Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1

Phosphopeptide binding by Sld3 links Dbf4‐dependent kinase to MCM replicative helicase activation

(2016) Tom D Deegan et al.   EMBO JOURNAL

Chromosome Duplication in Saccharomyces cerevisiae

(2016) S. P. Bell et al.   GENETICS

Mechanism of Archaeal MCM Helicase Recruitment to DNA Replication Origins

(2016) Rachel Y. Samson et al.   MOLECULAR CELL

Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation

(2016) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate

(2016) Ferdos Abid Ali et al.   Nature Communications

Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation

(2016) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Drosophilamodel of Meier-Gorlin syndrome based on the mutation in a conserved C-Terminal domain of Orc6

(2015) Maxim Balasov et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading

(2015) Simina Ticau et al.   CELL

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Semi-automated selection of cryo-EM particles in RELION-1.3

(2015) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Structure of the eukaryotic MCM complex at 3.8 Å

(2015) Ningning Li et al.   NATURE

Crystal structure of the eukaryotic origin recognition complex

(2015) Franziska Bleichert et al.   NATURE

Regulated eukaryotic DNA replication origin firing with purified proteins

(2015) Joseph T. P. Yeeles et al.   NATURE

Structure and regulatory role of the C-terminal winged helix domain of the archaeal minichromosome maintenance complex

(2015) Christoph Wiedemann et al.   NUCLEIC ACIDS RESEARCH

A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2–7 onto DNA

(2014) Stefan A. Samel et al.   GENES & DEVELOPMENT

Structural and mechanistic insights into Mcm2–7 double-hexamer assembly and function

(2014) Jingchuan Sun et al.   GENES & DEVELOPMENT

Multiple Functions for Mcm2–7 ATPase Motifs during Replication Initiation

(2014) Sukhyun Kang et al.   MOLECULAR CELL

Origin Licensing Requires ATP Binding and Hydrolysis by the MCM Replicative Helicase

(2014) Gideon Coster et al.   MOLECULAR CELL

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

(2014) A. Amunts et al.   SCIENCE

An ORC/Cdc6/MCM2-7 Complex Is Formed in a Multistep Reaction to Serve as a Platform for MCM Double-Hexamer Assembly

(2013) Alejandra Fernández-Cid et al.   MOLECULAR CELL

ATPase-dependent quality control of DNA replication origin licensing

(2013) Jordi Frigola et al.   NATURE

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

(2013) Xueming Li et al.   NATURE METHODS

Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA

(2013) Jingchuan Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization

(2013) C. Evrin et al.   NUCLEIC ACIDS RESEARCH

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation

(2013) Cecile Evrin et al.   NUCLEIC ACIDS RESEARCH

Principles and Concepts of DNA Replication in Bacteria, Archaea, and Eukarya

(2013) M. O'Donnell et al.   Cold Spring Harbor Perspectives in Biology

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

(2013) Franziska Bleichert et al.   eLife

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Cdc6-Induced Conformational Changes in ORC Bound to Origin DNA Revealed by Cryo-Electron Microscopy

(2012) Jingchuan Sun et al.   STRUCTURE

The structural basis for MCM2–7 helicase activation by GINS and Cdc45

(2011) Alessandro Costa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insights into the Cdt1-mediated MCM2–7 chromatin loading

(2011) Changdong Liu et al.   NUCLEIC ACIDS RESEARCH

How a DNA Polymerase Clamp Loader Opens a Sliding Clamp

(2011) B. A. Kelch et al.   SCIENCE

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Cyclin-dependent kinase-dependent initiation of chromosomal DNA replication

(2010) Hiroyuki Araki   CURRENT OPINION IN CELL BIOLOGY

Architecture of the RNA polymerase II–TFIIF complex revealed by cross-linking and mass spectrometry

(2010) Zhuo Angel Chen et al.   EMBO JOURNAL

Characterization and Structure Determination of the Cdt1 Binding Domain of Human Minichromosome Maintenance (Mcm) 6

(2010) Zhun Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Replication: Making Two Forks from One Prereplication Complex

(2010) Michael Botchan et al.   MOLECULAR CELL

Uncoupling of Sister Replisomes during Eukaryotic DNA Replication

(2010) Hasan Yardimci et al.   MOLECULAR CELL

MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases

(2010) Jennifer M. Doyle et al.   MOLECULAR CELL

The Dbf4–Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4

(2010) Yi-Jun Sheu et al.   NATURE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

Eukaryotic DNA replication control: Lock and load, then fire

(2009) Dirk Remus et al.   CURRENT OPINION IN CELL BIOLOGY

The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication

(2009) Tomás Aparicio et al.   NUCLEIC ACIDS RESEARCH

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing

(2009) V. De Marco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On helicases and other motor proteins

(2008) Eric J Enemark et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Mcm2-7 Complex Has In Vitro Helicase Activity

(2008) Matthew L. Bochman et al.   MOLECULAR CELL

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

The architecture of the DNA replication origin recognition complex in Saccharomyces cerevisiae

(2008) Z. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA