Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine - searching for the connections

Folic Acid Potentiates the Effect of Memantine on Spatial Learning and Neuronal Protection in an Alzheimer's Disease Transgenic Model

(2017) Ta-Fu Chen et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β Induces Caspase-Dependent Loss of PSD-95 and Synaptophysin Through NMDA Receptors

(2017) Jinping Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-  Peptide Oligomers Disrupt Axonal Transport through an NMDA Receptor-Dependent Mechanism That Is Mediated by Glycogen Synthase Kinase 3  in Primary Cultured Hippocampal Neurons

(2013) H. Decker et al.   JOURNAL OF NEUROSCIENCE

Multiple Defects in Energy Metabolism in Alzheimers Disease

(2012) I. L. Ferreira et al.   CURRENT DRUG TARGETS

Magnetic resonance imaging and neuropsychological results from a trial of memantine in Alzheimer’s disease

(2011) Michael W. Weiner et al.   Alzheimers & Dementia

Prolonged Exposure of Cortical Neurons to Oligomeric Amyloid-β Impairs NMDA Receptor Function Via NADPH Oxidase-Mediated ROS Production: Protective Effect of Green Tea (-)-Epigallocatechin-3-Gallate

(2011) Yan He et al.   ASN Neuro

Behavioural and cellular effects of exogenous amyloid-β peptides in rodents

(2011) Caroline Chambon et al.   BEHAVIOURAL BRAIN RESEARCH

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

(2011) Claire Thornton et al.   BIOCHEMICAL JOURNAL

Lithium, phenserine, memantine and pioglitazone reverse memory deficit and restore phospho-GSK3β decreased in hippocampus in intracerebroventricular streptozotocin induced memory deficit model

(2011) Teresa Ponce-Lopez et al.   BRAIN RESEARCH

New updated GRAC Fifth Edition with searchable online version Launch of new portal Guide to Pharmacology in association with NC-IUPHAR Transporter-Themed Issue

(2011) Steve Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

A β-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes

(2011) M Mezler et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amyloid β peptide oligomers directly activate NMDA receptors

(2011) Laura Texidó et al.   CELL CALCIUM

Aβ Oligomer-Induced Synapse Degeneration in Alzheimer’s Disease

(2011) Kyle C. Wilcox et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia

(2011) Urte Neniskyte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's Disease Brain-Derived Amyloid- -Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein

(2011) A. E. Barry et al.   JOURNAL OF NEUROSCIENCE

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

(2011) Jan Bieschke et al.   Nature Chemical Biology

AD synapses contain abundant Aβ monomer and multiple soluble oligomers, including a 56-kDa assembly

(2011) Sophie Sokolow et al.   NEUROBIOLOGY OF AGING

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices

(2011) Gerhard Rammes et al.   NEUROPHARMACOLOGY

Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer’s disease

(2011) Mohammed Filali et al.   NEUROPHARMACOLOGY

Calcium Ions Promote Formation of Amyloid β-Peptide (1–40) Oligomers Causally Implicated in Neuronal Toxicity of Alzheimer's Disease

(2011) Anna Itkin et al.   PLoS One

Synapses, NMDA receptor activity and neuronal Aβ production in Alzheimer’s disease

(2011) Karim Bordji et al.   REVIEWS IN THE NEUROSCIENCES

The basal forebrain cholinergic system in aging and dementia. Rescuing cholinergic neurons from neurotoxic amyloid-β42 with memantine

(2010) Csaba Nyakas et al.   BEHAVIOURAL BRAIN RESEARCH

Higher Soluble Amyloid β Concentration in Frontal Cortex of Young Adults than in Normal Elderly or Alzheimer's Disease

(2010) Zoë Van Helmond et al.   BRAIN PATHOLOGY

Inhibition of calpain prevents NMDA-induced cell death and β-amyloid-induced synaptic dysfunction in hippocampal slice cultures

(2010) V Nimmrich et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amyloid β oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors

(2010) Elena Alberdi et al.   CELL CALCIUM

Calcium Signaling and Amyloid Toxicity in Alzheimer Disease

(2010) Angelo Demuro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer’s toxic amyloid-β peptide oligomers

(2010) Helena Decker et al.   JOURNAL OF NEUROCHEMISTRY

Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-  Production

(2010) K. Bordji et al.   JOURNAL OF NEUROSCIENCE

Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses

(2010) P. Xia et al.   JOURNAL OF NEUROSCIENCE

A Mouse Model of Amyloid   Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo

(2010) T. Tomiyama et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

(2010) Marianne Renner et al.   NEURON

Brain amyloid β protein and memory disruption in Alzheimer’s disease

(2010) Weiming Xia   Neuropsychiatric Disease and Treatment

Memantine Improves Cognition and Reduces Alzheimer’s-Like Neuropathology in Transgenic Mice

(2009) Hilda Martinez-Coria et al.   AMERICAN JOURNAL OF PATHOLOGY

Pyroglutamate Formation Influences Solubility and Amyloidogenicity of Amyloid Peptides

(2009) Dagmar Schlenzig et al.   BIOCHEMISTRY

NMDA- and  -Amyloid1-42-Induced Neurotoxicity Is Attenuated in Serine Racemase Knock-Out Mice

(2009) R. Inoue et al.   JOURNAL OF NEUROSCIENCE

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Synaptic NMDA Receptor Activation Stimulates  -Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-  Production

(2009) S. E. Hoey et al.   JOURNAL OF NEUROSCIENCE

A Role for Synaptic Zinc in Activity-Dependent A  Oligomer Formation and Accumulation at Excitatory Synapses

(2009) A. Deshpande et al.   JOURNAL OF NEUROSCIENCE

 -Amyloid Monomers Are Neuroprotective

(2009) M. L. Giuffrida et al.   JOURNAL OF NEUROSCIENCE

Memantine lowers amyloid-β peptide levels in neuronal cultures and in APP/PS1 transgenic mice

(2009) George M. Alley et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Amyloid beta from axons and dendrites reduces local spine number and plasticity

(2009) Wei Wei et al.   NATURE NEUROSCIENCE

Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

(2009) Efrat Abramov et al.   NATURE NEUROSCIENCE

Protection against Aβ-mediated rapid disruption of synaptic plasticity and memory by memantine

(2009) Igor Klyubin et al.   NEUROBIOLOGY OF AGING

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Effects of memantine on soluble Αβ25-35-induced changes in peptidergic and glial cells in Alzheimer's disease model rat brain regions

(2009) M. Arif et al.   NEUROSCIENCE

Memantine treatment decreases levels of secreted Alzheimer's amyloid precursor protein (APP) and amyloid beta (Aβ) peptide in the human neuroblastoma cells

(2009) Balmiki Ray et al.   NEUROSCIENCE LETTERS

GluN2B subunit-containing NMDA receptor antagonists prevent A -mediated synaptic plasticity disruption in vivo

(2009) N.-W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term Course and Effectiveness of Combination Therapy in Alzheimer Disease

(2008) Alireza Atri et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Therapeutically relevant plasma concentrations of memantine produce significant L-N-methyl-D-aspartate receptor occupation and do not impair learning in rats

(2008) Lorenzo Morè et al.   BEHAVIOURAL PHARMACOLOGY

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

(2008) C.-X. Gong et al.   CURRENT MEDICINAL CHEMISTRY

Memantine protects rat cortical cultured neurons against β-amyloid-induced toxicity by attenuating tau phosphorylation

(2008) M. S. Song et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

β-amyloid and glutamate receptors

(2008) Laura Gasparini et al.   EXPERIMENTAL NEUROLOGY

Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2in cortical neurons

(2008) Phullara B. Shelat et al.   JOURNAL OF NEUROCHEMISTRY

Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging

(2008) Henrieta Scholtzova et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

Amyloid beta peptides and glutamatergic synaptic dysregulation

(2007) Kodeeswaran Parameshwaran et al.   EXPERIMENTAL NEUROLOGY

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL

Amyloid β-peptide activates nuclear factor-κB through an N-methyl-D-aspartate signaling pathway in cultured cerebellar cells

(2007) E. M. Kawamoto et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Aβ1–42 modulation of Akt phosphorylation via α7 nAChR and NMDA receptors

(2007) Jonathan J. Abbott et al.   NEUROBIOLOGY OF AGING

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

(2007) Fernanda G. De Felice et al.   NEUROBIOLOGY OF AGING

Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice

(2007) I. Dewachter et al.   NEUROBIOLOGY OF AGING

Calcium dysregulation in Alzheimer's disease

(2007) Lukasz Bojarski et al.   NEUROCHEMISTRY INTERNATIONAL

Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function

(2003) Steven W. Barger et al.   JOURNAL OF NEUROCHEMISTRY