Early etiology of Alzheimer’s disease: tipping the balance toward autophagy or endosomal dysfunction?

Autophagy in neuronal cells: general principles and physiological and pathological functions

(2014) Markus Damme et al.   ACTA NEUROPATHOLOGICA

ATGs

(2014) Nuria Martinez-Lopez et al.   Autophagy

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

(2014) V. A. Polito et al.   EMBO Molecular Medicine

Pharmacological chaperones stabilize retromer to limit APP processing

(2014) Vincent J Mecozzi et al.   Nature Chemical Biology

Lysosomal Sorting of Amyloid-  by the SORLA Receptor Is Impaired by a Familial Alzheimer's Disease Mutation

(2014) S. Caglayan et al.   Science Translational Medicine

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

(2014) Rania Ghossoub et al.   Nature Communications

A Paired RNAi and RabGAP Overexpression Screen Identifies Rab11 as a Regulator of β-Amyloid Production

(2014) Vinod Udayar et al.   Cell Reports

A fast growing spectrum of biological functions of γ-secretase in development and disease

(2013) Nathalie Jurisch-Yaksi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Diverse Autophagosome Membrane Sources Coalesce in Recycling Endosomes

(2013) Claudia Puri et al.   CELL

Atg6 is required for multiple vesicle trafficking pathways and hematopoiesis in Drosophila

(2013) B. V. Shravage et al.   DEVELOPMENT

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

(2013) Ikuko Maejima et al.   EMBO JOURNAL

Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease

(2013) Carmine Spampanato et al.   EMBO Molecular Medicine

Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic

(2013) Camilla Raiborg et al.   FEBS Journal

Sorting receptor SORLA - a trafficking path to avoid Alzheimer disease

(2013) T. E. Willnow et al.   JOURNAL OF CELL SCIENCE

Protein Sorting Motifs in the Cytoplasmic Tail of SorCS1 Control Generation of Alzheimer's Amyloid-  Peptide

(2013) R. F. Lane et al.   JOURNAL OF NEUROSCIENCE

Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization

(2013) Zsuzsanna Szatmári et al.   MOLECULAR BIOLOGY OF THE CELL

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Prefibrillar Tau Oligomers in Mild Cognitive Impairment and Alzheimer's Disease

(2013) Elliott J. Mufson et al.   Neurodegenerative Diseases

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system

(2013) Etienne Morel et al.   Nature Communications

Autophagy proteins regulate ERK phosphorylation

(2013) Nuria Martinez-Lopez et al.   Nature Communications

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

What Renders TAU Toxic

(2013) Jürgen Götz et al.   Frontiers in Neurology

Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer’s disease

(2012) Lara Wahlster et al.   ACTA NEUROPATHOLOGICA

Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Amyloid-β–Associated Clinical Decline Occurs Only in the Presence of Elevated P-tau

(2012) Rahul S. Desikan et al.   ARCHIVES OF NEUROLOGY

Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells

(2012) Martina Malnar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: Implications for lysosomal function

(2012) Kara M Neely Kayala et al.   BRAIN RESEARCH

ARF6-mediated endosomal transport of Telencephalin affects dendritic filopodia-to-spine maturation

(2012) Tim Raemaekers et al.   EMBO JOURNAL

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

Peptides based on the presenilin-APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain

(2012) Cary Esselens et al.   FASEB JOURNAL

Impaired proteolysis underlies autophagic dysfunction in Niemann–Pick type C disease

(2012) Matthew J. Elrick et al.   HUMAN MOLECULAR GENETICS

Hyperphosphorylation of Tau Induced by Naturally Secreted Amyloid-β at Nanomolar Concentrations Is Modulated by Insulin-dependent Akt-GSK3β Signaling Pathway

(2012) Takayoshi Tokutake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes

(2012) Andrea Longatti et al.   JOURNAL OF CELL BIOLOGY

Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells

(2012) Katrijn Coen et al.   JOURNAL OF CELL BIOLOGY

Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D

(2012) Kevin Moreau et al.   JOURNAL OF CELL BIOLOGY

Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking

(2012) H. J. Kim et al.   JOURNAL OF CELL SCIENCE

The retromer complex - endosomal protein recycling and beyond

(2012) M. N. J. Seaman   JOURNAL OF CELL SCIENCE

Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease

(2012) Jiaqi Yao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

 -Amyloid Inhibits Protein Prenylation and Induces Cholesterol Sequestration by Impairing SREBP-2 Cleavage

(2012) A. Mohamed et al.   JOURNAL OF NEUROSCIENCE

A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2

(2012) X. Zhang et al.   JOURNAL OF NEUROSCIENCE

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

(2012) Keiichi Inoue et al.   Molecular Neurodegeneration

PGC-1  Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

(2012) T. Tsunemi et al.   Science Translational Medicine

Membrane Trafficking Pathways in Alzheimer's Disease

(2012) Lawrence Rajendran et al.   TRAFFIC

Presenilin Deficiency or Lysosomal Inhibition Enhances Wnt Signaling through Relocalization of GSK3 to the Late-Endosomal Compartment

(2012) Radek Dobrowolski et al.   Cell Reports

Stages of granulovacuolar degeneration: their relation to Alzheimer’s disease and chronic stress response

(2011) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy inC. elegans

(2011) Alexander Ruck et al.   Autophagy

Endocytosis and signaling

(2011) Harald W Platta et al.   CURRENT OPINION IN CELL BIOLOGY

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A  in AD models

(2011) P. J. Khandelwal et al.   HUMAN MOLECULAR GENETICS

VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology

(2011) Lei Wen et al.   JOURNAL OF CELL BIOLOGY

Unesterified Cholesterol Accumulation in Late Endosomes/Lysosomes Causes Neurodegeneration and Is Prevented by Driving Cholesterol Export from This Compartment

(2011) A. Aqul et al.   JOURNAL OF NEUROSCIENCE

Presenilin Is Necessary for Efficient Proteolysis through the Autophagy-Lysosome System in a  -Secretase-Independent Manner

(2011) K. M. Neely et al.   JOURNAL OF NEUROSCIENCE

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

(2011) Tomohiro Umeda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes

(2011) D. B. Thimiri Govinda Raj et al.   Molecular Systems Biology

Potent amyloidogenicity and pathogenicity of Aβ43

(2011) Takashi Saito et al.   NATURE NEUROSCIENCE

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

The Mammalian Class 3 PI3K (PIK3C3) Is Required for Early Embryogenesis and Cell Proliferation

(2011) Xiang Zhou et al.   PLoS One

Granulovacuolar Degenerations Appear in Relation to Hippocampal Phosphorylated Tau Accumulation in Various Neurodegenerative Disorders

(2011) Yuu Yamazaki et al.   PLoS One

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

(2011) R. Sannerud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Links Between A  Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast

(2011) S. Treusch et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

(2010) Bart De Strooper et al.   Annual Review of Cell and Developmental Biology

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

(2010) Jessica M. Mc Donald et al.   BRAIN

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

The Beclin 1 interactome

(2010) Congcong He et al.   CURRENT OPINION IN CELL BIOLOGY

A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic

(2010) Sigrid B. Thoresen et al.   EXPERIMENTAL CELL RESEARCH

The RUN Domain of Rubicon Is Important for hVps34 Binding, Lipid Kinase Inhibition, and Autophagy Suppression

(2010) Qiming Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macroautophagy Is Not Directly Involved in the Metabolism of Amyloid Precursor Protein

(2010) Barry Boland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mouse Model of Amyloid   Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo

(2010) T. Tomiyama et al.   JOURNAL OF NEUROSCIENCE

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Granulovacuolar degeneration (GVD) bodies of Alzheimer's disease (AD) resemble late-stage autophagic organelles

(2010) K. E. Funk et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease

(2010) H.N. Dawson et al.   NEUROSCIENCE

Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex

(2010) Philipp A. Jaeger et al.   PLoS One

Mechanism of amyloid plaque formation suggests an intracellular basis of A  pathogenicity

(2010) R. P. Friedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway

(2010) X. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rubicon controls endosome maturation as a Rab7 effector

(2010) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of membrane biogenesis in autophagy via PI3P dynamics

(2010) Takeshi Noda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond

(2010) Sarah F. Funderburk et al.   TRENDS IN CELL BIOLOGY

The phospholipase D1 pathway modulates macroautophagy

(2010) Claudia Dall'Armi et al.   Nature Communications

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Atg14 and UVRAG: Mutually exclusive subunits of mammalian Beclin 1-PI3K complexes

(2009) Eisuke Itakura et al.   Autophagy

Phosphorylated Tau Interacts with c-Jun N-terminal Kinase-interacting Protein 1 (JIP1) in Alzheimer Disease

(2009) Lars M. Ittner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early endosomes and endosomal coatomer are required for autophagy

(2009) Minoo Razi et al.   JOURNAL OF CELL BIOLOGY

How do ESCRT proteins control autophagy?

(2009) T. E. Rusten et al.   JOURNAL OF CELL SCIENCE

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Abeta42-Induced Neurodegeneration via an Age-Dependent Autophagic-Lysosomal Injury in Drosophila

(2009) Daijun Ling et al.   PLoS One

ARF6-Mediated Endosome Recycling Reverses Lipid Accumulation Defects in Niemann-Pick Type C Disease

(2009) Jill Kuglin Schweitzer et al.   PLoS One

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

(2009) X. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The regulation of aging: does autophagy underlie longevity?

(2009) Tibor Vellai et al.   TRENDS IN CELL BIOLOGY

Transient intraneuronal Aβ rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice

(2008) Ditte Zerlang Christensen et al.   ACTA NEUROPATHOLOGICA

Tau Mutations in Neurodegenerative Diseases

(2008) Michael S. Wolfe   JOURNAL OF BIOLOGICAL CHEMISTRY

Building γ-secretase – the bits and pieces

(2008) Dragana Spasic et al.   JOURNAL OF CELL SCIENCE

Wild-Type But Not FAD Mutant Presenilin-1 Prevents Neuronal Degeneration by Promoting Phosphatidylinositol 3-Kinase Neuroprotective Signaling

(2008) L. Baki et al.   JOURNAL OF NEUROSCIENCE

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Loss of LR11/SORLA Enhances Early Pathology in a Mouse Model of Amyloidosis: Evidence for a Proximal Role in Alzheimer's Disease

(2008) S. E. Dodson et al.   JOURNAL OF NEUROSCIENCE

The Atg8 Conjugation System Is Indispensable for Proper Development of Autophagic Isolation Membranes in Mice

(2008) Yu-shin Sou et al.   MOLECULAR BIOLOGY OF THE CELL

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

(2008) Chengyu Liang et al.   NATURE CELL BIOLOGY

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

(2008) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microtubule-associated protein tau in development, degeneration and protection of neurons

(2008) Jian-Zhi Wang et al.   PROGRESS IN NEUROBIOLOGY

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE

Trafficking, a key player in regulated intramembrane proteolysis

(2008) Ragna Sannerud et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

(2007) Huaqi Xiong et al.   NEUROBIOLOGY OF DISEASE