Chronic Hippocampal Expression of Notch Intracellular Domain Induces Vascular Thickening, Reduces Glucose Availability, and Exacerbates Spatial Memory Deficits in a Rat Model of Early Alzheimer
出版年份 2018 全文链接
标题
Chronic Hippocampal Expression of Notch Intracellular Domain Induces Vascular Thickening, Reduces Glucose Availability, and Exacerbates Spatial Memory Deficits in a Rat Model of Early Alzheimer
作者
关键词
Spatial memory decline, Learning impairment, Notch intracellular domain (NICD), Early Alzheimer’s disease, Neuroinflammation, Blood-brain barrier permeability
出版物
MOLECULAR NEUROBIOLOGY
Volume -, Issue -, Pages -
出版商
Springer Nature
发表日期
2018-03-26
DOI
10.1007/s12035-018-1002-3
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Hippocampal CA1 activity correlated with the distance to the goal and navigation performance
- (2017) Hugo J. Spiers et al. HIPPOCAMPUS
- Early Preclinical Changes in Hippocampal CREB-Binding Protein Expression in a Mouse Model of Familial Alzheimer’s Disease
- (2017) Miren Ettcheto et al. MOLECULAR NEUROBIOLOGY
- Hippocampal Proteomic Analysis Reveals Distinct Pathway Deregulation Profiles at Early and Late Stages in a Rat Model of Alzheimer’s-Like Amyloid Pathology
- (2017) Sonia Do Carmo et al. MOLECULAR NEUROBIOLOGY
- Dynamic Nature of presenilin1/γ-Secretase: Implication for Alzheimer’s Disease Pathogenesis
- (2017) Katarzyna Marta Zoltowska et al. MOLECULAR NEUROBIOLOGY
- A Novel Transgenic Rat Model with a Full Alzheimer's-Like Amyloid Pathology Displays Pre-Plaque Intracellular Amyloid-β-Associated Cognitive Impairment
- (2017) Wanda Carolina Leon et al. JOURNAL OF ALZHEIMERS DISEASE
- Intraneuronal Amyloid Beta Accumulation Disrupts Hippocampal CRTC1-Dependent Gene Expression and Cognitive Function in a Rat Model of Alzheimer Disease
- (2016) Edward N. Wilson et al. CEREBRAL CORTEX
- Synaptosomal bioenergetic defects are associated with cognitive impairment in a transgenic rat model of early Alzheimer's disease
- (2016) Pamela V Martino Adami et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery
- (2016) Simon G. Patching MOLECULAR NEUROBIOLOGY
- Notch1 hallmarks fibrillary depositions in sporadic Alzheimer’s disease
- (2016) Emanuele Brai et al. Acta Neuropathologica Communications
- Notch Intracellular Domain (NICD) Suppresses Long-Term Memory Formation in Adult Drosophila Flies
- (2015) Jiabin Zhang et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- The Notch intracellular domain represses CRE-dependent transcription
- (2015) Rania Hallaq et al. CELLULAR SIGNALLING
- Dissecting the Contribution of Vascular Alterations and Aging to Alzheimer’s Disease
- (2015) Cátia Janota et al. MOLECULAR NEUROBIOLOGY
- The Essential Role of Soluble Aβ Oligomers in Alzheimer’s Disease
- (2015) Zi-Xuan Wang et al. MOLECULAR NEUROBIOLOGY
- Production, purification and titration of a lentivirus-based vector for gene delivery purposes
- (2014) Masoud Nasri et al. CYTOTECHNOLOGY
- MicroPET imaging and transgenic models: a blueprint for Alzheimer's disease clinical research
- (2014) Eduardo R. Zimmer et al. TRENDS IN NEUROSCIENCES
- Longitudinal analysis of the behavioral phenotype in a novel transgenic rat model of early stages of Alzheimer's disease
- (2014) Pablo Galeano et al. Frontiers in Behavioral Neuroscience
- Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study
- (2014) M Florencia Iulita et al. Acta Neuropathologica Communications
- Modeling Alzheimer’s disease in transgenic rats
- (2013) Sonia Do Carmo et al. Molecular Neurodegeneration
- Notch-1 Signaling Regulates Microglia Activation via NF-κB Pathway after Hypoxic Exposure In Vivo and In Vitro
- (2013) Linli Yao et al. PLoS One
- HMDB 3.0—The Human Metabolome Database in 2013
- (2012) David S. Wishart et al. NUCLEIC ACIDS RESEARCH
- Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: Implications for cellular Aβ metabolism
- (2011) María C. Leal et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Neurovascular function in Alzheimer's disease patients and experimental models
- (2011) Nektaria Nicolakakis et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Not(ch) just development: Notch signalling in the adult brain
- (2011) Jessica L. Ables et al. NATURE REVIEWS NEUROSCIENCE
- Cerebral amyloid angiopathy: pathogenetic mechanisms and link to dense amyloid plaques
- (2010) S. Kumar-Singh GENES BRAIN AND BEHAVIOR
- Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease
- (2010) Dimitrios Kapogiannis et al. LANCET NEUROLOGY
- Hippocampal long-term depression is required for the consolidation of spatial memory
- (2010) Y. Ge et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Notch-1 signalling is activated in brain arteriovenous malformations in humans
- (2009) Q. ZhuGe et al. BRAIN
- Notch Signaling: The Core Pathway and Its Posttranslational Regulation
- (2009) Mark E. Fortini DEVELOPMENTAL CELL
- Sustained Expression of α1-Antitrypsin after Transplantation of Manipulated Hematopoietic Stem Cells
- (2008) Andrew A. Wilson et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Notch1 Signaling in Pyramidal Neurons Regulates Synaptic Connectivity and Experience-Dependent Modifications of Acuity in the Visual Cortex
- (2008) M. Dahlhaus et al. JOURNAL OF NEUROSCIENCE
- HMDB: a knowledgebase for the human metabolome
- (2008) D. S. Wishart et al. NUCLEIC ACIDS RESEARCH
- Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease
- (2008) E. P. Meyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started