Natural History of the Bruise: Formation, Elimination, and Biological Effects of Oxidized Hemoglobin

Human Hp1-1 and Hp2-2 Phenotype-Specific Haptoglobin Therapeutics Are Both Effective In Vitro and in Guinea Pigs to Attenuate Hemoglobin Toxicity

(2013) Miriam Lipiski et al.   ANTIOXIDANTS & REDOX SIGNALING

Haptoglobin Phenotype Predicts Cerebral Vasospasm and Clinical Deterioration after Aneurysmal Subarachnoid Hemorrhage

(2013) Hiroyuki Ohnishi et al.   Journal of Stroke & Cerebrovascular Diseases

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

Metabolic Adaptation to Tissue Iron Overload Confers Tolerance to Malaria

(2012) Raffaella Gozzelino et al.   Cell Host & Microbe

Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions

(2012) Sambuddha Banerjee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antioxidant functions for the hemoglobin β93 cysteine residue in erythrocytes and in the vascular compartment in vivo

(2012) Dario A. Vitturi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structure of the haptoglobin–haemoglobin complex

(2012) Christian Brix Folsted Andersen et al.   NATURE

Haptoglobin genotype and its role in determining heme-iron mediated vascular disease

(2012) Hagit Goldenstein et al.   PHARMACOLOGICAL RESEARCH

Haptoglobin Genotype and Its Role in Diabetic Cardiovascular Disease

(2012) Tina Costacou et al.   Journal of Cardiovascular Translational Research

Macrophage Infiltration and Smooth Muscle Cells Content Associated With Haptoglobin Genotype in Human Atherosclerotic Carotid Plaques

(2011) Christos Lioupis et al.   ANGIOLOGY

Association of haptoglobin genotype and common cardiovascular risk factors with the amount of iron in atherosclerotic carotid plaques

(2011) Christos Lioupis et al.   ATHEROSCLEROSIS

Sickle Hemoglobin Confers Tolerance to Plasmodium Infection

(2011) Ana Ferreira et al.   CELL

Red Cells, Hemoglobin, Heme, Iron, and Atherogenesis

(2010) Emőke Nagy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Haptoglobin: Old protein with new functions

(2010) Abdu I. Alayash   CLINICA CHIMICA ACTA

Heme Amplifies the Innate Immune Response to Microbial Molecules through Spleen Tyrosine Kinase (Syk)-dependent Reactive Oxygen Species Generation

(2010) Patricia L. Fernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Mass Spectrometry Defines an Oxidative Hotspot in Hemoglobin that is Specifically Protected by Haptoglobin

(2010) Tatiana Pimenova et al.   JOURNAL OF PROTEOME RESEARCH

Effects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia

(2010) V. C. Sandrim et al.   MOLECULAR HUMAN REPRODUCTION

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

(2009) P. W. Buehler et al.   BLOOD

Peroxidase Activity of Hemoglobin·Haptoglobin Complexes

(2009) Alexandr Kapralov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidized Hemoglobin Is an Endogenous Proinflammatory Agonist That Targets Vascular Endothelial Cells

(2009) Gabriela Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heme oxygenase-1 affords protection against noncerebral forms of severe malaria

(2009) E. Seixas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The reaction of hydrogen peroxide with hemoglobin induces extensive α-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways

(2008) Florence Vallelian et al.   FREE RADICAL BIOLOGY AND MEDICINE

A central role for free heme in the pathogenesis of severe malaria: the missing link?

(2008) Ana Ferreira et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

SNO-hemoglobin is not essential for red blood cell–dependent hypoxic vasodilation

(2008) T Scott Isbell et al.   NATURE MEDICINE

Tyrosine as a redox-active center in electron transfer to ferryl heme in globins

(2007) Brandon J. Reeder et al.   FREE RADICAL BIOLOGY AND MEDICINE