Brain Glucose-Sensing Mechanism and Energy Homeostasis

A sweet taste receptor-dependent mechanism of glucosensing in hypothalamic tanycytes

(2017) Heather Benford et al.   GLIA

A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH

(2016) Henning Fenselau et al.   NATURE NEUROSCIENCE

Functional identification of a neurocircuit regulating blood glucose

(2016) Thomas H. Meek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ventromedial hypothalamic expression of Bdnf is required to establish normal patterns of afferent GABAergic connectivity and responses to hypoglycemia

(2016) Anna Kamitakahara et al.   Molecular Metabolism

Arcuate Na+,K+-ATPase senses systemic energy states and regulates feeding behavior through glucose-inhibited neurons

(2015) Hideharu Kurita et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Reduction in SGLT1 mRNA Expression in the Ventromedial Hypothalamus Improves the Counterregulatory Responses to Hypoglycemia in Recurrently Hypoglycemic and Diabetic Rats

(2015) Xiaoning Fan et al.   DIABETES

Glucose sensing by GABAergic neurons in the mouse nucleus tractus solitarii

(2015) Carie R. Boychuk et al.   JOURNAL OF NEUROPHYSIOLOGY

Hypoglycemia-Activated GLUT2 Neurons of the Nucleus Tractus Solitarius Stimulate Vagal Activity and Glucagon Secretion

(2014) Christophe M. Lamy et al.   Cell Metabolism

Brain glucose sensing, glucokinase and neural control of metabolism and islet function

(2014) E. O. Ogunnowo-Bada et al.   DIABETES OBESITY & METABOLISM

Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure

(2014) Yunhua L. Muller et al.   DIABETOLOGIA

Dynamic Localization of Glucokinase and Its Regulatory Protein in Hypothalamic Tanycytes

(2014) Magdiel Salgado et al.   PLoS One

Glucose Rapidly Induces Different Forms of Excitatory Synaptic Plasticity in Hypothalamic POMC Neurons

(2014) Jun Hu et al.   PLoS One

Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar

(2014) Ana I Domingos et al.   eLife

Neural pathways that control the glucose counterregulatory response

(2014) Anthony J. M. Verberne et al.   Frontiers in Neuroscience

The hypothalamus and metabolism: integrating signals to control energy and glucose homeostasis

(2013) Anthony P Coll et al.   CURRENT OPINION IN PHARMACOLOGY

Lactate-Induced Release of GABA in the Ventromedial Hypothalamus Contributes to Counterregulatory Failure in Recurrent Hypoglycemia and Diabetes

(2013) O. Chan et al.   DIABETES

Nervous glucose sensing regulates postnatal β cell proliferation and glucose homeostasis

(2013) David Tarussio et al.   JOURNAL OF CLINICAL INVESTIGATION

Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia

(2013) Raimund I. Herzog et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of Corticotropin-Releasing Hormone neurons in the Paraventricular Nucleus of the Hypothalamus of Crh-IRES-Cre Mutant Mice

(2013) Jaclyn I. Wamsteeker Cusulin et al.   PLoS One

MCT2 Expression and Lactate Influx in Anorexigenic and Orexigenic Neurons of the Arcuate Nucleus

(2013) Christian Cortes-Campos et al.   PLoS One

α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors

(2013) S.C. Robins et al.   Nature Communications

Regional distribution of SGLT activity in rat brain in vivo

(2012) Amy S. Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Gliotransmission and Brain Glucose Sensing: Critical Role of Endozepines

(2012) D. Lanfray et al.   DIABETES

Minireview: The Role of the Autonomic Nervous System in Mediating the Glucagon Response to Hypoglycemia

(2012) Gerald J. Taborsky et al.   ENDOCRINOLOGY

The dorsal motor nucleus of the vagus and regulation of pancreatic secretory function

(2012) Bashair M. Mussa et al.   EXPERIMENTAL PHYSIOLOGY

Updated Energy Budgets for Neural Computation in the Neocortex and Cerebellum

(2012) Clare Howarth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroanatomy of melanocortin-4 receptor pathway in the lateral hypothalamic area

(2012) Huxing Cui et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Deciphering a neuronal circuit that mediates appetite

(2012) Qi Wu et al.   NATURE

Relationship between Cerebrospinal Fluid Glucose and Serum Glucose

(2012) Lise E. Nigrovic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoglycemia and Risk of Death in Critically Ill Patients

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Melanin-concentrating hormone receptor 1 (MCH1-R) antagonism: Reduced appetite for calories and suppression of addictive-like behaviors

(2012) Camilla Karlsson et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain

(2012) Santosh Ramamurthy et al.   Experimental Neurobiology

Taste receptor signalling - from tongues to lungs

(2011) S. C. Kinnamon   Acta Physiologica

Astrocyte - neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions - in silico study supported by in vitro expression data

(2011) Seda Genc et al.   BMC Systems Biology

Increased GABAergic Output in the Ventromedial Hypothalamus Contributes to Impaired Hypoglycemic Counterregulation in Diabetic Rats

(2011) O. Chan et al.   DIABETES

Minireview: The Value of Looking Backward: The Essential Role of the Hindbrain in Counterregulatory Responses to Glucose Deficit

(2011) Sue Ritter et al.   ENDOCRINOLOGY

Glucosensing in parvocellular neurons of the rat hypothalamic paraventricular nucleus

(2011) Igor V. Melnick et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels

(2011) Juan A. Orellana et al.   GLIA

Regulation of Oligodendrocyte Development and Myelination by Glucose and Lactate

(2011) J. E. Rinholm et al.   JOURNAL OF NEUROSCIENCE

ATP-mediated glucosensing by hypothalamic tanycytes

(2011) Cameron Frayling et al.   JOURNAL OF PHYSIOLOGY-LONDON

MCT Expression and Lactate Influx/Efflux in Tanycytes Involved in Glia-Neuron Metabolic Interaction

(2011) Christian Cortés-Campos et al.   PLoS One

ATP-Sensitive Potassium Channel-Deficient Mice Show Hyperphagia but Are Resistant to Obesity

(2011) Yeul Bum Park et al.   Diabetes & Metabolism Journal

Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia

(2010) Wanling Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Detection of extracellular glucose by GLUT2 contributes to hypothalamic control of food intake

(2010) Emilie Stolarczyk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Rostroventrolateral medullary neurons modulate glucose homeostasis in the rat

(2010) A. J. M. Verberne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypothalamic Nitric Oxide in Hypoglycemia Detection and Counterregulation: A Two-Edged Sword

(2010) Xavier Fioramonti et al.   ANTIOXIDANTS & REDOX SIGNALING

Glial Glucokinase Expression in Adult and Post-Natal Development of the Hypothalamic Region

(2010) Carola Millán et al.   ASN Neuro

Glucose Stimulation of Hypothalamic MCH Neurons Involves KATP Channels, Is Modulated by UCP2, and Regulates Peripheral Glucose Homeostasis

(2010) Dong Kong et al.   Cell Metabolism

Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia

(2010) K. A. Diggs-Andrews et al.   DIABETES

Distribution of hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons in the hypothalamic paraventricular nucleus of the mouse

(2010) Andrea Kádár et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Enhanced Expression of the Sweet Taste Receptors and Alpha-gustducin in Reactive Astrocytes of the Rat Hippocampus Following Ischemic Injury

(2010) Yoo-Jin Shin et al.   NEUROCHEMICAL RESEARCH

Interactions between orexin–immunoreactive fibers and adrenaline or noradrenaline-expressing neurons of the lower brainstem in rats and mice

(2010) Nela Puskás et al.   PEPTIDES

A Single Amino Acid Change Converts the Sugar Sensor SGLT3 into a Sugar Transporter

(2010) Laura Bianchi et al.   PLoS One

AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons

(2009) Beth Ann Murphy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

UCP2, not a physiologically relevant uncoupler but a glucose sparing switch impacting ROS production and glucose sensing

(2009) Frédéric Bouillaud   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Loss of GABAergic Signaling by AgRP Neurons to the Parabrachial Nucleus Leads to Starvation

(2009) Qi Wu et al.   CELL

Hypothalamic Orexin Stimulates Feeding-Associated Glucose Utilization in Skeletal Muscle via Sympathetic Nervous System

(2009) Tetsuya Shiuchi et al.   Cell Metabolism

Ventromedial Hypothalamic Nitric Oxide Production Is Necessary for Hypoglycemia Detection and Counterregulation

(2009) X. Fioramonti et al.   DIABETES

Role of thyroid hormones in the developmental control of tissue glycogen in fetal sheep near term

(2009) Alison J. Forhead et al.   EXPERIMENTAL PHYSIOLOGY

UCP2, a metabolic sensor coupling glucose oxidation to mitochondrial metabolism?

(2009) Claire Pecqueur et al.   IUBMB LIFE

Paraventricular hypothalamic nucleus: Axonal projections to the brainstem

(2009) Joel C. Geerling et al.   JOURNAL OF COMPARATIVE NEUROLOGY

AMPK in the brain: its roles in energy balance and neuroprotection

(2009) Gabriele V. Ronnett et al.   JOURNAL OF NEUROCHEMISTRY

Contribution of the T1r3 Taste Receptor to the Response Properties of Central Gustatory Neurons

(2009) Christian H. Lemon et al.   JOURNAL OF NEUROPHYSIOLOGY

Role of Dorsomedial Hypothalamic Neuropeptide Y in Modulating Food Intake and Energy Balance

(2009) L. Yang et al.   JOURNAL OF NEUROSCIENCE

AMP-activated protein kinase inhibits TREK channels

(2009) Orsolya Kréneisz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Electrophysiological identification of glucose-sensing neurons in rat nodose ganglia

(2009) Gintautas Grabauskas et al.   JOURNAL OF PHYSIOLOGY-LONDON

Central Nervous System Regulation of Energy Metabolism

(2008) Ruben Nogueiras et al.   Annals of the New York Academy of Sciences

Dorsal Hindbrain 5′-Adenosine Monophosphate-Activated Protein Kinase as an Intracellular Mediator of Energy Balance

(2008) Matthew R. Hayes et al.   ENDOCRINOLOGY

Brain Regulation of Appetite and Satiety

(2008) Rexford S. Ahima et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Identification of Nitric Oxide as an Endogenous Activator of the AMP-activated Protein Kinase in Vascular Endothelial Cells

(2008) Junhua Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connexin 43 Hemichannels Are Permeable to ATP

(2008) J. Kang et al.   JOURNAL OF NEUROSCIENCE

Dissociation between sensing and metabolism of glucose in sugar sensing neurones

(2008) J. Antonio Gonzàlez et al.   JOURNAL OF PHYSIOLOGY-LONDON

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

(2008) Qingchun Tong et al.   NATURE NEUROSCIENCE

Food Reward in the Absence of Taste Receptor Signaling

(2008) Ivan E. de Araujo et al.   NEURON

Adaptive sugar sensors in hypothalamic feeding circuits

(2008) R. H. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prior hypoglycemia enhances glucose responsiveness in some ventromedial hypothalamic glucosensing neurons

(2007) Ling Kang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY