Mahogunin Ring Finger-1 (MGRN1), a Multifaceted Ubiquitin Ligase: Recent Unraveling of Neurobiological Mechanisms

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Mahogunin ring finger 1 suppresses misfolded polyglutamine aggregation and cytotoxicity

(2014) Deepak Chhangani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Differential Scales of Protein Quality Control

(2014) Suzanne Wolff et al.   CELL

Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157

(2014) A Matz et al.   CELL DEATH AND DIFFERENTIATION

The Protein Import Machinery of Mitochondria—A Regulatory Hub in Metabolism, Stress, and Disease

(2014) Angelika B. Harbauer et al.   Cell Metabolism

Sorting out the trash: the spatial nature of eukaryotic protein quality control

(2014) Emily M Sontag et al.   CURRENT OPINION IN CELL BIOLOGY

Barcoding heat shock proteins to human diseases: looking beyond the heat shock response

(2014) V. Kakkar et al.   Disease Models & Mechanisms

Misfolded Polyglutamine, Polyalanine, and Superoxide Dismutase 1 Aggregate via Distinct Pathways in the Cell

(2014) Saskia Polling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

(2014) E. L. Scotter et al.   JOURNAL OF CELL SCIENCE

Autophagy Coupling Interplay: Can Improve Cellular Repair and Aging?

(2014) Deepak Chhangani et al.   MOLECULAR NEUROBIOLOGY

A draft map of the human proteome

(2014) Min-Sik Kim et al.   NATURE

Sweetening protein quality control

(2014) Andrea Du Toit   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mahogunin-mediated α-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation

(2014) D Srivastava et al.   Cell Death & Disease

Interaction between misfolded PrP and the ubiquitin-proteasome system in prion-mediated neurodegeneration

(2013) Z. Lin et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

Cellular Mechanotransduction Relies on Tension-Induced and Chaperone-Assisted Autophagy

(2013) Anna Ulbricht et al.   CURRENT BIOLOGY

Functional conservation between mammalian MGRN1 and plant LOG2 ubiquitin ligases

(2013) Damian D. Guerra et al.   FEBS LETTERS

Transcellular chaperone signaling: an organismal strategy for integrated cell stress responses

(2013) P. van Oosten-Hawle et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Cellular Prion Protein (PrPC) of the Neuron Cell Transformed to a PK-Resistant Protein Under Oxidative Stress, Comprising Main Mitochondrial Damage in Prion Diseases

(2013) Fangzhong Yuan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The Arabidopsis RING E3 Ubiquitin Ligase AtAIRP3/LOG2 Participates in Positive Regulation of High-Salt and Drought Stress Responses

(2013) J. H. Kim et al.   PLANT PHYSIOLOGY

Levels of the Mahogunin Ring Finger 1 E3 Ubiquitin Ligase Do Not Influence Prion Disease

(2013) Derek Silvius et al.   PLoS One

Prions disturb post-Golgi trafficking of membrane proteins

(2013) Keiji Uchiyama et al.   Nature Communications

Mahogunin ring finger-1 (MGRN1) Suppresses Chaperone-Associated Misfolded Protein Aggregation and Toxicity

(2013) Deepak Chhangani et al.   Scientific Reports

The effect of mahogunin gene mutant on reproduction in male mice: a new sight for infertility?

(2012) D. Cheng et al.   ANDROLOGIA

Molecular mechanisms of selective autophagy

(2012) G M Fimia et al.   CELL DEATH AND DIFFERENTIATION

Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation

(2012) Juliane Winkler et al.   JOURNAL OF CELL BIOLOGY

Misfolded Proteins Recognition Strategies of E3 Ubiquitin Ligases and Neurodegenerative Diseases

(2012) Deepak Chhangani et al.   MOLECULAR NEUROBIOLOGY

MGRN1-dependent pigment-type switching requires its ubiquitination activity but not its interaction with TSG101 or NEDD4

(2012) Teresa M. Gunn et al.   Pigment Cell & Melanoma Research

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Mechanisms of Protein Seeding in Neurodegenerative Diseases

(2012) Lary C. Walker et al.   JAMA Neurology

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes

(2011) Nicholas T. Ingolia et al.   CELL

The E3 Ubiquitin LigaseMahoguninUbiquitinates the Melanocortin 2 Receptor

(2011) Sadani N. Cooray et al.   ENDOCRINOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Cellular Strategies of Protein Quality Control

(2011) B. Chen et al.   Cold Spring Harbor Perspectives in Biology

Chaperone-assisted degradation: multiple paths to destruction

(2010) Nadja Kettern et al.   BIOLOGICAL CHEMISTRY

Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections

(2010) R. Nau et al.   CLINICAL MICROBIOLOGY REVIEWS

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

Induction of Molecular Chaperones as a Therapeutic Strategy for the Polyglutamine Diseases

(2010) Yoshitaka Nagai et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Chemical Inducers of Targeted Protein Degradation

(2010) Kanak Raina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

(2010) Thomas Kirkegaard et al.   NATURE

Abnormal regulation of TSG101 in mice with spongiform neurodegeneration

(2009) Jian Jiao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Functional Depletion of Mahogunin by Cytosolically Exposed Prion Protein Contributes to Neurodegeneration

(2009) Oishee Chakrabarti et al.   CELL

Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation

(2009) Zheng Ying et al.   HUMAN MOLECULAR GENETICS

Mahogunin Ring Finger-1 (MGRN1) E3 Ubiquitin Ligase Inhibits Signaling from Melanocortin Receptor by Competition with Gαs

(2009) Ana B. Pérez-Oliva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piecing together the pigment-type switching puzzle

(2009) Will P. Walker et al.   Pigment Cell & Melanoma Research

Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway

(2009) Tokimasa Hida et al.   Pigment Cell & Melanoma Research

Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor

(2008) Tomoyuki Yamanaka et al.   EMBO JOURNAL

Lysosomes in iron metabolism, ageing and apoptosis

(2008) Tino Kurz et al.   HISTOCHEMISTRY AND CELL BIOLOGY

E6-AP Promotes Misfolded Polyglutamine Proteins for Proteasomal Degradation and Suppresses Polyglutamine Protein Aggregation and Toxicity

(2008) Amit Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE