Article
Clinical Neurology
Ming-Fung Wu, Thomas C. Thannickal, Songlin Li, Ronald McGregor, Yuan-Yang Lai, Jerome M. Siegel
Summary: Long-term use of sodium oxybate (SXB) can alleviate cataplexy and sleepiness in narcolepsy. However, unlike opioids, SXB increases the size of Hcrt neurons, decreases Hcrt levels in the hypothalamus, and reduces tyrosine hydroxylase levels in the locus coeruleus. Although there are some similar effects on narcoleptic symptoms, SXB does not produce anatomical changes similar to opioids.
Article
Biochemistry & Molecular Biology
Shin Takasawa, Ryogo Shobatake, Yoshinori Takeda, Tomoko Uchiyama, Akiyo Yamauchi, Mai Makino, Sumiyo Sakuramoto-Tsuchida, Keito Asai, Hiroyo Ota, Asako Itaya-Hironaka
Summary: Sleep apnea syndrome (SAS) is associated with hypertension and insulin resistance/diabetes. This study found that intermittent hypoxia (IH), a characteristic of SAS, increases the levels of catecholamine-metabolizing enzymes DBH and PNMT, potentially contributing to the development of hypertension. The up-regulation of DBH and PNMT is mediated by the inhibition of miR-375-mediated mRNA degradation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Nathalie C. Guerineau, Pauline Campos, Paul R. Le Tissier, David J. Hodson, Patrice Mollard
Summary: Reproduction, growth, stress, and metabolism are regulated by endocrine/neuroendocrine systems. Advances in technology have changed our understanding of endocrine gland organization and how cellular organization regulates hormone output.
COMPREHENSIVE PHYSIOLOGY
(2022)
Article
Zoology
William Joyce, Steve F. Perry
Summary: The study found no evidence that adrenergic cardiac control was perturbed in larval or adult zebrafish lacking Hif-1 alpha. This suggests that Hif-1 alpha is not essential for the normal development of cardiovascular control or adult sympathetic cardiac innervation in zebrafish, although it may play a redundant or auxiliary role.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Melanie R. Kuhn, Melanie Haffner-Luntzer, Elena Kempter, Stefan O. Reber, Hiroshi Ichinose, Jean Vacher, Anita Ignatius, Miriam E. A. Tschaffon-Mueller
Summary: Catecholamine signaling affects bone tissue, especially the synthesis of catecholamines under inflammatory conditions by myeloid cells, and plays a crucial role in immune cell-bone cell crosstalk and fracture healing.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Anna Gugula, Aleksandra Trenk, Aleksandra Celary, Katarzyna Cizio, Grzegorz Tylko, Anna Blasiak, Grzegorz Hess
Summary: Early-life stress has long-term consequences, including an increased risk for drug abuse and psychiatric disorders later in life, higher in women than in men. This study reveals the changes in stress sensitivity of specific neuronal populations in the ventral tegmental area and lateral hypothalamus caused by early-life stress.
Article
Neurosciences
Aaron E. Miller, Atul P. Daiwile, Jean Lud Cadet
Summary: This study found sex differences in dopamine metabolism in a methamphetamine addiction animal model, with the majority of differences observed in the mesocorticolimbic dopaminergic system.
NEUROTOXICITY RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Joshua Harle, Catherine Slater, Mauricio Cafiero
Summary: Recently, it has been discovered that paracetamol may extend the therapeutic window of l-DOPA treatment for Parkinson's disease by inhibiting pain signals in the spinal column. This study investigates the possibility that the therapeutic effect of paracetamol for Parkinson's disease patients may be due to the inhibition of enzymes responsible for dopamine and l-DOPA metabolism, thus prolonging the effectiveness of l-DOPA treatment.
Article
Hematology
Yang Liu, Qi Chen, Hyun-Woo Jeong, Dong Han, Joerg Fabian, Hannes C. A. Drexler, Martin Stehling, Hans R. Schoeler, Ralf H. Adams
Summary: This study reveals that dopamine derived from sympathetic nerves directly controls the behavior of hematopoietic stem and progenitor cells through D-2 subfamily dopamine receptors. Dopamine signaling affects proliferation, frequency, and transplantation efficiency of HSPCs.
Article
Medicine, Research & Experimental
Eslam Hassan, Shady Allam, Ahmed M. Mansour, Aya Shaheen, Salama A. Salama
Summary: The study investigated the effects of E2 and 2ME on RIR-induced kidney injury in OVX rats and the role of COMT. The results showed that E2 and 2ME treatment significantly improved biochemical parameters and related protein expression levels in OVX and RIR rats. Enacapone attenuated the effects of E2, but had no effect on 2ME treatment.
Article
Neurosciences
Aleksandar Rakovic, Dorothea Voss, Franca Vulinovic, Britta Meier, Ann-Katrin Hellberg, Carla Nau, Christine Klein, Enrico Leipold
Summary: Induced pluripotent stem cells can be used to create patient-specific in vitro models for studying Parkinson's disease and drug screening. However, current differentiation methods result in heterogeneous cell populations with low fractions of relevant dopaminergic neurons. This study utilized CRISPR/Cas9 technology to generate a reporter iPSC line and compared different differentiation protocols. The floor plate protocol was found to be the most efficient in generating electrophysiologically mature dopaminergic neurons.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Lily Sarrafha, Drew R. Neavin, Gustavo M. Parfitt, Ilya A. Kruglikov, Kristen Whitney, Ricardo Reyes, Elena Coccia, Tatyana Kareva, Camille Goldman, Regine Tipon, Gist Croft, John F. Crary, Joseph E. Powell, Joel Blanchard, Tim Ahfeldt
Summary: In this study, a differentiation protocol for hypothalamus organoids derived from human pluripotent stem cells (hPSCs) was established to model the cellular diversity of this brain region. Using electrophysiologically active hypothalamus organoids, the specific pathways and functions of dopaminergic neurons (DNs) were investigated. Single-cell RNA sequencing (scRNA-seq) revealed diverse neuronal and non-neuronal cell types in mature hypothalamus organoids. This 3D hypothalamus differentiation protocol can be used to study the development of this critical brain structure and to model diseases centered around the hypothalamus.
Article
Anatomy & Morphology
Illke B. Malungo, Reabetswe Mokale, Mads F. Bertelsen, Paul R. Manger
Summary: This study provides an analysis of the cholinergic, catecholaminergic, serotonergic, and orexinergic neuronal populations in the brain of the lesser hedgehog tenrec. The cholinergic system shows the most variation, while the other systems are broadly similar to those observed in other mammals. The lesser hedgehog tenrec has a significant mesencephalic flexure in its brain, which is not present in the greater otter shrew. This suggests either complex parallel evolution or a need to re-examine the classification of the Potomogalidae lineage.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Article
Biology
Gabriela Novak, Dimitrios Kyriakis, Kamil Grzyb, Michela Bernini, Sophie Rodius, Gunnar Dittmar, Steven Finkbeiner, Alexander Skupin
Summary: This study used single-cell RNA sequencing and gene expression analysis to investigate the differentiation of midbrain dopaminergic neurons in Parkinson's disease. The results revealed a core network of genes that interact with pathways associated with Parkinson's disease. These findings are important for understanding the pathology and phenotypic heterogeneity of Parkinson's disease.
COMMUNICATIONS BIOLOGY
(2022)
Article
Food Science & Technology
Marwa H. El-Azma, Nadia M. El-Beih, Karima A. El-Shamy, Khaled M. M. Koriem, Mahitab Elkassaby, Wael M. El-Sayed
Summary: This study investigates the potential of pumpkin seed oil and zinc to attenuate oxidative stress and neuroinflammation caused by chronic mild stress in the cerebral cortex of male rats. The findings suggest that pumpkin seed oil and zinc can alleviate stress-induced oxidative stress and neuroinflammation by improving the antioxidant and anti-inflammatory status of the cerebral cortex.
NUTRITION & FOOD SCIENCE
(2022)
Article
Behavioral Sciences
Jelena Petrovic, Dusanka Stanic, Zorica Bulat, Nela Puskas, Milica Labudovic-Borovic, Bojan Batinic, Dusko Mirkovic, Svetlana Ignjatovic, Vesna Pesic
HORMONES AND BEHAVIOR
(2018)
Review
Biochemistry & Molecular Biology
Dasiel O. Borroto-Escuela, Manuel Narvaez, Patrizia Ambrogini, Luca Ferraro, Ismel Brito, Wilber Romero-Fernandez, Yuniesky Andrade-Talavera, Antonio Flores-Burgess, Carmelo Millon, Belen Gago, Jose Angel Narvaez, Yuji Odagaki, Miklos Palkovits, Zaida Diaz-Cabiale, Kjell Fuxe
Article
Immunology
Nellie A. Martin, Viktor Molnar, Gabor T. Szilagyi, Maria L. Elkjaer, Arkadiusz Nawrocki, Justyna Okarmus, Agnieszka Wlodarczyk, Eva K. Thygesen, Miklos Palkovits, Ferenc Gallyas, Martin R. Larsen, Hans Lassmann, Eirikur Benedikz, Trevor Owens, Asa F. Svenningsen, Zsolt Illes
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Neurosciences
Ivan Zaletel, Marija Schwirtlich, Milka Perovic, Mirna Jovanovic, Milena Stevanovic, Selma Kanazir, Nela Puskas
JOURNAL OF ALZHEIMERS DISEASE
(2018)
Article
Oncology
Jelena Marjanovic Vicentic, Danijela Drakulic, Idoia Garcia, Vladanka Vukovic, Paula Aldaz, Nela Puskas, Igor Nikolic, Goran Tasic, Savo Raicevic, Laura Garros-Regulez, Nicolas Sampron, Michael J. Atkinson, Natasa Anastasov, Ander Matheu, Milena Stevanovic
Article
Materials Science, Multidisciplinary
Jasna Todorovic, Marko Dincic, Jelena Nesovic Ostojic, Ivan Zaletel, Srdjan Lopicic, Dusko Dundjerovic, Svetislav Tatic, Sanjin Kovacevic, Ivan Paunovic, Nela Puskas, Ljiljana Markovic
MICROSCOPY AND MICROANALYSIS
(2019)
Article
Multidisciplinary Sciences
Marko Vorkapic, Andrej Savic, Milica Jankovic, Nemanja Useinovic, Milica Isakovic, Nela Puskas, Olivera Stanojlovic, Dragan Hrncic
Article
Cell Biology
Nikola Sutulovic, Zeljko Grubac, Sonja Suvakov, Djurdja Jerotic, Nela Puskas, Djuro Macut, Aleksandra Rasic-Markovic, Tatjana Simic, Olivera Stanojlovic, Dragan Hrncic
Summary: The study found that rats with CP/CPPS exhibited scrotal allodynia and prostatitis, along with significantly increased anxiety-like behavior compared to sham-operated rats. These behavior patterns were correlated with increased brain oxidative stress, elevated serum corticosterone levels, and decreased number of hippocampal PV+ neurons.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Zeljko Grubac, Nikola Sutulovic, Sonja Suvakov, Djurdja Jerotic, Nela Puskas, Djuro Macut, Aleksandra Rasic-Markovic, Tatjana Simic, Olivera Stanojlovic, Dragan Hrncic
Summary: Research demonstrates that sleep fragmentation can lead to the occurrence of anxiety behaviors, with its effects depending on the duration and potentially mediated through oxidative stress in the brain. Results show that rats with fragmented sleep exhibit higher levels of oxidative stress and display anxiety-linked behaviors, while the activity of antioxidant enzymes is significantly decreased.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Endocrinology & Metabolism
Dusanka Stanic, Keren Oved, Ifat Israel-Elgali, Marin Jukic, Bojan Batinic, Nela Puskas, Noam Shomron, David Gurwitz, Vesna Pesic
Summary: This study aimed to explore the molecular mechanisms behind the antidepressant-like effects of oxytocin alone and in synergy with citalopram in corticosterone-treated rats. The results showed that oxytocin ameliorated corticosterone-induced reduction of neurogenesis, enhanced the anxiolytic and antidepressant effects of citalopram, and reversed the molecular changes induced by corticosterone treatment.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Behavioral Sciences
Milica Potrebic, Zeljko Pavkovic, Nela Puskas, Vesna Pesic
Summary: This study examined the effects of social isolation on social motivation and cognition in peripubertal rats and found that social isolation promotes appetitive behavior towards peers but harms the interest for social novelty. These findings highlight the importance of fulfilling social needs for social development.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Fanni Dora, Eva Renner, David Keller, Miklos Palkovits, Arpad Dobolyi
Summary: This study revealed extensive gene expressional alterations in the dorsomedial prefrontal cortex (DMPFC) related to suicidal behavior. Genes associated with depressive disorder, schizophrenia, and impaired cognition were found to be overexpressed, while pathways related to cytokine receptor signaling were downregulated and glutamatergic synaptic signaling were upregulated in suicide victims.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Eva Renner, Fanni Dora, Erzsebet Oszwald, Arpad Dobolyi, Miklos Palkovits
Summary: GLP-1 activates GLP-1R in the PVNmc, and the expression level of GLP-1R in the PVNmc is elevated in T2DM patients. GLP-1 fiber terminals are closely apposed to oxytocin neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Bobana Samardzija, Maja Jukovic, Beti Zaharija, Eva Renner, Miklos Palkovits, Nicholas J. Bradshaw
Summary: The study investigates the aggregation of proteins in the brains of individuals with mental illness. Multiple proteins, including CRMP1, DISC1, NPAS3, and TRIOBP-1, are found to form aggregates, but it is unclear whether they aggregate independently or interact with each other. The results show that while some proteins can co-aggregate, it is more common for them to aggregate in a parallel manner through independent mechanisms.
Article
Oncology
Miljan M. Folic, Ana V. Banko, Vera N. Todorovic, Nela S. Puskas, Jovica P. Milovanovic, Sanja B. Krejovic, Neda Z. Dragicevic-Babic, Zoran M. Bukumiric, Biljana R. Milicic, Ana D. Jotic, Vojko B. Djukic
Summary: This study found that HIF-1 alpha C1772T polymorphism was significantly associated with worse disease-free survival in patients with laryngeal carcinoma. The preoperative assessment of hypoxia-related biomarkers can be used to determine the treatment modalities for laryngeal carcinoma.
Article
Biochemistry & Molecular Biology
Giovanni Pacini, Bo Ahren
Summary: Tirzepatide stimulates both insulin secretion and glucose effectiveness, with stimulation of glucose effectiveness being the prominent process to reduce glucose.
Article
Biochemistry & Molecular Biology
Si -yu Wang, Yu-zhe Zhang, Xiao-han Liu, Xue-ci Guo, Xiao-fang Wang, Feng-tong Han, Yao Zhang, Chang -lin Wang
Summary: In the formalin pain test, the EM-2 analogs EM-2-Me, EM-2-Et, and EM-2-Bu showed significant analgesic effects with reduced tolerance and gastrointestinal side effects. These effects were mediated through central opioid mechanisms, with EM-2-Me possibly involving dynorphin A release and EM-2-Bu directly activating multiple opioid receptors.