Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function

Distinct CDR3 Conformations in TCRs Determine the Level of Cross-Reactivity for Diverse Antigens, but Not the Docking Orientation

(2014) L. L. Jones et al.   JOURNAL OF IMMUNOLOGY

Cytometry by Time-of-Flight Shows Combinatorial Cytokine Expression and Virus-Specific Cell Niches within a Continuum of CD8+ T Cell Phenotypes

(2012) Evan W. Newell et al.   IMMUNITY

Positive Selection in the Thymus: An Enigma Wrapped in a Mystery

(2012) S. M. Hedrick   JOURNAL OF IMMUNOLOGY

The Role of Naive T Cell Precursor Frequency and Recruitment in Dictating Immune Response Magnitude

(2012) M. K. Jenkins et al.   JOURNAL OF IMMUNOLOGY

Monoclonal TCR-redirected tumor cell killing

(2012) Nathaniel Liddy et al.   NATURE MEDICINE

Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4

(2012) Y. Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes

(2011) R. L. Warren et al.   GENOME RESEARCH

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

(2011) Jarrett J. Adams et al.   IMMUNITY

A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers

(2011) Lei Yin et al.   IMMUNITY

A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides

(2011) Linda Wooldridge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4+T cell responses

(2011) Joseph J. Sabatino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Mechanism for TCR Sharing between T Cell Subsets and Individuals Revealed by Pyrosequencing

(2011) Vanessa Venturi et al.   JOURNAL OF IMMUNOLOGY

Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex

(2011) X. X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell surface display of functional human MHC class II proteins: yeast display versus insect cell display

(2011) Fei Wen et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

Human T-cell memory consists mainly of unexpanded clones

(2010) Paul L. Klarenbeek et al.   IMMUNOLOGY LETTERS

Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection

(2010) Jeremy Juang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Altered Peptide Ligands Make Their Entry

(2010) E. R. Unanue   JOURNAL OF IMMUNOLOGY

High-affinity T cell receptor differentiates cognate peptide–MHC and altered peptide ligands with distinct kinetics and thermodynamics

(2010) Stephen P. Persaud et al.   MOLECULAR IMMUNOLOGY

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

Peptide-MHC Cellular Microarray with Innovative Data Analysis System for Simultaneously Detecting Multiple CD4 T-Cell Responses

(2010) Xinhui Ge et al.   PLoS One

Dendritic cells control T cell tonic signaling required for responsiveness to foreign antigen

(2010) K. Hochweller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput engineering and analysis of peptide binding to class II MHC

(2010) W. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets

(2010) C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors

(2010) D. H. Aggen et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Overlap and Effective Size of the Human CD8+ T Cell Receptor Repertoire

(2010) H. S. Robins et al.   Science Translational Medicine

Comprehensive assessment of T-cell receptor  -chain diversity in    T cells

(2009) H. S. Robins et al.   BLOOD

Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing

(2009) J. D. Freeman et al.   GENOME RESEARCH

T Cell Allorecognition via Molecular Mimicry

(2009) Whitney A. Macdonald et al.   IMMUNITY

New Design of MHC Class II Tetramers to Accommodate Fundamental Principles of Antigen Presentation

(2009) E. Landais et al.   JOURNAL OF IMMUNOLOGY

Modular Nucleic Acid Assembled p/MHC Microarrays for Multiplexed Sorting of Antigen-Specific T Cells

(2009) Gabriel A. Kwong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The molecular basis of TCR germline bias for MHC is surprisingly simple

(2009) K Christopher Garcia et al.   NATURE IMMUNOLOGY

Simultaneous detection of many T-cell specificities using combinatorial tetramer staining

(2009) Evan W Newell et al.   NATURE METHODS

High-Throughput Sequencing of the Zebrafish Antibody Repertoire

(2009) J. A. Weinstein et al.   SCIENCE

Next-Generation DNA Sequencing Methods

(2008) Elaine R. Mardis   Annual Review of Genomics and Human Genetics

Different Thermodynamic Binding Mechanisms and Peptide Fine Specificities Associated with a Panel of Structurally Similar High-Affinity T Cell Receptors†‡

(2008) Lindsay L. Jones et al.   BIOCHEMISTRY

Immunogenically optimized peptides derived from natural mutants of HIV CTL epitopes and peptide combinatorial libraries

(2008) Sylvie E. Blondelle et al.   BIOPOLYMERS

Endogenous Naive CD8+ T Cell Precursor Frequency Regulates Primary and Memory Responses to Infection

(2008) Joshua J. Obar et al.   IMMUNITY

Rapid identification of CD4+ T-cell epitopes using yeast displaying pathogen-derived peptide library

(2008) Fei Wen et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Engineering higher affinity T cell receptors using a T cell display system

(2008) Adam S. Chervin et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Peptide-binding motif prediction by using phage display library for SasaUBA*0301, a resistance haplotype of MHC class I molecule from Atlantic Salmon (Salmo salar)

(2008) Heng Zhao et al.   MOLECULAR IMMUNOLOGY

Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain VαVβ fragments

(2008) Sarah A. Richman et al.   MOLECULAR IMMUNOLOGY

Next-generation DNA sequencing

(2008) Jay Shendure et al.   NATURE BIOTECHNOLOGY

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

(2008) Angel Varela-Rohena et al.   NATURE MEDICINE