Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412

Memory T cells as an occupying force

(2011) Michael J. Bevan   EUROPEAN JOURNAL OF IMMUNOLOGY

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells

(2010) D Eastwood et al.   BRITISH JOURNAL OF PHARMACOLOGY

Type 1 Diabetes in BioBreeding Rats Is Critically Linked to an Imbalance between Th17 and Regulatory T Cells and an Altered TCR Repertoire

(2010) J. van den Brandt et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis

(2010) M. M. Zaiss et al.   JOURNAL OF IMMUNOLOGY

The safety and side effects of monoclonal antibodies

(2010) Trevor T. Hansel et al.   NATURE REVIEWS DRUG DISCOVERY

Inducing CTLA-4-Dependent Immune Regulation by Selective CD28 Blockade Promotes Regulatory T Cells in Organ Transplantation

(2010) N. Poirier et al.   Science Translational Medicine

Superagonistic CD28 stimulation of allogeneic T cells protects from acute graft-versus-host disease

(2009) N. Beyersdorf et al.   BLOOD

The molecular basis of TCR germline bias for MHC is surprisingly simple

(2009) K Christopher Garcia et al.   NATURE IMMUNOLOGY

Superagonistic CD28 Antibody Induces Donor-Specific Tolerance in Rat Renal Allografts

(2008) H. Azuma et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Protection from graft-versus-host disease with a novel B7 binding site-specific mouse anti-mouse CD28 monoclonal antibody

(2008) N. Beyersdorf et al.   BLOOD

Proliferative signals mediated by CD28 superagonists require the exchange factor Vav1 but not phosphoinositide 3-kinase in primary peripheral T cells

(2008) Tea Gogishvili et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD28 Superagonists: What Makes the Difference in Humans?

(2008) Burkhart Schraven et al.   IMMUNITY

Toward experimental assessment of receptor occupancy: TGN1412 revisited

(2008) Zoe Waibler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inhibition of ZAP-70 Kinase Activity via an Analog-sensitive Allele Blocks T Cell Receptor and CD28 Superagonist Signaling

(2008) Susan E. Levin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats

(2008) Nora Müller et al.   JOURNAL OF CLINICAL INVESTIGATION

Foxp3-expressing Regulatory T Cells Expanded With CD28 Superagonist Antibody Can Prevent Rat Cardiac Allograft Rejection

(2008) Yusuke Kitazawa et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Experimental Expansion of the Regulatory T Cell Population Increases Resistance to African Trypanosomiasis

(2008) Martin Guilliams et al.   JOURNAL OF INFECTIOUS DISEASES