DNA sensors are expressed in astrocytes and microgliain vitroand are upregulated during gliosis in neurodegenerative disease

Microglia-induced IL-6 protects against neuronal loss following HSV-1 infection of neural progenitor cells

(2014) Ana J. Chucair-Elliott et al.   GLIA

Activation and Regulation of Cellular Inflammasomes: Gaps in Our Knowledge for Central Nervous System Injury

(2014) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

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The PYRIN domain–only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

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The concentration of cell-free DNA in focal epilepsy

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Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β

(2013) Derek A. Costello et al.   HIPPOCAMPUS

The interferon response to intracellular DNA: Why so many receptors?

(2013) Leonie Unterholzner   IMMUNOBIOLOGY

Analysis of the Hippocampal Proteome in ME7 Prion Disease Reveals a Predominant Astrocytic Signature and Highlights the Brain-restricted Production of Clusterin in Chronic Neurodegeneration

(2013) Ayodeji A. Asuni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglia and a Functional Type I IFN Pathway Are Required To Counter HSV-1-Driven Brain Lateral Ventricle Enlargement and Encephalitis

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Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

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Microglia are required for astroglial toll-like receptor 4 response and for optimal TLR2 and TLR3 response

(2012) Thomas H. Holm et al.   GLIA

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

Astrogliosis involves activation of retinoic acid-inducible gene-like signaling in the innate immune response after spinal cord injury

(2011) Juan Pablo de Rivero Vaccari et al.   GLIA

Activation of interferon signaling pathways in spinal cord astrocytes from an ALS mouse model

(2011) Rengang Wang et al.   GLIA

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Cytosolic DNA sensors regulating type I interferon induction

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Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNα/β and IL-1β responses in the diseased brain and exacerbates chronic neurodegeneration

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The value of serial plasma nuclear and mitochondrial DNA levels in patients with acute ischemic stroke

(2010) Nai-Wen Tsai et al.   CLINICA CHIMICA ACTA

Injury-Induced Type I IFN Signaling Regulates Inflammatory Responses in the Central Nervous System

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Chronic Systemic Infection Exacerbates Ischemic Brain Damage via a CCL5 (Regulated on Activation, Normal T-Cell Expressed and Secreted)-Mediated Proinflammatory Response in Mice

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Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study

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IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

The viral TLR3 agonist poly(I:C) stimulates phagocytosis and intracellular killing of Escherichia coli by microglial cells

(2010) Sandra Ribes et al.   NEUROSCIENCE LETTERS

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

Interleukin-6 levels are increased in temporal lobe epilepsy but not in extra-temporal lobe epilepsy

(2009) Suvi Liimatainen et al.   JOURNAL OF NEUROLOGY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

A Protective Role for ELR+ Chemokines during Acute Viral Encephalomyelitis

(2009) Martin P. Hosking et al.   PLoS Pathogens

Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease

(2008) Colm Cunningham et al.   BIOLOGICAL PSYCHIATRY

Astrocytes recognize intracellular polyinosinic-polycytidylic acid via MDA-5

(2008) Joari De Miranda et al.   FASEB JOURNAL

Characterization of retinoic acid–inducible gene-I expression in primary murine glia following exposure to vesicular stomatitis virus

(2008) Samantha R Furr et al.   JOURNAL OF NEUROVIROLOGY

Blood Cell-Derived RANTES Mediates Cerebral Microvascular Dysfunction, Inflammation, and Tissue Injury After Focal Ischemia–Reperfusion

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