Article
Multidisciplinary Sciences
Xiaojie Yu, Christian M. Orr, H. T. Claude Chan, Sonya James, Christine A. Penfold, Jinny Kim, Tatyana Inzhelevskaya, C. Ian Mockridge, Kerry L. Cox, Jonathan W. Essex, Ivo Tews, Martin J. Glennie, Mark S. Cragg
Summary: Low affinity of immunomodulatory antibodies leads to greater activity through increased clustering, resulting in higher immune cell activation, T cell expansion, and antitumor activity. This discovery reveals a new mechanism for enhancing receptor activation across diverse receptor families and sheds light on the mechanism of antibody-mediated receptor signaling. Affinity engineering offers a rational, efficient, and tunable solution for delivering antibody-mediated receptor activity for the treatment of human disease.
Article
Immunology
Jenna M. DeLuca, Maegan K. Murphy, Xin Wang, Timothy J. Wilson
Summary: Regulation of FCRL1 signaling plays a crucial role in modulating B cell development and antibody responses by inhibiting ERK activation. FCRL1 has the potential to regulate peripheral B cell tolerance, homeostasis, and activation through its role in suppressing ERK activation.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Christopher Beneduce, Stephanie Nguyen, Nathaniel Washburn, John Schaeck, Robin Meccariello, Kimberly Holte, Daniel Ortiz, Anthony M. Manning, Carlos J. Bosques, Elma Kurtagic
Summary: Fc glycosylation is crucial for antibody activity, and Fc sialylation is important for anti-inflammatory effects of IgGs. However, in vitro models using monomeric forms of antibodies have limited ability to determine the structure-activity relationship of Fc glycosylation. To overcome this, we utilized Fc-containing molecules displayed in monovalent and multivalent forms, and found that sialic acid mediates the phosphorylation of Fc?RIIb when IgG-Fc is displayed in a multivalent manner. This study provides new insights into the impact of Fc sialylation on immune cell signaling and characterization of anti-inflammatory activity of Fc-containing therapeutics.
Article
Rheumatology
Chen Wang, Yan Gong, Ran You, Zhi-Ying Li, Ming-Hui Zhao, Min Chen
Summary: This study found that the expression of Fc gamma RIIB/CD32B on B cells is down-regulated in AAV patients and is associated with the disease activity of AAV.
Article
Dermatology
Kaori Sawada, Yasuhito Hamaguchi, Kie Mizumaki, Kyosuke Oishi, Shintaro Maeda, Yuka Ikawa, Akito Komuro, Kazuhiko Takehara, Takashi Matsushita
Summary: The study suggests that Fc gamma RIIB plays an inhibitory role in skin and lung fibrosis, with its deficiency leading to increased severity of fibrosis and potential therapeutic implications for SSc.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Review
Oncology
Kirsten M. Baecher, Mandy L. Ford
Summary: Fc receptors (FcRs) and the microbiome both impact cancer development, while checkpoint inhibitors are closely linked to both. Usage of checkpoint inhibitors has surged in the past decade, although host factors can affect their efficacy and safety. Current research is focused on investigating host factors such as the microbiome and FcR expression.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Sokratis A. Apostolidis, Mihir Kakara, Mark M. Painter, Rishi R. Goel, Divij Mathew, Kerry Lenzi, Ayman Rezk, Kristina R. Patterson, Diego A. Espinoza, Jessy C. Kadri, Daniel M. Markowitz, Clyde E. Markowitz, Ina Mexhitaj, Dina Jacobs, Allison Babb, Michael R. Betts, Eline T. Luning Prak, Daniela Weiskopf, Alba Grifoni, Kendall A. Lundgreen, Sigrid Gouma, Alessandro Sette, Paul Bates, Scott E. Hensley, Allison R. Greenplate, E. John Wherry, Rui Li, Amit Bar-Or
Summary: Patients with multiple sclerosis on anti-CD20 monotherapy exhibit significantly reduced SARS-CoV-2-specific antibodies and memory B cells, while CD4(+) and CD8(+) T cells are robustly activated compared to healthy controls after receiving BNT162b2 or mRNA-1273 mRNA vaccination.
Article
Immunology
Yukihiro Kitanaga, Daisuke Yamajuku, Satoshi Kubo, Koji Nakamura, Masashi Maeda, Mutsumi Seki, Yoko Kaneko, Fumitaka Kinugasa, Tatsuaki Morokata, Yuya Kondo, Hiroko Yoshinari, Shingo Nakayamada, Takayuki Sumida, Yoshiya Tanaka
Summary: The novel antibody ASP2713, with enhanced specificity for B cells, induces negative feedback signals to suppress B cell proliferation and antibody production, showing therapeutic potential for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Infectious Diseases
Jinglan Jin, Yuwei Liu, Xiaotong Xu, Zhongfeng Wang, Junqi Niu
Summary: The study revealed that Fc gamma RIIb levels were significantly lower in CHB patients compared to controls. These levels were negatively correlated with AST and ALT, but positively correlated with platelet count, suggesting a close association between Fc gamma RIIb and the progression of CHB.
BMC INFECTIOUS DISEASES
(2021)
Article
Cell Biology
Utsa Karmakar, Julia Y. Chu, Kruthika Sundaram, Anne L. Astier, Hannah Garside, Carsten G. Hansen, Ian Dransfield, Sonja Vermeren
Summary: Persistent neutrophilic inflammation plays a key role in autoimmune diseases characterized by abundant immune complexes. Insoluble immune complexes (iICs) not only activate pro-inflammatory neutrophil functions, but also promote inflammation resolution by inducing neutrophil apoptosis. iICs trigger FcγRIIa-dependent neutrophil macropinocytosis, leading to rapid uptake and degradation of iICs, providing a mechanism for neutrophil clearance of pro-inflammatory iICs.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Mengru Liu, Jingwen Zhou, Rui Yin, Hui Yin, Yue Ding, Feng Ma, Li Qian
Summary: Regulatory B cells play important roles in inflammation and autoimmune diseases. The protein HMGB1 is involved in the expansion and immunosuppressive function of CD19(hi) Fc gamma RIIb(hi) B cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Stephanie Trend, Jonatan Leffler, Ingrid Teige, Bjorn Frendeus, Allan G. Kermode, Martyn A. French, Prue H. Hart
Summary: The study found that B cell subsets from females with clinically isolated syndrome (CIS) or multiple sclerosis (MS) had lower levels of CD32b expression, which were associated with factors such as Epstein Barr Virus, B cell activating factor, etc. The impact of lower CD32b expression on these cells mainly affected the regulation of TNF expression, especially in naive and IgM(hi) MZ-like B cells, suggesting a potential role in the immunopathogenesis of MS in females.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Congqi Hu, Danbin Wu, Jiahui Yu, Jia Xu, Lijuan Liu, Mingying Zhang, Wei Jiao, Guangxing Chen
Summary: This study provides the first evidence that DHA may alleviate collagen-induced arthritis by activating the Fc gamma RIIb/Lyn/SHP-1 signaling pathway in B cells, inhibiting the activation, proliferation, and proinflammatory cytokine production.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhe Zhang, Zhujie Cao, Lin Hou, Meiyue Song, Yitian Zhou, Yiling Chen, Huiyuan Hu, Yangfeng Hou, Ying Liu, Bolun Li, Xiaomin Song, Weipeng Ge, Baicun Li, Xuehan Jiang, Jie Yang, Dingyun Song, Xinri Zhang, Junling Pang, Tiantian Zhang, Hong Zhang, Peiran Yang, Jing Wang, Chen Wang
Summary: Progressive fibrosing interstitial lung diseases (PF-ILDs) have high mortality rates and lack effective treatments. Macrophages play a role in the inflammation and fibrosis associated with PF-ILDs. This study found that Fc gamma RIIB, a receptor that regulates macrophages, is upregulated in the lungs of humans and mice exposed to silica. Deficiency of Fc gamma RIIB worsened lung dysfunction, inflammation, and fibrosis in silica-exposed mice. Increasing the expression of Fc gamma RIIB through genetic overexpression or adenoviral treatment improved lung function and histological changes in mice exposed to silica, suggesting that it could be a potential therapeutic strategy for PF-ILDs.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Cell Biology
Oscar A. Aguilar, Maria D. R. Gonzalez-Hinojosa, Janice S. Arakawa-Hoyt, Alberto J. Millan, Dagmar Gotthardt, Tsukasa Nabekura, Lewis L. Lanier
Summary: In this study, the expression and biological consequences of activating mouse NK cells through their Fc gamma receptors were characterized. It was found that most NK cells express the activating CD16 receptor, and a subset of NK cells also expresses the inhibitory CD32b receptor. These Fc gamma receptors are functional and can modulate antibody-mediated immune responses.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Article
Immunology
Hongzhao Li, Xun Wu, Sen Hou, Mouhannad Malek, Anna Kielkowska, Edward Noh, Kennedy J. Makondo, Qiujiang Du, John A. Wilkins, James B. Johnston, Spencer B. Gibson, Francis Lin, Aaron J. Marshall
JOURNAL OF IMMUNOLOGY
(2016)
Article
Oncology
Sandrine T. Lafarge, Sen Hou, Samantha D. Pauls, James B. Johnston, Spencer B. Gibson, Aaron J. Marshall
Article
Infectious Diseases
Chukwunonso Onyilagha, Ping Jia, Nipun Jayachandran, Sen Hou, Ifeoma Okwor, Shiby Kuriakose, Aaron Marshall, Jude E. Uzonna
PLOS NEGLECTED TROPICAL DISEASES
(2015)
Article
Immunology
Nipun Jayachandran, Ivan Landego, Sen Hou, Dario R. Alessi, Aaron J. Marshall
EUROPEAN JOURNAL OF IMMUNOLOGY
(2017)
Article
Immunology
Samantha D. Pauls, Arnab Ray, Sen Hou, Andrew T. Vaughan, Mark S. Cragg, Aaron J. Marshall
JOURNAL OF IMMUNOLOGY
(2016)
Article
Immunology
Nipun Jayachandran, Edgard M. Mejia, Kimia Sheikholeslami, Affan A. Sher, Sen Hou, Grant M. Hatch, Aaron J. Marshall
JOURNAL OF IMMUNOLOGY
(2018)
Letter
Hematology
Sandrine T. Lafarge, Hongzhao Li, Samantha D. Pauls, Sen Hou, James B. Johnston, Spencer B. Gibson, Aaron J. Marshall
BRITISH JOURNAL OF HAEMATOLOGY
(2015)
Article
Hematology
Ahmed Y. Ali, Qingdong Guan, Xun Wu, Sen Hou, Versha Banerji, James B. Johnston, Donna Wall, David Szwajcer, Spencer B. Gibson, Aaron J. Marshall
BRITISH JOURNAL OF HAEMATOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Samantha D. Pauls, Sen Hou, Aaron J. Marshall
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Review
Immunology
Folayemi Adefemi, David A. Fruman, Aaron J. Marshall
JOURNAL OF IMMUNOLOGY
(2020)
Article
Oncology
Subir Roy Chowdhury, Cheryl Peltier, Sen Hou, Amandeep Singh, James B. Johnston, Spencer B. Gibson, Aaron J. Marshall, Versha Banerji
Summary: This study evaluated the effect of ibrutinib dose on mitochondrial respiration of CLL cells, finding no difference in respiration rates between low and standard doses, supporting the safety and effectiveness of low-dose ibrutinib in clinical practice. Additionally, mitochondrial respiration of CLL cells was observed to parallel the increase in beta-2 M and LDH at progression, further establishing it as a biomarker for response and progression on ibrutinib in CLL cells.
Article
Biochemistry & Molecular Biology
Li Hao, Aaron J. Marshall, Lixin Liu
Summary: Studies have shown that Bam32 plays a suppressive role in chemokine-induced neutrophil chemotaxis by regulating Rap1 activation and relies on the activation of the PI3K effector Akt.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Ganchimeg Ishdorj, Erin Streu, Pascal Lambert, Harbhajan S. Dhaliwal, Salaheddin M. Mahmud, Spencer B. Gibson, Versha Banerji, Aaron J. Marshall, James B. Johnston
Article
Hematology
Tom N. Durrant, James L. Hutchinson, Kate J. Heesom, Karen E. Anderson, Len R. Stephens, Phillip T. Hawkins, Aaron J. Marshall, Samantha F. Moore, Ingeborg Hers
Review
Immunology
Samantha D. Pauls, Aaron J. Marshall
EUROPEAN JOURNAL OF IMMUNOLOGY
(2017)
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)