标题
The promise and challenges of immune agonist antibody development in cancer
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 17, Issue 7, Pages 509-527
出版商
Springer Nature
发表日期
2018-06-15
DOI
10.1038/nrd.2018.75
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The future of immune checkpoint cancer therapy after PD-1 and CTLA-4
- (2017) Andrew W Hahn et al. Immunotherapy
- Safety and Activity of Varlilumab, a Novel and First-in-Class Agonist Anti-CD27 Antibody, in Patients With Advanced Solid Tumors
- (2017) Howard A. Burris et al. JOURNAL OF CLINICAL ONCOLOGY
- Functional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization
- (2017) Di Zhang et al. mAbs
- Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling
- (2017) Cristian R Smulski et al. Cell Death & Disease
- Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity
- (2017) Dmitriy Zamarin et al. Nature Communications
- Concurrent PD-1 Blockade Negates the Effects of OX40 Agonist Antibody in Combination Immunotherapy through Inducing T-cell Apoptosis
- (2017) Rajeev K. Shrimali et al. Cancer Immunology Research
- MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential
- (2017) Natalie J. Tigue et al. OncoImmunology
- GITR ligand fusion protein agonist enhances the tumor antigen–specific CD8 T-cell response and leads to long-lasting memory
- (2017) Nick M. Durham et al. Journal for ImmunoTherapy of Cancer
- Influence of immunoglobulin isotype on therapeutic antibody function
- (2016) Stephen A. Beers et al. BLOOD
- Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade
- (2016) Haidong Tang et al. CANCER CELL
- Follicular B Lymphomas Generate Regulatory T Cells via the ICOS/ICOSL Pathway and Are Susceptible to Treatment by Anti-ICOS/ICOSL Therapy
- (2016) K.-S. Le et al. CANCER RESEARCH
- ICOS Promotes the Function of CD4+Effector T Cells during Anti-OX40–Mediated Tumor Rejection
- (2016) Todd C. Metzger et al. CANCER RESEARCH
- Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor Immunotherapy
- (2016) Ashley E. Mahne et al. CANCER RESEARCH
- Results from an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody
- (2016) Neil H. Segal et al. CLINICAL CANCER RESEARCH
- Rationale for anti-GITR cancer immunotherapy
- (2016) Deborah A. Knee et al. EUROPEAN JOURNAL OF CANCER
- Rationale for anti-OX40 cancer immunotherapy
- (2016) Sandrine Aspeslagh et al. EUROPEAN JOURNAL OF CANCER
- CD28 Costimulation: From Mechanism to Therapy
- (2016) Jonathan H. Esensten et al. IMMUNITY
- Co-stimulatory and Co-inhibitory Pathways in Autoimmunity
- (2016) Qianxia Zhang et al. IMMUNITY
- Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer
- (2016) George Plitas et al. IMMUNITY
- Despite slow progress, bispecifics generate buzz
- (2016) Cormac Sheridan NATURE BIOTECHNOLOGY
- Development of immuno-oncology drugs — from CTLA4 to PD1 to the next generations
- (2016) Axel Hoos NATURE REVIEWS DRUG DISCOVERY
- Conformation of the Human Immunoglobulin G2 Hinge Imparts Superagonistic Properties to Immunostimulatory Anticancer Antibodies
- (2015) Ann L. White et al. CANCER CELL
- Differential Fc-Receptor Engagement Drives an Anti-tumor Vaccinal Effect
- (2015) David J. DiLillo et al. CELL
- Principles of antibody-mediated TNF receptor activation
- (2015) H Wajant CELL DEATH AND DIFFERENTIATION
- Dual antibody therapy to harness the innate anti-tumor immune response to enhance antibody targeting of tumors
- (2015) Cariad Chester et al. CURRENT OPINION IN IMMUNOLOGY
- FcγR requirements leading to successful immunotherapy
- (2015) Lekh N. Dahal et al. IMMUNOLOGICAL REVIEWS
- Bispecific antibodies and their applications
- (2015) Gaowei Fan et al. Journal of Hematology & Oncology
- Integrated molecular analysis of adult T cell leukemia/lymphoma
- (2015) Keisuke Kataoka et al. NATURE GENETICS
- 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
- (2015) Adrienne H Long et al. NATURE MEDICINE
- A multi-trimeric fusion of CD40L and gp100 tumor antigen activates dendritic cells and enhances survival in a B16-F10 melanoma DNA vaccine model
- (2015) Sachin Gupta et al. VACCINE
- 4-1BB Agonists: Multi-Potent Potentiators of Tumor Immunity
- (2015) Todd Bartkowiak et al. Frontiers in Oncology
- OX40 Agonists and Combination Immunotherapy: Putting the Pedal to the Metal
- (2015) Stefanie N. Linch et al. Frontiers in Oncology
- Colloidal Drug Formulations Can Explain “Bell-Shaped” Concentration–Response Curves
- (2014) Shawn C. Owen et al. ACS Chemical Biology
- Upregulation of FcγRIIb on monocytes is necessary to promote the superagonist activity of TGN1412
- (2014) Khiyam Hussain et al. BLOOD
- Regulatory T cells in cancer immunotherapy
- (2014) Hiroyoshi Nishikawa et al. CURRENT OPINION IN IMMUNOLOGY
- TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants – past, present and future
- (2014) Lisa M. Sedger et al. CYTOKINE & GROWTH FACTOR REVIEWS
- OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy
- (2014) Yannick Bulliard et al. IMMUNOLOGY AND CELL BIOLOGY
- CD80 and CD86 IgC domains are important for quaternary structure, receptor binding and co-signaling function
- (2014) Tanya Girard et al. IMMUNOLOGY LETTERS
- Agonistic anti-CD137 antibody treatment leads to antitumor response in mice with liver cancer
- (2014) Vanessa Gauttier et al. INTERNATIONAL JOURNAL OF CANCER
- Targeting CD137 enhances the efficacy of cetuximab
- (2014) Holbrook E. Kohrt et al. JOURNAL OF CLINICAL INVESTIGATION
- Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy
- (2014) Xiaozhou Fan et al. JOURNAL OF EXPERIMENTAL MEDICINE
- ICOS Ligation Recruits the p50 PI3K Regulatory Subunit to the Immunological Synapse
- (2014) C. Fos et al. JOURNAL OF IMMUNOLOGY
- Fcγ Receptor Dependency of Agonistic CD40 Antibody in Lymphoma Therapy Can Be Overcome through Antibody Multimerization
- (2014) Ann L. White et al. JOURNAL OF IMMUNOLOGY
- Cell Contact-Dependent Priming and Fc Interaction with CD32+ Immune Cells Contribute to the TGN1412-Triggered Cytokine Response
- (2014) P. Bartholomaeus et al. JOURNAL OF IMMUNOLOGY
- Targeted delivery of CD40L promotes restricted activation of antigen-presenting cells and induction of cancer cell death
- (2014) Kim L Brunekreeft et al. Molecular Cancer
- Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
- (2014) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- IgG Subclasses and Allotypes: From Structure to Effector Functions
- (2014) Gestur Vidarsson et al. Frontiers in Immunology
- Long-term survival and immunological parameters in metastatic melanoma patients who responded to ipilimumab 10 mg/kg within an expanded access programme
- (2013) Anna Maria Di Giacomo et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- OX40 Is a Potent Immune-Stimulating Target in Late-Stage Cancer Patients
- (2013) B. D. Curti et al. CANCER RESEARCH
- Agonist Antibodies to TNFR Molecules That Costimulate T and NK Cells
- (2013) I. Melero et al. CLINICAL CANCER RESEARCH
- Agonistic CD40 Antibodies and Cancer Therapy
- (2013) R. H. Vonderheide et al. CLINICAL CANCER RESEARCH
- Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08
- (2013) Paula Tabares et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Fcγ receptors enable anticancer action of proapoptotic and immune-modulatory antibodies
- (2013) Jeong M. Kim et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies
- (2013) Yannick Bulliard et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
- (2013) Tyler R. Simpson et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Agonist Anti-Human CD27 Monoclonal Antibody Induces T Cell Activation and Tumor Immunity in Human CD27-Transgenic Mice
- (2013) L.-Z. He et al. JOURNAL OF IMMUNOLOGY
- Engineered antibody Fc variant with selectively enhanced Fc RIIb binding over both Fc RIIaR131 and Fc RIIaH131
- (2013) F. Mimoto et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Death Receptor-Ligand Systems in Cancer, Cell Death, and Inflammation
- (2013) H. Walczak Cold Spring Harbor Perspectives in Biology
- The Basic Principles of Chimeric Antigen Receptor Design
- (2013) Michel Sadelain et al. Cancer Discovery
- Role of Crosslinking for Agonistic CD40 Monoclonal Antibodies as Immune Therapy of Cancer
- (2013) L. P. Richman et al. Cancer Immunology Research
- Phase I study of the CD40 agonist antibody CP-870,893 combined with carboplatin and paclitaxel in patients with advanced solid tumors
- (2013) Robert H. Vonderheide et al. OncoImmunology
- Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity
- (2012) Timothy S. Fisher et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- ICOS-Ligand Expression on Plasmacytoid Dendritic Cells Supports Breast Cancer Progression by Promoting the Accumulation of Immunosuppressive CD4+ T Cells
- (2012) J. Faget et al. CANCER RESEARCH
- CD27 Signaling Increases the Frequency of Regulatory T Cells and Promotes Tumor Growth
- (2012) C. Claus et al. CANCER RESEARCH
- A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency
- (2012) M Chodorge et al. CELL DEATH AND DIFFERENTIATION
- Development of a Human Monoclonal Antibody for Potential Therapy of CD27-Expressing Lymphoma and Leukemia
- (2012) L. A. Vitale et al. CLINICAL CANCER RESEARCH
- Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer
- (2012) Holbrook E. Kohrt et al. JOURNAL OF CLINICAL INVESTIGATION
- Impact of Epidermal Growth Factor Receptor (EGFR) Cell Surface Expression Levels on Effector Mechanisms of EGFR Antibodies
- (2012) S. Derer et al. JOURNAL OF IMMUNOLOGY
- Association of OX40L Polymorphisms with Sporadic Breast Cancer in Northeast Chinese Han Population
- (2012) Yuan Weiguang et al. PLoS One
- Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fc receptor engagement
- (2012) F. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Association between genetic variations in tumor necrosis factor receptor genes and survival of patients with T-cell lymphoma
- (2012) Kan Zhai et al. Chinese Journal of Cancer
- Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412
- (2011) P. S. Romer et al. BLOOD
- Pharmacological modulation of GITRL/GITR system: therapeutic perspectives
- (2011) Giuseppe Nocentini et al. BRITISH JOURNAL OF PHARMACOLOGY
- Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumors
- (2011) Jens Rüter et al. CANCER BIOLOGY & THERAPY
- An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells
- (2011) Nicholas S. Wilson et al. CANCER CELL
- B7-H2 Is a Costimulatory Ligand for CD28 in Human
- (2011) Sheng Yao et al. IMMUNITY
- Science gone translational: the OX40 agonist story
- (2011) Andrew D. Weinberg et al. IMMUNOLOGICAL REVIEWS
- Interaction with Fc RIIB Is Critical for the Agonistic Activity of Anti-CD40 Monoclonal Antibody
- (2011) A. L. White et al. JOURNAL OF IMMUNOLOGY
- Costimulation Through the CD137/4-1BB Pathway Protects Human Melanoma Tumor-infiltrating Lymphocytes From Activation-induced Cell Death and Enhances Antitumor Effector Function
- (2011) Jessica Ann Hernandez-Chacon et al. JOURNAL OF IMMUNOTHERAPY
- Protective Effector Memory CD4 T Cells Depend on ICOS for Survival
- (2011) Tamson V. Moore et al. PLoS One
- Combination CTLA-4 Blockade and 4-1BB Activation Enhances Tumor Rejection by Increasing T-Cell Infiltration, Proliferation, and Cytokine Production
- (2011) Michael A. Curran et al. PLoS One
- CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans
- (2011) G. L. Beatty et al. SCIENCE
- Inhibitory Fc Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies
- (2011) F. Li et al. SCIENCE
- CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies
- (2010) H. E. Kohrt et al. BLOOD
- Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity
- (2010) E. Mossner et al. BLOOD
- Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells
- (2010) D Eastwood et al. BRITISH JOURNAL OF PHARMACOLOGY
- Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ
- (2010) Juan Dubrot et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Preoperative CTLA-4 Blockade: Tolerability and Immune Monitoring in the Setting of a Presurgical Clinical Trial
- (2010) B. C. Carthon et al. CLINICAL CANCER RESEARCH
- Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates
- (2010) Julie R. Brahmer et al. JOURNAL OF CLINICAL ONCOLOGY
- Stimulation of the Glucocorticoid-Induced TNF Receptor Family-Related Receptor on CD8 T Cells Induces Protective and High-Avidity T Cell Responses to Tumor-Specific Antigens
- (2010) A. L. Cote et al. JOURNAL OF IMMUNOLOGY
- CD137-Mediated Pathogenesis from Chronic Hepatitis to Hepatocellular Carcinoma in Hepatitis B Virus-Transgenic Mice
- (2010) J. Wang et al. JOURNAL OF IMMUNOLOGY
- CD40 Expression by Human Melanocytic Lesions and Melanoma Cell Lines and Direct CD40 Targeting With the Therapeutic Anti-CD40 Antibody CP-870,893
- (2010) Anusha Kalbasi et al. JOURNAL OF IMMUNOTHERAPY
- An Enigmatic Tail of CD28 Signaling
- (2010) J. S. Boomer et al. Cold Spring Harbor Perspectives in Biology
- Anti-CD30 Antibodies for Hodgkin Lymphoma
- (2010) Kelley V. Foyil et al. Current Hematologic Malignancy Reports
- PD-1 signaling in primary T cells
- (2009) James L. Riley IMMUNOLOGICAL REVIEWS
- LIGHT protein suppresses tumor growth by augmentation of immune response
- (2009) Tomohiro Morishige et al. IMMUNOLOGY LETTERS
- The Structure of the Trimer of Human 4-1BB Ligand Is Unique among Members of the Tumor Necrosis Factor Superfamily
- (2009) Eun-Young Won et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand
- (2009) A. Wyzgol et al. JOURNAL OF IMMUNOLOGY
- Impaired CD4 and CD8 Effector Function and Decreased Memory T Cell Populations in ICOS-Deficient Patients
- (2009) N. Takahashi et al. JOURNAL OF IMMUNOLOGY
- Anti-CTLA-4 therapy results in higher CD4+ICOShiT cell frequency and IFN-γ levels in both nonmalignant and malignant prostate tissues
- (2009) Hong Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Specificity and affinity of human Fc receptors and their polymorphic variants for human IgG subclasses
- (2008) P. Bruhns et al. BLOOD
- Assembling OX40 Aptamers on a Molecular Scaffold to Create a Receptor-Activating Aptamer
- (2008) Claudia M. Dollins et al. CHEMISTRY & BIOLOGY
- Toward experimental assessment of receptor occupancy: TGN1412 revisited
- (2008) Zoe Waibler et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice
- (2008) James O. McNamara et al. JOURNAL OF CLINICAL INVESTIGATION
- OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
- (2008) Silvia Piconese et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Structural basis for ligand-mediated mouse GITR activation
- (2008) Z. Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states
- (2008) Z. Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A soluble hexameric form of CD40 ligand activates human dendritic cells and augments memory T cell response
- (2008) Isabelle Miconnet et al. VACCINE
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