Activation and Regulation of Cellular Inflammasomes: Gaps in Our Knowledge for Central Nervous System Injury

Pannexin-1-Mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod2

(2014) N. Marina-Garcia et al.   JOURNAL OF IMMUNOLOGY

Inflammasome and cytokine blocking strategies in autoinflammatory disorders

(2013) Monika Moll et al.   CLINICAL IMMUNOLOGY

Inflammasomes and host defenses against bacterial infections

(2013) Gregory I Vladimer et al.   CURRENT OPINION IN MICROBIOLOGY

Caspase-11: The driving factor for noncanonical inflammasomes

(2013) Elena Viganò et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human astrocytes express a novel NLRP2 inflammasome

(2013) Julia Minkiewicz et al.   GLIA

Gene Deletion of Gabarap Enhances Nlrp3 Inflammasome-Dependent Inflammatory Responses

(2013) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

Salmonella Infection Induces Recruitment of Caspase-8 to the Inflammasome To Modulate IL-1  Production

(2013) S. M. Man et al.   JOURNAL OF IMMUNOLOGY

Inhibition of phagocytosis and lysosomal acidification suppresses neurotoxic prion peptide-induced NALP3 inflammasome activation in BV2 microglia

(2013) Fushan Shi et al.   JOURNAL OF NEUROIMMUNOLOGY

The NLRP3 Inflammasome in Alzheimer’s Disease

(2013) Meng-Shan Tan et al.   MOLECULAR NEUROBIOLOGY

Promises and pitfalls of a Pannexin1 transgenic mouse line

(2013) Regina Hanstein et al.   Frontiers in Pharmacology

Alarmins, inflammasomes and immunity

(2013) DavidM Ojcius et al.   Biomedical Journal

Pannexin: From discovery to bedside in 11±4 years?

(2012) Gerhard Dahl et al.   BRAIN RESEARCH

NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells

(2012) Seth L. Masters et al.   IMMUNITY

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity

(2012) Joshua N. Finger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Therapeutic Hypothermia on Inflammasome Signaling after Traumatic Brain Injury

(2012) Satoshi Tomura et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Purinergic regulation of inflammasome activation after central nervous system injury

(2012) Louis-Philippe Bernier   JOURNAL OF GENERAL PHYSIOLOGY

Activation of the NLRP3 Inflammasome by Group B Streptococci

(2012) A. Costa et al.   JOURNAL OF IMMUNOLOGY

P2X4 Receptors Influence Inflammasome Activation after Spinal Cord Injury

(2012) J. P. de Rivero Vaccari et al.   JOURNAL OF NEUROSCIENCE

Inflammasome proteins in cerebrospinal fluid of brain-injured patients as biomarkers of functional outcome

(2012) Stephanie Adamczak et al.   JOURNAL OF NEUROSURGERY

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

Rac1 Regulates the NLRP3 Inflammasome Which Mediates IL-1beta Production in Chlamydophila pneumoniae Infected Human Mononuclear Cells

(2012) Julia Eitel et al.   PLoS One

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

(2012) Jonathan L. Levinsohn et al.   PLoS Pathogens

Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats

(2011) Lana J Mawhinney et al.   BMC NEUROSCIENCE

Linking Lipid Metabolism to the Innate Immune Response in Macrophages through Sterol Regulatory Element Binding Protein-1a

(2011) Seung-Soon Im et al.   Cell Metabolism

Elevated AIM2-mediated pyroptosis triggered by hypercytotoxic Francisella mutant strains is attributed to increased intracellular bacteriolysis

(2011) Kaitian Peng et al.   CELLULAR MICROBIOLOGY

Activation of the NLRP3 inflammasome byMycobacterium tuberculosisis uncoupled from susceptibility to active tuberculosis

(2011) Anca Dorhoi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human keratinocytes express AIM2 and respond to dsDNA with IL-1β secretion

(2011) Verena Kopfnagel et al.   EXPERIMENTAL DERMATOLOGY

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Inflammasome activation and IL-1β/IL-18 processing are influenced by distinct pathways in microglia

(2011) Richa Hanamsagar et al.   JOURNAL OF NEUROCHEMISTRY

NLRP1, a regulator of innate immunity associated with vitiligo

(2011) Andrea D’Osualdo et al.   Pigment Cell & Melanoma Research

Targeting Pannexin1 Improves Seizure Outcome

(2011) Marcelo F. Santiago et al.   PLoS One

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

(2011) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pannexins in ischemia-induced neurodegeneration

(2011) P. Bargiotas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions

(2011) Y. Dombrowski et al.   Science Translational Medicine

Extracellular ATP Is a Danger Signal Activating P2X7Receptor in Lung Inflammation and Fibrosis

(2010) Nicolas Riteau et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

(2009) William R. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutively Active Inflammasome in Human Melanoma Cells Mediating Autoinflammation via Caspase-1 Processing and Secretion of Interleukin-1β

(2009) Miyako Okamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

(2009) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cutting Edge: TNF-  Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

(2009) L. Franchi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

XIAP mediates NOD signaling via interaction with RIP2

(2009) A. Krieg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of the Inflammasome Complex Reduces the Inflammatory Response after Thromboembolic Stroke in Mice

(2008) Denise P Abulafia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury

(2008) J. P. de Rivero Vaccari et al.   JOURNAL OF NEUROSCIENCE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1  secretion in response to Bacillus anthracis infection and muramyl dipeptide

(2008) L.-C. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA