Induction of NLRP3 Inflammasome Activation by Heme in Human Endothelial Cells

The AIM2 inflammasome: Sensor of pathogens and cellular perturbations

(2017) Jérôme Lugrin et al.   IMMUNOLOGICAL REVIEWS

The NLRC4 Inflammasome

(2017) Joseph A. Duncan et al.   IMMUNOLOGICAL REVIEWS

Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs)

(2017) K. Kinnunen et al.   Journal of Cell Communication and Signaling

Caspase-1 Inflammasome Activation Mediates Homocysteine-Induced Pyrop-Apoptosis in Endothelial CellsNovelty and Significance

(2016) Hang Xi et al.   CIRCULATION RESEARCH

Red alert: labile heme is an alarmin

(2016) Miguel P Soares et al.   CURRENT OPINION IN IMMUNOLOGY

Activation of the NLRP3 inflammasome by cellular labile iron

(2016) Kyohei Nakamura et al.   EXPERIMENTAL HEMATOLOGY

Red cell DAMPs and inflammation

(2016) Rafaela Mendonça et al.   INFLAMMATION RESEARCH

Activation of the TXNIP/NLRP3 inflammasome pathway contributes to inflammation in diabetic retinopathy: a novel inhibitory effect of minocycline

(2016) Wei Chen et al.   INFLAMMATION RESEARCH

Contribution of redox-dependent activation of endothelial Nlrp3 inflammasomes to hyperglycemia-induced endothelial dysfunction

(2016) Yang Chen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

SIRT1 inhibits inflammatory response partly through regulation of NLRP3 inflammasome in vascular endothelial cells

(2016) Yanxiang Li et al.   MOLECULAR IMMUNOLOGY

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

(2016) Letteria Minutoli et al.   Oxidative Medicine and Cellular Longevity

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Coronary Endothelial Dysfunction Induced by Nucleotide Oligomerization Domain-Like Receptor Protein with Pyrin Domain Containing 3 Inflammasome Activation During Hypercholesterolemia: Beyond Inflammation

(2015) Yang Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis

(2015) Yang Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

TLR4 and NALP3 inflammasome in the development of endothelial dysfunction in uraemia

(2015) Susana Martin-Rodriguez et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

The NLRP1 inflammasomes

(2015) Joseph Chavarría-Smith et al.   IMMUNOLOGICAL REVIEWS

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1

(2015) Yang Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy

(2015) Khurrum Shahzad et al.   KIDNEY INTERNATIONAL

Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders

(2015) Ann Smith et al.   Frontiers in Physiology

Heme Induces IL-1β Secretion Through Activating NLRP3 in Kidney Inflammation

(2014) Qianwei Li et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Hemolysis-induced lethality involves inflammasome activation by heme

(2014) Fabianno F. Dutra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Red blood cell, hemoglobin and heme in the progression of atherosclerosis

(2014) Viktória Jeney et al.   Frontiers in Physiology

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases

(2013) Francesca Vinchi et al.   CIRCULATION

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Atherogenesis May Involve the Prooxidant and Proinflammatory Effects of Ferryl Hemoglobin

(2013) László Potor et al.   Oxidative Medicine and Cellular Longevity

Natural History of the Bruise: Formation, Elimination, and Biological Effects of Oxidized Hemoglobin

(2013) Viktória Jeney et al.   Oxidative Medicine and Cellular Longevity

Clostridium perfringens Beta-Toxin Induces Necrostatin-Inhibitable, Calpain-Dependent Necrosis in Primary Porcine Endothelial Cells

(2013) Delphine Autheman et al.   PLoS One

Transfusion-Related Acute Lung Injury: The Work of DAMPs*

(2013) Walter G. Land   TRANSFUSION MEDICINE AND HEMOTHERAPY

Hemorrhagic Shock Activation of NLRP3 Inflammasome in Lung Endothelial Cells

(2011) M. Xiang et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Haptoglobin: Old protein with new functions

(2010) Abdu I. Alayash   CLINICA CHIMICA ACTA

Critical functions of priming and lysosomal damage for NLRP3 activation

(2010) Veit Hornung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Molecular Mechanism of NLRP3 Inflammasome Activation

(2010) Chengcheng Jin et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B

(2010) Marcela Rosas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Expression and function of the NALP3 inflammasome in rheumatoid synovium

(2009) Laeticia Kolly et al.   IMMUNOLOGY

Oxidized Hemoglobin Is an Endogenous Proinflammatory Agonist That Targets Vascular Endothelial Cells

(2009) Gabriela Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Hemopexin Prevents Endothelial Damage and Liver Congestion in a Mouse Model of Heme Overload

(2008) Francesca Vinchi et al.   AMERICAN JOURNAL OF PATHOLOGY