标题
Integrative omics for health and disease
作者
关键词
-
出版物
NATURE REVIEWS GENETICS
Volume 19, Issue 5, Pages 299-310
出版商
Springer Nature
发表日期
2018-02-26
DOI
10.1038/nrg.2018.4
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Using high-resolution variant frequencies to empower clinical genome interpretation
- (2017) Nicola Whiffin et al. GENETICS IN MEDICINE
- Fine-mapping inflammatory bowel disease loci to single-variant resolution
- (2017) Hailiang Huang et al. NATURE
- Enhancing GTEx by bridging the gaps between genotype, gene expression, and disease
- (2017) Barbara E Stranger et al. NATURE GENETICS
- Human genetic variation and the gut microbiome in disease
- (2017) Andrew Brantley Hall et al. NATURE REVIEWS GENETICS
- Network propagation: a universal amplifier of genetic associations
- (2017) Lenore Cowen et al. NATURE REVIEWS GENETICS
- Improving genetic diagnosis in Mendelian disease with transcriptome sequencing
- (2017) Beryl B. Cummings et al. Science Translational Medicine
- Genetic diagnosis of Mendelian disorders via RNA sequencing
- (2017) Laura S. Kremer et al. Nature Communications
- Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information
- (2017) Xiao Li et al. PLOS BIOLOGY
- Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer
- (2016) Hui Zhang et al. CELL
- Omics Profiling in Precision Oncology
- (2016) Kun-Hsing Yu et al. MOLECULAR & CELLULAR PROTEOMICS
- Proteogenomics connects somatic mutations to signalling in breast cancer
- (2016) Philipp Mertins et al. NATURE
- Analysis of protein-coding genetic variation in 60,706 humans
- (2016) Monkol Lek et al. NATURE
- Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer
- (2016) Akash Kumar et al. NATURE MEDICINE
- Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases
- (2016) Daniel Marbach et al. NATURE METHODS
- Gene expression elucidates functional impact of polygenic risk for schizophrenia
- (2016) Menachem Fromer et al. NATURE NEUROSCIENCE
- Type 2 diabetes: genetic data sharing to advance complex disease research
- (2016) Jason Flannick et al. NATURE REVIEWS GENETICS
- Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease
- (2016) Amit V. Khera et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genetic Misdiagnoses and the Potential for Health Disparities
- (2016) Arjun K. Manrai et al. NEW ENGLAND JOURNAL OF MEDICINE
- Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
- (2016) H. Chu et al. SCIENCE
- Quantifying prion disease penetrance using large population control cohorts
- (2016) Eric Vallabh Minikel et al. Science Translational Medicine
- CRISPR/Cas9 Targeted Gene Editing and Cellular Engineering in Fanconi Anemia
- (2016) Mark J. Osborn et al. STEM CELLS AND DEVELOPMENT
- Predicting non-small cell lung cancer prognosis by fully automated microscopic pathology image features
- (2016) Kun-Hsing Yu et al. Nature Communications
- The Genetic Basis of Mendelian Phenotypes: Discoveries, Challenges, and Opportunities
- (2015) Jessica X. Chong et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Strategies for fine-mapping complex traits
- (2015) Sarah L. Spain et al. HUMAN MOLECULAR GENETICS
- Noninvasive Prenatal Testing and Incidental Detection of Occult Maternal Malignancies
- (2015) Diana W. Bianchi et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials
- (2015) Jessica L Mega et al. LANCET
- Integrative analysis of 111 reference human epigenomes
- (2015) Anshul Kundaje et al. NATURE
- Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease
- (2015) Elizabeta Gjoneska et al. NATURE
- Cell-of-origin chromatin organization shapes the mutational landscape of cancer
- (2015) Paz Polak et al. NATURE
- Genetic studies of body mass index yield new insights for obesity biology
- (2015) Adam E. Locke et al. NATURE
- Factors influencing success of clinical genome sequencing across a broad spectrum of disorders
- (2015) Jenny C Taylor et al. NATURE GENETICS
- Identification of significantly mutated regions across cancer types highlights a rich landscape of functional molecular alterations
- (2015) Carlos L Araya et al. NATURE GENETICS
- Recurrent somatic mutations in regulatory regions of human cancer genomes
- (2015) Collin Melton et al. NATURE GENETICS
- Partitioning heritability by functional annotation using genome-wide association summary statistics
- (2015) Hilary K Finucane et al. NATURE GENETICS
- Return of genetic testing results in the era of whole-genome sequencing
- (2015) Bartha Maria Knoppers et al. NATURE REVIEWS GENETICS
- Methods of integrating data to uncover genotype–phenotype interactions
- (2015) Marylyn D. Ritchie et al. NATURE REVIEWS GENETICS
- The role of regulatory variation in complex traits and disease
- (2015) Frank W. Albert et al. NATURE REVIEWS GENETICS
- FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
- (2015) Melina Claussnitzer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Development of a high-resolution NGS-based HLA-typing and analysis pipeline
- (2015) M. Wittig et al. NUCLEIC ACIDS RESEARCH
- Noninvasive monitoring of infection and rejection after lung transplantation
- (2015) Iwijn De Vlaminck et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Plasma metabolomic profiles enhance precision medicine for volunteers of normal health
- (2015) Lining Guo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The human transcriptome across tissues and individuals
- (2015) M. Mele et al. SCIENCE
- The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
- (2015) et al. SCIENCE
- Long-term neural and physiological phenotyping of a single human
- (2015) Russell A. Poldrack et al. Nature Communications
- Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders
- (2015) Jingjing Li et al. Cell Systems
- Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases
- (2014) Alexander Gusev et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Joint Analysis of Functional Genomic Data and Genome-wide Association Studies of 18 Human Traits
- (2014) Joseph K. Pickrell AMERICAN JOURNAL OF HUMAN GENETICS
- Protein–protein interactions and genetic diseases: The interactome
- (2014) Kasper Lage BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Human Genetics Shape the Gut Microbiome
- (2014) Julia K. Goodrich et al. CELL
- The Integrative Human Microbiome Project: Dynamic Analysis of Microbiome-Host Omics Profiles during Periods of Human Health and Disease
- (2014) Cell Host & Microbe
- The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead
- (2014) Aleksandar D. Kostic et al. GASTROENTEROLOGY
- Estimating genotype error rates from high-coverage next-generation sequence data
- (2014) Jeffrey D. Wall et al. GENOME RESEARCH
- Clinical Exome Sequencing for Genetic Identification of Rare Mendelian Disorders
- (2014) Hane Lee et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Research Review: Polygenic methods and their application to psychiatric traits
- (2014) Naomi R. Wray et al. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
- “Is it Going to Hurt?”: The Impact of the Diagnostic Odyssey on Children and Their Families
- (2014) Nikkola Carmichael et al. Journal of Genetic Counseling
- Integrated systems analysis reveals a molecular network underlying autism spectrum disorders
- (2014) J. Li et al. Molecular Systems Biology
- An atlas of active enhancers across human cell types and tissues
- (2014) Robin Andersson et al. NATURE
- Proteogenomic characterization of human colon and rectal cancer
- (2014) Bing Zhang et al. NATURE
- Expanding the computational toolbox for mining cancer genomes
- (2014) Li Ding et al. NATURE REVIEWS GENETICS
- Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes
- (2014) A. R. Majithia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Circulating Cell-Free DNA Enables Noninvasive Diagnosis of Heart Transplant Rejection
- (2014) I. De Vlaminck et al. Science Translational Medicine
- Functional annotation of colon cancer risk SNPs
- (2014) Lijing Yao et al. Nature Communications
- Variants of uncertain significance in BRCA: a harbinger of ethical and policy issues to come?
- (2014) Jae Yeon Cheon et al. Genome Medicine
- Complex host genetics influence the microbiome in inflammatory bowel disease
- (2014) Dan Knights et al. Genome Medicine
- Integrated Genomic Characterization Reveals Novel, Therapeutically Relevant Drug Targets in FGFR and EGFR Pathways in Sporadic Intrahepatic Cholangiocarcinoma
- (2014) Mitesh J. Borad et al. PLoS Genetics
- ATHENA: the analysis tool for heritable and environmental network associations
- (2013) Emily R. Holzinger et al. BIOINFORMATICS
- Massively parallel sequencing, aCGH, and RNA-Seq technologies provide a comprehensive molecular diagnosis of Fanconi anemia
- (2013) S. C. Chandrasekharappa et al. BLOOD
- Making the genomic leap in HCT: application of second-generation sequencing to clinical advances in hematopoietic cell transplantation
- (2013) Yun R Li et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing
- (2013) Robert C. Green et al. GENETICS IN MEDICINE
- Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas
- (2013) Marco Gerlinger et al. JOURNAL OF PATHOLOGY
- Transcriptome and genome sequencing uncovers functional variation in humans
- (2013) Tuuli Lappalainen et al. NATURE
- The integrated landscape of driver genomic alterations in glioblastoma
- (2013) Veronique Frattini et al. NATURE GENETICS
- Integrated molecular analysis of clear-cell renal cell carcinoma
- (2013) Yusuke Sato et al. NATURE GENETICS
- High-resolution network biology: connecting sequence with function
- (2013) Colm J. Ryan et al. NATURE REVIEWS GENETICS
- Integrative approaches for finding modular structure in biological networks
- (2013) Koyel Mitra et al. NATURE REVIEWS GENETICS
- Bringing genome-wide association findings into clinical use
- (2013) Teri A. Manolio NATURE REVIEWS GENETICS
- Clinical Whole-Exome Sequencing for the Diagnosis of Mendelian Disorders
- (2013) Yaping Yang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Systematic functional regulatory assessment of disease-associated variants
- (2013) Konrad J. Karczewski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
- (2013) C. A. Rietveld et al. SCIENCE
- Genomics in Clinical Practice: Lessons from the Front Lines
- (2013) H. J. Jacob et al. Science Translational Medicine
- Five Years of GWAS Discovery
- (2012) Peter M. Visscher et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Comparison of Outcomes after HLA-Matched Sibling and Unrelated Donor Transplantation for Children with High-Risk Acute Lymphoblastic Leukemia
- (2012) Mei-Jie Zhang et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes
- (2012) Rui Chen et al. CELL
- A Bayesian Integrative Genomic Model for Pathway Analysis of Complex Traits
- (2012) Brooke L. Fridley et al. GENETIC EPIDEMIOLOGY
- Linking disease associations with regulatory information in the human genome
- (2012) M. A. Schaub et al. GENOME RESEARCH
- Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic Vulnerabilities
- (2012) D. W. Craig et al. MOLECULAR CANCER THERAPEUTICS
- Patterns and rates of exonic de novo mutations in autism spectrum disorders
- (2012) Benjamin M. Neale et al. NATURE
- Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- (2012) NATURE GENETICS
- Computational tools for prioritizing candidate genes: boosting disease gene discovery
- (2012) Yves Moreau et al. NATURE REVIEWS GENETICS
- Annual Summary of Vital Statistics: 2009
- (2012) K. D. Kochanek et al. PEDIATRICS
- Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development
- (2012) K. Lage et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High-throughput, high-fidelity HLA genotyping with deep sequencing
- (2012) C. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
- (2012) M. T. Maurano et al. SCIENCE
- Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
- (2012) Xochitl C Morgan et al. GENOME BIOLOGY
- Integrated genomic analyses of ovarian carcinoma
- (2011) D. Bell et al. NATURE
- Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus
- (2011) Indra Adrianto et al. NATURE GENETICS
- Universal noninvasive detection of solid organ transplant rejection
- (2011) T. M. Snyder et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Understanding the role of gut microbiome–host metabolic signal disruption in health and disease
- (2011) Elaine Holmes et al. TRENDS IN MICROBIOLOGY
- Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence
- (2011) Frederick E. Dewey et al. PLoS Genetics
- A Versatile Gene-Based Test for Genome-wide Association Studies
- (2010) Jimmy Z. Liu et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Making a definitive diagnosis: Successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease
- (2010) Elizabeth A Worthey et al. GENETICS IN MEDICINE
- Clinical assessment incorporating a personal genome
- (2010) Euan A Ashley et al. LANCET
- In silico research in the era of cloud computing
- (2010) Joel T Dudley et al. NATURE BIOTECHNOLOGY
- Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
- (2010) Nadja Larsen et al. PLoS One
- Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors
- (2010) A. K. Benson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Variation in Transcription Factor Binding Among Humans
- (2010) M. Kasowski et al. SCIENCE
- Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS
- (2010) Dan L. Nicolae et al. PLoS Genetics
- The case for cloud computing in genome informatics
- (2010) Lincoln D Stein GENOME BIOLOGY
- Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease
- (2009) Steven A McCarroll et al. NATURE GENETICS
- Exome sequencing identifies the cause of a mendelian disorder
- (2009) Sarah B Ng et al. NATURE GENETICS
- Alternative isoform regulation in human tissue transcriptomes
- (2008) Eric T. Wang et al. NATURE
- A core gut microbiome in obese and lean twins
- (2008) Peter J. Turnbaugh et al. NATURE
- Mapping and quantifying mammalian transcriptomes by RNA-Seq
- (2008) Ali Mortazavi et al. NATURE METHODS
- RNA-Seq: a revolutionary tool for transcriptomics
- (2008) Zhong Wang et al. NATURE REVIEWS GENETICS
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now