Autoregulation of Parkin activity through its ubiquitin-like domain

Impact of Autosomal Recessive Juvenile Parkinson’s Disease Mutations on the Structure and Interactions of the Parkin Ubiquitin-like Domain

(2011) Susan S. Safadi et al.   BIOCHEMISTRY

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

(2011) Dawn M. Wenzel et al.   NATURE

PINK1/Parkin direct mitochondria to autophagy

(2010) Cristofol Vives-Bauza et al.   Autophagy

Parkin occurs in a stable, non-covalent, ∼110-kDa complex in brain

(2010) Cindy Van Humbeeck et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients

(2010) A. Rakovic et al.   HUMAN MOLECULAR GENETICS

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

The role of parkin in familial and sporadic Parkinson's disease

(2010) Ted M. Dawson et al.   MOVEMENT DISORDERS

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

(2010) G. Poulogiannis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

(2010) H. S. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF- B signaling

(2009) D. Sha et al.   HUMAN MOLECULAR GENETICS

Identification of a Novel Zn2+-binding Domain in the Autosomal Recessive Juvenile Parkinson-related E3 Ligase Parkin

(2009) Ventzislava A. Hristova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Interaction of the E3 Ligase Parkin with the Proteasomal Subunit S5a and the Endocytic Protein Eps15

(2009) Susan S. Safadi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SH3 Domains from a Subset of BAR Proteins Define a Ubl-Binding Domain and Implicate Parkin in Synaptic Ubiquitination

(2009) Jean-François Trempe et al.   MOLECULAR CELL

Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

(2009) Selvaraju Veeriah et al.   NATURE GENETICS

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL

Aberrant Folding of Pathogenic Parkin Mutants

(2008) Julia S. Schlehe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin mediates the degradation-independent ubiquitination of Hsp70

(2008) Darren J. Moore et al.   JOURNAL OF NEUROCHEMISTRY

Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

(2008) Anjanabha Saha et al.   MOLECULAR CELL

Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail

(2008) K. Yamoah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis for the autoregulation of the protein acetyl transferase Rtt109

(2008) P. Stavropoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA