Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity
出版年份 2018 全文链接
标题
Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity
作者
关键词
Neuroinflammation, Amyloid beta, Alzheimer’s disease, Cdk5, Cytokines, Gene expression
出版物
Journal of Neuroinflammation
Volume 15, Issue 1, Pages -
出版商
Springer Nature
发表日期
2018-01-04
DOI
10.1186/s12974-017-1027-y
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- P2X7 receptor-pannexin 1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells
- (2017) Anna Wilkaniec et al. Purinergic Signalling
- Cyclin I-like (CCNI2) is a cyclin-dependent kinase 5 (CDK5) activator and is involved in cell cycle regulation
- (2017) Chengcheng Liu et al. Scientific Reports
- Tau Phosphorylation by cdk5 and Fyn in Response to Amyloid Peptide Aβ25–35: Involvement of Lipid Rafts
- (2017) Paula Hernandez et al. JOURNAL OF ALZHEIMERS DISEASE
- Reductions in Amyloid-β-Derived Neuroinflammation, with Minocycline, Restore Cognition but do not Significantly Affect Tau Hyperphosphorylation
- (2017) Anna Parachikova et al. JOURNAL OF ALZHEIMERS DISEASE
- Hydrogen Sulfide Protects Amyloid-β Induced Cell Toxicity in Microglia
- (2017) Yan-Ying Liu et al. JOURNAL OF ALZHEIMERS DISEASE
- Microbes and Alzheimer’s Disease
- (2016) Ruth F. Itzhaki et al. JOURNAL OF ALZHEIMERS DISEASE
- The mechanisms regulating cyclin-dependent kinase 5 in hippocampus during systemic inflammatory response: The effect on inflammatory gene expression
- (2016) Grzegorz A. Czapski et al. NEUROCHEMISTRY INTERNATIONAL
- Amyloid beta oligomers induce neuronal elasticity changes in age-dependent manner: a force spectroscopy study on living hippocampal neurons
- (2016) Andreea-Alexandra Ungureanu et al. Scientific Reports
- The dual roles of cytokines in Alzheimer’s disease: update on interleukins, TNF-α, TGF-β and IFN-γ
- (2016) Cong Zheng et al. Translational Neurodegeneration
- The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation
- (2016) Anja Henn ALTEX-Alternatives to Animal Experimentation
- Sequential activation of microglia and astrocyte cytokine expression precedes increased iba-1 or GFAP immunoreactivity following systemic immune challenge
- (2015) Diana M. Norden et al. GLIA
- Cdk5 at crossroads of protein oligomerization in neurodegenerative diseases: facts and hypotheses
- (2015) Anna Wilkaniec et al. JOURNAL OF NEUROCHEMISTRY
- Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD
- (2015) Antonella Tramutola et al. JOURNAL OF NEUROCHEMISTRY
- Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology
- (2015) Marie-Victoire Guillot-Sestier et al. NEURON
- IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior
- (2015) Paramita Chakrabarty et al. NEURON
- Effect of amyloid-β (Aβ) immunization on hyperphosphorylated tau: a potential role for glycogen synthase kinase (GSK)-3β
- (2015) Jay Amin et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins
- (2015) Magdalena Cieślik et al. PLoS One
- α-Asarone Ameliorates Memory Deficit in Lipopolysaccharide-Treated Mice via Suppression of Pro-Inflammatory Cytokines and Microglial Activation
- (2014) Jung-Won Shin et al. Biomolecules & Therapeutics
- A critical analysis of the ‘amyloid cascade hypothesis’
- (2014) Richard A. Armstrong FOLIA NEUROPATHOLOGICA
- Physiological and pathological phosphorylation of tau by Cdk5
- (2014) Taeko Kimura et al. Frontiers in Molecular Neuroscience
- Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice
- (2013) Antonio Currais et al. AGING CELL
- Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activated macrophages
- (2013) Maria Teixeira-Coelho et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Extracellular alpha-synuclein induces calpain-dependent overactivation of cyclin-dependent kinase 5 in vitro
- (2013) Grzegorz A. Czapski et al. FEBS LETTERS
- Review article What causes alzheimer’s disease?
- (2013) Richard A. Armstrong FOLIA NEUROPATHOLOGICA
- Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease
- (2013) Zhiyou Cai et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Xanthoceraside Inhibits Pro-inflammatory Cytokine Expression in Aβ25–35/IFN-γ–Stimulated Microglia Through the TLR2 Receptor, MyD88, Nuclear Factor-κB, and Mitogen-Activated Protein Kinase Signaling Pathways
- (2013) Yue Qi et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Interleukin-6: From basic biology to selective blockade of pro-inflammatory activities
- (2013) Jürgen Scheller et al. SEMINARS IN IMMUNOLOGY
- Transgenic Mouse Models of Tauopathy in Drug Discovery
- (2012) W. Noble et al. CNS & Neurological Disorders-Drug Targets
- Interleukin-6, a Major Cytokine in the Central Nervous System
- (2012) María Erta et al. International Journal of Biological Sciences
- Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways
- (2012) Norbert Zilka et al. Journal of Neuroinflammation
- Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice
- (2012) Dimitrije Krstic et al. Journal of Neuroinflammation
- Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration
- (2012) J. R. Sundaram et al. JOURNAL OF NEUROSCIENCE
- Deciphering the mechanism underlying late-onset Alzheimer disease
- (2012) Dimitrije Krstic et al. Nature Reviews Neurology
- S-nitrosylation of Cdk5
- (2012) Jing Qu et al. Prion
- Microglia Function in Alzheimer’s Disease
- (2012) Egle Solito et al. Frontiers in Pharmacology
- Cyclin-Dependent Kinases in Brain Development and Disease
- (2011) Susan C. Su et al. Annual Review of Cell and Developmental Biology
- Evaluating the role of Toll-like receptors in diseases of the central nervous system
- (2011) Michael Carty et al. BIOCHEMICAL PHARMACOLOGY
- Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-β and prion peptides
- (2011) João P. Lopes et al. CELL CYCLE
- Cyclin E Constrains Cdk5 Activity to Regulate Synaptic Plasticity and Memory Formation
- (2011) Junko Odajima et al. DEVELOPMENTAL CELL
- Alterations of Cyclin dependent kinase 5 expression and phosphorylation in Amyloid precursor protein (APP)-transfected PC12 cells
- (2011) Grzegorz A. Czapski et al. FEBS LETTERS
- AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice
- (2011) T Kiyota et al. GENE THERAPY
- Early Growth Response 1 (Egr-1) Regulates Phosphorylation of Microtubule-associated Protein Tau in Mammalian Brain
- (2011) Yifan Lu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TLR2 Is a Primary Receptor for Alzheimer's Amyloid Peptide To Trigger Neuroinflammatory Activation
- (2011) S. Liu et al. JOURNAL OF IMMUNOLOGY
- The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis
- (2011) Jie Zhao et al. Journal of Neuroinflammation
- The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
- (2011) Eric Karran et al. NATURE REVIEWS DRUG DISCOVERY
- Mechanism mediating oligomeric Aβ clearance by naïve primary microglia
- (2011) Cheng-Ning Yang et al. NEUROBIOLOGY OF DISEASE
- Striatal inhibition of calpains prevents levodopa-induced neurochemical changes and abnormal involuntary movements in the hemiparkinsonian rat model
- (2011) Laure Chagniel et al. NEUROBIOLOGY OF DISEASE
- High-Throughput Analysis of Calcium Signalling Kinetics in Astrocytes Stimulated with Different Neurotransmitters
- (2011) Laura R. James et al. PLoS One
- S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by -amyloid peptide
- (2011) J. Qu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cdk5: Multitasking between physiological and pathological conditions
- (2011) Joao P. Lopes et al. PROGRESS IN NEUROBIOLOGY
- Cdk5: a multifaceted kinase in neurodegenerative diseases
- (2011) Zelda H. Cheung et al. TRENDS IN CELL BIOLOGY
- Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease
- (2011) L Crews et al. Cell Death & Disease
- Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture
- (2011) C J Garwood et al. Cell Death & Disease
- Cdk5, the multifunctional surveyor
- (2010) Vassiliki Lalioti et al. CELL CYCLE
- Glia as a source of cytokines: Implications for neuronal excitability and survival
- (2010) Annamaria Vezzani et al. EPILEPSIA
- The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis
- (2010) Andrew E. Leitch et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Distinct modulation of microglial amyloid beta phagocytosis and migration by neuropeptides
- (2010) Sigal Fleisher-Berkovich et al. Journal of Neuroinflammation
- A novel mechanism of non-Aβ component of Alzheimer's disease amyloid (NAC) neurotoxicity. Interplay between p53 protein and cyclin-dependent kinase 5 (Cdk5)
- (2010) Anna Kaźmierczak et al. NEUROCHEMISTRY INTERNATIONAL
- Delayed Treatment with Systemic (S)-Roscovitine Provides Neuroprotection and Inhibits In Vivo CDK5 Activity Increase in Animal Stroke Models
- (2010) Bénédicte Menn et al. PLoS One
- No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro
- (2010) D. W. Peterson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synthetic amyloid- oligomers impair long-term memory independently of cellular prion protein
- (2010) C. Balducci et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anti-Inflammatory Impact of Minocycline in a Mouse Model of Tauopathy
- (2010) Claire J. Garwood et al. Frontiers in Psychiatry
- Neurodegeneration in an Aβ-induced model of Alzheimer’s disease: the role of Cdk5
- (2009) Joao P. Lopes et al. AGING CELL
- Conditional Deletion of Neuronal Cyclin-Dependent Kinase 5 in Developing Forebrain Results in Microglial Activation and Neurodegeneration
- (2009) Satoru Takahashi et al. AMERICAN JOURNAL OF PATHOLOGY
- Inhibition of CDKS by roscovitine suppressed LPS-induced ·NO production through inhibiting NFκB activation and BH4 biosynthesis in macrophages
- (2009) Jianhai Du et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Inhibition of cyclin-dependent kinases by olomoucine and roscovitine reduces lipopolysaccharide-induced inflammatory responses via down-regulation of nuclear factor κB
- (2009) R-S. Jhou et al. CELL PROLIFERATION
- Tumour Necrosis Factor Modulation for Treatment of Alzheimerʼs Disease
- (2009) Edward Tobinick CNS DRUGS
- Massive gliosis induced by interleukin-6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition
- (2009) Paramita Chakrabarty et al. FASEB JOURNAL
- Cyclin I activates Cdk5 and regulates expression of Bcl-2 and Bcl-XL in postmitotic mouse cells
- (2009) Paul T. Brinkkoetter et al. JOURNAL OF CLINICAL INVESTIGATION
- Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders
- (2009) Nicholas P. Whitney et al. JOURNAL OF NEUROCHEMISTRY
- Direct and Indirect Roles of Cyclin-dependent Kinase 5 as an Upstream Regulator in the c-Jun NH2-Terminal Kinase Cascade: Relevance to Neurotoxic Insults in Alzheimer's Disease
- (2009) Kai-Hui Sun et al. MOLECULAR BIOLOGY OF THE CELL
- Crosstalk between Cdk5 and GSK3β: Implications for Alzheimer's Disease
- (2009) Olivia Engmann Frontiers in Molecular Neuroscience
- Neurodegeneration and Neuroinflammation in cdk5/p25-Inducible Mice
- (2008) David Muyllaert et al. AMERICAN JOURNAL OF PATHOLOGY
- An Unusual Member of the Cdk Family: Cdk5
- (2008) Fatema A. Dhariwala et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Posttranscriptional Regulation of Il10 Gene Expression Allows Natural Killer Cells to Express Immunoregulatory Function
- (2008) Asher Maroof et al. IMMUNITY
- Tumor Necrosis Factor-α Regulates Cyclin-dependent Kinase 5 Activity during Pain Signaling through Transcriptional Activation of p35
- (2008) Elias Utreras et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing
- (2008) Yi Wen et al. NEURON
- Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain
- (2008) H SALLAM et al. PHARMACOLOGICAL RESEARCH
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