Facilitating Anti-Cancer Combinatorial Drug Discovery by Targeting Epistatic Disease Genes

Evolutionary and genetic features of drug targets

(2018) Yuan Quan et al.   MEDICINAL RESEARCH REVIEWS

ranger: A Fast Implementation of Random Forests for High Dimensional Data in C++ and R

(2017) Marvin N. Wright et al.   Journal of Statistical Software

Gene co-opening network deciphers gene functional relationships

(2017) Wenran Li et al.   Molecular BioSystems

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

(2017) Kyuho Han et al.   NATURE BIOTECHNOLOGY

Genetics-directed drug discovery for combating Mycobacterium tuberculosis infection

(2016) Yuan Quan et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

COSMIC: somatic cancer genetics at high-resolution

(2016) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Systematic synergy modeling: understanding drug synergy from a systems biology perspective

(2015) Di Chen et al.   BMC Systems Biology

Anticipating designer drug-resistant cancer cells

(2015) Mark L. Frangione et al.   DRUG DISCOVERY TODAY

The support of human genetic evidence for approved drug indications

(2015) Matthew R Nelson et al.   NATURE GENETICS

SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets

(2015) Jing Guo et al.   NUCLEIC ACIDS RESEARCH

GWASdb v2: an update database for human genetic variants identified by genome-wide association studies

(2015) Mulin Jun Li et al.   NUCLEIC ACIDS RESEARCH

DriverDBv2: a database for human cancer driver gene research

(2015) I-Fang Chung et al.   NUCLEIC ACIDS RESEARCH

DGIdb 2.0: mining clinically relevant drug–gene interactions

(2015) Alex H. Wagner et al.   NUCLEIC ACIDS RESEARCH

Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information

(2015) Hong Yang et al.   NUCLEIC ACIDS RESEARCH

Higher-order genetic interactions and their contribution to complex traits

(2015) Matthew B. Taylor et al.   TRENDS IN GENETICS

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

A community computational challenge to predict the activity of pairs of compounds

(2014) Mukesh Bansal et al.   NATURE BIOTECHNOLOGY

Detecting epistasis in human complex traits

(2014) Wen-Hua Wei et al.   NATURE REVIEWS GENETICS

DiseaseConnect: a comprehensive web server for mechanism-based disease–disease connections

(2014) Chun-Chi Liu et al.   NUCLEIC ACIDS RESEARCH

DCDB 2.0: a major update of the drug combination database

(2014) Y. Liu et al.   Database-The Journal of Biological Databases and Curation

Validating therapeutic targets through human genetics

(2013) Robert M. Plenge et al.   NATURE REVIEWS DRUG DISCOVERY

Epistasis and quantitative traits: using model organisms to study gene–gene interactions

(2013) Trudy F. C. Mackay   NATURE REVIEWS GENETICS

DrugBank 4.0: shedding new light on drug metabolism

(2013) Vivian Law et al.   NUCLEIC ACIDS RESEARCH

ClinVar: public archive of relationships among sequence variation and human phenotype

(2013) Melissa J. Landrum et al.   NUCLEIC ACIDS RESEARCH

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

(2013) Danielle Welter et al.   NUCLEIC ACIDS RESEARCH

Three-dimensional reconstruction of protein networks provides insight into human genetic disease

(2012) Xiujuan Wang et al.   NATURE BIOTECHNOLOGY

Use of genome-wide association studies for drug repositioning

(2012) Philippe Sanseau et al.   NATURE BIOTECHNOLOGY

GBOOST: a GPU-based tool for detecting gene–gene interactions in genome–wide case control studies

(2011) Ling Sing Yung et al.   BIOINFORMATICS

A novel bayesian graphical model for genome-wide multi-SNP association mapping

(2011) Yu Zhang   GENETIC EPIDEMIOLOGY

The ClinicalTrials.gov Results Database — Update and Key Issues

(2011) Deborah A. Zarin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Can medical genetics and evolutionary biology inspire drug target identification?

(2011) Zhong-Yi Wang et al.   TRENDS IN MOLECULAR MEDICINE

FastEpistasis: a high performance computing solution for quantitative trait epistasis

(2010) Thierry Schüpbach et al.   BIOINFORMATICS

The NIH Roadmap Epigenomics Mapping Consortium

(2010) Bradley E Bernstein et al.   NATURE BIOTECHNOLOGY

Combining Targeted Therapies: Practical Issues to Consider at the Bench and Bedside

(2010) J. Rodon et al.   ONCOLOGIST

Predictive rule inference for epistatic interaction detection in genome-wide association studies

(2009) Xiang Wan et al.   BIOINFORMATICS

Systems approaches and algorithms for discovery of combinatorial therapies

(2009) Jacob D. Feala et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine