期刊
CURRENT OPINION IN IMMUNOLOGY
卷 42, 期 -, 页码 71-75出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2016.05.016
关键词
-
类别
资金
- Deutsche Forschungsgemeinschaft (DFG) [SFB 1021, SPP1596]
- Japan Society for the Promotion of Science (JSPS)
Influenza A virus (FLUAV) is a severe pathogen of humans, able to unleash epidemics and pandemics of respiratory disease. For the host to survive virus infection, it is essential to rapidly recognize the pathogen and induce the synthesis of antiviral type I interferons (IFNs). The IFN system provides a broad spectrum of sensors that respond to conserved, virus associated molecular patterns. For FLUAV, the RNA helicase RIG-I represents the major innate immune sensor, mainly binding and reacting to the 5' triphosphate dsRNA 'panhandle' that is formed by the conserved 5' and 3' end sequences of the viral ssRNA genome. Besides the well-known function of RIG-I in the signaling chain that leads to IFN induction, recent data suggests that RIG-I performs also other antiviral activities. In this review, we summarize the current knowledge on RIG-I mediated recognition of FLUAV, and how RIG-I interferes with virus replication. We will highlight three major functions of RIG-I against FLUAV: IFN induction, signaling-independent direct antiviral activity, and assembly of an inflammasome.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据