Proteasome-mediated proteostasis: Novel medicinal and pharmacological strategies for diseases
出版年份 2018 全文链接
标题
Proteasome-mediated proteostasis: Novel medicinal and pharmacological strategies for diseases
作者
关键词
-
出版物
MEDICINAL RESEARCH REVIEWS
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2018-05-03
DOI
10.1002/med.21502
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Maintaining a Healthy Proteome during Oxidative Stress
- (2018) Dana Reichmann et al. MOLECULAR CELL
- Cilostazol, a phosphodiesterase 3 inhibitor, activates proteasome-mediated proteolysis and attenuates tauopathy and cognitive decline
- (2018) Ari W. Schaler et al. Translational Research
- Tyropeptins, proteasome inhibitors produced by Kitasatospora sp. MK993-dF2
- (2017) Isao Momose et al. JOURNAL OF ANTIBIOTICS
- Structure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism
- (2017) Ryan T. VanderLinden et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Proteasomal Dysfunction Induced By Diclofenac Engenders Apoptosis Through Mitochondrial Pathway
- (2017) Ayeman Amanullah et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Indomethacin elicits proteasomal dysfunctions develops apoptosis through mitochondrial abnormalities
- (2017) Ayeman Amanullah et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Effect of oleuropein against chemotherapy drug-induced histological changes, oxidative stress, and DNA damages in rat kidney injury
- (2017) Fatime Geyikoglu et al. JOURNAL OF FOOD AND DRUG ANALYSIS
- Probing the cooperativity ofThermoplasma acidophilumproteasome core particle gating by NMR spectroscopy
- (2017) Rui Huang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In situ structural studies of tripeptidyl peptidase II (TPPII) reveal spatial association with proteasomes
- (2017) Yoshiyuki Fukuda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural insights into the functional cycle of the ATPase module of the 26S proteasome
- (2017) Marc Wehmer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration
- (2017) Ayeman Amanullah et al. PROGRESS IN NEUROBIOLOGY
- Mitochondrial Dynamics: Coupling Mitochondrial Fitness with Healthy Aging
- (2017) David Sebastián et al. TRENDS IN MOLECULAR MEDICINE
- E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration
- (2017) Arun Upadhyay et al. Frontiers in Molecular Neuroscience
- Bufalin derivative BF211 inhibits proteasome activity in human lung cancer cells in vitro by inhibiting β1 subunit expression and disrupting proteasome assembly
- (2016) Peng Sun et al. ACTA PHARMACOLOGICA SINICA
- Chaperone mediated autophagy in aging: Starve to prosper
- (2016) Maria Xilouri et al. AGEING RESEARCH REVIEWS
- Coordinate regulation of autophagy and the ubiquitin proteasome system by MTOR
- (2016) Jinghui Zhao et al. Autophagy
- UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome
- (2016) Roland Hjerpe et al. CELL
- Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD
- (2016) Ryan D. Baldridge et al. CELL
- Phase I Clinical Trial of Marizomib (NPI-0052) in Patients with Advanced Malignancies Including Multiple Myeloma: Study NPI-0052-102 Final Results
- (2016) S. J. Harrison et al. CLINICAL CANCER RESEARCH
- Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients
- (2016) Tina Gruosso et al. EMBO Molecular Medicine
- The cryo-EM structure of thePlasmodium falciparum20S proteasome and its use in the fight against malaria
- (2016) Hao Li et al. FEBS Journal
- The effect of sulforaphane on the cell cycle, apoptosis and expression of cyclin D1 and p21 in the A549 non-small cell lung cancer cell line
- (2016) AGNIESZKA ŻURYŃ et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- A Central Role for Phosphorylated p38α in Linking Proteasome Inhibition-Induced Apoptosis and Autophagy
- (2016) Fang Guo et al. MOLECULAR NEUROBIOLOGY
- Gene therapy by proteasome activator, PA28γ, improves motor coordination and proteasome function in Huntington’s disease YAC128 mice
- (2016) J. Jeon et al. NEUROSCIENCE
- Unfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study
- (2016) Rui Huang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis for dynamic regulation of the human 26S proteasome
- (2016) Shuobing Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- E3 ubiquitin ligase SP1 regulates peroxisome biogenesis inArabidopsis
- (2016) Ronghui Pan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome
- (2016) Xiang Chen et al. STRUCTURE
- The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3
- (2016) Hui Song et al. Nature Communications
- Induction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo
- (2016) Christa A. Manton et al. Scientific Reports
- Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition
- (2016) Corey M Dambacher et al. eLife
- A Decade of Boon or Burden: What Has the CHIP Ever Done for Cellular Protein Quality Control Mechanism Implicated in Neurodegeneration and Aging?
- (2016) Vibhuti Joshi et al. Frontiers in Molecular Neuroscience
- Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing
- (2015) Arun Upadhyay et al. AGEING RESEARCH REVIEWS
- CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of β-secretase
- (2015) Amir Kumar Singh et al. AGING CELL
- UBE2L3 Polymorphism Amplifies NF-κB Activation and Promotes Plasma Cell Development, Linking Linear Ubiquitination to Multiple Autoimmune Diseases
- (2015) Myles J. Lewis et al. AMERICAN JOURNAL OF HUMAN GENETICS
- A Leucine-Rich Diet Modulates the Tumor-Induced Down-Regulation of the MAPK/ERK and PI3K/Akt/mTOR Signaling Pathways and Maintains the Expression of the Ubiquitin-Proteasome Pathway in the Placental Tissue of NMRI Mice1
- (2015) Laís Rosa Viana et al. BIOLOGY OF REPRODUCTION
- Strongylophorines, meroditerpenoids from the marine sponge Petrosia corticata, function as proteasome inhibitors
- (2015) Ai Noda et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Desmoglein 2–Dependent Arrhythmogenic Cardiomyopathy Is Caused by a Loss of Adhesive FunctionCLINICAL PERSPECTIVE
- (2015) Sebastian Kant et al. Circulation-Cardiovascular Genetics
- Solution Structure of Yeast Rpn9
- (2015) Yunfei Hu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The E3 Ubiquitin Ligase Parkin Is Recruited to the 26 S Proteasome via the Proteasomal Ubiquitin Receptor Rpn13
- (2015) Miguel A. Aguileta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- E3 ubiquitin ligases as drug targets and prognostic biomarkers in melanoma
- (2015) Kristina Bielskienė et al. Medicina-Lithuania
- Ibuprofen Induces Mitochondrial-Mediated Apoptosis Through Proteasomal Dysfunction
- (2015) Arun Upadhyay et al. MOLECULAR NEUROBIOLOGY
- Mahogunin Ring Finger-1 (MGRN1), a Multifaceted Ubiquitin Ligase: Recent Unraveling of Neurobiological Mechanisms
- (2015) Arun Upadhyay et al. MOLECULAR NEUROBIOLOGY
- Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
- (2015) Qing Zhou et al. NATURE GENETICS
- Crystal Structure of the Human 20S Proteasome in Complex with Carfilzomib
- (2015) Wayne Harshbarger et al. STRUCTURE
- The demographics of the ubiquitin system
- (2015) Michael J. Clague et al. TRENDS IN CELL BIOLOGY
- Proteasome inhibitors as experimental therapeutics of autoimmune diseases
- (2015) Sue Verbrugge et al. ARTHRITIS RESEARCH & THERAPY
- Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core
- (2015) Paula C.A. da Fonseca et al. Nature Communications
- Repression of the Central Splicing Regulator RBFox2 Is Functionally Linked to Pressure Overload-Induced Heart Failure
- (2015) Chaoliang Wei et al. Cell Reports
- Desmoglein 2–Dependent Arrhythmogenic Cardiomyopathy Is Caused by a Loss of Adhesive FunctionCLINICAL PERSPECTIVE
- (2015) Sebastian Kant et al. Circulation-Cardiovascular Genetics
- New Insights into the Function of the Immunoproteasome in Immune and Nonimmune Cells
- (2015) Hiroaki Kimura et al. Journal of Immunology Research
- E3 ubiquitin ligases as drug targets and prognostic biomarkers in melanoma
- (2015) Kristina Bielskienė et al. Medicina-Lithuania
- Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1
- (2014) Sue C. Bodine et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Regulation of the Proteasome: Evaluating the Lung Proteasome as a New Therapeutic Target
- (2014) Silke Meiners et al. ANTIOXIDANTS & REDOX SIGNALING
- Targeting the Ubiquitin-Proteasome System in Heart Disease: The Basis for New Therapeutic Strategies
- (2014) Oliver Drews et al. ANTIOXIDANTS & REDOX SIGNALING
- Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome
- (2014) Wen-Xing Ding et al. Autophagy
- Isoform-specific proteasomal degradation of Rbfox3 during chicken embryonic development
- (2014) Kee K. Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Phase 1 study of weekly dosing with the investigational oral proteasome inhibitor ixazomib in relapsed/refractory multiple myeloma
- (2014) S. K. Kumar et al. BLOOD
- Identification of plant-derived natural products as potential inhibitors of the Mycobacterium tuberculosis proteasome
- (2014) Yuejuan Zheng et al. BMC Complementary and Alternative Medicine
- Overview of Proteasome Inhibitor-Based Anti-cancer Therapies: Perspective on Bortezomib and Second Generation Proteasome Inhibitors versus Future Generation Inhibitors of Ubiquitin-Proteasome System
- (2014) Q. Dou et al. CURRENT CANCER DRUG TARGETS
- Galectin-3 Regulates Desmoglein-2 and Intestinal Epithelial Intercellular Adhesion
- (2014) Kun Jiang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Down-regulation of Cyclooxygenase-2 by the Carboxyl Tail of the Angiotensin II Type 1 Receptor
- (2014) Rapita Sood et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ubiquitination of Inositol-requiring Enzyme 1 (IRE1) by the E3 Ligase CHIP Mediates the IRE1/TRAF2/JNK Pathway
- (2014) Xu Zhu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species
- (2014) E. L. Scotter et al. JOURNAL OF CELL SCIENCE
- HDAC6–ubiquitin interaction controls the duration of HSF1 activation after heat shock
- (2014) Lydia Pernet et al. MOLECULAR BIOLOGY OF THE CELL
- Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy
- (2014) Vladimir Rogov et al. MOLECULAR CELL
- Quality Control Autophagy Degrades Soluble ERAD-Resistant Conformers of the Misfolded Membrane Protein GnRHR
- (2014) Scott A. Houck et al. MOLECULAR CELL
- Autophagy Coupling Interplay: Can Improve Cellular Repair and Aging?
- (2014) Deepak Chhangani et al. MOLECULAR NEUROBIOLOGY
- Cargo recognition and trafficking in selective autophagy
- (2014) Alexandra Stolz et al. NATURE CELL BIOLOGY
- Mutations in the deubiquitinase gene USP8 cause Cushing's disease
- (2014) Martin Reincke et al. NATURE GENETICS
- How the proteasome adapts to stress
- (2014) Kim Baumann NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Regulated protein turnover: snapshots of the proteasome in action
- (2014) Sucharita Bhattacharyya et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- New insights into ubiquitin E3 ligase mechanism
- (2014) Christopher E Berndsen et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Proteasome inhibitors in progressive renal diseases
- (2014) R. Coppo NEPHROLOGY DIALYSIS TRANSPLANTATION
- Interferon-γ Induces Immunoproteasomes and the Presentation of MHC I-Associated Peptides on Human Salivary Gland Cells
- (2014) Martha E. Arellano-Garcia et al. PLoS One
- The role of E3 ligases in the ubiquitin-dependent regulation of spermatogenesis
- (2014) John H. Richburg et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Betulinic acid-induced mitochondria-dependent cell death is counterbalanced by an autophagic salvage response
- (2014) L Potze et al. Cell Death & Disease
- P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP
- (2014) H R Ko et al. Cell Death & Disease
- Ubiquitin-proteasome dependent degradation of GABAAα1 in autism spectrum disorder
- (2014) Amanda Crider et al. Molecular Autism
- A bird’s-eye view of autophagy
- (2013) Petro Starokadomskyy et al. Autophagy
- PINK1 is degraded through the N-end rule pathway
- (2013) Koji Yamano et al. Autophagy
- Proteostasis and neurodegeneration: The roles of proteasomal degradation and autophagy
- (2013) Keiji Tanaka et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Regulation of proteasome activity in health and disease
- (2013) Marion Schmidt et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis
- (2013) Min-Xian Qian et al. CELL
- The machinery of macroautophagy
- (2013) Yuchen Feng et al. CELL RESEARCH
- Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress
- (2013) Eleni N. Tsakiri et al. FASEB JOURNAL
- Peptides that activate the 20S proteasome by gate opening increased oxidized protein removal and reduced protein aggregation
- (2013) Francisco H. Dal Vechio et al. FREE RADICAL BIOLOGY AND MEDICINE
- The LC3 interactome at a glance
- (2013) P. Wild et al. JOURNAL OF CELL SCIENCE
- Transcellular chaperone signaling: an organismal strategy for integrated cell stress responses
- (2013) P. van Oosten-Hawle et al. JOURNAL OF EXPERIMENTAL BIOLOGY
- Prokaryotic Proteasomes: Nanocompartments of Degradation
- (2013) Matthew A. Humbard et al. JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY
- The Ubiquitin-Proteasome System Regulates Mitochondrial Intermembrane Space Proteins
- (2013) P. Bragoszewski et al. MOLECULAR AND CELLULAR BIOLOGY
- Targeted Degradation of KRAS by an Engineered Ubiquitin Ligase Suppresses Pancreatic Cancer Cell Growth In Vitro and In Vivo
- (2013) Y. Ma et al. MOLECULAR CANCER THERAPEUTICS
- ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
- (2013) Ryan C. Russell et al. NATURE CELL BIOLOGY
- Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells
- (2013) H Jiang et al. Cell Death & Disease
- Effects of oleic acid on cell proliferation through an integrin-linked kinase signaling pathway in 786-O renal cell carcinoma cells
- (2013) ZHENHUA LIU et al. Oncology Letters
- Adenosine-to-inosine RNA editing and human disease
- (2013) William Slotkin et al. Genome Medicine
- The complex role of physical exercise and reactive oxygen species on brain
- (2013) Zsolt Radak et al. Journal of Sport and Health Science
- The next generation proteasome inhibitors carfilzomib and oprozomib activate prosurvival autophagy via induction of the unfolded protein response and ATF4
- (2012) Yan Zang et al. Autophagy
- A role for Atg8–PE deconjugation in autophagosome biogenesis
- (2012) Usha Nair et al. Autophagy
- MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors
- (2012) Céline Castanier et al. BMC BIOLOGY
- A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance
- (2012) Dharminder Chauhan et al. CANCER CELL
- Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?
- (2012) Ralph J. DeBerardinis et al. CELL
- DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88
- (2012) Valeria Tarallo et al. CELL
- NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1
- (2012) A Craxton et al. CELL DEATH AND DIFFERENTIATION
- Proteasome Inhibitors: An Expanding Army Attacking a Unique Target
- (2012) Alexei F. Kisselev et al. CHEMISTRY & BIOLOGY
- Cardiac Amyloidosis
- (2012) C. Cristina Quarta et al. CIRCULATION
- Carfilzomib and ONX 0912 Inhibit Cell Survival and Tumor Growth of Head and Neck Cancer and Their Activities Are Enhanced by Suppression of Mcl-1 or Autophagy
- (2012) Y. Zang et al. CLINICAL CANCER RESEARCH
- c-Myc and Cancer Metabolism
- (2012) D. M. Miller et al. CLINICAL CANCER RESEARCH
- Ageing as a Risk Factor for Disease
- (2012) Teresa Niccoli et al. CURRENT BIOLOGY
- Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation
- (2012) Casey Cook et al. HUMAN MOLECULAR GENETICS
- HECT and RING finger families of E3 ubiquitin ligases at a glance
- (2012) M. B. Metzger et al. JOURNAL OF CELL SCIENCE
- TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1
- (2012) Meng Zhang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The COP9 Signalosome Interacts with and Regulates Interferon Regulatory Factor 5 Protein Stability
- (2012) Justyna Korczeniewska et al. MOLECULAR AND CELLULAR BIOLOGY
- IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin
- (2012) Wei-Chieh Chiang et al. MOLECULAR BIOLOGY OF THE CELL
- Transcription factors: from enhancer binding to developmental control
- (2012) François Spitz et al. NATURE REVIEWS GENETICS
- Sirtuins as regulators of metabolism and healthspan
- (2012) Riekelt H. Houtkooper et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- SOCS2-Induced Proteasome-Dependent TRAF6 Degradation: A Common Anti-Inflammatory Pathway for Control of Innate Immune Responses
- (2012) Cortez McBerry et al. PLoS One
- Withaferin A Inhibits the Proteasome Activity in Mesothelioma In Vitro and In Vivo
- (2012) Huanjie Yang et al. PLoS One
- TRIM27 Negatively Regulates NOD2 by Ubiquitination and Proteasomal Degradation
- (2012) Birte Zurek et al. PLoS One
- Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach
- (2012) K. Lasker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chloroplast Biogenesis Is Regulated by Direct Action of the Ubiquitin-Proteasome System
- (2012) Q. Ling et al. SCIENCE
- Coordination of cell growth and division by the ubiquitin–proteasome system
- (2012) Jennifer A. Benanti SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Therapeutic targeting of cancer cell cycle using proteasome inhibitors
- (2012) Namrata Rastogi et al. Cell Division
- Prostaglandins and Inflammation
- (2011) Emanuela Ricciotti et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Selective autophagy mediated by autophagic adapter proteins
- (2011) Terje Johansen et al. Autophagy
- The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway
- (2011) Marija Cemma et al. Autophagy
- Autophagy: Renovation of Cells and Tissues
- (2011) Noboru Mizushima et al. CELL
- Interactome Networks and Human Disease
- (2011) Marc Vidal et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Chemical analysis of Greek pollen - Antioxidant, antimicrobial and proteasome activation properties
- (2011) Konstantia Graikou et al. Chemistry Central Journal
- Bortezomib as the First Proteasome Inhibitor Anticancer Drug: Current Status and Future Perspectives
- (2011) D. Chen et al. CURRENT CANCER DRUG TARGETS
- Microautophagy of Cytosolic Proteins by Late Endosomes
- (2011) Ranjit Sahu et al. DEVELOPMENTAL CELL
- Pin1 and WWP2 regulateGluR2Q/R site RNA editing by ADAR2 with opposing effects
- (2011) Roberto Marcucci et al. EMBO JOURNAL
- Cellular stress response pathways and ageing: intricate molecular relationships
- (2011) Nikos Kourtis et al. EMBO JOURNAL
- Ubiquilin-1 Is a Molecular Chaperone for the Amyloid Precursor Protein
- (2011) Emily S. Stieren et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Role of Small Ubiquitin-like Modifier-interacting Motif in the Assembly and Regulation of Metal-responsive Transcription Factor 1
- (2011) Ya-Chuan Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Promotion of Heat Shock Factor Hsf1 Degradation via Adaptor Protein Filamin A-interacting Protein 1-Like (FILIP-1L)
- (2011) Yanzhong Hu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sirtuin 1 (SIRT1) Protein Degradation in Response to Persistent c-Jun N-terminal Kinase 1 (JNK1) Activation Contributes to Hepatic Steatosis in Obesity
- (2011) Zhanguo Gao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKCζ
- (2011) Mingjin Yang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Rapid degradation of cyclooxygenase-1 and hematopoietic prostaglandin D synthase through ubiquitin–proteasome system in response to intracellular calcium level
- (2011) Misato Yazaki et al. MOLECULAR BIOLOGY OF THE CELL
- Proteasome Activators
- (2011) Beth M. Stadtmueller et al. MOLECULAR CELL
- Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?
- (2011) Markel Olabarria et al. Molecular Neurodegeneration
- ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation
- (2011) Shuji Wakatsuki et al. NATURE CELL BIOLOGY
- Age-Related Retinopathy in NRF2-Deficient Mice
- (2011) Zhenyang Zhao et al. PLoS One
- The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
- (2011) P. Walter et al. SCIENCE
- Chemical and Biological Approaches for Adapting Proteostasis to Ameliorate Protein Misfolding and Aggregation Diseases-Progress and Prognosis
- (2011) S. L. Lindquist et al. Cold Spring Harbor Perspectives in Biology
- Quality Control of Mitochondrial Proteostasis
- (2011) M. J. Baker et al. Cold Spring Harbor Perspectives in Biology
- Proteasome inhibitors in cancer therapy
- (2011) Lisa J. Crawford et al. Journal of Cell Communication and Signaling
- Regulation of Autophagy by Kinases
- (2011) Savitha Sridharan et al. Cancers
- Therapeutic Potential of Proteasome Inhibition in Duchenne and Becker Muscular Dystrophies
- (2010) Elisabetta Gazzerro et al. AMERICAN JOURNAL OF PATHOLOGY
- Ubiquitin–Proteasome System and mitochondria — Reciprocity
- (2010) Nurit Livnat-Levanon et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Chaperone-assisted degradation: multiple paths to destruction
- (2010) Nadja Kettern et al. BIOLOGICAL CHEMISTRY
- Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor
- (2010) Sachiko Tsukamoto et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Methylene Blue Reduces Aβ Levels and Rescues Early Cognitive Deficit by Increasing Proteasome Activity
- (2010) David X. Medina et al. BRAIN PATHOLOGY
- Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI-0052 (marizomib) in a human plasmacytoma xenograft murine model
- (2010) Ajita V. Singh et al. BRITISH JOURNAL OF HAEMATOLOGY
- The Fbw7 Tumor Suppressor Targets KLF5 for Ubiquitin-Mediated Degradation and Suppresses Breast Cell Proliferation
- (2010) Dong Zhao et al. CANCER RESEARCH
- Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells
- (2010) L. Mi et al. CARCINOGENESIS
- Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress
- (2010) Ulrike Seifert et al. CELL
- Sent to Destroy
- (2010) Monte S. Willis et al. CIRCULATION RESEARCH
- Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance
- (2010) Verena Arndt et al. CURRENT BIOLOGY
- Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy
- (2010) C. Rothenberg et al. HUMAN MOLECULAR GENETICS
- Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
- (2010) Atsushi Tanaka et al. JOURNAL OF CELL BIOLOGY
- RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network
- (2010) Liyi Geng et al. JOURNAL OF CELL BIOLOGY
- Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells
- (2010) Sonya G. Fonseca et al. JOURNAL OF CLINICAL INVESTIGATION
- Proteasomal Degradation of Glutamine Synthetase Regulates Schwann Cell Differentiation
- (2010) F. Saitoh et al. JOURNAL OF NEUROSCIENCE
- Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid- Generation
- (2010) M. Kaneko et al. JOURNAL OF NEUROSCIENCE
- Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess
- (2010) Kathryn E. Wellen et al. MOLECULAR CELL
- Pseudomonas syringaeVirulence Factor Syringolin A Counteracts Stomatal Immunity by Proteasome Inhibition
- (2010) Barbara Schellenberg et al. MOLECULAR PLANT-MICROBE INTERACTIONS
- Enhancement of proteasome activity by a small-molecule inhibitor of USP14
- (2010) Byung-Hoon Lee et al. NATURE
- Eaten alive: a history of macroautophagy
- (2010) Zhifen Yang et al. NATURE CELL BIOLOGY
- The Proteome in Balance
- (2010) D. Hutt et al. SCIENCE
- Autophagy and Metabolism
- (2010) J. D. Rabinowitz et al. SCIENCE
- Assembly, structure, and function of the 26S proteasome
- (2010) Lynn Bedford et al. TRENDS IN CELL BIOLOGY
- Integration of Clearance Mechanisms: The Proteasome and Autophagy
- (2010) E. Wong et al. Cold Spring Harbor Perspectives in Biology
- Regulation of Posttranscriptional Modification as a Possible Therapeutic Approach for Retinal Neuroprotection
- (2010) Yoko Ozawa et al. Journal of Ophthalmology
- Are isothiocyanates potential anti-cancer drugs?
- (2009) Xiang Wu et al. ACTA PHARMACOLOGICA SINICA
- IFN-γ Triggered STAT1-PKB/AKT Signalling Pathway Influences the Function of Alloantigen Reactive Regulatory T Cells
- (2009) B. Wei et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Biological and Chemical Approaches to Diseases of Proteostasis Deficiency
- (2009) Evan T. Powers et al. Annual Review of Biochemistry
- Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: Cross-talk between E3s in the endoplasmic reticulum
- (2009) Ayelet Shmueli et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Heteronemin, a spongean sesterterpene, inhibits TNFα-induced NF-κB activation through proteasome inhibition and induces apoptotic cell death
- (2009) Marc Schumacher et al. BIOCHEMICAL PHARMACOLOGY
- Ubiquitin-mediated control of oncogene and tumor suppressor gene products
- (2009) Kyoko Kitagawa et al. CANCER SCIENCE
- Stressing the ubiquitin-proteasome system
- (2009) N. P. Dantuma et al. CARDIOVASCULAR RESEARCH
- Multiple Proteasome-Interacting Proteins Assist the Assembly of the Yeast 19S Regulatory Particle
- (2009) Yasushi Saeki et al. CELL
- Therapeutic strategies within the ubiquitin proteasome system
- (2009) A G Eldridge et al. CELL DEATH AND DIFFERENTIATION
- NOD2-associated diseases: Bridging innate immunity and autoinflammation
- (2009) Arturo Borzutzky et al. CLINICAL IMMUNOLOGY
- Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3
- (2009) Martin Gamerdinger et al. EMBO JOURNAL
- Bortezomib induces autophagic death in proliferating human endothelial cells
- (2009) Daniela Belloni et al. EXPERIMENTAL CELL RESEARCH
- Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems
- (2009) Viktor I. Korolchuk et al. FEBS LETTERS
- The Endoplasmic Reticulum-associated Degradation of Transthyretin Variants Is Negatively Regulated by BiP in Mammalian Cells
- (2009) Seiko Susuki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The 20S Proteasome as an Assembly Platform for the 19S Regulatory Complex
- (2009) Klavs B. Hendil et al. JOURNAL OF MOLECULAR BIOLOGY
- Endoplasmic Reticulum Stress–Induced Cell Death in Dopaminergic Cells: Effect of Resveratrol
- (2009) Shankar J. Chinta et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Association of C-Terminal Ubiquitin Hydrolase BRCA1-Associated Protein 1 with Cell Cycle Regulator Host Cell Factor 1
- (2009) S. Misaghi et al. MOLECULAR AND CELLULAR BIOLOGY
- Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell death
- (2009) C. Li et al. MOLECULAR CANCER THERAPEUTICS
- A Role for Ubiquitin in Selective Autophagy
- (2009) Vladimir Kirkin et al. MOLECULAR CELL
- A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates
- (2009) Vladimir Kirkin et al. MOLECULAR CELL
- NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation
- (2009) X. He et al. MOLECULAR PHARMACOLOGY
- Ubiquitylation in innate and adaptive immunity
- (2009) Vijay G. Bhoj et al. NATURE
- An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
- (2009) Teresa A. Soucy et al. NATURE
- A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKγ to dampen the host NF-κB-mediated inflammatory response
- (2009) Hiroshi Ashida et al. NATURE CELL BIOLOGY
- A census of human transcription factors: function, expression and evolution
- (2009) Juan M. Vaquerizas et al. NATURE REVIEWS GENETICS
- Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system
- (2009) Xiaoju Wang et al. NEUROSCIENCE LETTERS
- RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2α
- (2009) Martijn van Hagen et al. NUCLEIC ACIDS RESEARCH
- Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells
- (2009) K Zhu et al. ONCOGENE
- Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
- (2009) A. Ben-Zvi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity
- (2009) Han Seok Ko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The transcriptional coactivator PGC-1α mediates exercise-induced angiogenesis in skeletal muscle
- (2009) Jessica Chinsomboon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ubiquitin, proteasomes and proteolytic mechanisms activated by kidney disease
- (2008) Vik Rajan et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Autophagy: A lysosomal degradation pathway with a central role in health and disease
- (2008) Eeva-Liisa Eskelinen et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Anti-inflammatory Activity of Pectolinarigenin and Pectolinarin Isolated from Cirsium chanroenicum
- (2008) Hyun Lim et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Autophagy and multivesicular bodies: two closely related partners
- (2008) C M Fader et al. CELL DEATH AND DIFFERENTIATION
- Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis
- (2008) John Hines et al. CHEMISTRY & BIOLOGY
- Erythropoietin and Oxidative Stress
- (2008) Kenneth Maiese et al. CURRENT NEUROVASCULAR RESEARCH
- Angiotensin II Type 1 Receptor Signaling Contributes to Synaptophysin Degradation and Neuronal Dysfunction in the Diabetic Retina
- (2008) T. Kurihara et al. DIABETES
- Natural products in drug discovery
- (2008) A HARVEY DRUG DISCOVERY TODAY
- Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue
- (2008) Jingzong Qi et al. EMBO JOURNAL
- Dissecting β-ring assembly pathway of the mammalian 20S proteasome
- (2008) Yuko Hirano et al. EMBO JOURNAL
- Overexpression of the PSMB5 gene contributes to bortezomib resistance in T-lymphoblastic lymphoma/leukemia cells derived from Jurkat line
- (2008) Shuqing Lü et al. EXPERIMENTAL HEMATOLOGY
- SCFCdc4 acts antagonistically to the PGC-1 transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis
- (2008) B. L. Olson et al. GENES & DEVELOPMENT
- Mitochondrial Protein Quality Control by the Proteasome Involves Ubiquitination and the Protease Omi
- (2008) Susanne Radke et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells
- (2008) Hewang Li et al. JOURNAL OF CLINICAL INVESTIGATION
- Proteomics applied on plant abiotic stresses: Role of heat shock proteins (HSP)
- (2008) Anna Maria Timperio et al. Journal of Proteomics
- Treating Metastatic Solid Tumors With Bortezomib and a Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor Agonist Antibody
- (2008) A. Shanker et al. JNCI-Journal of the National Cancer Institute
- The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane
- (2008) U. Bandyopadhyay et al. MOLECULAR AND CELLULAR BIOLOGY
- Ubiquitin–Proteasome-dependent Degradation of a Mitofusin, a Critical Regulator of Mitochondrial Fusion
- (2008) Mickael M.J. Cohen et al. MOLECULAR BIOLOGY OF THE CELL
- A missense variant in desmoglein-2 predisposes to dilated cardiomyopathy
- (2008) Maximilian G. Posch et al. MOLECULAR GENETICS AND METABOLISM
- Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
- (2008) Robert R Graham et al. NATURE GENETICS
- Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes
- (2008) Hideki Yashiroda et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A multimeric assembly factor controls the formation of alternative 20S proteasomes
- (2008) Andrew R Kusmierczyk et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Ubiquitin binding mediates the NF-κB inhibitory potential of ABIN proteins
- (2008) S Wagner et al. ONCOGENE
- Akt and CHIP coregulate tau degradation through coordinated interactions
- (2008) C. A. Dickey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FBXW7 Targets mTOR for Degradation and Cooperates with PTEN in Tumor Suppression
- (2008) Jian-Hua Mao et al. SCIENCE
- Adapting Proteostasis for Disease Intervention
- (2008) William E. Balch et al. SCIENCE
- Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response inCaenorhabditis elegans
- (2007) Nate W. Kahn et al. BIOCHEMICAL JOURNAL
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now