The α-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G protein–coupled receptor lysosomal sorting and signaling

G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

(2018) Krishna Sriram et al.   MOLECULAR PHARMACOLOGY

Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of β-arrestin

(2017) Thomas H. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells

(2017) Brian Bierie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting PAR1: Now What?

(2017) Robert Flaumenhaft et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Androgen receptor regulated microRNA miR-182-5p promotes prostate cancer progression by targeting the ARRDC3/ITGB4 pathway

(2016) Jingjing Yao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor

(2016) Xufan Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif

(2016) Michael R. Dores et al.   PLoS One

Protease-activated receptors (PARs)—biology and role in cancer invasion and metastasis

(2015) Marek Z. Wojtukiewicz et al.   CANCER AND METASTASIS REVIEWS

In vitro pharmacological characterization of vorapaxar, a novel platelet thrombin receptor antagonist

(2015) Brian E. Hawes et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases

(2015) Anukriti Singh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes

(2015) Neil J. Grimsey et al.   JOURNAL OF CELL BIOLOGY

The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein–coupled receptor lysosomal sorting

(2015) Michael R. Dores et al.   MOLECULAR BIOLOGY OF THE CELL

Dysregulated protease activated receptor 1 (PAR1) promotes metastatic phenotype in breast cancer through HMGA2

(2015) E Yang et al.   ONCOGENE

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

The Ras-related Protein, Rap1A, Mediates Thrombin-stimulated, Integrin-dependent Glioblastoma Cell Proliferation and Tumor Growth

(2014) Jacqueline Sayyah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Arrestins - new players in Notch and GPCR signaling pathways in mammals

(2014) L. Puca et al.   JOURNAL OF CELL SCIENCE

Promoter hypermethylation may be an important mechanism of the transcriptional inactivation of ARRDC3, GATA5, and ELP3 in invasive ductal breast carcinoma

(2014) Da Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Epigenetic silencing of ARRDC3 expression in basal-like breast cancer cells

(2014) Young Hwa Soung et al.   Scientific Reports

Atypical regulation of G protein-coupled receptor intracellular trafficking by ubiquitination

(2013) Michael R Dores et al.   CURRENT OPINION IN CELL BIOLOGY

Structural and Biochemical Basis for Ubiquitin Ligase Recruitment by Arrestin-related Domain-containing Protein-3 (ARRDC3)

(2013) Shiqian Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK-Induced Apoptosis, Compensatory Growth, and Cancer Stem Cells

(2012) F. Chen   CANCER RESEARCH

Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking

(2012) Sang-Oh Han et al.   EMBO REPORTS

ALIX binds a YPX3L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting

(2012) Michael R. Dores et al.   JOURNAL OF CELL BIOLOGY

Cooperation of protease-activated receptor 1 and integrin ανβ5 in thrombin-mediated lung cancer cell invasion

(2012) LINGYUN ZHU et al.   ONCOLOGY REPORTS

Multiple Analyses of G-Protein Coupled Receptor (GPCR) Expression in the Development of Gefitinib-Resistance in Transforming Non-Small-Cell Lung Cancer

(2012) Naoko Kuzumaki et al.   PLoS One

Adaptor Protein Complex-2 (AP-2) and Epsin-1 Mediate Protease-activated Receptor-1 Internalization via Phosphorylation- and Ubiquitination-dependent Sorting Signals

(2011) Buxin Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma

(2011) Todd D Prickett et al.   NATURE GENETICS

G12 Signaling through c-Jun NH2-Terminal Kinase Promotes Breast Cancer Cell Invasion

(2011) Juhi Juneja et al.   PLoS One

Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the β2-adrenergic receptor

(2010) Joseph F Nabhan et al.   EMBO REPORTS

The ESCRT-Associated Protein Alix Recruits the Ubiquitin Ligase Nedd4-1 To Facilitate HIV-1 Release through the LYPXnL L Domain Motif

(2010) P. Sette et al.   JOURNAL OF VIROLOGY

Multiple Interactions between the ESCRT Machinery and Arrestin-Related Proteins: Implications for PPXY-Dependent Budding

(2010) S. Rauch et al.   JOURNAL OF VIROLOGY

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

Membrane budding and scission by the ESCRT machinery: it's all in the neck

(2010) James H. Hurley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ARRDC3 suppresses breast cancer progression by negatively regulating integrin β4

(2010) K M Draheim et al.   ONCOGENE

Blockade of PAR1 Signaling with Cell-Penetrating Pepducins Inhibits Akt Survival Pathways in Breast Cancer Cells and Suppresses Tumor Survival and Metastasis

(2009) E. Yang et al.   CANCER RESEARCH

PAR1 is selectively over expressed in high grade breast cancer patients: a cohort study

(2009) Norma A Hernández et al.   Journal of Translational Medicine

On the origins of arrestin and rhodopsin

(2008) Carlos E Alvarez   BMC EVOLUTIONARY BIOLOGY

Analysis of Integrin  4 Expression in Human Breast Cancer: Association with Basal-like Tumors and Prognostic Significance

(2008) S. Lu et al.   CLINICAL CANCER RESEARCH

Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion

(2008) P Arora et al.   ONCOGENE