NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease
出版年份 2015 全文链接
标题
NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease
作者
关键词
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出版物
HUMAN MOLECULAR GENETICS
Volume 24, Issue 11, Pages 3058-3081
出版商
Oxford University Press (OUP)
发表日期
2015-02-17
DOI
10.1093/hmg/ddv059
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Truncation of Tau Protein and its Pathological Significance in Alzheimer's Disease
- (2017) Francisco García-Sierra et al. JOURNAL OF ALZHEIMERS DISEASE
- A NH2 Tau Fragment Targets Neuronal Mitochondria at AD Synapses: Possible Implications for Neurodegeneration
- (2017) Giuseppina Amadoro et al. JOURNAL OF ALZHEIMERS DISEASE
- Insights into links between familial and sporadic Parkinson's disease: Physical relationship between UCH-L1 variants and chaperone-mediated autophagy
- (2014) Tomohiro Kabuta et al. Autophagy
- Autophagy of Mitochondria: A Promising Therapeutic Target for Neurodegenerative Disease
- (2014) Pradip K. Kamat et al. CELL BIOCHEMISTRY AND BIOPHYSICS
- Dynamic survey of mitochondria by ubiquitin
- (2014) M. Escobar-Henriques et al. EMBO REPORTS
- Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis
- (2014) Konstantinos Palikaras et al. EXPERIMENTAL GERONTOLOGY
- Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L Mice
- (2014) M. V. Rao et al. JOURNAL OF NEUROSCIENCE
- Roles of Autophagy in MPP+-Induced Neurotoxicity In Vivo: The Involvement of Mitochondria and α-Synuclein Aggregation
- (2014) Kai-Chih Hung et al. PLoS One
- Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1
- (2014) L F Burbulla et al. Cell Death & Disease
- Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway
- (2014) Giuseppina Amadoro et al. Frontiers in Aging Neuroscience
- Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer’s disease model
- (2013) Manuela Polydoro et al. ACTA NEUROPATHOLOGICA
- After the banquet
- (2013) Jianhui Zhu et al. Autophagy
- Mitochondrial dismissal in mammals, from protein degradation to mitophagy
- (2013) Silvia Campello et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: Redox proteomics analysis of human brain
- (2013) Fabio Di Domenico et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice
- (2013) Margot Fournier et al. BMC NEUROSCIENCE
- Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism
- (2013) Xinde Zheng et al. CELL RESEARCH
- Age-Related Mitochondrial Alterations without Neuronal Loss in the Hippocampus of a Transgenic Model of Alzheimer's Disease
- (2013) Mar Cuadrado-Tejedor et al. Current Alzheimer Research
- Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission
- (2013) Nguyen-Vi Mohamed et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons
- (2013) Fumika Koyano et al. GENES TO CELLS
- Hexokinase activity is required for recruitment of parkin to depolarized mitochondria
- (2013) Melissa K. McCoy et al. HUMAN MOLECULAR GENETICS
- β-Amyloid (Aβ) Oligomers Impair Brain-derived Neurotrophic Factor Retrograde Trafficking by Down-regulating Ubiquitin C-terminal Hydrolase, UCH-L1
- (2013) Wayne W. Poon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial Alterations near Amyloid Plaques in an Alzheimer's Disease Mouse Model
- (2013) Hong Xie et al. JOURNAL OF NEUROSCIENCE
- Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory
- (2013) Andrea Pristerà et al. NEUROBIOLOGY OF AGING
- AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons
- (2013) G. Amadoro et al. NEUROBIOLOGY OF DISEASE
- A role for tau at the synapse in Alzheimer's disease pathogenesis
- (2013) Amy M. Pooler et al. NEUROPHARMACOLOGY
- Profiling of Parkin-Binding Partners Using Tandem Affinity Purification
- (2013) Alessandra Zanon et al. PLoS One
- Why size matters – balancing mitochondrial dynamics in Alzheimer's disease
- (2013) Brian DuBoff et al. TRENDS IN NEUROSCIENCES
- Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up?
- (2013) Karl Grenier et al. Frontiers in Neurology
- Aβ1-42-mediated down-regulation of Uch-L1 is dependent on NF-κB activation and impaired BACE1 lysosomal degradation
- (2012) Michela Guglielmotto et al. AGING CELL
- The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System
- (2012) Hwan-Ching Tai et al. AMERICAN JOURNAL OF PATHOLOGY
- Mutant LRRK2 Elicits Calcium Imbalance and Depletion of Dendritic Mitochondria in Neurons
- (2012) Salvatore J. Cherra et al. AMERICAN JOURNAL OF PATHOLOGY
- Long time-lapse imaging reveals unique features of PARK2/Parkin-mediated mitophagy in mature cortical neurons
- (2012) Qian Cai et al. Autophagy
- Mitochondrial quality control by the ubiquitin–proteasome system: Figure 1
- (2012) Eric B. Taylor et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- A Double-Edged Sword with Therapeutic Potential: An Updated Role of Autophagy in Ischemic Cerebral Injury
- (2012) Kai Wei et al. CNS Neuroscience & Therapeutics
- Spatial Parkin Translocation and Degradation of Damaged Mitochondria via Mitophagy in Live Cortical Neurons
- (2012) Qian Cai et al. CURRENT BIOLOGY
- Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury
- (2012) Kathleen M. Schoch et al. EXPERIMENTAL NEUROLOGY
- Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons
- (2012) Seungmin Lee et al. HUMAN MOLECULAR GENETICS
- Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage
- (2012) M. Manczak et al. HUMAN MOLECULAR GENETICS
- Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease
- (2012) M. Manczak et al. HUMAN MOLECULAR GENETICS
- Regulation of parkin and PINK1 by neddylation
- (2012) Y. S. Choo et al. HUMAN MOLECULAR GENETICS
- ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons
- (2012) Alvin P. Joselin et al. HUMAN MOLECULAR GENETICS
- Phosphatase and Tensin Homolog (PTEN)-induced Putative Kinase 1 (PINK1)-dependent Ubiquitination of Endogenous Parkin Attenuates Mitophagy
- (2012) Aleksandar Rakovic et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitofusin2 Mutations Disrupt Axonal Mitochondrial Positioning and Promote Axon Degeneration
- (2012) A. L. Misko et al. JOURNAL OF NEUROSCIENCE
- Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway
- (2012) Keiichi Inoue et al. Molecular Neurodegeneration
- The interplay of neuronal mitochondrial dynamics and bioenergetics: Implications for Parkinson's disease
- (2012) Victor S. Van Laar et al. NEUROBIOLOGY OF DISEASE
- Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease
- (2012) Eugenia Trushina et al. PLoS One
- Differential Effects of UCHL1 Modulation on Alpha-Synuclein in PD-Like Models of Alpha-Synucleinopathy
- (2012) Anna E. Cartier et al. PLoS One
- Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits
- (2012) Julie A. Harris et al. PLoS One
- Analysis of a membrane-enriched proteome from postmortem human brain tissue in Alzheimer's disease
- (2012) Laura E. Donovan et al. Proteomics Clinical Applications
- Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2
- (2012) J H Zhu et al. Cell Death & Disease
- Neurodegeneration as a consequence of failed mitochondrial maintenance
- (2011) Mariusz Karbowski et al. ACTA NEUROPATHOLOGICA
- Synaptic Mitochondrial Pathology in Alzheimer's Disease
- (2011) Heng Du et al. ANTIOXIDANTS & REDOX SIGNALING
- Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics
- (2011) P. Hemachandra Reddy et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease
- (2011) P. Hemachandra Reddy BRAIN RESEARCH
- PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
- (2011) Xinnan Wang et al. CELL
- Autoregulation of Parkin activity through its ubiquitin-like domain
- (2011) Viduth K Chaugule et al. EMBO JOURNAL
- The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons
- (2011) Wendou Yu et al. HUMAN MOLECULAR GENETICS
- Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease
- (2011) M. J. Calkins et al. HUMAN MOLECULAR GENETICS
- Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy
- (2011) Nickie C. Chan et al. HUMAN MOLECULAR GENETICS
- Amyloid β-Mediated Cell Death of Cultured Hippocampal Neurons Reveals Extensive Tau Fragmentation without Increased Full-length Tau Phosphorylation
- (2011) Jack Reifert et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane
- (2011) Saori R. Yoshii et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dynamics of the Degradation of Ubiquitinated Proteins by Proteasomes and Autophagy
- (2011) Natura Myeku et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy
- (2011) Vinay Choubey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders
- (2011) Pravir Kumar et al. JOURNAL OF NEUROCHEMISTRY
- Parkin Interacts with Ambra1 to Induce Mitophagy
- (2011) C. Van Humbeeck et al. JOURNAL OF NEUROSCIENCE
- Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and α-synuclein aggregation
- (2011) Chia-Fu Chang et al. JOURNAL OF PINEAL RESEARCH
- Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease
- (2011) Alan S. L. Wong et al. NATURE CELL BIOLOGY
- Interaction between NH2-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration
- (2011) Giuseppina Amadoro et al. NEUROBIOLOGY OF AGING
- Truncated tau and Aβ cooperatively impair mitochondria in primary neurons
- (2011) Rodrigo A. Quintanilla et al. NEUROBIOLOGY OF AGING
- Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicity
- (2011) Anne Eckert et al. Alzheimers Research & Therapy
- Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD Mice
- (2011) Merina Varghese et al. Translational Neuroscience
- How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?
- (2010) Elena Ziviani et al. Autophagy
- Proteolytic processing of tau
- (2010) Yipeng Wang et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Mitochondrial Dynamics in Alzheimerʼs Disease
- (2010) David J. Bonda et al. DRUGS & AGING
- Role of autophagy in protection afforded by hypoxic preconditioning against MPP+-induced neurotoxicity in SH-SY5Y cells
- (2010) Y.W. Tzeng et al. FREE RADICAL BIOLOGY AND MEDICINE
- The Mitochondrial Inner Membrane GTPase, Optic Atrophy 1 (Opa1), Restores Mitochondrial Morphology and Promotes Neuronal Survival following Excitotoxicity
- (2010) Arezu Jahani-Asl et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
- (2010) Atsushi Tanaka et al. JOURNAL OF CELL BIOLOGY
- Mitofusin 2 Is Necessary for Transport of Axonal Mitochondria and Interacts with the Miro/Milton Complex
- (2010) A. Misko et al. JOURNAL OF NEUROSCIENCE
- Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo
- (2010) Shankar J. Chinta et al. NEUROSCIENCE LETTERS
- Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction
- (2010) F. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
- (2010) H. S. Ko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
- (2010) H. Du et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Parkin promotes intracellular A 1-42 clearance
- (2009) M. P. Burns et al. HUMAN MOLECULAR GENETICS
- Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons
- (2009) Rodrigo A. Quintanilla et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s disease
- (2009) Xinglong Wang et al. JOURNAL OF NEUROCHEMISTRY
- Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
- (2009) X. Wang et al. JOURNAL OF NEUROSCIENCE
- Regulation of Synaptic Structure by Ubiquitin C-Terminal Hydrolase L1
- (2009) A. E. Cartier et al. JOURNAL OF NEUROSCIENCE
- A Role for Ubiquitin in Selective Autophagy
- (2009) Vladimir Kirkin et al. MOLECULAR CELL
- Parkin Deficiency Delays Motor Decline and Disease Manifestation in a Mouse Model of Synucleinopathy
- (2009) Margot Fournier et al. PLoS One
- Membrane-associated farnesylated UCH-L1 promotes -synuclein neurotoxicity and is a therapeutic target for Parkinson's disease
- (2009) Z. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reversal of long-term dendritic spine alterations in Alzheimer disease models
- (2009) D. L. Smith et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Amyloid- and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
- (2009) V. Rhein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function
- (2009) Eleanor J. Davison et al. PROTEOMICS
- Reactive oxygen species generation is modulated by mitochondrial kinases: Correlation with mitochondrial antioxidant peroxidases in rat tissues
- (2008) Ana Paula S.A. Santiago et al. BIOCHIMIE
- Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice
- (2008) Jose A. Rodríguez-Navarro et al. HUMAN MOLECULAR GENETICS
- The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells
- (2008) Elli Kyratzi et al. HUMAN MOLECULAR GENETICS
- Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy
- (2008) Tomohiro Kabuta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease
- (2008) Fabrizio Trinchese et al. JOURNAL OF CLINICAL INVESTIGATION
- Effects of UCH-L1 on α-synuclein over-expression mouse model of Parkinson’s disease
- (2008) Toru Yasuda et al. JOURNAL OF NEUROCHEMISTRY
- Marked Calpastatin (CAST) Depletion in Alzheimer's Disease Accelerates Cytoskeleton Disruption and Neurodegeneration: Neuroprotection by CAST Overexpression
- (2008) M. V. Rao et al. JOURNAL OF NEUROSCIENCE
- Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer's disease models
- (2008) V. Corsetti et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity
- (2008) B.J. Walters et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Amyloid- overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
- (2008) X. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Extracellular protons differentially potentiate the responses of native AMPA receptor subtypes regulating neurotransmitter release
- (2005) Anna Pittaluga et al. BRITISH JOURNAL OF PHARMACOLOGY
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