Archaeal MCM Proteins as an Analog for the Eukaryotic Mcm2–7 Helicase to Reveal Essential Features of Structure and Function

Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement

(2015) Tatjana Petojevic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An approach to sequential NMR assignments of proteins: application to chemical shift restraint-based structure prediction

(2014) Christoph Wiedemann et al.   JOURNAL OF BIOMOLECULAR NMR

The solution structure of full-length dodecameric MCM by SANS and molecular modeling

(2014) Susan Krueger et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Diversity of the DNA Replication System in theArchaeaDomain

(2014) Felipe Sarmiento et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Analysis of the crystal structure of an active MCM hexamer

(2014) Justin M Miller et al.   eLife

DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome

(2014) Alessandro Costa et al.   eLife

A conserved MCM single-stranded DNA binding element is essential for replication initiation

(2014) Clifford A Froelich et al.   eLife

The Hexameric Helicase DnaB Adopts a Nonplanar Conformation during Translocation

(2012) Ornchuma Itsathitphaisarn et al.   CELL

Atomistic Ensemble Modeling and Small-Angle Neutron Scattering of Intrinsically Disordered Protein Complexes: Applied to Minichromosome Maintenance Protein

(2011) S. Krueger et al.   BIOPHYSICAL JOURNAL

Selective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase

(2011) Yu V. Fu et al.   CELL

Mutational analysis of conserved aspartic acid residues in the Methanothermobacter thermautotrophicus MCM helicase

(2011) Nozomi Sakakibara et al.   EXTREMOPHILES

The structural basis for MCM2–7 helicase activation by GINS and Cdc45

(2011) Alessandro Costa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Thermococcus kodakarensis encodes three MCM homologs but only one is essential

(2011) Miao Pan et al.   NUCLEIC ACIDS RESEARCH

Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding

(2011) Brian W. Graham et al.   NUCLEIC ACIDS RESEARCH

Solution NMR Structure of the C-terminal DNA Binding Domain of Mcm10 Reveals a Conserved MCM Motif

(2010) Patrick D. Robertson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization and Structure Determination of the Cdt1 Binding Domain of Human Minichromosome Maintenance (Mcm) 6

(2010) Zhun Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncoupling of Sister Replisomes during Eukaryotic DNA Replication

(2010) Hasan Yardimci et al.   MOLECULAR CELL

Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins

(2010) Ivar Ilves et al.   MOLECULAR CELL

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATP Hydrolysis and DNA Binding Confer Thermostability on the MCM Helicase†

(2009) Nozomi Sakakibara et al.   BIOCHEMISTRY

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

Running in Reverse: The Structural Basis for Translocation Polarity in Hexameric Helicases

(2009) Nathan D. Thomsen et al.   CELL

Intersubunit allosteric communication mediated by a conserved loop in the MCM helicase

(2009) E. R. Barry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the Architecture of the Replicative Helicase from the Structure of an Archaeal MCM Homolog

(2009) Brian Bae et al.   STRUCTURE

Biochemical Characterization of the Minichromosome Maintenance (MCM) Protein of the CrenarchaeoteAeropyrum pernixand Its Interactions with the Origin Recognition Complex (ORC) Proteins†

(2008) Neli Atanassova et al.   BIOCHEMISTRY

SnapShot: Nucleic Acid Helicases and Translocases

(2008) James M. Berger   CELL

Cryo-electron microscopy reveals a novel DNA-binding site on the MCM helicase

(2008) Alessandro Costa et al.   EMBO JOURNAL

Biochemical characterization of the minichromosome maintenance protein from the archaeon Thermoplasma acidophilum

(2008) Gyri Teien Haugland et al.   EXTREMOPHILES

Functional Conservation of  -Hairpin DNA Binding Domains in the Mcm Protein of Methanobacterium thermoautotrophicum and the Mcm5 protein of Saccharomyces cerevisiae

(2008) R. P. Leon et al.   GENETICS

Mutations in Subdomain B of the Minichromosome Maintenance (MCM) Helicase Affect DNA Binding and Modulate Conformational Transitions

(2008) Elizabeth R. Jenkinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mcm2-7 Complex Has In Vitro Helicase Activity

(2008) Matthew L. Bochman et al.   MOLECULAR CELL

Structural frameworks for considering microbial protein- and nucleic acid-dependent motor ATPases

(2008) Nathan D. Thomsen et al.   MOLECULAR MICROBIOLOGY

The 'glutamate switch' provides a link between ATPase activity and ligand binding in AAA+ proteins

(2008) Xiaodong Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Coupling of DNA binding and helicase activity is mediated by a conserved loop in the MCM protein

(2008) Nozomi Sakakibara et al.   NUCLEIC ACIDS RESEARCH

Structural analysis of the Sulfolobus solfataricus MCM protein N-terminal domain

(2008) W. Liu et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of a near-full-length archaeal MCM: Functional insights for an AAA+ hexameric helicase

(2008) A. S. Brewster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA