Parkinson’s disease-linked DNAJC13 mutation aggravates alpha-synuclein-induced neurotoxicity through perturbation of endosomal trafficking

Longitudinal study of cognitive and cerebral metabolic changes in Parkinson's disease

(2017) Toru Baba et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes

(2017) Anne Norris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Trafficking Illuminates a Path to Parkinson’s Disease

(2017) Takafumi Hasegawa et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

(2016) Patrick P. Michel et al.   NEURON

Endocytic membrane trafficking and neurodegenerative disease

(2015) Andrea M. A. Schreij et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling

(2015) Maria J. Gomez-Lamarca et al.   JOURNAL OF CELL BIOLOGY

The endosomal pathway in Parkinson's disease

(2015) Rebecca M. Perrett et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation

(2014) Ian J. McGough et al.   CURRENT BIOLOGY

Lys-63-linked Ubiquitination by E3 Ubiquitin Ligase Nedd4-1 Facilitates Endosomal Sequestration of Internalized α-Synuclein

(2014) Naoto Sugeno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation

(2014) C. L. Freeman et al.   JOURNAL OF CELL SCIENCE

DNAJC13genetic variants in parkinsonism

(2014) Emil K. Gustavsson et al.   MOVEMENT DISORDERS

Clinical, positron emission tomography, and pathological studies of DNAJC13 p.N855S Parkinsonism

(2014) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease

(2014) Emiko Miura et al.   NEUROBIOLOGY OF DISEASE

Neural Substrates of Cognitive Subtypes in Parkinson's Disease: A 3-Year Longitudinal Study

(2014) Yumiko Shoji et al.   PLoS One

Regulation of WASH-Dependent Actin Polymerization and Protein Trafficking by Ubiquitination

(2013) Yi-Heng Hao et al.   CELL

The secreted oligomeric form of α-synuclein affects multiple steps of membrane trafficking

(2013) Ye-Jin Chai et al.   FEBS LETTERS

DNAJC13 mutations in Parkinson disease

(2013) Carles Vilariño-Güell et al.   HUMAN MOLECULAR GENETICS

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

(2013) David A. MacLeod et al.   NEURON

Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis

(2013) David Freeman et al.   PLoS One

Retromer-mediated endosomal protein sorting: all WASHed up!

(2013) Matthew N.J. Seaman et al.   TRENDS IN CELL BIOLOGY

Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

(2012) Masatoshi Konno et al.   Molecular Neurodegeneration

A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease

(2011) Alexander Zimprich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

VPS35 Mutations in Parkinson Disease

(2011) Carles Vilariño-Güell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human α-synuclein modulates vesicle trafficking through its interaction with prenylated Rab acceptor protein 1

(2011) Hak Joo Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Receptor mediated endocytosis 8 is a novel PI(3)P binding protein regulated by myotubularin-related 2

(2011) Besa Xhabija et al.   FEBS LETTERS

Identification of a novel candidate gene for non-syndromic autosomal recessive intellectual disability: the WASH complex member SWIP

(2011) F. Ropers et al.   HUMAN MOLECULAR GENETICS

Differentiating Parkinson’s disease from multiple system atrophy by [123I] meta-iodobenzylguanidine myocardial scintigraphy and olfactory test

(2011) Akio Kikuchi et al.   PARKINSONISM & RELATED DISORDERS

Improved Immunodetection of Endogenous α-Synuclein

(2011) Byung Rho Lee et al.   PLoS One

The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of α-Synuclein

(2011) Takafumi Hasegawa et al.   PLoS One

SNX-BAR-Mediated Endosome Tubulation is Co-ordinated with Endosome Maturation

(2011) Jan R.T. van Weering et al.   TRAFFIC

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Arp2/3 Activator WASH Controls the Fission of Endosomes through a Large Multiprotein Complex

(2009) Emmanuel Derivery et al.   DEVELOPMENTAL CELL

A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting

(2009) Timothy S. Gomez et al.   DEVELOPMENTAL CELL

Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8

(2009) Anbing Shi et al.   EMBO JOURNAL

Analysis of Articulation Between Clathrin and Retromer in Retrograde Sorting on Early Endosomes

(2009) Vincent Popoff et al.   TRAFFIC

Human RME-8 Is Involved in Membrane Trafficking through Early Endosomes

(2008) Akemi Fujibayashi et al.   CELL STRUCTURE AND FUNCTION

A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C . elegans

(2008) Tomoki Kuwahara et al.   HUMAN MOLECULAR GENETICS

Calcium(II) selectively induces α-synuclein annular oligomers via interaction with the C-terminal domain

(2004) Rachel Lowe et al.   PROTEIN SCIENCE