Article
Gastroenterology & Hepatology
Fatemeh Hesampour, Charles N. Bernstein, Jean-Eric Ghia
Summary: Inflammatory bowel disease (IBD) is a chronic condition with no known cause. Vagus nerve stimulation (VNS) has shown potential as a therapeutic approach for IBD by reducing inflammation. Noninvasive techniques for VNS have been developed, making it a promising treatment option.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Neurosciences
Chanon Srihagulang, Jirapong Vongsfak, Tanat Vaniyapong, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide, characterized by immediate neuronal destruction and secondary brain injury mechanisms. Vagus nerve stimulation (VNS) shows potential for neuroprotection in TBI through various mechanisms, providing beneficial effects in animal models and patients. Further research is needed to fully understand the therapeutic potential of VNS in treating TBI.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhenyu Zhu, Yuxiu Gu, Cuirong Zeng, Man Yang, Hao Yu, Hui Chen, Bikui Zhang, Hualin Cai
Summary: Long-term use of olanzapine may lead to lipid metabolic disorders. This study investigates the role of the gut microbiota-brain axis in olanzapine-induced lipid disturbances. The results show that olanzapine causes weight gain, increased adipose tissue ratio, and elevated triglyceride and cholesterol levels. Furthermore, olanzapine affects gut microbiota and their metabolites, as well as neuropeptide expression in the hypothalamus.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Zeping Jin, Jing Dong, Yang Wang, Yunpeng Liu
Summary: Vagus nerve stimulation (VNS) shows potential for managing various brain diseases, but its mechanisms and benefits are not fully understood. Recent studies have found that VNS can inhibit inflammation, promote neuroprotection, and even transmit signals from the gut flora to the brain.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Behavioral Sciences
Yue Wang, Gaofeng Zhan, Ziwen Cai, Bo Jiao, Yilin Zhao, Shiyong Li, Ailin Luo
Summary: With the development of medical technology, vagus nerve stimulation (VNS) has been approved by the FDA as an alternative treatment for refractory epilepsy, refractory depression, cluster headaches, and migraines. Although VNS has shown promising results for more brain diseases like Parkinson's disease, autistic spectrum disorder, and traumatic brain injury, the specific biological mechanisms underlying its beneficial effects remain incompletely understood.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Clinical Neurology
Jorge A. Ramos-Castaneda, Carlos Federico Barreto-Cortes, Diego Losada-Floriano, Sandra Milena Sanabria-Barrera, Federico A. Silva-Sieger, Ronald G. Garcia
Summary: This systematic review summarizes the scientific evidence on the safety and efficacy of Vagus Nerve Stimulation (VNS) on upper limb motor recovery after stroke. The results demonstrate that VNS, together with physical rehabilitation, significantly improves upper limb motor function in stroke patients and is a safe intervention.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Josh McGovern, Stephen Leadbitter, Gillian Miller, Adam Hounat, Irvine Kamande, Ross D. D. Dolan, Paul G. G. Horgan, David K. K. Chang, Nigel B. B. Jamieson, Donald C. C. McMillan
Summary: In this study, high vagal nerve activity, as measured by HRV, was not significantly associated with TNM stage, co-morbidity, systemic inflammation, or survival in patients undergoing potentially curative surgery for colorectal cancer (CRC). These findings suggest that HRV may not be a relevant factor in the treatment and survival of CRC.
SCIENTIFIC REPORTS
(2023)
Review
Neurosciences
Bruno Bonaz, Valerie Sinniger, Sonia Pellissier
Summary: The vagus nerve has dual anti-inflammatory properties and may be used in the treatment of chronic inflammatory bowel diseases. Its activation can inhibit the release of tumor necrosis factor (TNF) alpha by various mechanisms, making it a potential non-drug therapeutic approach.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Matthew J. McGinley, Steven T. Lee
Summary: This article investigates the mechanistic aspects of vagus nerve stimulation (VNS) in clinical applications and finds that VNS timed with positive reinforcement improves motor learning and cortical function through a cholinergic mechanism.
Review
Integrative & Complementary Medicine
Jaeyoung Park, Ju-Young Oh, Hi -Joon Park
Summary: This review examines the similarities in the mechanisms of action between acupuncture and neuromodulation and explores the potential role of acupuncture in the treatment of Parkinson's disease. The study suggests that acupuncture can alleviate Parkinson's symptoms by modulating inflammation and brain functional connectivity, similar to the effects of neuromodulation. Based on these shared mechanisms, acupuncture may offer new treatment options as personalized neuromodulating therapies for Parkinson's disease patients.
INTEGRATIVE MEDICINE RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Anna Carolyna L. Gianlorenco, Paulo S. de Melo, Anna Marduy, Angela Yun Kim, Chi Kyung Kim, Hyuk Choi, Jae-Jun Song, Felipe Fregni
Summary: Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive stimulation method that shows potential therapeutic benefits. This study conducted a systematic review on the effects of taVNS on EEG measures, finding that it increases activity in lower frequency bands and alters early components related to inhibitory tasks. Further research is needed to establish specific effects and metrics.
Review
Biochemistry & Molecular Biology
Fahim Muhammad, Bufang Fan, Ruoxi Wang, Jiayan Ren, Shuhui Jia, Liping Wang, Zuxin Chen, Xin-An Liu
Summary: The gut and the brain are connected through millions of nerves, immune factors, and hormones in the circulatory system. The gut microbiota plays a crucial role in the bidirectional communication, regulating intestinal homeostasis and influencing brain activity. Changes in gut microbiota composition and function affect neurophysiological development and immune regulatory disorders, making it a potential therapeutic target for neurodevelopmental diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Daniel H. Lench, Travis H. Turner, Colin McLeod, Heather A. Boger, Lilia Lovera, Lisa Heidelberg, Jordan Elm, Anh Phan, Bashar W. Badran, Vanessa K. Hinson
Summary: This study evaluated the feasibility, safety, and efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) in participants with mild to moderate Parkinson's disease. The results showed that taVNS treatment was safe and well-tolerated, but daily in-office visits were burdensome for participants. Although there were no significant differences in MDS-UPDRS scores or self-reported measures, verbal fluency decreased in the taVNS group. Future studies should explore at-home stimulation devices and optimize stimulation parameters.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Erin Trifilio, Destin Shortell, Sarah Olshan, Alexandria O'Neal, Jozee Coyne, Damon Lamb, Eric Porges, John Williamson
Summary: Evidence has been accumulating over the past 15 years on the clinically meaningful benefits of transcutaneous vagus nerve stimulation (VNS). This novel non-invasive brain stimulation technique has been applied to various neuropsychiatric disorders and more recently, in healthy aging populations. This review discusses the possible mechanisms, considerations for older adults, and the use of non-invasive VNS in conjunction with existing behavioral interventions to promote healthy aging.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Chemistry, Physical
Padinhare Cholakkal Harikesh, Chi-Yuan Yang, Han-Yan Wu, Silan Zhang, Mary J. Donahue, April S. Caravaca, Jun-Da Huang, Peder S. Olofsson, Magnus Berggren, Deyu Tu, Simone Fabiano
Summary: Biointegrated neuromorphic hardware offers new protocols for recording and regulating signaling in biological systems. Previous artificial neural circuits based on silicon or negative differential resistance lack biocompatibility and ion/chemical-based modulation features. This study introduces a biorealistic conductance-based organic electrochemical neuron (c-OECN) that can emulate critical biological neural features, demonstrate stochastic spiking, and enable neurotransmitter/chemical/ion-based modulation. These c-OECNs have the potential for in vivo stimulation of biological nerves.
Article
Neurosciences
K. C. Halmos, P. Gyarmati, H. Xu, S. Maimaiti, G. Jancso, G. Benedek, B. N. Smith
Article
Chemistry, Analytical
Yajing Song, Peter Gyarmati, Ana Catarina Araujo, Joakim Lundeberg, Harry Brumer, Patrik L. Stahl
ANALYTICAL CHEMISTRY
(2014)
Article
Biotechnology & Applied Microbiology
P. Gyarmati, Y. Song, J. Hallman, M. Kaller
JOURNAL OF BIOTECHNOLOGY
(2013)
Article
Multidisciplinary Sciences
Yajing Song, Christian G. Giske, Patrik Gille-Johnson, Olof Emanuelsson, Joakim Lundeberg, Peter Gyarmati
Article
Multidisciplinary Sciences
Peter Gyarmati, Christian Kjellander, Carl Aust, Mats Kalin, Lars Ohrmalm, Christian G. Giske
Article
Multidisciplinary Sciences
Yajing Song, Peter Gyarmati
Article
Multidisciplinary Sciences
Yajing Song, Peter Gyarmati
Article
Chemistry, Analytical
Yajing Song, Peter Gyarmati
Article
Microbiology
Yajing Song, Peter Gyarmati
Editorial Material
Microbiology
Yajing Song, Michael Neff, Peter Gyarmati
Summary: Despite its comprehensive nature, shotgun metagenomics is the most expensive method, requiring specialized equipment and significant computing power.
FUTURE MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yajing Song, Katherine Perlman, Peter Gyarmati
Summary: This study investigated the changes in the intestinal and fecal microbiome and their roles in the pathogenesis of bloodstream infection in a pediatric T-ALL mouse model. The results showed that the alterations in the microbiome and SCFA levels contribute significantly to the development of BSI.
Article
Pediatrics
Peter Gyarmati, Yajing Song, James Dotimas, Grace Yoshiba, Amy Christison
Summary: Limited studies have associated changes in microbiota composition and metabolites with obesity among children and adolescents. This study aimed to characterize faecal microbiota composition, diversity, F/B ratio, and SCFA levels in different weight categories of children aged 5 to 12. Results showed no significant differences in diversity or F/B ratios between weight categories, but relative abundance of Proteobacteria and lack of Verrucomicrobia were demonstrated in severe obesity. Additionally, SCFA concentrations increased progressively with weight category, especially in the class 3 obesity group, indicating an association between severe childhood obesity and changes in gut microbiome composition.
Article
Y. Song, P. Gyarmati
GENOME ANNOUNCEMENTS
(2017)
Article
Veterinary Sciences
Kiss Istvan, Balint Adam, Gyarmati Peter, Kecskemeti Sandor, Belak Sandor
MAGYAR ALLATORVOSOK LAPJA
(2010)