Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery

Vascular Risk Factors: Imaging and Neuropathologic Correlates

(2017) David S. Knopman et al.   JOURNAL OF ALZHEIMERS DISEASE

Pre-Clinical Detection of Alzheimer's Disease Using FDG-PET, with or without Amyloid Imaging

(2017) Lisa Mosconi et al.   JOURNAL OF ALZHEIMERS DISEASE

Glucose and hypothalamic astrocytes: More than a fueling role?

(2016) C. Leloup et al.   NEUROSCIENCE

Cell Microenvironment-Controlled Antitumor Drug Releasing-Nanomicelles for GLUT1-Targeting Hepatocellular Carcinoma Therapy

(2015) Yubo Guo et al.   ACS Applied Materials & Interfaces

Intriguing possibilities and beneficial aspects of transporter-conscious drug design

(2015) Toshihiko Tashima   BIOORGANIC & MEDICINAL CHEMISTRY

Parallel Regulation of Thyroid Hormone Transporters OATP1c1 and MCT8 During and After Endotoxemia at the Blood-Brain Barrier of Male Rodents

(2015) Gábor Wittmann et al.   ENDOCRINOLOGY

Blood–brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery

(2015) William M Pardridge   EXPERT OPINION ON THERAPEUTIC TARGETS

The dynamic blood-brain barrier

(2015) James Keaney et al.   FEBS Journal

Quantitative Determination of Luminal and Abluminal Membrane Distributions of Transporters in Porcine Brain Capillaries by Plasma Membrane Fractionation and Quantitative Targeted Proteomics

(2015) Yoshiyuki Kubo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

In Vitro Blood–Brain Barrier Models—An Overview of Established Models and New Microfluidic Approaches

(2015) Anette Wolff et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Protective effects of vascular endothelial growth factor in cultured brain endothelial cells against hypoglycemia

(2015) Fei Zhao et al.   METABOLIC BRAIN DISEASE

Molecular basis of ligand recognition and transport by glucose transporters

(2015) Dong Deng et al.   NATURE

Structure and mechanism of the mammalian fructose transporter GLUT5

(2015) Norimichi Nomura et al.   NATURE

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

(2015) Ethan A Winkler et al.   NATURE NEUROSCIENCE

The role of type 2 diabetes in neurodegeneration

(2015) Giuseppe Verdile et al.   NEUROBIOLOGY OF DISEASE

Linking insulin with Alzheimer’s disease: emergence as type III diabetes

(2015) Sara Ahmed et al.   NEUROLOGICAL SCIENCES

Relationship between cerebral sodium–glucose transporter and hyperglycemia in cerebral ischemia

(2015) Yui Yamazaki et al.   NEUROSCIENCE LETTERS

Ultrasound effects on brain-targeting mannosylated liposomes: in vitro and blood–brain barrier transport investigations

(2015) Ahmed Zidan et al.   Drug Design Development and Therapy

Efflux transporters in blood-brain interfaces of the developing brain

(2015) Nathalie Strazielle et al.   Frontiers in Neuroscience

Smart Nanodevice Combined Tumor-Specific Vector with Cellular Microenvironment-Triggered Property for Highly Effective Antiglioma Therapy

(2014) Kun Shao et al.   ACS Nano

The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer's disease

(2014) David A. Drachman   Alzheimers & Dementia

Human erythrocytes transport dehydroascorbic acid and sugars using the same transporter complex

(2014) Jay M. Sage et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond

(2014) Scott A. Yuzwa et al.   CHEMICAL SOCIETY REVIEWS

Biological Mechanisms Linking Alzheimer’s Disease and Type-2 Diabetes Mellitus

(2014) Gohar Mushtaq et al.   CNS & Neurological Disorders-Drug Targets

Molecular Links Between Endothelial Dysfunction and Neurodegeneration in Alzheimer's Disease

(2014) Epameinondas Lyros et al.   Current Alzheimer Research

Alzheimer’s Disease and Type 2 Diabetes: Multiple Mechanisms Contribute to Interactions

(2014) Anusha Jayaraman et al.   Current Diabetes Reports

Challenges in the Design of Clinically Useful Brain-targeted Drug Nanocarriers

(2014) L. Costantino et al.   CURRENT MEDICINAL CHEMISTRY

Editorial (Thematic Issue: Targeting Transporters for CNS Drug Delivery)

(2014) Patrick Ronaldson   CURRENT PHARMACEUTICAL DESIGN

The Role of Blood-Brain Barrier Transporters in Pathophysiology and Pharmacotherapy of Stroke

(2014) Kaushik Shah et al.   CURRENT PHARMACEUTICAL DESIGN

Transporter-Based Delivery of Anticancer Drugs to the Brain: Improving Brain Penetration by Minimizing Drug Efflux at the Blood-Brain Barrier

(2014) Ngoc On et al.   CURRENT PHARMACEUTICAL DESIGN

Transporters at CNS Barrier Sites: Obstacles or Opportunities for Drug Delivery?

(2014) Lucy Sanchez-Covarrubias et al.   CURRENT PHARMACEUTICAL DESIGN

Dietary Treatments and New Therapeutic Perspective in GLUT1 Deficiency Syndrome

(2014) Pierangelo Veggiotti et al.   Current Treatment Options in Neurology

Design, synthesis and biological evaluation of brain targeting l-ascorbic acid prodrugs of ibuprofen with “lock-in” function

(2014) Yi Zhao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review

(2014) Joana Bicker et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A critical analysis of the ‘amyloid cascade hypothesis’

(2014) Richard A. Armstrong   FOLIA NEUROPATHOLOGICA

The Emerging Link betweenO-GlcNAc and Alzheimer Disease

(2014) Yanping Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GLUT2-Mediated Glucose Uptake and Availability Are Required for Embryonic Brain Development in Zebrafish

(2014) Rubén Marín-Juez et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The role of glucose transporters in the distribution of p-aminophenyl-α-d-mannopyranoside modified liposomes within mice brain

(2014) Dan Du et al.   JOURNAL OF CONTROLLED RELEASE

Glucose transporter and folic acid receptor-mediated Pluronic P105 polymeric micelles loaded with doxorubicin for brain tumor treating

(2014) Jiangxiu Niu et al.   JOURNAL OF DRUG TARGETING

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

(2014) Nga Bien-Ly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GLUT1 deficiency syndrome into adulthood: a follow-up study

(2014) W. G. Leen et al.   JOURNAL OF NEUROLOGY

In Vitro Models of the Blood–Brain Barrier for the Study of Drug Delivery to the Brain

(2014) Imola Wilhelm et al.   MOLECULAR PHARMACEUTICS

Crystal structure of the human glucose transporter GLUT1

(2014) Dong Deng et al.   NATURE

Cerebral glucose transporter: The possible therapeutic target for ischemic stroke

(2014) Shuai Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Brain glucose transporters: Implications for neurologic disease

(2014) E. E. Benarroch   NEUROLOGY

Refractory Absence Epilepsy and Glut1 Deficiency Syndrome: A New Case Report and Literature Review

(2014) Francesca Ragona et al.   NEUROPEDIATRICS

Sodium-glucose transporter type 3-mediated neuroprotective effect of acetylcholine suppresses the development of cerebral ischemic neuronal damage

(2014) Y. Yamazaki et al.   NEUROSCIENCE

Long-term effects of a ketogenic diet on body composition and bone mineralization in GLUT-1 deficiency syndrome: A case series

(2014) Simona Bertoli et al.   NUTRITION

In Vitro Cerebrovascular Modeling in the 21st Century: Current and Prospective Technologies

(2014) Christopher A. Palmiotti et al.   PHARMACEUTICAL RESEARCH

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

(2014) Romeo Cecchelli et al.   PLoS One

Metabolic costs and evolutionary implications of human brain development

(2014) C. W. Kuzawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional architecture of MFS D-glucose transporters

(2014) M. G. Madej et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-Culture Models of the Blood–Brain Barrier

(2014) Yarong He et al.   STROKE

Functionalized Nanoscale Micelles with Brain Targeting Ability and Intercellular Microenvironment Biosensitivity for Anti-Intracranial Infection Applications

(2014) Kun Shao et al.   Advanced Healthcare Materials

Erratum to “A Survey of FDG- and Amyloid-PET Imaging in Dementia and GRADE Analysis”

(2014) Daniela Perani et al.   Biomed Research International

PET Approaches for Diagnosis of Dementia

(2013) K. Ishii   AMERICAN JOURNAL OF NEURORADIOLOGY

Nano-enabled delivery systems across the blood–brain barrier

(2013) Seung Rim Hwang et al.   ARCHIVES OF PHARMACAL RESEARCH

Nanoparticles of 2-deoxy-d-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment

(2013) Xinyi Jiang et al.   BIOMATERIALS

Hypoglycemia Induces Tau Hyperphosphorylation

(2013) Chu-Wan Lee et al.   Current Alzheimer Research

Alzheimer Disease and Diabetes Mellitus: Do They have Anything in Common?

(2013) Ernest Adeghate et al.   Current Alzheimer Research

Phenotypic Spectrum of Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS)

(2013) Toni S. Pearson et al.   Current Neurology and Neuroscience Reports

Design, synthesis and biological evaluation of multivalent glucosides with high affinity as ligands for brain targeting liposomes

(2013) Boyi Qu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Liposomes modified with P-aminophenyl-α-d-mannopyranoside: A carrier for targeting cerebral functional regions in mice

(2013) Zhong-fei Hao et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Connecting Type 2 diabetes to Alzheimer’s disease

(2013) Fernanda G De Felice   Expert Review of Neurotherapeutics

Glut1 Deficiency Syndrome and Novel Ketogenic Diets

(2013) Joerg Klepper et al.   JOURNAL OF CHILD NEUROLOGY

The Many Faces of Glut1 Deficiency Syndrome

(2013) Michal Tzadok et al.   JOURNAL OF CHILD NEUROLOGY

Characterization and Modulation of Glucose Uptake in a Human Blood–Brain Barrier Model

(2013) Manuela Meireles et al.   JOURNAL OF MEMBRANE BIOLOGY

Chromium modulates expressions of neuronal plasticity markers and glial fibrillary acidic proteins in hypoglycemia-induced brain injury

(2013) Kazim Sahin et al.   LIFE SCIENCES

Solute carriers as drug targets: Current use, clinical trials and prospective

(2013) Mathias Rask-Andersen et al.   MOLECULAR ASPECTS OF MEDICINE

The SLC2 (GLUT) family of membrane transporters

(2013) Mike Mueckler et al.   MOLECULAR ASPECTS OF MEDICINE

Glucose transport families SLC5 and SLC50

(2013) Ernest M. Wright   MOLECULAR ASPECTS OF MEDICINE

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

(2013) William A Flavahan et al.   NATURE NEUROSCIENCE

Design, Synthesis and Brain Uptake of LAT1-Targeted Amino Acid Prodrugs of Dopamine

(2013) Lauri Peura et al.   PHARMACEUTICAL RESEARCH

Glucose-Coated Gold Nanoparticles Transfer across Human Brain Endothelium and Enter Astrocytes In Vitro

(2013) Radka Gromnicova et al.   PLoS One

Crystal structure of a glucose/H+ symporter and its mechanism of action

(2013) C. V. Iancu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

(2013) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

GLUT1 deficiency syndrome: An update

(2013) D. Gras et al.   REVUE NEUROLOGIQUE

GLUT1 deficiency syndrome 2013: Current state of the art

(2013) Valentina De Giorgis et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Neurovascular Dysfunction and Faulty Amyloid  -Peptide Clearance in Alzheimer Disease

(2013) A. P. Sagare et al.   Cold Spring Harbor Perspectives in Medicine

Cerebrospinal Fluid Analysis in the Workup of GLUT1 Deficiency Syndrome

(2013) Wilhelmina G. Leen et al.   JAMA Neurology

Regional distribution of SGLT activity in rat brain in vivo

(2012) Amy S. Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Glucose transporter 1 deficiency in the idiopathic generalized epilepsies

(2012) Todor Arsov et al.   ANNALS OF NEUROLOGY

Reliable permeability assay system in a microfluidic device mimicking cerebral vasculatures

(2012) Ju Hun Yeon et al.   BIOMEDICAL MICRODEVICES

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Post-ischemic hyperglycemia exacerbates the development of cerebral ischemic neuronal damage through the cerebral sodium-glucose transporter

(2012) Yui Yamazaki et al.   BRAIN RESEARCH

Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation

(2012) Sónia C. Correia et al.   BRAIN RESEARCH

Diffusion of d-glucose measured in the cytosol of a single astrocyte

(2012) Marko Kreft et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hurdles with Using In Vitro Models to Predict Human Blood-brain Barrier Drug Permeability: A Special Focus on Transporters and Metabolizing Enzymes

(2012) Ramzi Shawahna et al.   CURRENT DRUG METABOLISM

In Vitro Modeling of the Blood-Brain Barrier: Simplicity Versus Complexity

(2012) Omolara O. Ogunshola   CURRENT PHARMACEUTICAL DESIGN

Early onset absence epilepsy: 1 in 10 cases is caused by GLUT1 deficiency

(2012) Todor Arsov et al.   EPILEPSIA

The major facilitator superfamily (MFS) revisited

(2012) Vamsee S. Reddy et al.   FEBS Journal

The Role of Glucose Transporters in Brain Disease: Diabetes and Alzheimer's Disease

(2012) Kaushik Shah et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Investigation of glucose-modified liposomes using polyethylene glycols with different chain lengths as the linkers for brain targeting

(2012) Fulan Xie et al.   International Journal of Nanomedicine

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP

Overlapped Metabolic and Therapeutic Links between Alzheimer and Diabetes

(2012) Waqar Ahmad   MOLECULAR NEUROBIOLOGY

Quantitative Targeted Absolute Proteomic Analysis of Transporters, Receptors and Junction Proteins for Validation of Human Cerebral Microvascular Endothelial Cell Line hCMEC/D3 as a Human Blood–Brain Barrier Model

(2012) Sumio Ohtsuki et al.   MOLECULAR PHARMACEUTICS

Nanobiotechnology-based strategies for crossing the blood–brain barrier

(2012) Kewal K Jain   Nanomedicine

Crystal structure of a bacterial homologue of glucose transporters GLUT1–4

(2012) Linfeng Sun et al.   NATURE

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

(2012) Ethan S Lippmann et al.   NATURE BIOTECHNOLOGY

GLUT1 mutations are a rare cause of familial idiopathic generalized epilepsy

(2012) P. Striano et al.   NEUROLOGY

Insulin in the brain: There and back again

(2012) William A. Banks et al.   PHARMACOLOGY & THERAPEUTICS

Transcriptional Profiling of Human Brain Endothelial Cells Reveals Key Properties Crucial for Predictive In Vitro Blood-Brain Barrier Models

(2012) Eduard Urich et al.   PLoS One

Can Alzheimer Disease Be a Form of Type 3 Diabetes?

(2012) Giulia Accardi et al.   REJUVENATION RESEARCH

Glut1 deficiency syndrome and erythrocyte glucose uptake assay

(2011) Hong Yang et al.   ANNALS OF NEUROLOGY

Determinants of Ligand Binding Affinity and Cooperativity at the GLUT1 Endofacial Site

(2011) Trista Robichaud et al.   BIOCHEMISTRY

Brain glucose transporter (Glut3) haploinsufficiency does not impair mouse brain glucose uptake

(2011) Charles A. Stuart et al.   BRAIN RESEARCH

Design, synthesis and preliminary bio-evaluation of glucose–cholesterol derivatives as ligands for brain targeting liposomes

(2011) Fan Lei et al.   CHINESE CHEMICAL LETTERS

Prodrugs and Endogenous Transporters: Are They Suitable Tools for Drug Targeting into the Central Nervous System?

(2011) Barbara Pavan et al.   CURRENT PHARMACEUTICAL DESIGN

Prodrugs - An Efficient Way to Breach Delivery and Targeting Barriers

(2011) Kristiina M. Huttunen et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Glut1 deficiency: When to suspect and how to diagnose?

(2011) A. Verrotti et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy

(2011) Vincent T. Marchesi   FASEB JOURNAL

Glucose transporters GLUT4 and GLUT8 are upregulated after facial nerve axotomy in adult mice

(2011) Olga Gómez et al.   JOURNAL OF ANATOMY

GLUT-1 glucose transporters in the blood-brain barrier: Differential phosphorylation

(2011) Kavi Devraj et al.   JOURNAL OF NEUROSCIENCE RESEARCH

In Vitro Blood–Brain Barrier Models: Current and Perspective Technologies

(2011) Pooja Naik et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunction

(2011) P M Abdul Muneer et al.   Molecular Neurodegeneration

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Inducible astrocytic glucose transporter-3 contributes to the enhanced storage of intracellular glycogen during reperfusion after ischemia

(2011) Sadahiro Iwabuchi et al.   NEUROCHEMISTRY INTERNATIONAL

Paroxysmal choreoathetosis/spasticity (DYT9) is caused by a GLUT1 defect

(2011) Y. G. Weber et al.   NEUROLOGY

Biology of Human Sodium Glucose Transporters

(2011) Ernest M. Wright et al.   PHYSIOLOGICAL REVIEWS

Methamphetamine Inhibits the Glucose Uptake by Human Neurons and Astrocytes: Stabilization by Acetyl-L-Carnitine

(2011) P. M. Abdul Muneer et al.   PLoS One

Atherosclerosis and Dementia

(2011) Claudia K. Suemoto et al.   STROKE

Vascular risk factor detection and control may prevent Alzheimer's disease

(2010) Jack C. de la Torre   AGEING RESEARCH REVIEWS

Functional expression of SGLTs in rat brain

(2010) Amy S. Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Glut1 deficiency: Inheritance pattern determined by haploinsufficiency

(2010) Michael Rotstein et al.   ANNALS OF NEUROLOGY

Glut1/SLC2A1 is crucial for the development of the blood-brain barrier in vivo

(2010) Ping-Pin Zheng et al.   ANNALS OF NEUROLOGY

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?

(2010) Kawser Akter et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Shear stress and the endothelial transport barrier

(2010) John M. Tarbell   CARDIOVASCULAR RESEARCH

Acute Modulation of Sugar Transport in Brain Capillary Endothelial Cell Cultures during Activation of the Metabolic Stress Pathway

(2010) Anthony J. Cura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vitroandin vivoinvestigation of glucose-mediated brain-targeting liposomes

(2010) Yao Qin et al.   JOURNAL OF DRUG TARGETING

ABC and SLC Transporter Expression and Pot Substrate Characterization across the Human CMEC/D3 Blood−Brain Barrier Cell Line

(2010) Stephen M. Carl et al.   MOLECULAR PHARMACEUTICS

Neurodegeneration and the neurovascular unit

(2010) Berislav V Zlokovic   NATURE MEDICINE

Absence epilepsies with widely variable onset are a key feature of familial GLUT1 deficiency

(2010) S. A. Mullen et al.   NEUROLOGY

Autosomal Recessive Inheritance of GLUT1 Deficiency Syndrome

(2010) J. Klepper et al.   NEUROPEDIATRICS

Inhibitory effects of alcohol on glucose transport across the blood–brain barrier leads to neurodegeneration: preventive role of acetyl-l-carnitine

(2010) P. M. Abdul Muneer et al.   PSYCHOPHARMACOLOGY

Review: Obesity and Alzheimer’s Disease: A Link Between Body Weight and Cognitive Function in Old Age

(2009) Ebrahim K. Naderali et al.   American Journal of Alzheimers Disease and Other Dementias

GLUT8, the enigmatic intracellular hexose transporter

(2009) Stefan Schmidt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Will the original glucose transporter isoform please stand up!

(2009) Anthony Carruthers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucose transporters in the 21st Century

(2009) Bernard Thorens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Early-onset absence epilepsy caused by mutations in the glucose transporter GLUT1

(2009) Arvid Suls et al.   ANNALS OF NEUROLOGY

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

(2009) F. Liu et al.   BRAIN

The expanding phenotype of GLUT1-deficiency syndrome

(2009) Knut Brockmann   BRAIN & DEVELOPMENT

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

Novel and emerging strategies in drug delivery for overcoming the blood–brain barrier

(2009) David D Stenehjem et al.   Future Medicinal Chemistry

Synthesis, in vitro and in vivo characterization of glycosyl derivatives of ibuprofen as novel prodrugs for brain drug delivery

(2009) Qian Chen et al.   JOURNAL OF DRUG TARGETING

Glucose Promoiety Enables Glucose Transporter Mediated Brain Uptake of Ketoprofen and Indomethacin Prodrugs in Rats

(2009) Mikko Gynther et al.   JOURNAL OF MEDICINAL CHEMISTRY

Brain glucose transporters,O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer’s disease

(2009) Ying Liu et al.   JOURNAL OF NEUROCHEMISTRY

Trivalent arsenicals and glucose use different translocation pathways in mammalian GLUT1

(2009) Xuan Jiang et al.   Metallomics

GLUT1 gene mutations cause sporadic paroxysmal exercise-induced dyskinesias

(2009) Susanne A. Schneider et al.   MOVEMENT DISORDERS

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Increased densities of monocarboxylate transport protein MCT1 after chronic administration of nicotine in rat brain

(2009) Martin Canis et al.   NEUROSCIENCE RESEARCH

The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction

(2009) Britta Engelhardt et al.   Seminars in Immunopathology

α- and β-Monosaccharide transport in human erythrocytes

(2008) Jeffry M. Leitch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The facilitative glucose transporter GLUT3: 20 years of distinction

(2008) Ian A. Simpson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of the fructose transporter GLUT5 in health and disease

(2008) Veronique Douard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Potential Role of Glucose Transport Changes in Hot Flash Physiology: A Hypothesis

(2008) S. L. Dormire   Biological Research for Nursing

Paroxysmal exercise-induced dyskinesia and epilepsy is due to mutations in SLC2A1, encoding the glucose transporter GLUT1

(2008) A. Suls et al.   BRAIN

Hypertension and Cerebrovascular Dysfunction

(2008) Costantino Iadecola et al.   Cell Metabolism

Getting into the Brain

(2008) Mayur M Patel et al.   CNS DRUGS

Glucose transporter deficiency syndrome (GLUT1DS) and the ketogenic diet

(2008) Jörg Klepper   EPILEPSIA

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

(2008) Ying Liu et al.   FEBS LETTERS

Slc2a5 (Glut5) Is Essential for the Absorption of Fructose in the Intestine and Generation of Fructose-induced Hypertension

(2008) Sharon Barone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies

(2008) Birk Poller et al.   JOURNAL OF NEUROCHEMISTRY

A Functional Role for Sodium-Dependent Glucose Transport across the Blood-Brain Barrier during Oxygen Glucose Deprivation

(2008) S. Vemula et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Progress in Drug Delivery to the Central Nervous System by the Prodrug Approach

(2008) Barbara Pavan et al.   MOLECULES

Central obesity and increased risk of dementia more than three decades later

(2008) R. A. Whitmer et al.   NEUROLOGY

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON