Article
Immunology
Gustavo Ferreira Alves, Ian Stoppa, Eleonora Aimaretti, Chiara Monge, Raffaella Mastrocola, Elisa Porchietto, Giacomo Einaudi, Debora Collotta, Ilaria Bertocchi, Elena Boggio, Casimiro Luca Gigliotti, Nausicaa Clemente, Manuela Aragno, Daniel Fernandes, Carlo Cifani, Christoph Thiemermann, Chiara Dianzani, Umberto Dianzani, Massimo Collino
Summary: ICOS-Fc can act as an immunomodulatory drug to protect against sepsis by modulating cytokine release and cell migration, reducing inflammation and organ damage.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Barbara Molon, Cristina Liboni, Antonella Viola
Summary: This article discusses the important role of T cells in immune response and the regulatory mechanisms of signaling compartmentalization during T cell activation and functions, focusing on the role of CD28, chemokine receptors, and the actin cytoskeleton. It also considers the detrimental effect of mutations in signaling proteins on T cell functionality.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Helene Vitet, Julie Bruyere, Hao Xu, Claire Seris, Jacques Brocard, Yah-Se Abada, Benoit Delatour, Chiara Scaramuzzino, Laurent Venance, Frederic Saudou
Summary: Neurotransmitters are released at synapses by synaptic vesicles (SVs), and the axonal transport of SV precursors (SVPs) has been thought to have no effect on synaptic function. However, phosphorylation of the Huntingtin protein (HTT) has been found to increase axonal transport of SVPs, leading to increased synaptic glutamate release and affecting synaptic plasticity and motor skill learning.
Article
Multidisciplinary Sciences
Audun Kvalvaag, Salvatore Valvo, Pablo F. Cespedes, David G. Saliba, Elke Kurz, Kseniya Korobchevskaya, Michael L. Dustin
Summary: Ligation of TCR to pMHC induces TCR ubiquitination and either internalization by T cell or release in extracellular vesicles. Clathrin-mediated ectocytosis facilitates the release of TCR, while clathrin-mediated trans-endocytosis enables the uptake of pMHC-TCR conjugates from the APC.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Jose Luis Rodriguez-Fernandez, Olga Criado-Garcia
Summary: Dendritic cells are powerful antigen-presenting cells that control T cell activation through the immunological synapse. While most studies focus on the T cell side, dendritic cell side also plays a significant role in T cell activation, especially through actin polarization at the IS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiang-Hong Ran, Jia-Wu Zhu, Run-Ze Ni, Yong-Tang Zheng, Ya-Yun Chen, Wei-Hua Zheng, Dan Mu
Summary: Tripartite motif-containing protein 5 alpha (TRIM5 alpha) plays a crucial role in maintaining viral latency. Knockdown of TRIM5 alpha enhances the transcription of HIV-1, which can be reversed by shRNA-resistant TRIM5 alpha. TRIM5 alpha suppresses HIV-1 gene expression by binding to and enhancing the recruitment of histone deacetylase 1 (HDAC1) to NF-kappa B and Sp1.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Sara Danielli, Zhongming Ma, Eirini Pantazi, Amrendra Kumar, Benjamin Demarco, Fabian A. Fischer, Usha Paudel, Jillian Weissenrieder, Robert J. Lee, Sebastian Joyce, J. Kevin Foskett, Jelena S. Bezbradica
Summary: CALHM6, a membrane ion channel, promotes cell-cell crosstalk at neuronal synapses via ATP release and is highly expressed in immune cells. It has been linked to NK cell anti-tumor activity, but its mechanism of action and broader functions in the immune system remain unclear.
Article
Biology
Vincent Panneton, Barbara C. Mindt, Yasser Bouklouch, Antoine Bouchard, Saba Mohammaei, Jinsam Chang, Nikoletta Diamantopoulos, Mariko Witalis, Joanna Li, Albert Stancescu, John E. Bradley, Troy Randall, Jorg H. Fritz, Woong-Kyung Suh
Summary: ICOS is a critical T-cell costimulatory receptor for the generation and function of Tfh cells, but its role in Tfr cell differentiation remains unclear. Through ICOS knockout experiments in Treg-lineage cells, researchers found that ICOS deficiency significantly reduces the number of Tfr cells during GC reactions. Single-cell transcriptome analysis of Foxp3+ cells suggests that ICOS normally inhibits Klf2 expression and promotes follicular features. Additionally, ICOS costimulation promotes nuclear localization of NFAT2, a driver of CXCR5 expression. The study also revealed expanded autoreactive B cells and elevated autoantibody titers in ICOS-deficient mice. This research highlights the critical role of ICOS costimulation in Tfr cell differentiation and the importance of Tfr cells in maintaining humoral immune tolerance during GC reactions.
LIFE SCIENCE ALLIANCE
(2023)
Article
Immunology
Bonah Kim, Hee Young Kim, Won-Woo Lee
Summary: Zinc, an essential microelement, plays immunoregulatory roles by influencing signaling pathways to enhance immune function. Zinc deficiency impairs immunity and increases susceptibility to infection. The interaction between Zip6-mediated zinc influx and TCR activation regulates T-cell responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Juan Jose Saez, Stephanie Dogniaux, Massiullah Shafaq-Zadah, Ludger Johannes, Claire Hivroz, Andres Ernesto Zucchetti
Summary: The paragraph discusses the important role of LAT in the signaling cascade induced by TCR activation, and its distribution and trafficking pathways in T cells upon activation. It shows that different proteins play specific roles in regulating the retrograde and anterograde transport of LAT during T cell activation.
Review
Cell Biology
Yanqing Liu, Qiong Liu, Zhe Zhang, Yaru Yang, Yazhe Zhou, Huanle Yan, Xin Wang, Xiaoru Li, Jing Zhao, Jingyan Hu, Shulin Yang, Yifan Tian, Yu Yao, Zhenye Qiu, Yanbin Song, Yang Yang
Summary: Ageing is a process characterized by progressive cell dysfunction, leading to various age-related disorders. The PI3K signalling pathway, as a central regulator of ageing, is closely associated with cellular characteristics and molecular features. This review thoroughly explains the PI3K signalling pathway, summarizes its link to ageing pathogenesis, and investigates its key regulatory roles in ageing-related illnesses. It reveals that targeting PI3K in drug development and clinical applications is a promising strategy for delaying ageing and treating age-related diseases in the future.
AGEING RESEARCH REVIEWS
(2023)
Correction
Immunology
Philippos Demetriou, Enas Abu-Shah, Salvatore Valvo, Sarah McCuaig, Viveka Mayya, Audun Kvalvaag, Thomas Starkey, Kseniya Korobchevskaya, Lennard Y. W. Lee, Matthias Friedrich, Elizabeth Mann, Mikhail A. Kutuzov, Matteo Morotti, Nina Wietek, Heather Rada, Shamsideen Yusuf, Jehan Afrose, Anastasios Siokis, Michael Meyer-Hermann, Ahmed Ashour Ahmed, David Depoil, Michael L. Dustin
Summary: A revised version of this paper has been published, which can be accessed through a link at the top of the paper.
Article
Cell Biology
Yanan Li, Anshuman Bhanja, Arpita Upadhyaya, Xiaodong Zhao, Wenxia Song
Summary: This study examines the role of WASp-mediated branched actin polymerization in the GCB immunological synapse. Results reveal essential roles for WASp in the generation and maintenance of unique structures for GCB immunological synapses.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sara R. Roig, Silvia Cassinelli, Maria Navarro-Perez, Mireia Perez-Verdaguer, Irene Estadella, Jesusa Capera, Antonio Felipe
Summary: The Kv beta family is a group of modulators that regulate Kv channels, with Kv beta 2.1 clustering into immunological synapses during leukocyte activation. The localization of Kv beta 2.1 is mainly affected by S-acylation and a pair of C-terminal cysteines, and its targeting to lipid raft microdomains is influenced by various stimuli.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Juncal Fernandez-Orth, Leoni Rolfes, Lukas Gola, Stefan Bittner, Joseph Andronic, Vladimir L. Sukhorukov, Dmitri Sisario, Peter Landgraf, Daniela C. Dieterich, Manuela Cerina, Karl-Heinz Smalla, Thilo Kaehne, Thomas Budde, Stjepana Kovac, Tobias Ruck, Markus Sauer, Sven G. Meuth
Summary: The immunological synapse is a junction between a T cell and an antigen-presenting cell, involving CRAC, K(v)1.3, and KCa3.1 channels. TASK2 channels are newly identified players recruited to the immunological synapse, potentially contributing to T cell activation and treatment of autoimmune diseases.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Editorial Material
Immunology
Jacques A. Nunes, Daniel Olive
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Ilona Berestjuk, Margaux Lecacheur, Alexandrine Carminati, Serena Diazzi, Christopher Rovera, Virginie Prod'homme, Mickael Ohanna, Ana Popovic, Aude Mallavialle, Frederic Larbret, Sabrina Pisano, Stephane Audebert, Thierry Passeron, Cedric Gaggioli, Christophe A. Girard, Marcel Deckert, Sophie Tartare-Deckert
Summary: The study reveals that physical and structural signals from fibroblast-derived ECM can cause the antiproliferative responses to BRAF/MEK inhibitors to fail in melanoma. Drug-induced linear clustering of DDR1 and DDR2 mediates ECM-mediated drug resistance. Targeting DDR1 and DDR2 can overcome resistance to BRAF-targeted therapy mediated by ECM.
EMBO MOLECULAR MEDICINE
(2022)
Article
Oncology
Pierre-Louis Bernard, Rebecca Delconte, Sonia Pastor, Vladimir Laletin, Cathy Costa Da Silva, Armelle Goubard, Emmanuelle Josselin, Remy Castellano, Adrien Krug, Julien Vernerey, Raynier Devillier, Daniel Olive, Els Verhoeyen, Eric Vivier, Nicholas D. Huntington, Jacques Nunes, Geoffrey Guittard
Summary: This study investigates the impact of targeting an inhibiting protein called CISH in natural killer (NK) cells on their functions and antitumor properties. The results show that CISH deletion enhances NK cell activation and killing abilities, while limiting NK cell exhaustion. Furthermore, CISH deletion optimizes NK cell accumulation in tumors and improves the effectiveness of antitumor responses. Therefore, CISH has been validated as a potential therapeutic target to enhance NK cell immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Medicine, Research & Experimental
Riccardo Rigo, Rabie Chelbi, Julie Agopian, Sebastien Letard, Aurelien Griffon, Hussein Ghamlouch, Julien Vernerey, Vasileios Ladopoulos, Edwige Voisset, Paulo De Sepulveda, Geoffrey Guittard, Jacques A. Nunes, Ghislain Bidaut, Berthold Gottgens, Michael Weber, Olivier A. Bernard, Patrice Dubreuil, Erinn Soucie
Summary: Research suggests that mutation of TET2 is associated with various immune pathologies, particularly in mast cells. TET2 deficiency leads to hypermethylation of immune response gene regions, affecting gene expression and inflammation signals, ultimately resulting in immune tolerance and pathological inflammation.
Article
Biotechnology & Applied Microbiology
Thi Khanh Le, Chaima Cherif, Kenneth Omabe, Clement Paris, Francois Lannes, Stephane Audebert, Emilie Baudelet, Mourad Hamimed, Dominique Barbolosi, Pascal Finetti, Cyrille Bastide, Ladan Fazli, Martin Gleave, Francois Bertucci, David Taieb, Palma Rocchi
Summary: The heat shock protein 27 (Hsp27) plays a crucial role in the progression of castration-resistant prostate cancer (CRPC), and an antisense oligonucleotide (ASO) against Hsp27 has been evaluated in clinical trials. This study demonstrates that Hsp27 regulates the expression of the human DEAD-box protein 5 (DDX5) and identifies DDX5 as a potential therapeutic target for CRPC treatment.
Article
Immunology
Francoise Gondois-Rey, Thomas Miller, Vladimir Laletin, Xavier Morelli, Yves Collette, Jacques Nunes, Daniel Olive
Summary: Immunotherapies targeting the CD47-SIRPα immune checkpoint have promising clinical potential but are limited by toxicities associated with non-tumor cell destruction. This study found that anti-CD47 antibodies can kill T cells through a combination of trogocytosis and respiratory burst induced by ADCC and CD47-SIRPα checkpoint blockade. The results also suggest that SIRPα tightly controls activation of NADPH oxidase, which is important for immature PMNs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Laurys Boudin, Alexandre De Nonneville, Pascal Finetti, Geoffrey Guittard, Jacques A. Nunes, Daniel Birnbaum, Emilie Mamessier, Francois Bertucci
Summary: This study found that high expression of CISH is associated with better metastasis-free interval in triple-negative breast cancer (TNBC), especially when PDL1 is also upregulated. The two-gene model of CISH and PDL1 provides more prognostic information than each gene alone and maintains its prognostic value in multivariate analysis. These findings highlight the potential therapeutic relevance of combining CISH inhibition with an anti-PD1/PDL1 immune checkpoint inhibitor in TNBC.
Article
Biochemistry & Molecular Biology
Sarah Barelier, Romain Avellan, Giri Raj Gnawali, Patrick Fourquet, Veronique Roig-Zamboni, Isabelle Poncin, Vanessa Point, Yves Bourne, Stephane Audebert, Luc Camoin, Christopher D. Spilling, Stephane Canaan, Jean-Francois Cavalier, Gerlind Sulzenbacher
Summary: We report the synthesis of new CyC alkyne-containing inhibitors (CyCyne) and their use for the direct fishing of target proteins in M. tb culture via bio-orthogonal click-chemistry activity-based protein profiling (CC-ABPP). This approach led to the capture and identification of a variety of enzymes, including HsaD, which is required for the survival of M. tb within macrophages and is a potential therapeutic target. The specificity of HsaD inhibition by the CyC analogues was confirmed through biochemical and structural approaches.
Editorial Material
Pharmacology & Pharmacy
Amelie Rebillard, Jacques A. Nunes, Alice Carrier
Summary: Exercise has been shown to have antitumor activity by enhancing immune activation. Further understanding of the mechanisms is needed for developing new therapeutic strategies. Recent research reveals that exercise engages IL-15 signaling and pharmacological activation of the IL-15/IL-15R axis mimics the immune cell-mediated cytotoxicity in pancreatic cancer induced by exercise.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Article
Environmental Sciences
Caroline Arcanjo, Sandrine Frelon, Olivier Armant, Luc Camoin, Stephane Audebert, Virginie Camilleri, Isabelle Cavalie, Christelle Adam-Guillermin, Beatrice Gagnaire
Summary: In this study, the effects of tritiated water (HTO) on zebrafish larvae were investigated. Transcriptomic and proteomic analyses revealed similar impacts on biological pathways such as defence response, muscle integrity and contraction, and potential visual alterations. Interestingly, these effects partly overlapped with those induced by gamma irradiation, suggesting potential common modes of action. This study provides evidence of the molecular-level effects of HTO on zebrafish larvae, and further research could explore whether these effects persist in adult organisms.
JOURNAL OF ENVIRONMENTAL RADIOACTIVITY
(2023)
Editorial Material
Immunology
Jacques A. Nunes, Trisha M. Wise-Draper, Claude Lambert
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Clemence Demerle, Laurent Gorvel, Marielle Mello, Sonia Pastor, Clara Degos, Ana Zarubica, Fabien Angelis, Frederic Fiore, Jacques A. Nunes, Bernard Malissen, Laurent Greillier, Geoffrey Guittard, Herve Luche, Fabrice Barlesi, Daniel Olive
Summary: The study found that anti-HVEM18-10 can enhance the activity of human αβ-T cells and trigger T cell activation in the presence of PD-L1-negative cells. Anti-HVEM18-10 treatment inhibits the growth of HVEM-positive tumors in mouse models and promotes the presence of effector memory CD4+ T cells while suppressing exhausted CD8+ T cells and regulatory T cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Oncology
Vladimir Laletin, Pierre-Louis Bernard, Cathy Costa da Silva, Geoffrey Guittard, Jacques A. Nunes
Summary: Immunotherapy strategies targeting T cells have been effective in treating cancer by blocking immune checkpoints. However, many patients do not respond to these treatments, so alternative approaches are needed. In addition to membrane-associated inhibitory molecules, intracellular immune checkpoints (iICPs) may also downregulate TCR signaling and inhibiting them shows promise for future cancer immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Medicine, General & Internal
Abdessamad El Kaoutari, Nicolas A. Fraunhoffer, Luc Camoin, Yolande Berthois, Odile Gayet, Julie Roques, Martin Bigonnet, Claire Bongrain, Joseph Ciccolini, Juan L. Iovanna, Nelson J. Dusetti, Philippe Soubeyran
Summary: Through specific proteomic tools and bioinformatics analysis, we established the ubiquitin dependent proteome of 60 PDAC, identifying 38 ubiquitination site profiles correlated with tumor phenotype and having prognostic capabilities. These findings have potential application in predicting chemotherapy response and personalized treatment in clinical settings.
Article
Biology
Clement Car, Andre Gilles, Elen Goujon, Marie-Laure Delignette Muller, Luc Camoin, Sandrine Frelon, Pablo Burraco, Samuel Granjeaud, Emilie Baudelet, Stephane Audebert, German Orizaola, Jean Armengaud, Arthur Tenenhaus, Imene Garali, Jean-Marc Bonzom, Olivier Armant
Summary: By analyzing the radar observation data from the Urumqi Satellite Receiving Station, researchers have found that the mass balance of the Yabulangsha Glacier has undergone significant changes over time. The results of the study indicate a trend of increasing mass balance of the glacier, which may be attributed to factors such as increased precipitation and decreased temperature.