Article
Multidisciplinary Sciences
Rafael Kramann
Summary: Myocardial infarction, also known as heart attack, is one of the deadliest diseases worldwide. Analyzing the changes in human tissue after a heart attack, both spatially and at the single-cell level, provides valuable insights into disease mechanisms and serves as a resource for therapeutic discoveries.
Article
Dermatology
Maggie M. Hodges, Carlos Zgheib, Kenneth W. Liechty
Summary: The study aims to develop a more accurate model for identifying therapeutic targets to mitigate heart failure following myocardial infarction, utilizing a fetal ovine model of myocardial regeneration. By comparing the different responses in fetal and adult mammalian models to MI, critical pathways in the mammalian response to MI have been identified to improve the identification of therapeutic targets.
ADVANCES IN WOUND CARE
(2021)
Article
Chemistry, Multidisciplinary
Jialu Yao, Ke Huang, Dashuai Zhu, Tan Chen, Yufeng Jiang, Junyi Zhang, Lijie Mi, He Xuan, Shiqi Hu, Junlang Li, Yafeng Zhou, Ke Cheng
Summary: Myocardial infarction is the most common cause of death worldwide, with heart failure becoming a major determinant of adverse prognosis in survivors. Exosome spray (EXOS) based on MSC exosomes and biomaterials shows promise in improving heart function, reducing fibrosis, and promoting angiomyogenesis for heart repair, making it a feasible and safe strategy for future therapeutic delivery.
Article
Cardiac & Cardiovascular Systems
Elvira Forte, Bryant Perkins, Amalia Sintou, Harkaran S. Kalkat, Angelos Papanikolaou, Catherine Jenkins, Mashael Alsubaie, Rasheda A. Chowdhury, Theodore M. Duffy, Daniel A. Skelly, Jane Branca, Mohamed Bellahcene, Michael D. Schneider, Sian E. Harding, Milena B. Furtado, Fu Siong Ng, Muneer G. Hasham, Nadia Rosenthal, Susanne Sattler
Summary: After ischemic injury to the heart, cross-priming dendritic cells play a role in activating cytotoxic CD8(+) T cells by presenting self-antigens from necrotic cardiac cells. Research suggests that activation of cytotoxic CD8(+) T cells by cross-priming DC may exacerbate inflammatory damage of the myocardium and corresponding decline in cardiac function.
Article
Immunology
Pei Zhang, Tian-Yu Wang, Zi-Yue Luo, Jun-Can Ding, Qiang Yang, Peng-Fei Hu
Summary: This study aims to investigate the mechanism of action of empagliflozin in treating heart failure. Through mouse models and gene sequencing analysis, Col17a1 and Gria4 were identified as key immune-related genes in the treatment of heart failure after myocardial infarction with empagliflozin.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Amil. M. M. Shah, Brian Claggett, Narayana Prasad, Guichu Li, Mayra Volquez, Karola Jering, Maja Cikes, Attila Kovacs, Wilfried Mullens, Jose C. Nicolau, Lars Kober, Peter Van der Meer, Pardeep. S. S. Jhund, Ghionul Ibram, Martin Lefkowitz, Yinong Zhou, Scott. D. D. Solomon, Marc A. Pfeffer
Summary: This study compared the effects of sacubitril/valsartan and ramipril on left ventricular function and adverse remodeling after acute myocardial infarction (AMI). The results showed that patients randomized to sacubitril/valsartan had better improvements in filling pressure, left ventricular volume changes, and other aspects compared to those randomized to ramipril.
Review
Biochemistry & Molecular Biology
Joachim Neumann, Britt Hofmann, Stefan Dhein, Ulrich Gergs
Summary: Glucagon has various effects on the mammalian heart, including changes in contraction force, heart rate, and cardiac conduction system axis. The effects of glucagon on the heart differ depending on species, region, age, and concurrent disease. Glucagon is present in the mammalian heart and can act on cardiac glucagon receptors through autocrine or paracrine mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ingrid Gomez, Virginie Robert, Paul Alayrac, Adele Arlat, Vincent Duval, Marie-Laure Renoud, Jose Vilar, Mathilde Lemitre, Jean-Sebastien Silvestre, Beatrice Cousin
Summary: Medullary and extra-medullary hematopoiesis play a significant role in regulating inflammatory cell infiltration and cardiac remodeling after acute myocardial infarction. Adipose tissue can serve as an alternative source of immune cell production and affect cardiac homeostasis. However, in the presence of diabetes, the function of immune cells derived from adipose tissue is compromised.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Huiyun Chen, Yu Gong, Fangcan Sun, Bing Han, Bingyuan Zhou, Jiali Fan, Xinxian Gu
Summary: This study used two-dimensional speckle tracking echocardiography to evaluate myocardial strain in preterm children aged 5 to 8 years with severe preeclampsia. The results showed that severe preeclampsia did not have a significant impact on cardiac structure in premature children at this age, but they had a higher resting heart rate which may be associated with long-term cardiovascular disease.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Genetics & Heredity
Qixin Chen, Qijin Yin, Junxian Song, Chuanfen Liu, Hong Chen, Sufang Li
Summary: This study identified 827 hub genes associated with post-AMI HF in PBMCs using weighted gene co-expression network analysis. By combining single-cell RNA-sequencing data and bulk RNA-sequencing data, 25 common genes related to inflammation and collagen metabolism were discovered, with CUX1, CTSD, and ADD3 showing consistent changes in three independent studies. These findings provided three monocyte-related biomarkers for the early prediction of HF development after AMI and potential therapeutic targets.
BMC MEDICAL GENOMICS
(2021)
Editorial Material
Cell Biology
Suresh Kumar, Ruheena Javed, Masroor A. A. Paddar, Eeva-Liisa Eskelinen, Graham S. Timmins, Vojo Deretic
Summary: Mammalian autophagosomes form from a hybrid membrane compartment known as a prophagophore or HyPAS, which originates from preexisting membranes and undergoes lipid transfer and fusion with lysosomes. The formation of the prophagophore involves fusion of RB1CC1/FIP200-containing vesicles from the cis-Golgi with endosomally derived ATG16L1 membranes, and is regulated by a Ca2+-responsive apparatus. The process of autophagic prophagophore formation is inhibited during SARS-CoV-2 infection and can be replicated by expressing SARS-CoV-2 nsp6. These findings highlight the convergence of secretory and endosomal pathways in the formation of mammalian autophagosomal prophagophores and the influence of microbial factors.
Article
Cardiac & Cardiovascular Systems
Hanjay Wang, Camille E. Hironaka, Danielle M. Mullis, Haley J. Lucian, Hye Sook Shin, Nicholas A. Tran, Akshara D. Thakore, Shreya Anilkumar, Matthew A. Wu, Michael J. Paulsen, Yuanjia Zhu, Sam W. Baker, Y. Joseph Woo
Summary: A neonatal rabbit model of myocardial infarction shows age-dependent natural heart regeneration, but this ability diminishes over time.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Chemistry, Multidisciplinary
Siyuan Bao, Yao Lu, Jian Zhang, Le Xue, Yewei Zhang, Peng Wang, Fengxiang Zhang, Ning Gu, Jianfei Sun
Summary: The magnetic vagus nerve stimulation system, consisting of an injectable hydrogel with superparamagnetic iron oxide nanoparticles and a mild magnetic pulse sequence, has shown potential in improving cardiac function in patients with myocardial infarction.
Article
Cardiac & Cardiovascular Systems
Maria Fedchenko, Zacharias Mandalenakis, Kok Wai Giang, Annika Rosengren, Peter Eriksson, Mikael Dellborg
Summary: Patients with congenital heart disease have a higher risk of myocardial infarction compared to controls, and also a higher risk of developing new-onset heart failure, recurrent MI, or death after the index MI. Proper management of modifiable cardiovascular risk factors is crucial in reducing morbidity and mortality in these patients.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Madison B. Argo, David J. Barron, Pirooz Eghtesady, Can Yerebakan, Williams M. DeCampli, Bahaaldin Alsou, Osami Honjo, Jeffrey P. Jacobs, Tharini Paramananthan, Maha Rahman, Linda M. Lambert, Anusha Jegatheeswaran, Sergio A. Carrillo, S. Adil Husain, Karthik Ramakrishnan, Christopher A. Caldarone, Tara Karamlou, Jennifer Nelson, Chelsea Mannie, Jennifer C. Romano, Joseph W. Turek, Eugene H. Blackstone, Mark E. Galantowicz, James K. Kirklin, Michael E. Mitchell, Brian W. McCrindle
Summary: Hybrid palliation is an initial management strategy for infants with critical left heart obstruction, but the mortality rate remains high. Some infants may achieve biventricular repair through hybrid palliation, while for others, this method may serve as stabilization for intended functional univentricular palliation or primary transplantation.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zhen Hu, Libo Zhang, Atasi Chakraborty, Gianluca D'Olimpio, Jun Fujii, Anping Ge, Yuanchen Zhou, Changlong Liu, Amit Agarwal, Ivana Vobornik, Daniel Farias, Chia-Nung Kuo, Chin Shan Lue, Antonio Politano, Shao-Wei Wang, Weida Hu, Xiaoshuang Chen, Wei Lu, Lin Wang
Summary: This study reports the observation of the second-order NLHE in type-II Dirac semimetal CoTe2 under time-reversal symmetry. The NLHE is determined by the disorder-induced extrinsic contribution on the broken-inversion-symmetry surface, and terahertz rectification at room temperature is achieved without the need for semiconductor junctions or bias voltage. Remarkable photoresponsivity, response time, and mean noise equivalent power are achieved. This opens a new pathway for low-energy photon harvesting in strongly spin-orbit-coupled and inversion-symmetry-breaking systems.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Chenyu Yao, Libo Zhang, Yulu Chen, Cheng Guo, Liu Yang, Yang Lu, Kai Zhang, Lin Wang, Xiaoshuang Chen
Summary: Topological insulators (TIs) are being extensively studied in condensed matter physics due to their unique electronic properties. However, current research on the photocurrent generation in topological surface states (TSS) lacks sufficient evidence to differentiate from bulk states, which hampers their application in optoelectronics. In this study, the synthesis of GeBi4Te7 crystal through chemical vapor transport (CVT) with Ge intercalation is achieved, resulting in isolated Dirac points and high-mobility Dirac carriers, as well as larger Seebeck coefficients. A GeBi4Te7-based antenna-coupled photodetector is then developed, demonstrating sensitive terahertz response without bias. The GeBi4Te7-based photodetector exhibits a short response time and high photoresponsivity, with the potential for further improvement using the GeBi4Te7-graphene heterostructure.
PHYSICA STATUS SOLIDI-RAPID RESEARCH LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Kaixuan Zhang, Zhen Hu, Libo Zhang, Yulu Chen, Dong Wang, Mengjie Jiang, Gianluca D'Olimpio, Li Han, Chenyu Yao, Zhiqingzi Chen, Huaizhong Xing, Chia-Nung Kuo, Chin Shan Lue, Ivana Vobornik, Shao-Wei Wang, Antonio Politano, Weida Hu, Lin Wang, Xiaoshuang Chen, Wei Lu
Summary: This study exploits low-energy type-II Dirac fermions in topological semimetals for ultrasensitive THz detection, and demonstrates a novel photodetector combining two Dirac materials, graphene and NiTeSe, with high responsivity, fast response time, and outstanding stability.
Letter
Cell Biology
Mingjun Zhang, Wenjuan Pu, Jie Li, Maoying Han, Ximeng Han, Zhenqian Zhang, Zan Lv, Nicola Smart, Lixin Wang, Bin Zhou
Article
Physics, Multidisciplinary
Qing-Xin Dong, Bin-Bin Ruan, Yi-Fei Huang, Yi-Yan Wang, Li-Bo Zhang, Jian-Li Bai, Qiao-Yu Liu, Jing-Wen Cheng, Zhi-An Ren, Gen-Fu Chen
Summary: We conducted a comprehensive study on the layered-structure compound NaZn4As3 and found that it undergoes a structural transformation from rhombohedral to monoclinic phase with temperature. The electric resistivity shows a metal-to-insulator-like transition at around 100 K and then develops a plateau at low temperature, indicating the presence of protected topologically conducting surface states. First-principles calculations confirmed that NaZn4As3 is a topological insulator in both phases rather than a topological semimetal as previously proposed. The Hall resistivity indicates a dominance of hole carriers in the transport properties across the temperature range, and the thermopower exhibits a noticeable kink possibly related to the structure transition around 170 K. The large thermopower and moderate kappa suggest that NaZn4As3 and its derivatives can be a promising platform for optimizing and studying thermoelectric performance.
Article
Computer Science, Artificial Intelligence
Ruyi Ji, Jiaying Li, Libo Zhang
Summary: In this paper, a new Siamese Self-supervised Learning method is proposed to align different views of one image using attention mechanism and Siamese network. The center loss is introduced to ensure consistency between different views. Experimental results show that the proposed method performs on par with the state-of-the-art methods on three public benchmarks.
COMPUTER VISION AND IMAGE UNDERSTANDING
(2023)
Article
Immunology
Jing Ding, Changli Yue, Chengshuo Wang, Wei Liu, Libo Zhang, Bo Chen, Shen Shen, Yingshi Piao, Luo Zhang
Summary: This study aimed to establish the CRSAI 1.0, a convenient and accurate evaluation platform for chronic rhinosinusitis, based on four phenotypes of nasal polyps. Tissue sections were analyzed using the Unet++ algorithm with Efficientnet-B4 backbone to remove redundant tissues. Four types of inflammatory cells were detected and used to train the CRSAI 1.0. The results showed that CRSAI 1.0 can accurately identify various types of inflammatory cells in CRSwNP, enabling rapid diagnosis and personalized treatment.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Article
Neurosciences
Xuejing Lu, Xin Hou, Libo Zhang, Hong Li, Yiheng Tu, Huqing Shi, Li Hu
Summary: Music shows great potential in pain relief due to its non-pharmacological nature, but the specific mechanisms behind music-induced analgesia (MIA) are not well understood. Positive emotional state induced by music is one of the key factors explaining MIA.
HUMAN BRAIN MAPPING
(2023)
Article
Engineering, Electrical & Electronic
Boying Wang, Ruyi Ji, Libo Zhang, Yanjun Wu
Summary: This paper proposes a multi-scale context-aware feature pyramid network that leverages cross-scale context aggregation block and adaptive context aggregation block to make full use of context information in the feature pyramid, improving the effectiveness of object detection.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY
(2023)
Article
Crystallography
Shijian Tian, Libo Zhang, Yuan Liang, Ruikuan Xie, Li Han, Shiqi Lan, Aijiang Lu, Yan Huang, Huaizhong Xing, Xiaoshuang Chen
Summary: The electronic and magnetic properties of Ga14N16-nGd2Cn monolayers were investigated through first principle calculation. The study considered the generalized gradient approximation (GGA) of density functional theory with the on-site Coulomb energy U (GGA + U). It was found that the magnetic moment of Ga14N16Gd2 monolayer is 14 mu B with an antiferromagnetic (AFM) phase. The substitutional impurity of C atoms effectively changed the magnetic state of Ga14N16-nGd2Cn monolayers to ferromagnetic phases (FM), with an increase in magnetic moment of 1 mu B/1C. The stable FM phase was attributed to the p-d coupling orbitals between C-2p and Gd-5d states. Moreover, a Curie temperature (T-C) close to room temperature (T-R, 300 K) was observed in Ga14N16Gd2C2 monolayer, with the highest value reaching 261.46 K. The strain effect had a significant positive impact on the TC of Ga14N16-nGd2Cn monolayer, surpassing TR, with the highest value at 525.50 K. This provides an opportunity to further explore the application of two-dimensional magnetic materials in spintronic devices.
Correction
Cell Biology
Mingjun Zhang, Wenjuan Pu, Jie Li, Maoying Han, Ximeng Han, Zhenqian Zhang, Zan Lv, Nicola Smart, Lixin Wang, Bin Zhou
Article
Physics, Multidisciplinary
Chenyu Yao, Mengjie Jiang, Dong Wang, Libo Zhang, Ning Zhang, Lin Wang, Xiaoshuang Chen
Summary: A self-mixing terahertz detector based on a hemispherical silicon lens and antenna-coupled InGaAs/AlGaAs high electron mobility transistor (HEMT) is developed, enabling wide spectrum detection and improved performance.
FRONTIERS IN PHYSICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Pinyu Liu, Qingxin Dong, Binbin Ruan, Libo Zhang, Jianli Bai, Jingwen Cheng, Qiaoyu Liu, Cundong Li, Yingrui Sun, Yu Huang, Gang Li, Zhian Ren, Genfu Chen
Summary: A new quasi-one-dimensional compound KNi5Bi5.6 has been synthesized and its crystal structure has been determined. The structure consists of double-walled anionic nanowires [Ni5Bi5.6] separated by potassium cations. KNi5Bi5.6 belongs to a new series of compounds with [Ni5Bi5.6]x (x = 1+, 0, 1-) nanowires, which can have cationic, neutral or anionic charge without significantly affecting the structure and composition. This provides a new platform for studying charge invertible quasi-one-dimensional transition metal systems. Resistivity measurement shows metallic conductivity and magnetic susceptibility exhibits modified Curie-Weiss behavior with weak magnetic anisotropy.
JOURNAL OF SOLID STATE CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Yunrui Li, Libo Zhang, Ying Han, Wenxi Ji, Zhongyuan Liu, Baoshun Wang, Siming Zhao, Xueke Wu, Longgui Zhang, Rufan Zhang
Summary: Rechargeable Zn-air batteries (RZABs) are promising for energy storage due to their safety, energy density, material abundance, and environmental friendliness. However, slow kinetics of oxygen reactions hinder their large-scale application. Effective interface engineering of bifunctional oxygen electrocatalysts can enhance catalytic performance. This review summarizes recent advances in interfacial engineering of bifunctional electrocatalysts and discusses strategies for efficient RZABs.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Optics
Chen-Yu Yao, Li-Bo Zhang, Ying-Dong Wei, Wang Lin, Xiao-Shuang Chen, Wei Lu
Summary: A highly sensitive terahertz photodetector has been achieved by synthesizing a novel topological insulator material, GeBi4Te7, and constructing a van der Waals heterojunction with Bi2Te3. The device can generate photocurrents in low-energy terahertz bands at room temperature, and exhibits wide spectral detection and fast response. These findings open up new possibilities for low-energy optoelectronic applications.
JOURNAL OF INFRARED AND MILLIMETER WAVES
(2023)