Alzheimer’s Disease: Recent Concepts on the Relation of Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation, and Kynurenines

Recent Progress in Alzheimer’s Disease Research, Part 1: Pathology

(2017) Francis T. Hane et al.   JOURNAL OF ALZHEIMERS DISEASE

Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects against Amyloid-β-Induced Neurotoxicity

(2017) Yan Huang et al.   JOURNAL OF ALZHEIMERS DISEASE

Recent Progress in Alzheimer’s Disease Research, Part 3: Diagnosis and Treatment

(2017) Francis T. Hane et al.   JOURNAL OF ALZHEIMERS DISEASE

Recent Progress in Alzheimer’s Disease Research, Part 2: Genetics and Epidemiology

(2017) Morgan Robinson et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer’s Disease

(2017) Qian Cai et al.   JOURNAL OF ALZHEIMERS DISEASE

Re-imagining Alzheimer's disease - the diminishing importance of amyloid and a glimpse of what lies ahead

(2017) Kai-Hei Tse et al.   JOURNAL OF NEUROCHEMISTRY

Kynurenine pathway metabolites and enzymes involved in redox reactions

(2017) D. González Esquivel et al.   NEUROPHARMACOLOGY

Unlike PPARgamma, neither other PPARs nor PGC-1alpha is elevated in the cerebrospinal fluid of patients with multiple sclerosis

(2017) Levente Szalardy et al.   NEUROSCIENCE LETTERS

Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains

(2017) Wei Wei et al.   Acta Neuropathologica Communications

Erratum to: Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains

(2017) Wei Wei et al.   Acta Neuropathologica Communications

Manipulating Kynurenic Acid Levels in the Brain – On the Edge Between Neuroprotection and Cognitive Dysfunction

(2017) Levente Szalardy et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Mitochondrial Amyloid-β Levels are Associated with the Extent of Mitochondrial Dysfunction in Different Brain Regions and the Degree of Cognitive Impairment in Alzheimer's Transgenic Mice

(2017) Natasa Dragicevic et al.   JOURNAL OF ALZHEIMERS DISEASE

Astrocytic and neuronal localization of kynurenine aminotransferase-2 in the adult mouse brain

(2016) Judit Herédi et al.   Brain Structure & Function

Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012–2015)

(2016) Dénes Zádori et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The Role of Cerebrospinal Fluid Biomarkers in the Evolution of Diagnostic Criteria in Alzheimer’s Disease: Shortcomings in Prodromal Diagnosis

(2016) Levente Szalárdy et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Regulatory Pathways in the Pathogenesis of Alzheimer’s Disease

(2016) Reginald C. Adiele et al.   JOURNAL OF ALZHEIMERS DISEASE

Follow-up evaluation of cognitive function in the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial and its Follow-up Study

(2015)   Alzheimers & Dementia

Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer’s disease

(2015) Amandine Grimm et al.   BIOGERONTOLOGY

Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-β or hyperphosphorylated tau protein

(2015) Amandine Grimm et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β

(2015) Keith A. Vossel et al.   JOURNAL OF CELL BIOLOGY

Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells

(2015) Junghyung Park et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease

(2015) Joannee Zumkehr et al.   NEUROBIOLOGY OF AGING

IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior

(2015) Paramita Chakrabarty et al.   NEURON

Mitochondrial dysfunction related to cell damage induced by 3-hydroxykynurenine and 3-hydroxyanthranilic acid: Non-dependent-effect of early reactive oxygen species production

(2015) J. Reyes-Ocampo et al.   NEUROTOXICOLOGY

Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer’s Disease

(2015) Fabian A. Cabezas-Opazo et al.   Oxidative Medicine and Cellular Longevity

Systemic L-Kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57Bl/6 mice

(2015) Dániel Varga et al.   Frontiers in Behavioral Neuroscience

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

(2015) Jan Lewerenz et al.   Frontiers in Neuroscience

The Janus faces of 3-hydroxykynurenine: Dual redox modulatory activity and lack of neurotoxicity in the rat striatum

(2014) Ana Laura Colín-González et al.   BRAIN RESEARCH

Mitochondrial trafficking and anchoring in neurons: New insight and implications

(2014) Zu-Hang Sheng   JOURNAL OF CELL BIOLOGY

Prostaglandin signaling suppresses beneficial microglial function in Alzheimer’s disease models

(2014) Jenny U. Johansson et al.   JOURNAL OF CLINICAL INVESTIGATION

The endogenous α7 nicotinic acetylcholine receptor antagonist kynurenic acid modulates amyloid-β-induced inflammation in BV-2 microglial cells

(2014) Levke Steiner et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Body Fluid Cytokine Levels in Mild Cognitive Impairment and Alzheimer’s Disease: a Comparative Overview

(2014) Frederic Brosseron et al.   MOLECULAR NEUROBIOLOGY

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

(2014) T. Raj et al.   SCIENCE

Microglia actions in Alzheimer’s disease

(2013) Stefan Prokop et al.   ACTA NEUROPATHOLOGICA

Recombinant soluble neprilysin reduces amyloid-beta accumulation and improves memory impairment in Alzheimer's disease mice

(2013) Min Hee Park et al.   BRAIN RESEARCH

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Principles of the mitochondrial fusion and fission cycle in neurons

(2013) M. Cagalinec et al.   JOURNAL OF CELL SCIENCE

IFN-  Production by Amyloid  -Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease

(2013) T. C. Browne et al.   JOURNAL OF IMMUNOLOGY

Amyloid- 1-42 Slows Clearance of Synaptically Released Glutamate by Mislocalizing Astrocytic GLT-1

(2013) A. Scimemi et al.   JOURNAL OF NEUROSCIENCE

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

(2013) Elizabeth M Bradshaw et al.   NATURE NEUROSCIENCE

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

β-Amyloid impairs the regulation of N-methyl-D-aspartate receptors by glycogen synthase kinase 3

(2013) Yulei Deng et al.   NEUROBIOLOGY OF AGING

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

(2013) Kurt M. Lucin et al.   NEURON

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

NMDA receptors in nervous system diseases

(2013) Qiang Zhou et al.   NEUROPHARMACOLOGY

The neuroprotector kynurenic acid increases neuronal cell survival through neprilysin induction

(2013) Christian Klein et al.   NEUROPHARMACOLOGY

Elevated levels of PPAR-gamma in the cerebrospinal fluid of patients with multiple sclerosis

(2013) Levente Szalardy et al.   NEUROSCIENCE LETTERS

Paradox effects of kynurenines on LTP induction in the Wistar rat. An in vivo study

(2013) I. Demeter et al.   NEUROSCIENCE LETTERS

Quinolinic Acid: An Endogenous Neurotoxin with Multiple Targets

(2013) Rafael Lugo-Huitrón et al.   Oxidative Medicine and Cellular Longevity

Microglia Actively Regulate the Number of Functional Synapses

(2013) Kyungmin Ji et al.   PLoS One

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

(2013) Grietje Krabbe et al.   PLoS One

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation

(2012) Kristina Leuner et al.   ANTIOXIDANTS & REDOX SIGNALING

Effect of Complement CR1 on Brain Amyloid Burden During Aging and Its Modification by APOE Genotype

(2012) Madhav Thambisetty et al.   BIOLOGICAL PSYCHIATRY

Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine - searching for the connections

(2012) Wojciech Danysz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial Disturbances, Tryptophan Metabolites and Neurodegeneration: Medicinal Chemistry Aspects

(2012) L. Szalardy et al.   CURRENT MEDICINAL CHEMISTRY

Increased 3-Hydroxykynurenine serum concentrations differentiate Alzheimer’s disease patients from controls

(2012) Markus J. Schwarz et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Aryl hydrocarbon receptor ligand effects in RBL2H3 cells

(2012) Kristina Maaetoft-Udsen et al.   Journal of Immunotoxicology

PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

(2012) M. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease

(2012) J. L. Furman et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders

(2012) Dénes Zádori et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A New Link to Mitochondrial Impairment in Tauopathies

(2012) Kathrin L. Schulz et al.   MOLECULAR NEUROBIOLOGY

Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition

(2012) Paramita Chakrabarty et al.   Molecular Neurodegeneration

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

(2012) Johannes vom Berg et al.   NATURE MEDICINE

Kynurenines in the CNS: recent advances and new questions

(2012) László Vécsei et al.   NATURE REVIEWS DRUG DISCOVERY

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Neuroinflammatory phenotype in early Alzheimer's disease

(2012) Tiffany L. Sudduth et al.   NEUROBIOLOGY OF AGING

Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study

(2012) Alie Schuitemaker et al.   NEUROBIOLOGY OF AGING

Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo

(2012) Brian DuBoff et al.   NEURON

3-Hydroxykynurenine: An intriguing molecule exerting dual actions in the Central Nervous System

(2012) Ana Laura Colín-González et al.   NEUROTOXICOLOGY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment–dementia converters measured by positron emission tomography with [11C]DAA1106

(2012) Fumihiko Yasuno et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Gas chromatography/tandem mass spectrometry detection of extracellular kynurenine and related metabolites in normal and lesioned rat brain

(2011) Francesca M. Notarangelo et al.   ANALYTICAL BIOCHEMISTRY

Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons

(2011) Marcus J. Calkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Synthesis and biological effects of some kynurenic acid analogs

(2011) K. Nagy et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease

(2011) P. Hemachandra Reddy   BRAIN RESEARCH

Amyloid beta peptide 1–42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures

(2011) I.L. Ferreira et al.   CELL CALCIUM

Impact and Therapeutic Potential of PPARs in Alzheimers Disease

(2011) Michael T. Heneka et al.   Current Neuropharmacology

Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia

(2011) Levente Gellért et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice

(2011) Magali Dumont et al.   FASEB JOURNAL

Multiple cellular and molecular mechanisms Are involved in human Aβ clearance by transplanted adult astrocytes

(2011) Rea Pihlaja et al.   GLIA

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

Behavioural studies with a newly developed neuroprotective KYNA-amide

(2011) Levente Gellért et al.   JOURNAL OF NEURAL TRANSMISSION

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease

(2011) Baiyang Sheng et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of Amyloid-  (A ) Peptide-Binding Alcohol Dehydrogenase-A  Interaction Reduces A  Accumulation and Improves Mitochondrial Function in a Mouse Model of Alzheimer's Disease

(2011) J. Yao et al.   JOURNAL OF NEUROSCIENCE

Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-  Expression for Microglial A  Phagocytosis

(2011) D. Terwel et al.   JOURNAL OF NEUROSCIENCE

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo

(2011) Paramita Chakrabarty et al.   Molecular Neurodegeneration

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Fluctuations in Endogenous Kynurenic Acid Control Hippocampal Glutamate and Memory

(2011) Ana Pocivavsek et al.   NEUROPSYCHOPHARMACOLOGY

On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress

(2011) R. Lugo-Huitrón et al.   NEUROTOXICOLOGY AND TERATOLOGY

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Kynurenine and its metabolites in Alzheimer's disease patients

(2010) E Gulaj et al.   Advances in Medical Sciences

Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory

(2010) Daniela Puzzo et al.   ANNALS OF NEUROLOGY

Protective effect of systemic l-kynurenine and probenecid administration on behavioural and morphological alterations induced by toxic soluble amyloid beta (25–35) in rat hippocampus

(2010) Paul Carrillo-Mora et al.   BEHAVIOURAL BRAIN RESEARCH

The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice

(2010) Dong-Hoon Hyun et al.   EXPERIMENTAL NEUROLOGY

Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease

(2010) Hung-Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kynurenines, neurodegeneration and Alzheimer’s disease

(2010) Zsigmond Tamas Kincses et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Endogenous neuroprotection in chronic neurodegenerative disorders: with particular regard to the kynurenines

(2010) Dénes Zádori et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Neuroprotective effects of a novel kynurenic acid analogue in a transgenic mouse model of Huntington’s disease

(2010) Dénes Zádori et al.   JOURNAL OF NEURAL TRANSMISSION

The role of microglia in amyloid clearance from the AD brain

(2010) C. Y. Daniel Lee et al.   JOURNAL OF NEURAL TRANSMISSION

Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-  Production

(2010) K. Bordji et al.   JOURNAL OF NEUROSCIENCE

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease

(2010) Heather A. Scott et al.   NEUROBIOLOGY OF AGING

Time-course correlation of early toxic events in three models of striatal damage: Modulation by proteases inhibition

(2010) Verónica Pérez-De La Cruz et al.   NEUROCHEMISTRY INTERNATIONAL

Amyloid-β-Derived Diffusible Ligands Cause Impaired Axonal Transport of Mitochondria in Neurons

(2010) Xinglong Wang et al.   Neurodegenerative Diseases

Reduction of Endogenous Kynurenic Acid Formation Enhances Extracellular Glutamate, Hippocampal Plasticity and Cognitive Behavior

(2010) Michelle C Potter et al.   NEUROPSYCHOPHARMACOLOGY

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease

(2010) David J. Bonda et al.   REDOX REPORT

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

(2010) Brett C. DiNatale et al.   TOXICOLOGICAL SCIENCES

PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia

(2009) Weiping Qin et al.   ARCHIVES OF NEUROLOGY

L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning

(2009) Amy C. Chess et al.   BEHAVIOURAL BRAIN RESEARCH

Inflammation in transgenic mouse models of neurodegenerative disorders

(2009) Claudia Schwab et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential

(2009) Laetitia Mony et al.   BRITISH JOURNAL OF PHARMACOLOGY

Syntheses, Transformations and Pharmaceutical Applications of Kynurenic Acid Derivatives

(2009) F. Fulop et al.   CURRENT MEDICINAL CHEMISTRY

Massive gliosis induced by interleukin-6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition

(2009) Paramita Chakrabarty et al.   FASEB JOURNAL

Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons

(2009) Nady Braidy et al.   FEBS Journal

Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies

(2009) D. Zádori et al.   JOURNAL OF NEURAL TRANSMISSION

Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease

(2009) Ka Ting et al.   Journal of Neuroinflammation

Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis

(2009) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E4 (1–272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells

(2009) Toshiyuki Nakamura et al.   Molecular Neurodegeneration

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

(2009) Efrat Abramov et al.   NATURE NEUROSCIENCE

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

The Excitotoxin Quinolinic Acid Induces Tau Phosphorylation in Human Neurons

(2009) Abdur Rahman et al.   PLoS One

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-  and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

(2009) V. Rhein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cognitive Function Over Time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT)

(2008)   ARCHIVES OF NEUROLOGY

Oligomeric and fibrillar species of β-amyloid (Aβ42) both impair mitochondrial function in P301L tau transgenic mice

(2008) Anne Eckert et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Janus-face kynurenic acid

(2008) Éva Rózsa et al.   JOURNAL OF NEURAL TRANSMISSION

The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

(2008) Michela Guglielmotto et al.   JOURNAL OF NEUROCHEMISTRY

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

(2008) Terrence Town et al.   NATURE MEDICINE

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice

(2008) S. Hauptmann et al.   NEUROBIOLOGY OF AGING

Soluble TNF receptors are associated with Aβ metabolism and conversion to dementia in subjects with mild cognitive impairment

(2008) Peder Buchhave et al.   NEUROBIOLOGY OF AGING

Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades

(2008) M. Matos et al.   NEUROSCIENCE

Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slices

(2008) S.M. Goebel-Goody et al.   NEUROSCIENCE

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid beta peptides and glutamatergic synaptic dysregulation

(2007) Kodeeswaran Parameshwaran et al.   EXPERIMENTAL NEUROLOGY