Neddylation mediates ventricular chamber maturation through repression of Hippo signaling

The Hippo signaling functions through the Notch signaling to regulate intrahepatic bile duct development in mammals

(2017) Nan Wu et al.   LABORATORY INVESTIGATION

Left ventricular noncompaction cardiomyopathy: cardiac, neuromuscular and genetic factors

(2017) Josef Finsterer et al.   Nature Reviews Cardiology

Identification of a hybrid myocardial zone in the mammalian heart after birth

(2017) Xueying Tian et al.   Nature Communications

PPARγ neddylation essential for adipogenesis is a potential target for treating obesity

(2016) H-S Park et al.   CELL DEATH AND DIFFERENTIATION

The Ubiquitin-Like SUMO System and Heart Function

(2016) Luca Mendler et al.   CIRCULATION RESEARCH

iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy

(2016) Kazuki Kodo et al.   NATURE CELL BIOLOGY

Enzymatic Activity of the Scaffold Protein Rapsyn for Synapse Formation

(2016) Lei Li et al.   NEURON

New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics

(2016) Mingjing He et al.   Cell Division

Hippo and TGF-β interplay in the lung field

(2015) Akira Saito et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

COP9 Signalosome Controls the Degradation of Cytosolic Misfolded Proteins and Protects Against Cardiac ProteotoxicityNovelty and Significance

(2015) Huabo Su et al.   CIRCULATION RESEARCH

The Hippo Pathway in Heart Development, Regeneration, and Diseases

(2015) Q. Zhou et al.   CIRCULATION RESEARCH

Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma

(2015) J. J. Shah et al.   CLINICAL CANCER RESEARCH

NEDD8 Ultimate Buster 1 Long (NUB1L) Protein Suppresses Atypical Neddylation and Promotes the Proteasomal Degradation of Misfolded Proteins

(2015) Jie Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APC controls asymmetric Wnt/β-catenin signaling and cardiomyocyte proliferation gradient in the heart

(2015) Bo Ye et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sequential Notch activation regulates ventricular chamber development

(2015) Gaetano D’Amato et al.   NATURE CELL BIOLOGY

Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition

(2015) Annette M Vogl et al.   NATURE NEUROSCIENCE

Protein neddylation: beyond cullin–RING ligases

(2015) Radoslav I. Enchev et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cullin7 Is Required for Lung Cancer Cell Proliferation and Is Overexpressed in Lung Cancer

(2015) Xuelin Men et al.   ONCOLOGY RESEARCH

Merlin/NF2 Loss-Driven Tumorigenesis Linked to CRL4DCAF1-Mediated Inhibition of the Hippo Pathway Kinases Lats1 and 2 in the Nucleus

(2014) Wei Li et al.   CANCER CELL

Deletion of Yes-Associated Protein (YAP) Specifically in Cardiac and Vascular Smooth Muscle Cells Reveals a Crucial Role for YAP in Mouse Cardiovascular Development

(2014) Yong Wang et al.   CIRCULATION RESEARCH

The Hippo signal transduction network in skeletal and cardiac muscle

(2014) H. Wackerhage et al.   Science Signaling

Molecular mechanism of ventricular trabeculation/compaction and the pathogenesis of the left ventricular noncompaction cardiomyopathy (LVNC)

(2013) Wenjun Zhang et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Embryonic cardiac chamber maturation: Trabeculation, conduction, and cardiomyocyte proliferation

(2013) Leigh Ann Samsa et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Posttranslational Modification and Quality Control

(2013) Xuejun Wang et al.   CIRCULATION RESEARCH

The COP9 Signalosome Is Required for Autophagy, Proteasome-Mediated Proteolysis, and Cardiomyocyte Survival in Adult Mice

(2013) Huabo Su et al.   Circulation-Heart Failure

Enhanced autophagy ameliorates cardiac proteinopathy

(2013) Md. Shenuarin Bhuiyan et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy

(2013) Guillermo Luxán et al.   NATURE MEDICINE

Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair

(2013) Mei Xin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cullin7: a new gene involved in liver carcinogenesis related to metabolic syndrome

(2012) Valerie Paradis et al.   GUT

Yes-associated Protein Isoform 1 (Yap1) Promotes Cardiomyocyte Survival and Growth to Protect against Myocardial Ischemic Injury

(2012) Dominic P. Del Re et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

14-3-3  Plays a Role in Cardiac Ventricular Compaction by Regulating the Cardiomyocyte Cell Cycle

(2012) Y. Kosaka et al.   MOLECULAR AND CELLULAR BIOLOGY

YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy

(2012) A. von Gise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

COP9 Signalosome Regulates Autophagosome Maturation

(2011) Huabo Su et al.   CIRCULATION

Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice

(2011) Jie Li et al.   JOURNAL OF CLINICAL INVESTIGATION

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

Expression of Sumoylation Deficient Nkx2.5 Mutant in Nkx2.5 Haploinsufficient Mice Leads to Congenital Heart Defects

(2011) Eun Young Kim et al.   PLoS One

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

Regulation of Insulin-Like Growth Factor Signaling by Yap Governs Cardiomyocyte Proliferation and Embryonic Heart Size

(2011) M. Xin et al.   Science Signaling

Perturbation of Cullin Deneddylation via Conditional Csn8 Ablation Impairs the Ubiquitin–Proteasome System and Causes Cardiomyocyte Necrosis and Dilated Cardiomyopathy in Mice

(2010) Huabo Su et al.   CIRCULATION RESEARCH

A dual role for ErbB2 signaling in cardiac trabeculation

(2010) J. Liu et al.   DEVELOPMENT

SUMO-Specific Protease 2 Is Essential for Suppression of Polycomb Group Protein-Mediated Gene Silencing during Embryonic Development

(2010) Xunlei Kang et al.   MOLECULAR CELL

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Origin and function of ubiquitin-like proteins

(2009) Mark Hochstrasser   NATURE

Smad7 Is Required for the Development and Function of the Heart

(2008) Qian Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ErbB receptors, their ligands, and the consequences of their activation and inhibition in the myocardium

(2008) Stephen J. Fuller et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The CUL7 E3 Ubiquitin Ligase Targets Insulin Receptor Substrate 1 for Ubiquitin-Dependent Degradation

(2008) Xinsong Xu et al.   MOLECULAR CELL