Red cell DAMPs and inflammation

Toll-like receptors mediating vascular malfunction: Lessons from receptor subtypes

(2016) Yu Wang et al.   PHARMACOLOGY & THERAPEUTICS

Acute hemolytic vascular inflammatory processes are prevented by nitric oxide replacement or a single dose of hydroxyurea

(2015) C. B. Almeida et al.   BLOOD

Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease

(2015) S. M. Camus et al.   BLOOD

Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease

(2015) Narendranath Reddy Chintagari et al.   BLOOD CELLS MOLECULES AND DISEASES

Pathogenesis of non-antibody mediated transfusion-related acute lung injury from bench to bedside

(2015) Anna L. Peters et al.   BLOOD REVIEWS

Review paper Neutrophil extracellular traps (Nets) impact upon autoimmune disorders

(2015) Michał Przemysław Pruchniak et al.   Central European Journal of Immunology

Role of hemoglobin/heme scavenger protein hemopexin in atherosclerosis and inflammatory diseases

(2015) Niyati U. Mehta et al.   CURRENT OPINION IN LIPIDOLOGY

Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy

(2015) Huei-Fen Jheng et al.   Disease Models & Mechanisms

Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation

(2015) Ari B. Molofsky et al.   IMMUNITY

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Methemoglobin Is an Endogenous Toll-Like Receptor 4 Ligand—Relevance to Subarachnoid Hemorrhage

(2015) Min Kwon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Red Blood Cells Store and Release Interleukin-33

(2015) Jianxin Wei et al.   JOURNAL OF INVESTIGATIVE MEDICINE

New dog and new tricks: evolving roles for IL-33 in type 2 immunity

(2015) Jeremy M. Lott et al.   JOURNAL OF LEUKOCYTE BIOLOGY

At the Bench: Neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases

(2015) Peter C. Grayson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-33 reflects dynamics of disease activity in patients with autoimmune hemolytic anemia by regulating autoantibody production

(2015) Xiangmao Bu et al.   Journal of Translational Medicine

Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain

(2015) Mariana C. Souza et al.   MEDIATORS OF INFLAMMATION

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Possible mechanisms for intravenous immunoglobulin-associated hemolysis: clues obtained from review of clinical case reports

(2015) Ruth Padmore   TRANSFUSION

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

STUDY OF SERUM HAPTOGLOBIN LEVEL AND ITS RELATION TO ERYTHROPOIETIC ACTIVITY IN BETA THALASSEMIA CHILDREN .

(2015) Seham Ragab   Mediterranean Journal of Hematology and Infectious Diseases

Haptoglobin genotypes polymorphism as a risk factor for subclinical atherosclerosis in beta-thalassemia major children; a single center Egyptian study

(2015) Seham M. Ragab et al.   Hematology

The Human Endogenous Protection System against Cell-Free Hemoglobin and Heme Is Overwhelmed in Preeclampsia and Provides Potential Biomarkers and Clinical Indicators

(2015) Magnus Gram et al.   PLoS One

Heme-Mediated Induction of CXCL10 and Depletion of CD34+ Progenitor Cells Is Toll-Like Receptor 4 Dependent

(2015) Carmen M. Dickinson-Copeland et al.   PLoS One

Intravascular Hemolysis: A Disease Mechanism Not to Be Ignored

(2014) Nicola Conran   ACTA HAEMATOLOGICA

Intravascular Hemolysis, Vascular Endothelial Cell Activation and Thrombophilia in Splenectomized Patients with Hemoglobin E/β-Thalassemia Disease

(2014) Vichai Atichartakarn et al.   ACTA HAEMATOLOGICA

Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease

(2014) Mark D. Turner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Extracellular nucleotide and nucleoside signaling in vascular and blood disease

(2014) M. Idzko et al.   BLOOD

Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease

(2014) G. Chen et al.   BLOOD

IL-1β and IL-18: inflammatory markers or mediators of hypertension?

(2014) S M Krishnan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Heme Induces IL-1β Secretion Through Activating NLRP3 in Kidney Inflammation

(2014) Qianwei Li et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Oxidative modification enhances the immunostimulatory effects of extracellular mitochondrial DNA on plasmacytoid dendritic cells

(2014) Kitti Pazmandi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin

(2014) Todd L. Mollan et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Role of Adenosine Signaling in Sickle Cell Therapeutics

(2014) Joshua J. Field et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Inflammatory Mediators of Endothelial Injury in Sickle Cell Disease

(2014) Carolyn C. Hoppe   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Blood transfusion products contain mitochondrial DNA damage-associated molecular patterns: a potential effector of transfusion-related acute lung injury

(2014) Yann-Leei Lee et al.   JOURNAL OF SURGICAL RESEARCH

Nucleotide signalling during inflammation

(2014) Marco Idzko et al.   NATURE

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Hemolysis-induced lethality involves inflammasome activation by heme

(2014) Fabianno F. Dutra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma ATP is Required for Neutrophil Activation in a Mouse Sepsis Model

(2014) Yuka Sumi et al.   SHOCK

Heme-related molecules induce rapid production of neutrophil extracellular traps

(2014) Mari Kono et al.   TRANSFUSION

Heme on innate immunity and inflammation

(2014) Fabianno F. Dutra et al.   Frontiers in Pharmacology

Haptoglobin, hemopexin, and related defense pathways—basic science, clinical perspectives, and drug development

(2014) Dominik J. Schaer et al.   Frontiers in Physiology

Characterization of heme binding to recombinant α1-microglobulin

(2014) Elena Karnaukhova et al.   Frontiers in Physiology

Reactive oxygen species at the crossroads of inflammasome and inflammation

(2014) Anantha Harijith et al.   Frontiers in Physiology

ATP, an extracellular signaling molecule in red blood cells: A messenger for malaria?

(2014) Gordon Langsley et al.   Biomedical Journal

Human Hp1-1 and Hp2-2 Phenotype-Specific Haptoglobin Therapeutics Are Both Effective In Vitro and in Guinea Pigs to Attenuate Hemoglobin Toxicity

(2013) Miriam Lipiski et al.   ANTIOXIDANTS & REDOX SIGNALING

Haptoglobin 2 allele associates with unstable carotid plaque and major cardiovascular events

(2013) Petra Ijäs et al.   ATHEROSCLEROSIS

Mast cell activation contributes to sickle cell pathobiology and pain in mice

(2013) L. Vincent et al.   BLOOD

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Nucleosomes and neutrophil activation in sickle cell disease painful crisis

(2013) M. Schimmel et al.   HAEMATOLOGICA

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Extracellular hemin crisis triggers acute chest syndrome in sickle mice

(2013) Samit Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of hemolysis-associated platelet activation

(2013) C. C. Helms et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Haptoglobin phenotype prevalence and cytokine profiles during Plasmodium falciparum infection in Dogon and Fulani ethnic groups living in Mali

(2013) Olaf Perdijk et al.   MALARIA JOURNAL

TLR 2 and 4 Responsiveness from Isolated Peripheral Blood Mononuclear Cells from Rats and Humans as Potential Chronic Pain Biomarkers

(2013) Yuen H. Kwok et al.   PLoS One

 -Thalassemia Intermedia: A Clinical Perspective

(2013) K. M. Musallam et al.   Cold Spring Harbor Perspectives in Medicine

Cell-Free Hemoglobin and Its Scavenger Proteins: New Disease Models Leading the Way to Targeted Therapies

(2013) D. J. Schaer et al.   Cold Spring Harbor Perspectives in Medicine

Functions of NOD-Like Receptors in Human Diseases

(2013) Yifei Zhong et al.   Frontiers in Immunology

Genotype-Dependent Impairment of Hemoglobin Clearance Increases Oxidative and Inflammatory Response in Human Diabetic Atherosclerosis

(2012) Meerarani Purushothaman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice

(2012) G. M. Thomas et al.   BLOOD

Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production

(2012) G. B. Fortes et al.   BLOOD

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis

(2012) Yvonne Döring et al.   CIRCULATION

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Neutrophil Extracellular Trap-Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages

(2012) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage

(2012) Sen Lin et al.   Journal of Neuroinflammation

Erythrocyte-derived ATP and Perfusion Distribution: Role of Intracellular and Intercellular Communication

(2012) RANDY S. SPRAGUE et al.   MICROCIRCULATION

Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management

(2011) Erfan Nur et al.   AMERICAN JOURNAL OF HEMATOLOGY

Structural Biology of the Toll-Like Receptor Family

(2011) Jin Young Kang et al.   Annual Review of Biochemistry

Heme Induces Heme Oxygenase 1 via Nrf2

(2011) Joseph J. Boyle et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammasome activation: from inflammatory disease to infection: Figure 1

(2011) Aisling Dunne   BIOCHEMICAL SOCIETY TRANSACTIONS

Biomarkers of Inflammation, Growth Factor, and Coagulation Activation in Patients With Sickle Cell Disease

(2011) M. H. Qari et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Cyclophilin A Is a Damage-Associated Molecular Pattern Molecule That Mediates Acetaminophen-Induced Liver Injury

(2011) J. W. Dear et al.   JOURNAL OF IMMUNOLOGY

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids

(2010) D. R. Kohli et al.   BLOOD

Acute phase proteins and interleukins in steady state sickle cell disease

(2010) Konstantinos L. Bourantas et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

TNF family members and malaria: Old observations, new insights and future directions

(2010) Louise M. Randall et al.   EXPERIMENTAL PARASITOLOGY

Heme Amplifies the Innate Immune Response to Microbial Molecules through Spleen Tyrosine Kinase (Syk)-dependent Reactive Oxygen Species Generation

(2010) Patricia L. Fernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of TLR4-Mediated NFB Signaling in Hemorrhagic Brain in Rats

(2010) Weiyu Teng et al.   MEDIATORS OF INFLAMMATION

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Detrimental effects of adenosine signaling in sickle cell disease

(2010) Yujin Zhang et al.   NATURE MEDICINE

Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancies

(2009) Attila Molvarec et al.   CELL STRESS & CHAPERONES

Hemoglobin disorders and endothelial cell interactions

(2009) Nicola Conran et al.   CLINICAL BIOCHEMISTRY

Newer Aspects of the Pathophysiology of Sickle Cell Disease Vaso-Occlusion

(2009) Nicola Conran et al.   HEMOGLOBIN

P2X1 Ion Channels Promote Neutrophil Chemotaxis through Rho Kinase Activation

(2009) C. Lecut et al.   JOURNAL OF IMMUNOLOGY

The lipocalinα1-microglobulin protects erythroid K562 cells against oxidative damage induced by heme and reactive oxygen species

(2008) Magnus G. Olsson et al.   FREE RADICAL RESEARCH

Cerebral malaria and the hemolysis/methemoglobin/heme hypothesis: Shedding new light on an old disease

(2008) Ana Pamplona et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy

(2008) C. Lanaro et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Heme induces endothelial tissue factor expression: potential role in hemostatic activation in patients with hemolytic anemia

(2008) B. N. Y. SETTY et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Hereditary spherocytosis

(2008) Silverio Perrotta et al.   LANCET

Haptoglobin, inflammation and disease

(2008) Isaac K. Quaye   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE