guanidinonaltrindole (6′-GNTI) Is a G Protein-biased κ-Opioid Receptor Agonist That Inhibits Arrestin Recruitment

(2012) Marie-Laure Rives et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Pharmacological Evaluation of a Diphenethylamine Derivative (HS665), a Highly Potent and Selective κ Opioid Receptor Agonist

(2012) Mariana Spetea et al.   JOURNAL OF MEDICINAL CHEMISTRY

Next-generation proteomics: towards an integrative view of proteome dynamics

(2012) A. F. Maarten Altelaar et al.   NATURE REVIEWS GENETICS

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

Towards the miniaturization of GPCR-based live-cell screening assays

(2012) Sofia A.M. Martins et al.   TRENDS IN BIOTECHNOLOGY

The β-Arrestin Pathway-selective Type 1A Angiotensin Receptor (AT1A) Agonist [Sar1,Ile4,Ile8]Angiotensin II Regulates a Robust G Protein-independent Signaling Network

(2011) Ryan T. Kendall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

(2011) Courtney S. Jernigan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Distinct Phosphorylation Sites on the  2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of  -Arrestin

(2011) K. N. Nobles et al.   Science Signaling

Quantitative Phosphoproteomics Dissection of Seven-transmembrane Receptor Signaling Using Full and Biased Agonists

(2010) Gitte L. Christensen et al.   MOLECULAR & CELLULAR PROTEOMICS

Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurements

(2010) Ralf Schröder et al.   NATURE BIOTECHNOLOGY

Global phosphorylation analysis of  -arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)

(2010) K. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Based Design, Synthesis, and Biochemical and Pharmacological Characterization of Novel Salvinorin A Analogues as Active State Probes of the κ-Opioid Receptor

(2009) Feng Yan et al.   BIOCHEMISTRY

Dynorphin, stress, and depression

(2009) Allison T. Knoll et al.   BRAIN RESEARCH

30 years of dynorphins — New insights on their functions in neuropsychiatric diseases

(2009) Christoph Schwarzer   PHARMACOLOGY & THERAPEUTICS

A phosphatase cascade by which rewarding stimuli control nucleosomal response

(2008) Alexandre Stipanovich et al.   NATURE