CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential

Diverse Epitope Specificity, Immunodominance Hierarchy, and Functional Avidity of Effector CD4 T Cells Established During Priming Is Maintained in Lung After Influenza A Virus Infection

(2018) Katherine A. Richards et al.   Frontiers in Immunology

The Pathway to a Universal Influenza Vaccine

(2017) Catharine I. Paules et al.   IMMUNITY

CD4 + T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness

(2017) Tomasz Ahrends et al.   IMMUNITY

Targeting C-type lectin receptors: a high-carbohydrate diet for dendritic cells to improve cancer vaccines

(2017) Dieke van Dinther et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cytotoxic CD4 T Cells—Friend or Foe during Viral Infection?

(2017) Jennifer A. Juno et al.   Frontiers in Immunology

The Other Function: Class II-Restricted Antigen Presentation by B Cells

(2017) Lital N. Adler et al.   Frontiers in Immunology

CD4 CTL, a Cytotoxic Subset of CD4+ T Cells, Their Differentiation and Function

(2017) Arata Takeuchi et al.   Frontiers in Immunology

Selective pre-priming of HA-specific CD4 T cells restores immunological reactivity to HA on heterosubtypic influenza infection

(2017) Shabnam Alam et al.   PLoS One

Maternal influenza vaccine strategies in Kenya: Which approach would have the greatest impact on disease burden in pregnant women and young infants?

(2017) Meredith L. McMorrow et al.   PLoS One

Pandemic 2009 H1N1 Influenza Venus reporter virus reveals broad diversity of MHC class II-positive antigen-bearing cells following infection in vivo

(2017) Anthony DiPiazza et al.   Scientific Reports

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

Standing on three legs: antiviral activities of RIG-I against influenza viruses

(2016) Michaela Weber-Gerlach et al.   CURRENT OPINION IN IMMUNOLOGY

CD4+ T-cell help amplifies innate signals for primary CD8+ T-cell immunity

(2016) Sammy Bedoui et al.   IMMUNOLOGICAL REVIEWS

Competition within the virus-specific CD4 T-cell pool limits the T follicular helper response after influenza infection

(2016) Matthew R Olson et al.   IMMUNOLOGY AND CELL BIOLOGY

Seasonal influenza vaccine policy, use and effectiveness in the tropics and subtropics - a systematic literature review

(2016) Siddhivinayak Hirve et al.   Influenza and Other Respiratory Viruses

Human Circulating T Follicular Helper Cell Subsets in Health and Disease

(2016) Hideki Ueno   JOURNAL OF CLINICAL IMMUNOLOGY

Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8 + T cells

(2016) Andreas Muschaweckh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection

(2016) Nikki B. Marshall et al.   JOURNAL OF IMMUNOLOGY

Priming Vaccination With Influenza Virus H5 Hemagglutinin Antigen Significantly Increases the Duration of T cell Responses Induced by a Heterologous H5 Booster Vaccination

(2016) Daniel F. Hoft et al.   JOURNAL OF INFECTIOUS DISEASES

Mosaic H5 Hemagglutinin Provides Broad Humoral and Cellular Immune Responses against Influenza Viruses

(2016) Attapon Kamlangdee et al.   JOURNAL OF VIROLOGY

Antigen Presentation to B Cells

(2016) Balthasar A. Heesters et al.   TRENDS IN IMMUNOLOGY

Vaccination of special populations: Protecting the vulnerable

(2016) Mark Doherty et al.   VACCINE

A global review of national influenza immunization policies: Analysis of the 2014 WHO/UNICEF Joint Reporting Form on immunization

(2016) Justin R. Ortiz et al.   VACCINE

Universal influenza vaccines: Shifting to better vaccines

(2016) Francesco Berlanda Scorza et al.   VACCINE

Binding of RNA by the Nucleoproteins of Influenza Viruses A and B

(2016) Alice Labaronne et al.   Viruses-Basel

Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining

(2016) Hannes Uchtenhagen et al.   Nature Communications

Epitope-Specific Vaccination Limits Clonal Expansion of Heterologous Naive T Cells during Viral Challenge

(2016) Lexus R. Johnson et al.   Cell Reports

Heterosubtypic T-Cell Immunity to Influenza in Humans: Challenges for Universal T-Cell Influenza Vaccines

(2016) Saranya Sridhar   Frontiers in Immunology

New Insights into the Generation of CD4 Memory May Shape Future Vaccine Strategies for Influenza

(2016) Priyadharshini Devarajan et al.   Frontiers in Immunology

The Differentiation and Protective Function of Cytolytic CD4 T Cells in Influenza Infection

(2016) Deborah M. Brown et al.   Frontiers in Immunology

The Role of CD4 T Cell Memory in Generating Protective Immunity to Novel and Potentially Pandemic Strains of Influenza

(2016) Anthony DiPiazza et al.   Frontiers in Immunology

Viral Escape Mutant Epitope Maintains TCR Affinity for Antigen yet Curtails CD8 T Cell Responses

(2016) Shayla K. Shorter et al.   PLoS One

Natural T Cell–mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study

(2015) Andrew C. Hayward et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

(2015) Jamie Rossjohn et al.   Annual Review of Immunology

The Nicaraguan pediatric influenza cohort study: design, methods, use of technology, and compliance

(2015) Aubree Gordon et al.   BMC INFECTIOUS DISEASES

The regulation of T follicular helper responses during infection

(2015) Noah S Butler et al.   CURRENT OPINION IN IMMUNOLOGY

T cells compete by cleaving cell surface CD27 and blocking access to CD70-bearing APCs

(2015) Matthew A. Burchill et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Epitope specific T-cell responses against influenza A in a healthy population

(2015) Miloje Savic et al.   IMMUNOLOGY

Effect of Varying Doses of a Monovalent H7N9 Influenza Vaccine With and Without AS03 and MF59 Adjuvants on Immune Response

(2015) Lisa A. Jackson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

T follicular regulatory cells in the regulation of B cell responses

(2015) Peter T. Sage et al.   TRENDS IN IMMUNOLOGY

A global map of hemispheric influenza vaccine recommendations based on local patterns of viral circulation

(2015) Wladimir J. Alonso et al.   Scientific Reports

Diverse Heterologous Primary Infections Radically Alter Immunodominance Hierarchies and Clinical Outcomes Following H7N9 Influenza Challenge in Mice

(2015) Susu Duan et al.   PLoS Pathogens

Deconstructing the Peptide-MHC Specificity of T Cell Recognition

(2014) Michael E. Birnbaum et al.   CELL

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection

(2014) Brian J. Laidlaw et al.   IMMUNITY

Immunodominance of CD4 T Cells to Foreign Antigens Is Peptide Intrinsic and Independent of Molecular Context: Implications for Vaccine Design

(2014) J. M. Weaver et al.   JOURNAL OF IMMUNOLOGY

Healthy Human Subjects Have CD4+ T Cells Directed against H5N1 Influenza Virus

(2014) M. Roti et al.   JOURNAL OF IMMUNOLOGY

IDO-Independent Suppression of T Cell Effector Function by IFN- -Licensed Human Mesenchymal Stromal Cells

(2014) R. Chinnadurai et al.   JOURNAL OF IMMUNOLOGY

Effect of Influenza A(H5N1) Vaccine Prepandemic Priming on CD4+ T-Cell Responses

(2014) Jennifer L. Nayak et al.   JOURNAL OF INFECTIOUS DISEASES

Seasonal Influenza Can Poise Hosts for CD4 T-Cell Immunity to H7N9 Avian Influenza

(2014) Katherine A. Richards et al.   JOURNAL OF INFECTIOUS DISEASES

Immunodominant CD4+ T-Cell Responses to Influenza A Virus in Healthy Individuals Focus on Matrix 1 and Nucleoprotein

(2014) L. Chen et al.   JOURNAL OF VIROLOGY

The Pulmonary Localization of Virus-Specific T Lymphocytes Is Governed by the Tissue Tropism of Infection

(2014) C. J. Knudson et al.   JOURNAL OF VIROLOGY

At the centre: influenza A virus ribonucleoproteins

(2014) Amie J. Eisfeld et al.   NATURE REVIEWS MICROBIOLOGY

Enabling the 'host jump': structural determinants of receptor-binding specificity in influenza A viruses

(2014) Yi Shi et al.   NATURE REVIEWS MICROBIOLOGY

Inflammation Enhances IL-2 Driven Differentiation of Cytolytic CD4 T Cells

(2014) Aspen M. Workman et al.   PLoS One

Alteration of Protein Levels during Influenza Virus H1N1 Infection in Host Cells: A Proteomic Survey of Host and Virus Reveals Differential Dynamics

(2014) Susann Kummer et al.   PLoS One

Heterologous Prime-Boost Vaccination with MF59-Adjuvanted H5 Vaccines Promotes Antibody Affinity Maturation towards the Hemagglutinin HA1 Domain and Broad H5N1 Cross-Clade Neutralization

(2014) Surender Khurana et al.   PLoS One

Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation

(2014) S. Keck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Cell Culture-Derived MF59-Adjuvanted Pandemic A/H7N9 Vaccine Is Immunogenic in Adults

(2014) S. A. Bart et al.   Science Translational Medicine

T cell mediated immunity to influenza: mechanisms of viral control

(2014) Nicole L. La Gruta et al.   TRENDS IN IMMUNOLOGY

Factors associated with influenza vaccine receipt in community dwelling adults and their children

(2014) Ryan Malosh et al.   VACCINE

Early BCR Events and Antigen Capture, Processing, and Loading on MHC Class II on B Cells

(2014) Ana M. Avalos et al.   Frontiers in Immunology

Molecular Mechanisms of Inhibition of Influenza by Surfactant Protein D Revealed by Large-Scale Molecular Dynamics Simulation

(2013) Boon Chong Goh et al.   BIOCHEMISTRY

The role of lung dendritic cell subsets in immunity to respiratory viruses

(2013) Katrijn Neyt et al.   IMMUNOLOGICAL REVIEWS

Influenza vaccines: an Asia-Pacific perspective

(2013) Lance C. Jennings   Influenza and Other Respiratory Viruses

CD4+ T cells recognize unique and conserved 2009 H1N1 influenza hemagglutinin epitopes after natural infection and vaccination

(2013) Junbao Yang et al.   INTERNATIONAL IMMUNOLOGY

Viral infection of the lung: Host response and sequelae

(2013) Jae-Kwang Yoo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Competition for Antigen at the Level of the APC Is a Major Determinant of Immunodominance during Memory Inflation in Murine Cytomegalovirus Infection

(2013) L. A. Farrington et al.   JOURNAL OF IMMUNOLOGY

Orchestration of CD4 T Cell Epitope Preferences after Multipeptide Immunization

(2013) J. Tung et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Heterosubtypic Influenza Infection Antagonizes Elicitation of Immunological Reactivity to Hemagglutinin

(2013) J. L. Nayak et al.   JOURNAL OF IMMUNOLOGY

CD4 T Cell Help Is Limiting and Selective during the Primary B Cell Response to Influenza Virus Infection

(2013) S. Alam et al.   JOURNAL OF VIROLOGY

Cytokine-Dependent Induction of CD4+ T cells with Cytotoxic Potential during Influenza Virus Infection

(2013) L. Hua et al.   JOURNAL OF VIROLOGY

Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus

(2013) Stephanie K. Dougan et al.   NATURE

Burden of Seasonal and Pandemic Influenza-Associated Hospitalization during and after 2009 A(H1N1)pdm09 Pandemic in a Rural Community in India

(2013) Mandeep S. Chadha et al.   PLoS One

The versatility of the αβ T-cell antigen receptor

(2013) Mugdha Bhati et al.   PROTEIN SCIENCE

Evaluation of safety and immunogenicity of recombinant influenza hemagglutinin (H5/Indonesia/05/2005) formulated with and without a stable oil-in-water emulsion containing glucopyranosyl-lipid A (SE+GLA) adjuvant

(2013) John J. Treanor et al.   VACCINE

H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity

(2013) D. M. Morens et al.   mBio

Role of T cell immunity in recovery from influenza virus infection

(2013) Jie Sun et al.   Current Opinion in Virology

Low immunogenicity predicted for emerging avian-origin H7N9

(2013) Anne S. De Groot et al.   Human Vaccines & Immunotherapeutics

The Control of the Specificity of CD4 T Cell Responses: Thresholds, Breakpoints, and Ceilings

(2013) Andrea J. Sant et al.   Frontiers in Immunology

Two Distinct Epitopes on the Ovalbumin 323-339 Peptide Differentiating CD4+T Cells into the Th2 or Th1 Phenotype

(2012) Haruyo NAKAJIMA-ADACHI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Using an Ancient Tool for Igniting and Propagating Immune Tolerance: IDO as an Inducer and Amplifier of Regulatory T Cell Functions

(2012) F. Fallarino et al.   CURRENT MEDICINAL CHEMISTRY

Indoleamine 2,3-dioxygenase: From catalyst to signaling function

(2012) Francesca Fallarino et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

From crucial to negligible: Functional CD8+T-cell responses and their dependence on CD4+T-cell help

(2012) Melanie Wiesel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function

(2012) Michael E. Birnbaum et al.   IMMUNOLOGICAL REVIEWS

CD4+ T-Cell Expansion Predicts Neutralizing Antibody Responses to Monovalent, Inactivated 2009 Pandemic Influenza A(H1N1) Virus Subtype H1N1 Vaccine

(2012) Jennifer L. Nayak et al.   JOURNAL OF INFECTIOUS DISEASES

Multifunctional CD4 Cells Expressing Gamma Interferon and Perforin Mediate Protection against Lethal Influenza Virus Infection

(2012) D. M. Brown et al.   JOURNAL OF VIROLOGY

How the TCR balances sensitivity and specificity for the recognition of self and pathogens

(2012) Gerald P Morris et al.   NATURE IMMUNOLOGY

Incidence and Epidemiology of Hospitalized Influenza Cases in Rural Thailand during the Influenza A (H1N1)pdm09 Pandemic, 2009–2010

(2012) Henry C. Baggett et al.   PLoS One

Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins

(2012) Katherine A. Richards et al.   VACCINE

Blood sample volumes in child health research: review of safe limits

(2011) Stephen RC Howie   BULLETIN OF THE WORLD HEALTH ORGANIZATION

CD8+T-cell cross-competition is governed by peptide-MHC class I stability

(2011) Ian Galea et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Structural and biophysical determinants of αβ T-cell antigen recognition

(2011) John S. Bridgeman et al.   IMMUNOLOGY

The memory phase of the CD4 T-cell response to influenza virus infection maintains its diverse antigen specificity

(2011) Katherine A. Richards et al.   IMMUNOLOGY

Hallmarks of CD4 T cell immunity against influenza

(2011) K. K. McKinstry et al.   JOURNAL OF INTERNAL MEDICINE

The kynurenine system and immunoregulation

(2011) Yvette Mándi et al.   JOURNAL OF NEURAL TRANSMISSION

Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis

(2011) Harish Nair et al.   LANCET

CD4+ T cells support cytotoxic T lymphocyte priming by controlling lymph node input

(2011) Y. Kumamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MF59 Adjuvant Enhances Diversity and Affinity of Antibody-Mediated Immune Response to Pandemic Influenza Vaccines

(2011) S. Khurana et al.   Science Translational Medicine

T cell responses during influenza infection: getting and keeping control

(2011) Taeg S. Kim et al.   TRENDS IN IMMUNOLOGY

Influenza vaccine for pregnant women in resource-constrained countries: A review of the evidence to inform policy decisions

(2011) Justin R. Ortiz et al.   VACCINE

Influenza virus assembly and budding

(2011) Jeremy S. Rossman et al.   VIROLOGY

Induction and evasion of type I interferon responses by influenza viruses

(2011) Adolfo García-Sastre   VIRUS RESEARCH

Cytolytic CD4 cells: Direct mediators in infectious disease and malignancy

(2010) Deborah M. Brown   CELLULAR IMMUNOLOGY

Clinical Attack Rate and Presentation of Pandemic H1N1 Influenza versus Seasonal Influenza A and B in a Pediatric Cohort in Nicaragua

(2010) Aubree Gordon et al.   CLINICAL INFECTIOUS DISEASES

Repetitive Antigen Stimulation Induces Stepwise Transcriptome Diversification but Preserves a Core Signature of Memory CD8+ T Cell Differentiation

(2010) Thomas C. Wirth et al.   IMMUNITY

MHC Class II epitope predictive algorithms

(2010) Morten Nielsen et al.   IMMUNOLOGY

Memory CD4 T cells: generation, reactivation and re-assignment

(2010) Megan K.L. MacLeod et al.   IMMUNOLOGY

Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection

(2010) Taeg S. Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: CD4 T Cells Generated from Encounter with Seasonal Influenza Viruses and Vaccines Have Broad Protein Specificity and Can Directly Recognize Naturally Generated Epitopes Derived from the Live Pandemic H1N1 Virus

(2010) K. A. Richards et al.   JOURNAL OF IMMUNOLOGY

Memory CD4 T Cells Direct Protective Responses to Influenza Virus in the Lungs through Helper-Independent Mechanisms

(2010) J. R. Teijaro et al.   JOURNAL OF VIROLOGY

Memory CD4+ T cells induce innate responses independently of pathogen

(2010) Tara M Strutt et al.   NATURE MEDICINE

Structure of influenza virus ribonucleoprotein complexes and their packaging into virions

(2010) Takeshi Noda et al.   REVIEWS IN MEDICAL VIROLOGY

Role of T cell competition in the induction of cytotoxic T lymphocyte activity during viral vector-based immunization regimens

(2010) Annechien J.A. Lambeck et al.   VACCINE

It's All About Change: The Antigen-driven Initiation of B-Cell Receptor Signaling

(2010) W. Liu et al.   Cold Spring Harbor Perspectives in Biology

IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells

(2009) Deborah M. Brown et al.   CELLULAR IMMUNOLOGY

Genome-wide screening of human T-cell epitopes in influenza A virus reveals a broad spectrum of CD4+ T-cell responses to internal proteins, hemagglutinins, and neuraminidases

(2009) Jenny Aurielle B. Babon et al.   HUMAN IMMUNOLOGY

Infection of HLA-DR1 Transgenic Mice with a Human Isolate of Influenza A Virus (H1N1) Primes a Diverse CD4 T-Cell Repertoire That Includes CD4 T Cells with Heterosubtypic Cross-Reactivity to Avian (H5N1) Influenza Virus

(2009) K. A. Richards et al.   JOURNAL OF VIROLOGY

Abortive activation of CD4 T cell responses during competitive priming in vivo

(2009) J. M. Weaver et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels

(2009) G. Galli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of HLA class II H5N1 hemagglutinin epitopes following subvirion influenza A (H5N1) vaccination

(2009) John W. Zinckgraf et al.   VACCINE

Host Restriction of Avian Influenza Viruses at the Level of the Ribonucleoproteins

(2008) Nadia Naffakh et al.   Annual Review of Microbiology

DC-SIGN mediates avian H5N1 influenza virus infection in cis and in trans

(2008) Sheng-Fan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

T cell receptor specificity for major histocompatibility complex proteins

(2008) Philippa Marrack et al.   CURRENT OPINION IN IMMUNOLOGY

Cytotoxic human CD4+ T cells

(2008) Pablo J van de Berg et al.   CURRENT OPINION IN IMMUNOLOGY

Immune Responses of Healthy Subjects to a Single Dose of Intramuscular Inactivated Influenza A/Vietnam/1203/2004 (H5N1) Vaccine after Priming with an Antigenic Variant

(2008) Nega Ali Goji et al.   JOURNAL OF INFECTIOUS DISEASES

Immunomic Analysis of the Repertoire of T-Cell Specificities for Influenza A Virus in Humans

(2008) E. Assarsson et al.   JOURNAL OF VIROLOGY

In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses

(2008) Mary Dawn T. Co et al.   VACCINE