The ring-shaped hexameric helicases that function at DNA replication forks

Mcm10 regulates DNA replication elongation by stimulating the CMG replicative helicase

(2017) Marko Lõoke et al.   GENES & DEVELOPMENT

Chromatin Constrains the Initiation and Elongation of DNA Replication

(2017) Sujan Devbhandari et al.   MOLECULAR CELL

Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer

(2017) Yuanliang Zhai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1

(2017) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation

(2017) Roxana Georgescu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CMG–Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome

(2017) Jin Chuan Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of the replisome reveals multiple interactions coordinating DNA synthesis

(2017) Arkadiusz W. Kulczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading

(2017) Gideon Coster et al.   SCIENCE

Hybrid Methods Reveal Multiple Flexibly Linked DNA Polymerases within the Bacteriophage T7 Replisome

(2017) Jamie R. Wallen et al.   STRUCTURE

Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer

(2017) Yuanliang Zhai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1

(2017) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chromosome Duplication in Saccharomyces cerevisiae

(2016) S. P. Bell et al.   GENETICS

Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation

(2016) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Archaeal orthologs of Cdc45 and GINS form a stable complex that stimulates the helicase activity of MCM

(2016) Yuli Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate

(2016) Ferdos Abid Ali et al.   Nature Communications

Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation

(2016) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the eukaryotic MCM complex at 3.8 Å

(2015) Ningning Li et al.   NATURE

Regulated eukaryotic DNA replication origin firing with purified proteins

(2015) Joseph T. P. Yeeles et al.   NATURE

The architecture of a eukaryotic replisome

(2015) Jingchuan Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement

(2015) Tatjana Petojevic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The architecture of a eukaryotic replisome

(2015) Jingchuan Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Archaeal MCM Proteins as an Analog for the Eukaryotic Mcm2–7 Helicase to Reveal Essential Features of Structure and Function

(2015) Justin M. Miller et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2–7 onto DNA

(2014) Stefan A. Samel et al.   GENES & DEVELOPMENT

CMG helicase and DNA polymerase   form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication

(2014) L. D. Langston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic look at DNA unwinding by a replicative helicase

(2014) Seung-Jae Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Conservation of the Pre-Sensor One Beta-Finger Hairpin (PS1-hp) Structures in Mini-Chromosome Maintenance Proteins of Saccharomyces cerevisiae and Archaea

(2014) Christopher J. Ramey et al.   G3-Genes Genomes Genetics

A conserved MCM single-stranded DNA binding element is essential for replication initiation

(2014) Clifford A Froelich et al.   eLife

The Hexameric Helicase DnaB Adopts a Nonplanar Conformation during Translocation

(2012) Ornchuma Itsathitphaisarn et al.   CELL

Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components

(2012) Mai Kanke et al.   EMBO JOURNAL

Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

(2012) Frederick van Deursen et al.   EMBO JOURNAL

Bypass of a protein barrier by a replicative DNA helicase

(2012) Hasan Yardimci et al.   NATURE

Eukaryotic Origin-Dependent DNA Replication In Vitro Reveals Sequential Action of DDK and S-CDK Kinases

(2011) Ryan C. Heller et al.   CELL

Selective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase

(2011) Yu V. Fu et al.   CELL

The nuts and bolts of ring-translocase structure and mechanism

(2011) Artem Y Lyubimov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

ATP-induced helicase slippage reveals highly coordinated subunits

(2011) Bo Sun et al.   NATURE

The structural basis for MCM2–7 helicase activation by GINS and Cdc45

(2011) Alessandro Costa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Origin DNA melting and unwinding in DNA replication

(2010) Dahai Gai et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins

(2010) Ivar Ilves et al.   MOLECULAR CELL

Common ancestry put to the test

(2010) Mike Steel et al.   NATURE

A formal test of the theory of universal common ancestry

(2010) Douglas L. Theobald   NATURE

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

Running in Reverse: The Structural Basis for Translocation Polarity in Hexameric Helicases

(2009) Nathan D. Thomsen et al.   CELL

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the Architecture of the Replicative Helicase from the Structure of an Archaeal MCM Homolog

(2009) Brian Bae et al.   STRUCTURE

On helicases and other motor proteins

(2008) Eric J Enemark et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Subunit Organization of Mcm2-7 and the Unequal Role of Active Sites in ATP Hydrolysis and Viability

(2008) M. L. Bochman et al.   MOLECULAR AND CELLULAR BIOLOGY

The Mcm2-7 Complex Has In Vitro Helicase Activity

(2008) Matthew L. Bochman et al.   MOLECULAR CELL

Structural analysis of the Sulfolobus solfataricus MCM protein N-terminal domain

(2008) W. Liu et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of a near-full-length archaeal MCM: Functional insights for an AAA+ hexameric helicase

(2008) A. S. Brewster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA