Article
Cell Biology
Hui Li, Shufen Zhao, Liwei Shen, Peige Wang, Shihai Liu, Yingji Ma, Zhiwei Liang, Gongjun Wang, Jing Lv, Wensheng Qiu
Summary: The study revealed that high expression of E2F2 in gastric cancer is associated with poor prognosis, and it promotes cancer cell migration and invasion by inhibiting autophagy through the PI3K/Akt/mTOR pathway. E2F2 may also modulate tumor immunity.
Article
Cell Biology
Michael P. Wilczek, Francesca J. Armstrong, Colleen L. Mayberry, Benjamin L. King, Melissa S. Maginnis
Summary: Astrocytes are a main target of JCPyV in the CNS, leading to PML. Research highlights the importance of the PI3K/AKT/mTOR signaling pathway in JCPyV infection of primary human astrocytes.
Article
Biology
Suresh Mickymaray, Faiz Abdulaziz Alfaiz, Anand Paramasivam, Vishnu Priya Veeraraghavan, Nanthini Devi Periadurai, Krishna Mohan Surapaneni, Guangfeng Niu
Summary: The study demonstrated that Rhaponticin exhibited potent anticancer effects against human osteosarcoma cells, especially MG-63 cells, by inducing cytotoxicity, inhibiting cell growth, and inducing apoptosis through various biological mechanisms.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Plant Sciences
Meixu Wan, Kunkun Yin, Jing Yuan, Shiyan Ma, Qing Xu, Dekun Li, Hui Gao, Xiangbo Gou
Summary: The Yiqi Fumai lyophilized injection (YQFM) demonstrated protective effects in cardiac hypertrophy by inhibiting cardiomyocyte apoptosis, regulating autophagy pathway, and activating the PI3K/AKT/mTOR pathway to attenuate cardiac hypertrophy.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Stefano Ratti, Raffaella Mauro, Cristina Rocchi, Sara Mongiorgi, Giulia Ramazzotti, Mauro Gargiulo, Lucia Manzoli, Lucio Cocco, Roberta Fiume
Summary: This review examines the importance of critical enzymes such as PI3K, AKT, and mTOR in the maturation and failure of arteriovenous fistula (AVF) for haemodialysis treatment. These enzymes play a role in various cellular activities and are associated with multiple diseases. They are also druggable targets, which can be targeted to control specific aspects of AVF and provide more personalized therapy.
Article
Immunology
Junjie Yang, Jiayu Liu, Jing Li, Ming Jing, Leiming Zhang, Mengmeng Sun, Qiaoyun Wang, Hongliu Sun, Guige Hou, Chunhua Wang, Wenyu Xin
Summary: The study found that celastrol improves rheumatoid arthritis by up-regulating autophagy through inhibiting the PI3K/AKT/mTOR pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Oncology
Wojciech Wiese, Julia Barczuk, Olga Racinska, Natalia Siwecka, Wioletta Rozpedek-Kaminska, Artur Slupianek, Radoslaw Sierpinski, Ireneusz Majsterek
Summary: The PI3K/Akt/mTOR pathway is crucial in cancer development and can be a potential therapeutic target for leukemia. Recent research indicates that inhibition of this pathway may lead to improved treatment outcomes for leukemia.
Article
Oncology
Liwei Wang, Jiazhong Shi, Sha Liu, Yaqin Huang, Hua Ding, Baixiong Zhao, Yuting Liu, Wuxing Wang, Jin Yang, Zhiwen Chen
Summary: The study found that RAC3 is highly expressed in bladder cancer and is associated with poor prognosis. Silencing RAC3 can exert anti-tumor effects by enhancing PI3K/AKT/mTOR-mediated autophagy. Simultaneously targeting RAC3 and autophagy may be a potential therapeutic strategy for inhibiting bladder cancer progression and prolonging survival.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Eun Jin Sun, Miriam Wankell, Pranavan Palamuthusingam, Craig McFarlane, Lionel Hebbard
Summary: This review article discusses the pivotal role of the PI3K/Akt/mTOR pathway in HCC, focusing on its impact on cellular processes and providing an update on the ongoing clinical development of therapies targeting this pathway for HCC treatments.
Review
Biochemistry & Molecular Biology
Antonino Glaviano, Aaron S. C. Foo, Hiu Y. Lam, Kenneth C. H. Yap, William Jacot, Robert H. Jones, Huiyan Eng, Madhumathy G. Nair, Pooyan Makvandi, Birgit Geoerger, Matthew H. Kulke, Richard D. Baird, Jyothi S. Prabhu, Daniela Carbone, Camilla Pecoraro, Daniel B. L. Teh, Gautam Sethi, Vincenzo Cavalieri, Kevin H. Lin, Nathalie R. Javidi-Sharifi, Eneda Toska, Matthew S. Davids, Jennifer R. Brown, Patrizia Diana, Justin Stebbing, David A. Fruman, Alan P. Kumar
Summary: The PI3K/AKT/mTOR (PAM) signaling pathway plays a crucial role in cell survival, growth, and cell cycle progression. Dysregulation of this pathway is associated with cancer development and resistance to therapy. This review focuses on the major dysregulations in the PAM signaling pathway in cancer and discusses strategies for overcoming treatment resistance. The role of PAM signaling in immunology and immunotherapies is also discussed.
Article
Endocrinology & Metabolism
Rui Lu, Zhiyi He, Weikai Zhang, Yingguang Wang, Peng Cheng, Zhengtao Lv, Xuefeng Yuan, Fengjing Guo, Hongbo You, An-min Chen, Weihua Hu
Summary: This study explored the potential chondroprotective effect of Oroxin B (OB) in osteoarthritis (OA) and elucidated its mechanism. The results showed that OB protected chondrocytes by inhibiting inflammation, suppressing the PI3K/AKT/mTOR signaling pathway, and enhancing autophagy. These findings suggest that OB may be a promising agent for the treatment of OA, providing a new direction for OA therapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Ye Lu, Wenshan Zhong, Yuanyuan Liu, Weimou Chen, Jinming Zhang, Zhaojin Zeng, Haohua Huang, Yujie Qiao, Xuan Wan, Xiaojing Meng, Shaoxi Cai, Hangming Dong
Summary: Research has found that anti-PD-L1 monoclonal antibodies can effectively alleviate lung damage in a pulmonary fibrosis model, inhibit fibroblast proliferation and migration, and alleviate autophagy impairment. This provides a new strategy for the treatment of pulmonary fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Cell Biology
Kunrui Zhu, Yanqi Wu, Ping He, Yu Fan, Xiaorong Zhong, Hong Zheng, Ting Luo
Summary: Phosphatidylinositol 3-kinase (PI3K), protein kinase B (PKB/AKT) and mechanistic target of rapamycin (mTOR) (PAM) pathways play important roles in breast tumorigenesis and offer potential targets for cancer therapy.
Article
Plant Sciences
Ruoqi Li, Yingyi Zheng, Jiaxue Zhang, Yuan Zhou, Xiang Fan
Summary: This study demonstrates the therapeutic potential of Gomisin N (GN) in ischemic stroke, showing its ability to suppress autophagy by activating the PI3K/AKT/mTOR signaling pathway and protect neurons from ischemic damage. GN has potential neuroprotective effects on stroke patients and further research is warranted.
Review
Pharmacology & Pharmacy
Nazanin Momeni Roudsari, Naser-Aldin Lashgari, Saeideh Momtaz, Shaghayegh Abaft, Fatemeh Jamali, Pardis Safaiepour, Kiyana Narimisa, Gloria Jackson, Anusha Bishayee, Nima Rezaei, Amir Hossein Abdolghaffari, Anupam Bishayee
Summary: The importance of the PI3K/Akt/mTOR pathway in prostate cancer treatment and the clinical applications of natural agents and small molecule inhibitors targeting this pathway are discussed in the study. Research suggests that natural mTOR inhibitors can interfere with the PI3K/Akt/mTOR pathway through multiple mechanisms, with inhibition of Akt and suppression of mTOR 1 activity being the main therapeutic approaches. Combination therapy has been shown to improve the efficacy of these inhibitors in suppressing prostate cancer progression or overcoming resistance by cancer cells.
Review
Oncology
Wolfgang A. Schulz, Alexander Lang, Julian Koch, Annemarie Greife
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Biochemistry & Molecular Biology
Patcharawalai Whongsiri, Chaowat Pimratana, Udomsak Wijitsettakul, Anapat Sanpavat, Depicha Jindatip, Michele J. Hoffmann, Wolfgang Goering, Wolfgang A. Schulz, Chanchai Boonla
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Ananda Ayyappan Jaguva Vasudevan, Michele J. Hoffmann, Michael L. C. Beck, Gereon Poschmann, Patrick Petzsch, Constanze Wiek, Kai Stuehler, Karl Koehrer, Wolfgang A. Schulz, Guenter Niegisch
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Oncology
Alexander Lang, Merve Yilmaz, Christiane Hader, Sammy Murday, Xenia Kunz, Nicholas Wagner, Constanze Wiek, Patrick Petzsch, Karl Koehrer, Julian Koch, Michele J. Hoffmann, Annemarie Greife, Wolfgang A. Schulz
Article
Genetics & Heredity
Amit Sharma, Muhammad A. Jamil, Nicole Nuesgen, Albertas Dauksa, Antanas Gulbinas, Wolfgang A. Schulz, Johannes Oldenburg, Osman El-Maarri
MOLECULAR GENETICS & GENOMIC MEDICINE
(2019)
Article
Oncology
Madeleine Sassenberg, Johanna Droop, Wolfgang A. Schulz, Dimo Dietrich, Sophia Marie Loick, Constanze Wiek, Kathrin Scheckenbach, Nadine T. Gaisa, Michele J. Hoffmann
Editorial Material
Biochemistry & Molecular Biology
Wolfgang A. Schulz, Karina D. Sorensen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Oncology
Chenyin Wang, Alexandra Hamacher, Patrick Petzsch, Karl Koehrer, Guenter Niegisch, Michele J. Hoffmann, Wolfgang A. Schulz, Matthias U. Kassack
Article
Oncology
Alexander Lang, Patcharawalai Whongsiri, Merve Yilmaz, Tobias Lautwein, Patrick Petzsch, Annemarie Greife, Cagatay Guenes, Karl Koehrer, Guenter Niegisch, Michele Hoffmann, Wolfgang A. Schulz
Article
Biochemistry & Molecular Biology
Annabelle Friedrich, Ann-Sophie Assmann, Lena Schumacher, Jana V. Stuijvenberg, Matthias U. Kassack, Wolfgang A. Schulz, Wynand P. Roos, Finn K. Hansen, Marc Pflieger, Thomas Kurz, Gerhard Fritz
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Patcharawalai Whongsiri, Wolfgang Goering, Tobias Lautwein, Christiane Hader, Gunter Niegisch, Karl Koehrer, Michele J. Hoffmann, Wolfgang A. Schulz
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Genetics & Heredity
Michele J. Hoffmann, Sarah Meneceur, Katrin Hommel, Wolfgang A. Schulz, Gunter Niegisch
Summary: In urothelial carcinoma, inhibition of HDAC1/2 induces cell cycle arrest at G2/M transition, independent of mutations in cell cycle genes. Inhibition of HDAC1/2 leads to DNA damage, suggesting potential synergistic effects with DNA repair inhibitors.
Article
Oncology
Sophia Thy, Alexandra Hommel, Sarah Meneceur, Anna L. Bartkowiak, Wolfgang A. Schulz, Gunter Niegisch, Michele J. Hoffmann
Summary: Muscle-invasive urothelial carcinoma (UC) is usually treated with cisplatin-based chemotherapy, which may be only temporarily effective due to drug resistance. However, a study found that using the epigenetic drug PLX51107 can overcome resistance and sensitize UC cells to other drugs, showing potential for improving current standard therapy and developing new treatment options for UC patients.
Review
Biochemistry & Molecular Biology
Simeon Santourlidis, Wolfgang A. Schulz, Marcos J. Arauzo-Bravo, Daniela Gerovska, Pauline Ott, Marcelo L. Bendhack, Mohamed Hassan, Lars Erichsen
Summary: Epigenetic mechanisms play a fundamental role in the initiation and development of melanoma, but research in this area is relatively limited compared to other cancers. This review provides a brief summary of the epigenetic aspects relevant to melanoma pathogenesis and introduces new perspectives from epigenetic research in other cancers that may have potential for melanoma diagnosis and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Michele J. Hoffmann, Wolfgang A. Schulz
Summary: Urinary bladder cancer is among the top ten major cancers worldwide, with higher incidences in males, smokers, and highly industrialized countries. Gene mutations play a crucial role in the development of bladder cancer, particularly in a group of proteins regulating chromatin state and gene expression that are discovered to be frequently affected.